ATE293102T1 - Naphthalene derivate ,ihre herstellung und verwendung - Google Patents
Naphthalene derivate ,ihre herstellung und verwendungInfo
- Publication number
- ATE293102T1 ATE293102T1 AT99917102T AT99917102T ATE293102T1 AT E293102 T1 ATE293102 T1 AT E293102T1 AT 99917102 T AT99917102 T AT 99917102T AT 99917102 T AT99917102 T AT 99917102T AT E293102 T1 ATE293102 T1 AT E293102T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- substituted
- group
- hydrogen atom
- sub
- Prior art date
Links
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical class C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 2
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- IHOBBYHEOBWAPZ-UHFFFAOYSA-L steroid c Chemical compound [Na+].[Na+].C1CC2CC(OS([O-])(=O)=O)C(OS([O-])(=O)=O)CC2(C)C(CCC23C)C1C3CC(O1)C2C2(C)OC1OC2CC(C(C)C)=C(C)C IHOBBYHEOBWAPZ-UHFFFAOYSA-L 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Fats And Perfumes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11380198 | 1998-04-23 | ||
| PCT/JP1999/002143 WO1999054309A1 (en) | 1998-04-23 | 1999-04-22 | Naphthalene derivatives, their production and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE293102T1 true ATE293102T1 (de) | 2005-04-15 |
Family
ID=14621427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99917102T ATE293102T1 (de) | 1998-04-23 | 1999-04-22 | Naphthalene derivate ,ihre herstellung und verwendung |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6573289B1 (de) |
| EP (1) | EP1073640B1 (de) |
| AT (1) | ATE293102T1 (de) |
| AU (1) | AU3534699A (de) |
| CA (1) | CA2328973A1 (de) |
| DE (1) | DE69924717T2 (de) |
| WO (1) | WO1999054309A1 (de) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070129282A1 (en) * | 1998-11-24 | 2007-06-07 | Ahlem Clarence N | Pharmaceutical treatments and compositions |
| WO2000042213A1 (en) | 1999-01-13 | 2000-07-20 | The Research Foundation Of State University Of New York | A novel method for designing protein kinase inhibitors |
| WO2000078727A1 (en) * | 1999-06-22 | 2000-12-28 | Takeda Chemical Industries, Ltd. | Process for the preparation of imidazole derivatives |
| PT1955700E (pt) * | 1999-09-30 | 2011-05-04 | Harbor Biosciences Inc | Tratamento terap?utico de doen?as associadas ao receptor de androg?nios |
| PE20010781A1 (es) | 1999-10-22 | 2001-08-08 | Takeda Chemical Industries Ltd | Compuestos 1-(1h-imidazol-4-il)-1-(naftil-2-sustituido)etanol, su produccion y utilizacion |
| AU7950100A (en) * | 1999-10-22 | 2001-05-08 | Takeda Chemical Industries Ltd. | 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof |
| WO2001030763A1 (en) * | 1999-10-22 | 2001-05-03 | Takeda Chemical Industries, Ltd. | Process for producing optically active naphthalene derivative and optical resolver therefor |
| PE20020596A1 (es) | 2000-11-17 | 2002-08-13 | Takeda Chemical Industries Ltd | Derivados de imidazol, metodos de produccion e intermediarios del mismo |
| ATE502030T1 (de) | 2000-11-20 | 2011-04-15 | Takeda Pharmaceutical | Imidazolderivate, verfahren zu deren herstellung und deren verwendung |
| CA2431171A1 (en) * | 2000-12-08 | 2002-06-13 | Takeda Chemical Industries, Ltd. | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof |
| ATE498408T1 (de) * | 2001-08-10 | 2011-03-15 | Takeda Pharmaceutical | Gnrh-agonistische kombinationsmittel |
| US7005445B2 (en) | 2001-10-22 | 2006-02-28 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors and methods for designing them |
| WO2003035621A1 (en) * | 2001-10-22 | 2003-05-01 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors, methods for designing them, and methods of using them |
