ES2043820T3 - Nuevas 1-1 alkil-1-sulfonil-2-alkoxicarbonilsulfenilhidrazinas que tienen actividad antineoplastica. - Google Patents
Nuevas 1-1 alkil-1-sulfonil-2-alkoxicarbonilsulfenilhidrazinas que tienen actividad antineoplastica.Info
- Publication number
- ES2043820T3 ES2043820T3 ES88305132T ES88305132T ES2043820T3 ES 2043820 T3 ES2043820 T3 ES 2043820T3 ES 88305132 T ES88305132 T ES 88305132T ES 88305132 T ES88305132 T ES 88305132T ES 2043820 T3 ES2043820 T3 ES 2043820T3
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl
- antineoplastic activity
- alkoxicarbonilsulfenilhidrazinas
- alkil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000000118 anti-neoplastic effect Effects 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 238000007080 aromatic substitution reaction Methods 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
- C07C329/02—Monothiocarbonic acids; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
COMPUESTOS DE FORMULA (I) EN DONDE R1 ES UN GRUPO ALQUILO DE 1 A 6 C, BENCILO, FENILO QUE PUEDE ESTAR SUSTITUIDO POR HALOGENO, ALQUILO O ALQCOXI DE 1 A 4 C, AMINO O CARBONILO, O -RN(R'')2 EN QUE R Y R'' SON INDEPENDIENTEMENTE ALQUILO DE 1 A 4 C,; R2 ES UN HETEROCICLO O UN GRUPO AROMATICO Y CADA A SE SELECCIONA INDEPENDIENTEMENTE DE H, ALQUILO O ALCOXI DE 1 A 4 C, HALOGENO, -NO2, -NH2, -COOH Y -NHCOCH3. ESTOS COMPUESTOS SON AGENTES ALQUILANTES CON ACTIVIDAD ANTINEOPLASICA PARA EMPLEO EN LA INHIBICION DEL CRECIMIENTO DE TUMORES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/058,161 US4962114A (en) | 1986-01-21 | 1987-06-04 | 1-alkyl-1-sulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2043820T3 true ES2043820T3 (es) | 1994-01-01 |
Family
ID=22015073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES88305132T Expired - Lifetime ES2043820T3 (es) | 1987-06-04 | 1988-06-06 | Nuevas 1-1 alkil-1-sulfonil-2-alkoxicarbonilsulfenilhidrazinas que tienen actividad antineoplastica. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4962114A (es) |
| EP (1) | EP0294238B1 (es) |
| JP (1) | JP2686961B2 (es) |
| AT (1) | ATE79863T1 (es) |
| CA (1) | CA1304383C (es) |
| DE (1) | DE3873997T2 (es) |
| ES (1) | ES2043820T3 (es) |
| GR (1) | GR3006348T3 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6040338A (en) * | 1997-11-03 | 2000-03-21 | Yale University | N,n-bis(sulfonyl)hydrazines useful as antineoplastic agents |
| AU2002322720B2 (en) | 2001-07-25 | 2008-11-13 | Raptor Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| CN102379684B (zh) | 2005-04-28 | 2014-11-19 | 普罗透斯数字保健公司 | 药物信息系统 |
| KR20090071598A (ko) | 2006-09-18 | 2009-07-01 | 랩터 파마슈티컬 인코포레이티드 | 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료 |
| EP2398500B1 (en) | 2009-02-20 | 2019-03-13 | 2-BBB Medicines B.V. | Glutathione-based drug delivery system |
| ES2942923T3 (es) | 2009-05-06 | 2023-06-07 | Laboratory Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3975530A (en) * | 1972-09-05 | 1976-08-17 | Smith Kline & French Laboratories Limited | N-cyano-N'-heterocyclic-alkyl quanidine inhibitors of H2 histamine receptors |
| US4210658A (en) * | 1977-09-08 | 1980-07-01 | Smith Kline & French Laboratories Limited | Amidinosulphonic acid derivatives |
