ES2178626T3 - Procedimiento para la preparacion de 5-carboxiftalida. - Google Patents

Procedimiento para la preparacion de 5-carboxiftalida.

Info

Publication number
ES2178626T3
ES2178626T3 ES00203602T ES00203602T ES2178626T3 ES 2178626 T3 ES2178626 T3 ES 2178626T3 ES 00203602 T ES00203602 T ES 00203602T ES 00203602 T ES00203602 T ES 00203602T ES 2178626 T3 ES2178626 T3 ES 2178626T3
Authority
ES
Spain
Prior art keywords
preparation
carboxiftalida
procedure
carboxyphthalide
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00203602T
Other languages
English (en)
Other versions
ES2178626T5 (es
Inventor
Asta Leone Dall
Umberto Casazza
Giovanni Cotticelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Infosint SA
Original Assignee
Infosint SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26332721&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2178626(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Infosint SA filed Critical Infosint SA
Application granted granted Critical
Publication of ES2178626T3 publication Critical patent/ES2178626T3/es
Publication of ES2178626T5 publication Critical patent/ES2178626T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Seasonings (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Procedimiento para la preparación de 5-carboxiftalida de fórmula A en un reactor abierto y de cualquier modo no presurizado, que comprende la adición de formaldehído y de ácido tereftálico de fórmula I al ácido sulfúrico fumante que contiene por lo menos el 20% en peso de SO3, calentar la mezcla a 120-145º C y aislar la 5-carboxiftalida obtenida de este modo.
ES00203602T 2000-01-18 2000-10-17 Procedimiento para la preparación de 5-carboxiftalida. Expired - Lifetime ES2178626T5 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT2000MI000050A IT1317729B1 (it) 2000-01-18 2000-01-18 Procedimento per la preparazione della 5-carbossiftalide.
ITMI00A0050 2000-01-18
US09/690,301 US6458973B1 (en) 2000-01-18 2000-10-17 Process for the preparation of 5-carboxyphthalide

Publications (2)

Publication Number Publication Date
ES2178626T3 true ES2178626T3 (es) 2003-01-01
ES2178626T5 ES2178626T5 (es) 2011-06-02

Family

ID=26332721

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00203602T Expired - Lifetime ES2178626T5 (es) 2000-01-18 2000-10-17 Procedimiento para la preparación de 5-carboxiftalida.

Country Status (21)

Country Link
US (4) US6458973B1 (es)
EP (2) EP1118614B2 (es)
JP (1) JP4558182B2 (es)
CN (1) CN1184220C (es)
AT (1) ATE219489T1 (es)
AU (1) AU779581B2 (es)
BG (1) BG65763B1 (es)
BR (1) BR0107853A (es)
CA (1) CA2397497C (es)
DE (1) DE60000226T3 (es)
DK (1) DK1118614T4 (es)
ES (1) ES2178626T5 (es)
HK (1) HK1042290B (es)
HU (1) HUP0204187A3 (es)
IT (1) IT1317729B1 (es)
MX (1) MXPA02007031A (es)
PL (1) PL356563A1 (es)
PT (1) PT1118614E (es)
RO (1) RO121737B1 (es)
WO (1) WO2001053284A1 (es)
ZA (1) ZA200205475B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR026063A1 (es) * 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
CZ20023100A3 (cs) * 2000-03-13 2003-02-12 H. Lundbeck A/S Způsob výroby citalopramu
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CN101362743A (zh) * 2003-03-21 2009-02-11 H.隆德贝克有限公司 用于制备西酞普兰和依他普仑的中间体
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
WO2006090409A1 (en) * 2005-02-28 2006-08-31 Kekule Pharma Ltd., An improved process for the preparation of 5 - carboxyphthalide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3607884A (en) * 1969-03-11 1971-09-21 Mobil Oil Corp Preparation of 5-carboxyphthalide in liquid sodium trioxide
US3976751A (en) † 1974-10-21 1976-08-24 Allied Chemical Corporation Stabilization of liquid sulfur trioxide
DE2630927A1 (de) 1976-07-09 1978-01-19 Basf Ag Verfahren zur herstellung von phthalidcarbonsaeure-(5)
DE3605716A1 (de) 1986-02-22 1987-09-03 Henkel Kgaa Verwendung von unloeslichen schmutzsammlern zur regenerierung von wasch- und reinigungsloesungen
TR200000066T2 (tr) * 1997-07-08 2000-11-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem.
PL199423B1 (pl) * 1998-10-20 2008-09-30 Lundbeck & Co As H Sposób wytwarzania citalopramu
AU1130901A (en) 1999-11-01 2001-05-14 H. Lundbeck A/S Method for the preparation of 5-carboxyphthalide
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram

Also Published As

Publication number Publication date
BR0107853A (pt) 2002-10-29
DE60000226T2 (de) 2003-03-06
RO121737B1 (ro) 2008-03-28
EP1118614A2 (en) 2001-07-25
DK1118614T3 (da) 2002-10-14
EP1187822A1 (en) 2002-03-20
PT1118614E (pt) 2002-11-29
HK1042290A1 (en) 2002-08-09
US20080249319A1 (en) 2008-10-09
WO2001053284A1 (en) 2001-07-26
US6703516B2 (en) 2004-03-09
DE60000226D1 (de) 2002-07-25
ES2178626T5 (es) 2011-06-02
DE60000226T3 (de) 2012-02-16
EP1118614A3 (en) 2001-10-24
CA2397497C (en) 2010-07-06
ZA200205475B (en) 2003-12-31
EP1118614B1 (en) 2002-06-19
US20030009038A1 (en) 2003-01-09
US20040171851A1 (en) 2004-09-02
AU779581B2 (en) 2005-01-27
HUP0204187A2 (hu) 2003-03-28
HK1042290B (en) 2003-07-18
BG65763B1 (bg) 2009-10-30
ITMI20000050A1 (it) 2001-07-18
JP4558182B2 (ja) 2010-10-06
AU2679801A (en) 2001-07-31
CN1406236A (zh) 2003-03-26
US6458973B1 (en) 2002-10-01
BG106925A (bg) 2004-01-30
ITMI20000050A0 (it) 2000-01-18
PL356563A1 (en) 2004-06-28
HUP0204187A3 (en) 2005-05-30
ATE219489T1 (de) 2002-07-15
MXPA02007031A (es) 2004-09-06
CA2397497A1 (en) 2001-07-26
DK1118614T4 (da) 2011-06-27
IT1317729B1 (it) 2003-07-15
JP2001206881A (ja) 2001-07-31
EP1118614B2 (en) 2011-03-09
CN1184220C (zh) 2005-01-12

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