| MXPA06000401A (es) * | 2003-07-10 | 2006-03-17 | Osi Pharm Inc | Derivados de naftileno como inhibidores de citocromo p450. |
| JP2007518823A (ja) | 2004-01-23 | 2007-07-12 | アムゲン インコーポレイテッド | キノリン、キナゾリン、ピリジン、及びピリミジン化合物と炎症、血管新生、及び癌に対する治療におけるそれら化合物の用途 |
| GEP20084439B (en) | 2004-01-23 | 2008-07-25 | Amgen Inc | Nitrogen-containing heterocyclic derivatives and pharmaceutical use thereof |
| US7662844B2 (en) | 2004-07-12 | 2010-02-16 | Osi Pharmaceuticals, Inc. | Naphthylene derivatives as cytochrome P450 inhibitors |
| JP2008521900A (ja) * | 2004-11-30 | 2008-06-26 | アムジエン・インコーポレーテツド | キノリン及びキナゾリン類似体並びにがん治療のための医薬としてのその使用 |
| JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| RU2008130448A (ru) * | 2006-01-27 | 2010-03-10 | Ф. Хоффманн-Ля Рош Аг (Ch) | Применение производных 4-имидазола для расстройств цнс |
| US7838542B2 (en) | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| AU2007312389B2 (en) * | 2006-10-19 | 2012-02-23 | F. Hoffmann-La Roche Ag | Aminomethyl-2-imidazoles with affinity with the trace amine associated receptors |
| RU2009112496A (ru) * | 2006-10-19 | 2010-11-27 | Ф. Хоффманн-Ля Рош Аг (Ch) | Аминометил-4-имидазолы |
| CA2668454A1 (en) | 2006-11-02 | 2008-05-08 | F. Hoffmann-La Roche Ag | Substituted 2-imidazoles |
| JP2010510184A (ja) * | 2006-11-16 | 2010-04-02 | エフ．ホフマン−ラ ロシュ アーゲー | 置換４−イミダゾール類 |
| CA2672617A1 (en) * | 2006-12-13 | 2008-06-19 | F. Hoffmann-La Roche Ag | Novel 2-imidazoles as ligands for trace amine associated receptors (taar) |
| US20080146523A1 (en) * | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
| CN101600700B (zh) * | 2007-02-02 | 2013-08-21 | 弗·哈夫曼-拉罗切有限公司 | 作为taar1配体用于cns病症的新的2-氨基噁唑啉 |
| KR101222412B1 (ko) * | 2007-02-15 | 2013-01-15 | 에프. 호프만-라 로슈 아게 | Ｔａａｒ1 리간드로서의 2-아미노옥사졸린 |
| CN101687812A (zh) | 2007-07-02 | 2010-03-31 | 弗·哈夫曼-拉罗切有限公司 | 对痕量胺相关受体(taar)具有良好亲和性的2-咪唑啉化合物 |
| CA2691704A1 (en) * | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
| CA2694362A1 (en) * | 2007-07-27 | 2009-02-05 | F. Hoffmann-La Roche Ag | 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands |
| CN101765425A (zh) * | 2007-08-02 | 2010-06-30 | 弗·哈夫曼-拉罗切有限公司 | 苯甲酰胺衍生物用于治疗cns障碍的用途 |
| JP5341084B2 (ja) * | 2007-08-03 | 2013-11-13 | エフ．ホフマン−ラ ロシュ アーゲー | Ｔａａｒ１リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体 |
| CA2703257C (en) * | 2007-10-29 | 2013-02-19 | Amgen Inc. | Benzomorpholine derivatives and methods of use |
| US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
| CN102083805A (zh) * | 2008-07-24 | 2011-06-01 | 弗·哈夫曼-拉罗切有限公司 | 4,5-二氢-唑-2-基衍生物 |
| US20100311798A1 (en) * | 2009-06-05 | 2010-12-09 | Decoret Guillaume | 2-aminooxazolines as taar1 ligands |
| WO2010149755A1 (en) | 2009-06-26 | 2010-12-29 | Novartis Ag | 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17 |
| US8354441B2 (en) * | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
| US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| EP2521545B1 (de) | 2010-01-07 | 2019-11-27 | Alkermes Pharma Ireland Limited | Prodrugs aus heteroaromatischen verbindungen |
| KR101926320B1 (ko) | 2010-08-04 | 2018-12-06 | 펠피큐어 파마슈티걸즈 아이엔씨 | 전립선 암종의 치료를 위한 병용 요법 |
| JP2013537210A (ja) | 2010-09-16 | 2013-09-30 | ノバルティス アーゲー | １７α−ヒドロキシラーゼ／Ｃ１７，２０−リアーゼ阻害剤 |
| KR101848077B1 (ko) * | 2010-11-13 | 2018-04-11 | 이노크린 파마슈티컬즈, 인크. | 금속효소 억제제 화합물 |
| US9029399B2 (en) | 2011-04-28 | 2015-05-12 | Novartis Ag | 17α-hydroxylase/C17,20-lyase inhibitors |
| EP2751117A4 (de) * | 2011-08-30 | 2015-06-24 | Innocrin Pharmaceuticals Inc | Metalloenzymhemmerverbindungen |
| CA2902335C (en) | 2013-03-14 | 2021-09-14 | Pellficure Pharmaceuticals, Inc. | Novel therapy for prostate carcinoma |
| WO2016040896A1 (en) | 2014-09-12 | 2016-03-17 | Pellficure Pharmaceuticals, Inc. | Compositions and methods for treatment of prostate carcinoma |
| CN108713019B (zh) | 2016-03-17 | 2021-06-15 | 豪夫迈·罗氏有限公司 | 具有作为taar的激动剂的活性的5-乙基-4-甲基-吡唑-3-甲酰胺衍生物 |
| AU2017350690A1 (en) | 2016-10-24 | 2019-06-13 | Pellficure Pharmaceuticals Inc. | Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione |
| CN114213296B (zh) * | 2021-12-23 | 2024-01-26 | 中节能万润股份有限公司 | 含异硫氰基的萘系列液晶单体化合物以及制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1154722A (en) * | 1965-07-08 | 1969-06-11 | Boots Pure Drug Co Ltd | 2,4,5-Tribromoimidazole Derivatives and Compositions thereof |
| US3759934A (en) | 1970-12-09 | 1973-09-18 | Sandoz Ag | 2,3 or 4-pyri dinemethanol-alpha-substituted or unsubstituted phenyls-alpha-(2 or 3-alkoxy-1-naphthyls) |
| DE3373467D1 (en) * | 1982-06-14 | 1987-10-15 | Takeda Chemical Industries Ltd | Vinyl carboxylic acid derivatives, their production and use |
| DE3508903A1 (de) | 1985-03-13 | 1986-09-18 | Hoechst Ag, 6230 Frankfurt | Neue 3-pyridylmethylnaphtylderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| EP0273647B1 (de) | 1986-12-27 | 1992-03-11 | Takeda Chemical Industries, Ltd. | 2,3-Dihydro-Cumaron-Derivate, ihre Herstellung und Verwendung |
| FR2617478B1 (fr) * | 1987-07-01 | 1990-01-05 | Esteve Labor Dr | Nouveaux derives d'aryl-heteroaryl cetones, leur procede de preparation ainsi que leur application a titre de medicament |
| IL101291A0 (en) | 1991-03-22 | 1992-11-15 | Nippon Soda Co | 2-pyridine derivatives,their preparation and their use as fungicides |
| SE9302333D0 (sv) | 1993-07-06 | 1993-07-06 | Ab Astra | New compounds |
| ZA944647B (en) | 1993-07-06 | 1995-01-06 | Astra Ab | Novel (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclcl)methylamine derivatives |
| WO1995009157A1 (en) * | 1993-09-30 | 1995-04-06 | Yamanouchi Pharmaceutical Co., Ltd. | Azole derivative and pharmaceutical composition thereof |
| CA2213246A1 (en) | 1995-03-01 | 1996-09-06 | Yamanouchi Pharmaceutical Co., Ltd. | Imidazole derivatives and medicinal composition thereof |
| AU710875B2 (en) | 1995-12-06 | 1999-09-30 | Tokuyama Corporation | Chromene compounds and photochromic materials |
| WO2000078727A1 (en) * | 1999-06-22 | 2000-12-28 | Takeda Chemical Industries, Ltd. | Process for the preparation of imidazole derivatives |
| WO2001003082A1 (de) * | 1999-07-06 | 2001-01-11 | Gsi Gesellschaft Für Systemtechnik Und Informatik Mbh | Mobiltelefon |
| WO2001030763A1 (en) | 1999-10-22 | 2001-05-03 | Takeda Chemical Industries, Ltd. | Process for producing optically active naphthalene derivative and optical resolver therefor |
-
1999
- 1999-04-22 EP EP99917102A patent/EP1073640B1/de not_active Expired - Lifetime
- 1999-04-22 DE DE69924717T patent/DE69924717T2/de not_active Expired - Lifetime
- 1999-04-22 US US09/673,591 patent/US6573289B1/en not_active Expired - Lifetime
- 1999-04-22 WO PCT/JP1999/002143 patent/WO1999054309A1/en not_active Ceased
- 1999-04-22 CA CA002328973A patent/CA2328973A1/en not_active Abandoned
- 1999-04-22 AT AT99917102T patent/ATE293102T1/de not_active IP Right Cessation
- 1999-04-22 AU AU35346/99A patent/AU3534699A/en not_active Abandoned
-
2003
- 2003-05-22 US US10/443,379 patent/US7084149B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7084149B2 (en) | 2006-08-01 |
| WO1999054309A1 (en) | 1999-10-28 |
| US20030236274A1 (en) | 2003-12-25 |
| DE69924717D1 (de) | 2005-05-19 |
| DE69924717T2 (de) | 2006-03-09 |
| AU3534699A (en) | 1999-11-08 |
| EP1073640A1 (de) | 2001-02-07 |
| CA2328973A1 (en) | 1999-10-28 |
| US6573289B1 (en) | 2003-06-03 |
| EP1073640B1 (de) | 2005-04-13 |
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