| US4684747A (en) * | 1984-12-20 | 1987-08-04 | Yale University | N,N'-bis(sulfonyl)hydrazines having antineoplastic activity |
| US4892887A (en) * | 1984-12-20 | 1990-01-09 | Yale University | N,N'-bis(sulfonyl)hydrazines having antineoplastic activity |
| US4849563A (en) * | 1986-01-21 | 1989-07-18 | Yale University | Novel 1-alkyl-1-arenesulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity |
-
1987
- 1987-06-04 US US07/058,161 patent/US4962114A/en not_active Expired - Fee Related
-
1988
- 1988-06-03 JP JP63137157A patent/JP2686961B2/ja not_active Expired - Lifetime
- 1988-06-03 CA CA000568600A patent/CA1304383C/en not_active Expired - Lifetime
- 1988-06-06 EP EP88305132A patent/EP0294238B1/en not_active Expired - Lifetime
- 1988-06-06 AT AT88305132T patent/ATE79863T1/de not_active IP Right Cessation
- 1988-06-06 ES ES88305132T patent/ES2043820T3/es not_active Expired - Lifetime
- 1988-06-06 DE DE8888305132T patent/DE3873997T2/de not_active Expired - Fee Related
-
1992
- 1992-11-26 GR GR920402706T patent/GR3006348T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3006348T3 (es) | 1993-06-21 |
| DE3873997D1 (de) | 1992-10-01 |
| DE3873997T2 (de) | 1993-01-21 |
| JP2686961B2 (ja) | 1997-12-08 |
| US4962114A (en) | 1990-10-09 |
| CA1304383C (en) | 1992-06-30 |
| JPH01258665A (ja) | 1989-10-16 |
| EP0294238B1 (en) | 1992-08-26 |
| ATE79863T1 (de) | 1992-09-15 |
| EP0294238A1 (en) | 1988-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8601146A1 (es) | Procedimiento para preparar derivados azolicos | |
| DK1106612T3 (da) | Quinolinderivater, der er nyttige til inhibering af farnesylproteintransferase | |
| PT941082E (pt) | Nova utilizacao para derivados de 1,3-propanodiol | |
| ATE356624T1 (de) | Phenoxypropanolamin-derivate, ihre herstellung und therapeutische verwendung | |
| GR3023838T3 (en) | Geneserine derivatives as cholinesterase inhibitors. | |
| DE3572170D1 (de) | Quinolonecarboxylic acid derivatives | |
| DE3873997D1 (de) | 1-alkyl-1-sulfonyl-2-alkoxycarbonylsulfenylhydrazine mit anti-neoplasma-wirksamkeit. | |
| DE69828197D1 (de) | Amidderivate zur behandlung neurodegenerativer erkrankungen der netzhaut | |
| DK415789D0 (da) | Tetracykliske antidepressive midler | |
| MXPA02003952A (es) | Derivados de imidazol como inhibidores de la fosfodieterasa vii. | |
| ES8707497A1 (es) | Un procedimiento para preparar derivados de azetidinona | |
| NZ505596A (en) | Fungicidal mixtures based on amide compounds and morpholine or piperidine derivatives | |
| AU551411B2 (en) | Diazolylalkanols useful as antimycotic agents | |
| DK0514942T3 (da) | Hidtil ukendte benzopyranderivater og fremgangsmåder til fremstilling deraf | |
| KR880009954A (ko) | 피리디닐-s-트리아진 유도체 그의 제조방법 및 그를 함유하는 살진규제 | |
| ES8607265A1 (es) | Un procedimiento para la preparacion de nuevos derivados de aminoalcoholes | |
| NZ221004A (en) | 2,6-piperazinediones and pharamceutical compositions | |
| DK382588D0 (da) | Anti-psykotiske sammensaetninger indeholdende dioxopiperidin derivater | |
| MY104048A (en) | New allylaminoethylazoles. | |
| GB8714805D0 (en) | Chemical compounds | |
| TH21683A (th) | อนุพันธ์ต่างๆ ของแคมพโทธีซิน, การเตรียมสารพวก?นี้และตัวสารยับยั้งการเจริญเติบโตของเนื้องอก |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 294238 Country of ref document: ES |