DK1076561T3 - Kombinationsterapi til behandlingen af tumorer - Google Patents

Kombinationsterapi til behandlingen af tumorer

Info

Publication number: DK1076561T3
Authority: DK; Denmark
Prior art keywords: combination therapy; tumors; treatment; gastrin; combination
Prior art date: 1998-05-15

Application number

DK99921972T

Other languages

Danish (da)

English (en)

Inventor

Philip C Gevas

Stephen Grimes

Dov Michaeli

Stephen L Karr

Susan A Watson

Original Assignee

Aphton Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-15

Filing date

1999-05-14

Publication date

2005-06-06

1999-05-14 Application filed by Aphton Corp filed Critical Aphton Corp

2005-06-06 Application granted granted Critical

2005-06-06 Publication of DK1076561T3 publication Critical patent/DK1076561T3/da

Links

206010028980 Neoplasm Diseases 0.000 title abstract 2
238000002648 combination therapy Methods 0.000 title abstract 2
FOQYDURHXZVLFT-UHFFFAOYSA-N 2-phenyl-2-pyridin-2-ylethanethioamide Chemical compound C=1C=CC=NC=1C(C(=S)N)C1=CC=CC=C1 FOQYDURHXZVLFT-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 abstract 1
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 abstract 1
102100021022 Gastrin Human genes 0.000 abstract 1
108010052343 Gastrins Proteins 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 abstract 1
229940127089 cytotoxic agent Drugs 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
229960002949 fluorouracil Drugs 0.000 abstract 1
VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 abstract 1
235000008191 folinic acid Nutrition 0.000 abstract 1
239000011672 folinic acid Substances 0.000 abstract 1
238000002649 immunization Methods 0.000 abstract 1
230000003053 immunization Effects 0.000 abstract 1
230000002163 immunogen Effects 0.000 abstract 1
229960001691 leucovorin Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2207—Gastrins; Cholecystokinins [CCK]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Epidemiology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Mycology (AREA)
Endocrinology (AREA)
Microbiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK99921972T 1998-05-15 1999-05-14 Kombinationsterapi til behandlingen af tumorer DK1076561T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8568798P	1998-05-15	1998-05-15
PCT/US1999/010750 WO1999059628A2 (en)	1998-05-15	1999-05-14	Combination therapy for the treatment of tumors

Publications (1)

Publication Number	Publication Date
DK1076561T3 true DK1076561T3 (da)	2005-06-06

Family

ID=22193286

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99921972T DK1076561T3 (da)	1998-05-15	1999-05-14	Kombinationsterapi til behandlingen af tumorer

Country Status (15)

Country	Link
EP (1)	EP1076561B1 (de)
JP (1)	JP2002515457A (de)
KR (1)	KR100699574B1 (de)
CN (1)	CN1216605C (de)
AT (1)	ATE291918T1 (de)
AU (1)	AU745749B2 (de)
CA (1)	CA2327439C (de)
DE (1)	DE69924483T2 (de)
DK (1)	DK1076561T3 (de)
ES (1)	ES2237103T3 (de)
HU (1)	HUP0101947A3 (de)
PL (1)	PL193109B1 (de)
PT (1)	PT1076561E (de)
WO (1)	WO1999059628A2 (de)
ZA (1)	ZA200005962B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2005508838A (ja) *	2001-03-23	2005-04-07	アフトンコーポレーション	膵癌の組合せ治療
AU2002326356A1 (en) *	2001-07-09	2003-01-29	Aphton Corporation	Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus
US20040208920A1 (en) *	2002-07-03	2004-10-21	Dov Michaeli	Liposomal vaccine
WO2004088326A2 (en)	2003-03-28	2004-10-14	Aphton Corporation	Gastrin hormone immunoassays
US20050053664A1 (en) *	2003-09-08	2005-03-10	Eliezer Zomer	Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer
US8674064B2 (en)	2010-03-03	2014-03-18	Onkologix Ltd	Immunogenic compositions against human progastrin peptides
CN101797382B (zh) *	2010-03-03	2013-11-20	戚胜美	抗人前胃液素多肽免疫组合物
EA201100464A1 (ru) *	2011-04-06	2012-10-30	Ооо "Метамакс" (Ооо "Метамах")	Фармацевтическая композиция для лечения гиперпролиферативных заболеваний и её применение
CA2929858C (en)	2013-11-22	2022-03-29	CL BioSciences LLC	Gastrin antagonists (eg yf476, netazepide) for treatment and prevention of osteoporosis
KR102772810B1 (ko)	2017-06-15	2025-02-28	캔서 어드밴시스 아이엔씨	종양 및 암에 대한 체액성 및 세포 면역을 유도하기 위한 조성물 및 방법
US12150978B2 (en)	2017-06-15	2024-11-26	Cancer Advances Inc.	Compositions and methods for preventing tumors and cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1341281C (en) *	1986-07-09	2001-08-07	Hubert J.P. Schoemaker	Immunotherapy of tumor with monoclonal antibody against the 17-1a antigen
ES2063912T3 (es) *	1989-01-24	1995-01-16	Aphton Corp	Composiciones inmunogenicas frente a peptidos de gastrina.
US5468494A (en) *	1993-11-12	1995-11-21	Aphton Corp.	Immunogenic compositions against human gastrin 17

