ATE293108T1 - Herstellung von alpha-tocopherol - Google Patents

Herstellung von alpha-tocopherol

Info

Publication number: ATE293108T1
Authority: AT; Austria
Prior art keywords: solvent; acid; alpha; tocopherol; mixture
Prior art date: 2001-10-31

Application number

AT02785282T

Other languages

English (en)

Inventor

Werner Bonrath

David Carl Burdick

Thomas Netscher

Frank Schager

Dominik Thomas

Original Assignee

Dsm Ip Assets Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-31

Filing date

2002-10-23

Publication date

2005-04-15

2002-10-23 Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv

2005-04-15 Application granted granted Critical

2005-04-15 Publication of ATE293108T1 publication Critical patent/ATE293108T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 title 2
229940087168 alpha tocopherol Drugs 0.000 title 1
229960000984 tocofersolan Drugs 0.000 title 1
239000002076 α-tocopherol Substances 0.000 title 1
235000004835 α-tocopherol Nutrition 0.000 title 1
239000002904 solvent Substances 0.000 abstract 4
239000002253 acid Substances 0.000 abstract 3
GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 abstract 3
238000000034 method Methods 0.000 abstract 3
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 abstract 2
239000003054 catalyst Substances 0.000 abstract 2
239000011877 solvent mixture Substances 0.000 abstract 2
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 abstract 2
OFEQNCKDGRVQKM-MRIFWDATSA-N 2,3,5-trimethyl-6-[(e,7r,11r)-3,7,11,15-tetramethylhexadec-2-enyl]benzene-1,4-diol Chemical compound CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CC1=C(C)C(O)=C(C)C(C)=C1O OFEQNCKDGRVQKM-MRIFWDATSA-N 0.000 abstract 1
229910015900 BF3 Inorganic materials 0.000 abstract 1
239000002841 Lewis acid Substances 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical group OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
229930003427 Vitamin E Natural products 0.000 abstract 1
238000007171 acid catalysis Methods 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 abstract 1
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract 1
239000011964 heteropoly acid Substances 0.000 abstract 1
150000007517 lewis acids Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000001737 promoting effect Effects 0.000 abstract 1
238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
239000001117 sulphuric acid Substances 0.000 abstract 1
235000011149 sulphuric acid Nutrition 0.000 abstract 1
239000011732 tocopherol Substances 0.000 abstract 1
229960001295 tocopherol Drugs 0.000 abstract 1
239000011709 vitamin E Substances 0.000 abstract 1
229940046009 vitamin E Drugs 0.000 abstract 1
235000019165 vitamin E Nutrition 0.000 abstract 1
235000005074 zinc chloride Nutrition 0.000 abstract 1
239000011592 zinc chloride Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pyrane Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT02785282T 2001-10-31 2002-10-23 Herstellung von alpha-tocopherol ATE293108T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01125966		2001-10-31
PCT/EP2002/011819 WO2003037883A1 (en)	2001-10-31	2002-10-23	Manufacture of alpha- tocopherol

Publications (1)

Publication Number	Publication Date
ATE293108T1 true ATE293108T1 (de)	2005-04-15

Family

ID=8179127

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02785282T ATE293108T1 (de)	2001-10-31	2002-10-23	Herstellung von alpha-tocopherol

Country Status (8)

Country	Link
US (1)	US7626046B2 (de)
EP (1)	EP1446398B1 (de)
JP (1)	JP2005507422A (de)
CN (1)	CN1271065C (de)
AT (1)	ATE293108T1 (de)
DE (1)	DE60203734T2 (de)
ES (1)	ES2239260T3 (de)
WO (1)	WO2003037883A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60317553T2 (de)	2002-11-21	2008-10-23	Dsm Ip Assets B.V.	Herstellung von tocoferylazetaten
CN100344621C (zh) *	2003-01-13	2007-10-24	帝斯曼知识产权资产管理有限公司	α－生育酚乙酸酯的生产方法
EP1664067A2 (de) *	2003-09-15	2006-06-07	DSM IP Assets B.V.	NEUE ROUTE ZU alpha-TOCOPHEROL, alpha-TOCOPHERYLALKANOATEN UND VORSTUFEN DAVON
WO2005026142A2 (en) *	2003-09-15	2005-03-24	Dsm Ip Assets B.V.	Synthesis of alpha-tocopheryl alkanoates and precursors thereof
US20200131145A1 (en) *	2017-07-12	2020-04-30	Dsm Ip Assets B.V.	Novel synthesis of intermediates for the preparation of alpha-tocopherol
CN113640395B (zh) *	2020-04-27	2024-10-01	深圳波顿香料有限公司	电子烟油中的生育酚乙酸酯的合相色谱分析方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4208334A (en)	1978-12-22	1980-06-17	Hoffmann-La Roches Inc.	Process for preparation of α-tocopherol
US6369242B2 (en) *	2000-03-17	2002-04-09	Roche Vitamins Inc.	Tocopherol manufacture by tris(perfluorohydrocarbylsulphonyl) methane or metal methides thereof

2002
- 2002-10-23 EP EP02785282A patent/EP1446398B1/de not_active Expired - Lifetime
- 2002-10-23 ES ES02785282T patent/ES2239260T3/es not_active Expired - Lifetime
- 2002-10-23 WO PCT/EP2002/011819 patent/WO2003037883A1/en not_active Ceased
- 2002-10-23 AT AT02785282T patent/ATE293108T1/de not_active IP Right Cessation
- 2002-10-23 US US10/494,005 patent/US7626046B2/en not_active Expired - Fee Related
- 2002-10-23 JP JP2003540164A patent/JP2005507422A/ja active Pending
- 2002-10-23 DE DE60203734T patent/DE60203734T2/de not_active Expired - Lifetime
- 2002-10-23 CN CN02821423.4A patent/CN1271065C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1446398A1 (de)	2004-08-18
CN1578777A (zh)	2005-02-09
CN1271065C (zh)	2006-08-23
JP2005507422A (ja)	2005-03-17
US20050187393A1 (en)	2005-08-25
WO2003037883A1 (en)	2003-05-08
DE60203734T2 (de)	2006-02-09
DE60203734D1 (de)	2005-05-19
US7626046B2 (en)	2009-12-01
ES2239260T3 (es)	2005-09-16
EP1446398B1 (de)	2005-04-13

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Legal Events

Date	Code	Title	Description
2005-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties