ATE293976T1 - Verbindungen enthaltend s-tofisopam sowie verwendung dieser verbindungen zur herstellung eines medikamentes zur behandlung oder prophylaxe von krämpfen und anfällen - Google Patents

Verbindungen enthaltend s-tofisopam sowie verwendung dieser verbindungen zur herstellung eines medikamentes zur behandlung oder prophylaxe von krämpfen und anfällen

Info

Publication number: ATE293976T1
Authority: AT; Austria
Prior art keywords: tofisopam; compounds; seizures; treatment; conseus
Prior art date: 2001-05-18

Application number

AT02253420T

Other languages

English (en)

Inventor

Steven M Leventer

Robert Kucharik

Original Assignee

Vela Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-18

Filing date

2002-05-16

Publication date

2005-05-15

2002-05-16 Application filed by Vela Pharmaceuticals Inc filed Critical Vela Pharmaceuticals Inc

2005-05-15 Application granted granted Critical

2005-05-15 Publication of ATE293976T1 publication Critical patent/ATE293976T1/de

Links

229960002501 tofisopam Drugs 0.000 title abstract 3
238000011282 treatment Methods 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title 2
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
238000011321 prophylaxis Methods 0.000 title 1
206010010904 Convulsion Diseases 0.000 abstract 4
239000000203 mixture Substances 0.000 abstract 3
RUJBDQSFYCKFAA-HNNXBMFYSA-N (5r)-1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5h-2,3-benzodiazepine Chemical compound C1([C@H](C(=NN=2)C)CC)=CC(OC)=C(OC)C=C1C=2C1=CC=C(OC)C(OC)=C1 RUJBDQSFYCKFAA-HNNXBMFYSA-N 0.000 abstract 2
230000036461 convulsion Effects 0.000 abstract 2
230000001773 anti-convulsant effect Effects 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
229960003965 antiepileptics Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Virology (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Respiratory Apparatuses And Protective Means (AREA)
Medicinal Preparation (AREA)

AT02253420T 2001-05-18 2002-05-16 Verbindungen enthaltend s-tofisopam sowie verwendung dieser verbindungen zur herstellung eines medikamentes zur behandlung oder prophylaxe von krämpfen und anfällen ATE293976T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US29202601P	2001-05-18	2001-05-18
US10/008,516 US6649607B2 (en)	2001-05-18	2001-11-08	Compositions and methods for treating or preventing convulsions or seizures

Publications (1)

Publication Number	Publication Date
ATE293976T1 true ATE293976T1 (de)	2005-05-15

Family

ID=26678275

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02253420T ATE293976T1 (de)	2001-05-18	2002-05-16	Verbindungen enthaltend s-tofisopam sowie verwendung dieser verbindungen zur herstellung eines medikamentes zur behandlung oder prophylaxe von krämpfen und anfällen

Country Status (13)

Country	Link
US (3)	US6649607B2 (de)
EP (1)	EP1262184B1 (de)
JP (2)	JP2003012518A (de)
AT (1)	ATE293976T1 (de)
AU (2)	AU3702802A (de)
BR (1)	BR0201862A (de)
CA (1)	CA2381637A1 (de)
DE (1)	DE60203847T2 (de)
ES (1)	ES2241962T3 (de)
GB (1)	GB2377636A (de)
IL (1)	IL149134A (de)
NZ (1)	NZ518675A (de)
WO (1)	WO2002094189A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6649607B2 (en) *	2001-05-18	2003-11-18	Vela Pharmaceuticals, Inc.	Compositions and methods for treating or preventing convulsions or seizures
JP4630665B2 (ja) *	2002-09-13	2011-02-09	モタック・ニューロサイエンス・リミテッド	２，３−ベンゾジアゼピンによる基底核関連運動障害の治療
CA2499200A1 (en) *	2002-09-17	2004-04-01	Motac Neuroscience Limited	Use of compounds in the treatment of dyskinesia
WO2004069155A2 (en) *	2002-12-03	2004-08-19	Vela Pharmaceuticals, Inc.	Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof
US6864251B2 (en) *	2002-12-03	2005-03-08	Vela Pharmaceuticals, Inc.	Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US7745431B2 (en) *	2002-12-03	2010-06-29	Vela Acquisition Corporation	Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5H-2,3-benzodiazepine and uses thereof
US6638928B1 (en) *	2002-12-03	2003-10-28	Vela Pharmaceuticals, Inc.	Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US7265106B2 (en)	2003-05-09	2007-09-04	Vela Aquisition Corporation	Method for isolating (R)-tofisopam
US20050288277A1 (en) *	2004-06-25	2005-12-29	Kucharik Robert F	Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S)-2,3-benzodiazepine
US20070021412A1 (en) *	2003-05-16	2007-01-25	Vela Pharmaceuticals, Inc.	Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
CA2525273C (en) *	2003-05-16	2012-04-17	Vela Pharmaceuticals, Inc.	Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (r) 2,3-benzodiazepine
US20070032479A1 (en) *	2003-12-03	2007-02-08	Leventer Steven M	Treatment of inflammatory disorders of the epithelium with low dose 2,3-benzodiazepines
US20060111743A1 (en) *	2004-11-19	2006-05-25	Gurney Harry C Jr	Method for arresting seizure activity
US7541355B2 (en) *	2005-05-23	2009-06-02	Vela Acquisition Corporation	Conversion process for 2,3-benzodiazepine enantiomers
WO2007082546A1 (en) *	2006-01-20	2007-07-26	H. Lundbeck A/S	Use of tofisopam as a pde10a inhibitor
JP2008174495A (ja) *	2007-01-19	2008-07-31	Reverse Proteomics Research Institute Co Ltd	創薬標的タンパク質及び標的遺伝子、並びにスクリーニング方法
US9408852B2 (en)	2011-07-27	2016-08-09	Pharmos Corporation	Method of lowering serum uric acid levels with (S)-tofisopam
CN102836162A (zh) *	2012-04-10	2012-12-26	珠海亿邦制药股份有限公司	一种以托非索泮为活性成分的口服固体制剂及其应用
CN105363006A (zh) *	2015-12-16	2016-03-02	张景英	一种用于护理治疗小儿高热惊厥的中药药膏

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ZA712798B (en)	1970-11-06	1972-02-23	Egyt Gyogyszervegyeszeti Gyar	New,pharmaceutically active 2,3-diazabicyclo(5.4.0)undecapentaene derivative and process for preparing same
HU179018B (en)	1978-10-19	1982-08-28	Gyogyszerkutato Intezet	Process for producing new 5h-2,3-benzodiazepine derivatives
HU186760B (en)	1981-03-12	1985-09-30	Gyogyszerkutato Intezet	Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
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US6017965A (en)	1993-02-08	2000-01-25	Nps Pharmaceuticals, Inc.	Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
HU219777B (hu)	1993-07-02	2001-07-30	Gyógyszerkutató Intézet Kft.	Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására
EP1157992B1 (de)	1994-08-31	2005-08-24	Eli Lilly And Company	Dihydro-2,3-Benzodiazepinderivate
HU224435B1 (hu)	1995-02-09	2005-10-28	EGIS Gyógyszergyár Rt.	Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények
US5891871A (en)	1996-03-21	1999-04-06	Cocensys, Inc.	Substituted 2,3-benzodiazepin-4-ones and the use thereof
HK1040908B (en)	1998-10-27	2005-04-22	Vela Pharmaceuticals Inc.	Use of optically pure (r)-tofisopam for treating and preventing anxiety disorders
US6080736A (en)	1999-10-27	2000-06-27	Janus Pharmaceuticals, Inc.	Methods and compositions for treating and preventing anxiety and anxiety disorders using optically pure (R) tofisopam
US6649607B2 (en) *	2001-05-18	2003-11-18	Vela Pharmaceuticals, Inc.	Compositions and methods for treating or preventing convulsions or seizures

2001
- 2001-11-08 US US10/008,516 patent/US6649607B2/en not_active Expired - Lifetime
2002
- 2002-04-11 CA CA002381637A patent/CA2381637A1/en not_active Abandoned
- 2002-04-15 IL IL149134A patent/IL149134A/en not_active IP Right Cessation
- 2002-04-26 AU AU37028/02A patent/AU3702802A/en not_active Abandoned
- 2002-05-01 NZ NZ518675A patent/NZ518675A/en unknown
- 2002-05-15 JP JP2002139802A patent/JP2003012518A/ja active Pending
- 2002-05-16 AT AT02253420T patent/ATE293976T1/de not_active IP Right Cessation
- 2002-05-16 DE DE60203847T patent/DE60203847T2/de not_active Expired - Fee Related
- 2002-05-16 EP EP02253420A patent/EP1262184B1/de not_active Expired - Lifetime
- 2002-05-16 GB GB0211247A patent/GB2377636A/en not_active Withdrawn
- 2002-05-16 ES ES02253420T patent/ES2241962T3/es not_active Expired - Lifetime
- 2002-05-17 BR BR0201862-4A patent/BR0201862A/pt not_active IP Right Cessation
- 2002-05-17 AU AU2002303817A patent/AU2002303817A1/en not_active Abandoned
- 2002-05-17 WO PCT/US2002/015996 patent/WO2002094189A2/en not_active Ceased
2003
- 2003-07-23 US US10/625,754 patent/US7078398B2/en not_active Expired - Fee Related
2006
- 2006-03-24 US US11/388,399 patent/US20060166976A1/en not_active Abandoned
2007
- 2007-07-17 JP JP2007185953A patent/JP2007262096A/ja active Pending

Also Published As

Publication number	Publication date
NZ518675A (en)	2003-07-25
ES2241962T3 (es)	2005-11-01
WO2002094189A3 (en)	2003-04-10
DE60203847T2 (de)	2006-01-26
AU2002303817A1 (en)	2002-12-03
US7078398B2 (en)	2006-07-18
IL149134A0 (en)	2002-11-10
GB2377636A (en)	2003-01-22
EP1262184B1 (de)	2005-04-27
WO2002094189A2 (en)	2002-11-28
EP1262184A1 (de)	2002-12-04
AU3702802A (en)	2002-11-21
JP2003012518A (ja)	2003-01-15
US20030055048A1 (en)	2003-03-20
US20050075329A1 (en)	2005-04-07
US20060166976A1 (en)	2006-07-27
IL149134A (en)	2007-06-17
JP2007262096A (ja)	2007-10-11
CA2381637A1 (en)	2002-11-18
US6649607B2 (en)	2003-11-18
DE60203847D1 (de)	2005-06-02
BR0201862A (pt)	2003-03-25
GB0211247D0 (en)	2002-06-26

Legal Events

Date	Code	Title	Description
2005-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60203847D1 (de)	2005-06-02	Verbindungen enthaltend S-Tofisopam sowie Verwendung dieser Verbindungen zur Herstellung eines Medikamentes zur Behandlung oder Prophylaxe von Krämpfen und Anfällen
ATE523194T1 (de)	2011-09-15	Bis(thiohydrazidamide) in kombination mit taxol für die behandlung von krebs
ATE396174T1 (de)	2008-06-15	Hydroxyalkylaminderivate als beta-secretase- inhibitoren und deren verwendung zur behandlung der alzheimerschen krankheit oder ähnlicher krankheiten
ATE445405T1 (de)	2009-10-15	Vorbeugung und behandlung von oxidativer-stress- erkrankungen mit verbindungen die den intrazellulären spiegel von glutathion oder phase-ii-entgiftungsenzymen erhöhen
DE60126980D1 (de)	2007-04-12	Therapeutische agentien und methoden ihrer verwendung zur behandlung von amyloidogenen erkrankungen
ATE253932T1 (de)	2003-11-15	Verwendung von erythropoietin oder erythropoietin-derivaten zur behandlung von cerebralen ischämien
ATE489379T1 (de)	2010-12-15	2-oxo-1,3,5-perhydrotriazapinderivate, die sich zur behandlung von hyperproliferativen, angiogenen und entzündlichen erkrankungen eignen
TW200420550A (en)	2004-10-16	Thiazole compounds for the treatment of neurodegenerative disorders
ATE414524T1 (de)	2008-12-15	Verwendung von myoblasten zur herstellung eines medikaments zur behandlung der stressbedingten harninkontinenz
ATE439833T1 (de)	2009-09-15	Pharmazeutische zubereitung enthaltend ein catechin, ascorbinsäure, prolin und lysin zur behandlung von neoplastischen krankheiten
ATE541583T1 (de)	2012-02-15	Enzym-enthaltendes präparat, verfahren zur herstellung und verwendung
DE602004021847D1 (de)	2009-08-13	Verfahren zur prävention und behandlung von diabetes mit neurturin
ATE425752T1 (de)	2009-04-15	Verwendung von pipamperon und einem sndri, snri oder ssri zur behandlung von stimmungs- oder angststírungen
ATE309817T1 (de)	2005-12-15	Pharmazeutische zusammensetzung die trkaig2 enthält zur verwendung in der vorbeugung und/oder behandlung von krebs
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