1999
- 1999-05-14 JP JP2000549292A patent/JP2002515457A/ja active Pending
- 1999-05-14 KR KR1020007012783A patent/KR100699574B1/ko not_active Expired - Fee Related
- 1999-05-14 WO PCT/US1999/010750 patent/WO1999059628A2/en not_active Ceased
- 1999-05-14 PL PL344414A patent/PL193109B1/pl not_active IP Right Cessation
- 1999-05-14 AT AT99921972T patent/ATE291918T1/de not_active IP Right Cessation
- 1999-05-14 DE DE69924483T patent/DE69924483T2/de not_active Expired - Lifetime
- 1999-05-14 ES ES99921972T patent/ES2237103T3/es not_active Expired - Lifetime
- 1999-05-14 AU AU39045/99A patent/AU745749B2/en not_active Expired
- 1999-05-14 CA CA002327439A patent/CA2327439C/en not_active Expired - Lifetime
- 1999-05-14 DK DK99921972T patent/DK1076561T3/da active
- 1999-05-14 CN CN998060119A patent/CN1216605C/zh not_active Expired - Lifetime
- 1999-05-14 HU HU0101947A patent/HUP0101947A3/hu unknown
- 1999-05-14 EP EP99921972A patent/EP1076561B1/de not_active Expired - Lifetime
- 1999-05-14 PT PT99921972T patent/PT1076561E/pt unknown
2000
- 2000-10-24 ZA ZA200005962A patent/ZA200005962B/en unknown

Also Published As

Publication number	Publication date
HUP0101947A2 (hu)	2001-11-28
CA2327439A1 (en)	1999-11-25
CN1303288A (zh)	2001-07-11
ZA200005962B (en)	2002-01-24
PL193109B1 (pl)	2007-01-31
PT1076561E (pt)	2005-08-31
AU3904599A (en)	1999-12-06
KR20010052355A (ko)	2001-06-25
DE69924483T2 (de)	2006-02-09
CN1216605C (zh)	2005-08-31
JP2002515457A (ja)	2002-05-28
AU745749B2 (en)	2002-03-28
CA2327439C (en)	2005-07-05
ES2237103T3 (es)	2005-07-16
EP1076561B1 (de)	2005-03-30
ATE291918T1 (de)	2005-04-15
KR100699574B1 (ko)	2007-03-23
HK1032360A1 (en)	2001-07-20
WO1999059628A3 (en)	2000-01-13
DE69924483D1 (de)	2005-05-04
HUP0101947A3 (en)	2001-12-28
PL344414A1 (en)	2001-11-05
EP1076561A2 (de)	2001-02-21
WO1999059628A2 (en)	1999-11-25

Publication	Publication Date	Title
ATE393831T1 (de)	2008-05-15	Zusammensetzung zur in vivo erzeugung von therapeutischen produkten
EA200000994A1 (ru)	2001-02-26	Применение кабэрголина при лечении синдрома усталых ног
TW366342B (en)	1999-08-11	The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
UA39158C2 (uk)	2001-06-15	Похідні n4-оксикарбоніл-5'-дезокси-5-фторцитидину та фармацевтичний препарат на їх основі
CY2431B1 (en)	2004-11-12	Novel phenanthridines substituted in the 6 position.
AP9700952A0 (en)	1997-04-30	Antineoplastic cocoa extracts and method for making and using the same.
PL349028A1 (en)	2002-07-01	Cancer treatment composition and method using natural plant essential oils
SE9404196D0 (sv)	1994-12-02	New antithrombotic formulation
WO2002076499A3 (en)	2003-05-30	Combination treatment of pancreatic cancer
GR3022321T3 (en)	1997-04-30	Use of il-4 to treat solid tumors
PT1076561E (pt)	2005-08-31	Terapia de combinacao para o tratamento de tumores
ATE368455T1 (de)	2007-08-15	Verwendung von (+)-tramadol, o-demethyltramadol, o-desmethyl-n-mono-desmethyl-tramadol zur therapie der harninkontinenz
DK0944389T3 (da)	2008-11-17	Oprensede sammensætninger af 10-propargyl-10-deazaaminopterin og fremgangsmåder til anvendelse deraf i behandlingen af tumorer
SE9603725D0 (sv)	1996-10-11	New teatment
DE69316013D1 (de)	1998-02-05	Verwendung von phosphinate zur behandlung der osteoporose
GR3020355T3 (en)	1996-09-30	Aminosulfonyl urea acat inhibitors
MX9701187A (es)	1997-05-31	Nuevas lactamas naftofusionadas n-substituidas.
NO983177L (no)	1998-07-10	Anvendelse av 1-enantiomeren av centkroman til fremstilling av et farmasaytisk preparat for behandling eller profylakse av brystkreft
PL357179A1 (en)	2004-07-26	Use of 2-methyl-thiazolidin-2,4-dicarboxylic acid (2-mtdc) and/or physiologically compatible salts for treating and/or preventing cancers
IL131478A0 (en)	2001-01-28	Methods for treatment of scar tissue
MXPA01007952A (es)	2004-03-26	Formulaciones a base de l-arginina para tratar enfermedades, y metodos para usarlas.
DK0572549T3 (da)	2003-01-06	Behandling af ikke-småcellet lungecarcinom
DE59101818D1 (de)	1994-07-14	Arzneimittelzubereitung, enthaltend Stigmasta-4-en-3-on sowie deren Verwendung.
DE69734349D1 (de)	2006-02-23	Behandlung von knochenleiden mit adrenomedullin
NO985695L (no)	1999-02-04	Formulering og fremgangsmÕte for Õ behandle kongestiv hjerteinfarkt