BR0201862A - Composições e métodos para tratar ou prevenir convulsões ou ataques apoplécticos - Google Patents
Composições e métodos para tratar ou prevenir convulsões ou ataques apoplécticosInfo
- Publication number
- BR0201862A BR0201862A BR0201862-4A BR0201862A BR0201862A BR 0201862 A BR0201862 A BR 0201862A BR 0201862 A BR0201862 A BR 0201862A BR 0201862 A BR0201862 A BR 0201862A
- Authority
- BR
- Brazil
- Prior art keywords
- seizures
- compositions
- treating
- methods
- preventing
- Prior art date
Links
- 206010010904 Convulsion Diseases 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 4
- RUJBDQSFYCKFAA-HNNXBMFYSA-N (5r)-1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5h-2,3-benzodiazepine Chemical compound C1([C@H](C(=NN=2)C)CC)=CC(OC)=C(OC)C=C1C=2C1=CC=C(OC)C(OC)=C1 RUJBDQSFYCKFAA-HNNXBMFYSA-N 0.000 abstract 2
- 230000036461 convulsion Effects 0.000 abstract 2
- 229960002501 tofisopam Drugs 0.000 abstract 2
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Virology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Respiratory Apparatuses And Protective Means (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29202601P | 2001-05-18 | 2001-05-18 | |
| US10/008,516 US6649607B2 (en) | 2001-05-18 | 2001-11-08 | Compositions and methods for treating or preventing convulsions or seizures |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0201862A true BR0201862A (pt) | 2003-03-25 |
Family
ID=26678275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0201862-4A BR0201862A (pt) | 2001-05-18 | 2002-05-17 | Composições e métodos para tratar ou prevenir convulsões ou ataques apoplécticos |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6649607B2 (pt) |
| EP (1) | EP1262184B1 (pt) |
| JP (2) | JP2003012518A (pt) |
| AT (1) | ATE293976T1 (pt) |
| AU (2) | AU3702802A (pt) |
| BR (1) | BR0201862A (pt) |
| CA (1) | CA2381637A1 (pt) |
| DE (1) | DE60203847T2 (pt) |
| ES (1) | ES2241962T3 (pt) |
| GB (1) | GB2377636A (pt) |
| IL (1) | IL149134A (pt) |
| NZ (1) | NZ518675A (pt) |
| WO (1) | WO2002094189A2 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6649607B2 (en) * | 2001-05-18 | 2003-11-18 | Vela Pharmaceuticals, Inc. | Compositions and methods for treating or preventing convulsions or seizures |
| WO2004024163A1 (en) * | 2002-09-13 | 2004-03-25 | Motac Neuroscience Limited | Treatment of basal ganglia-related movement disorders with 2,3-benzodiazepines |
| ATE360415T1 (de) * | 2002-09-17 | 2007-05-15 | Motac Neuroscience Ltd | Behandlung von dyskinesie |
| CA2510275A1 (en) * | 2002-12-03 | 2004-08-19 | Vela Pharmaceuticals, Inc. | Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof |
| AU2003293405A1 (en) * | 2002-12-03 | 2004-06-23 | Vela Pharmaceuticals, Inc. | Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof |
| US6638928B1 (en) * | 2002-12-03 | 2003-10-28 | Vela Pharmaceuticals, Inc. | Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines |
| US6864251B2 (en) * | 2002-12-03 | 2005-03-08 | Vela Pharmaceuticals, Inc. | Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines |
| US7265106B2 (en) | 2003-05-09 | 2007-09-04 | Vela Aquisition Corporation | Method for isolating (R)-tofisopam |
| CA2525273C (en) * | 2003-05-16 | 2012-04-17 | Vela Pharmaceuticals, Inc. | Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (r) 2,3-benzodiazepine |
| US20050288277A1 (en) * | 2004-06-25 | 2005-12-29 | Kucharik Robert F | Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S)-2,3-benzodiazepine |
| US20070021412A1 (en) * | 2003-05-16 | 2007-01-25 | Vela Pharmaceuticals, Inc. | Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine |
| US20070032479A1 (en) * | 2003-12-03 | 2007-02-08 | Leventer Steven M | Treatment of inflammatory disorders of the epithelium with low dose 2,3-benzodiazepines |
| US20060111743A1 (en) * | 2004-11-19 | 2006-05-25 | Gurney Harry C Jr | Method for arresting seizure activity |
| US7541355B2 (en) * | 2005-05-23 | 2009-06-02 | Vela Acquisition Corporation | Conversion process for 2,3-benzodiazepine enantiomers |
| WO2007082546A1 (en) * | 2006-01-20 | 2007-07-26 | H. Lundbeck A/S | Use of tofisopam as a pde10a inhibitor |
| JP2008174495A (ja) * | 2007-01-19 | 2008-07-31 | Reverse Proteomics Research Institute Co Ltd | 創薬標的タンパク質及び標的遺伝子、並びにスクリーニング方法 |
| US9408852B2 (en) | 2011-07-27 | 2016-08-09 | Pharmos Corporation | Method of lowering serum uric acid levels with (S)-tofisopam |
| CN102836162A (zh) * | 2012-04-10 | 2012-12-26 | 珠海亿邦制药股份有限公司 | 一种以托非索泮为活性成分的口服固体制剂及其应用 |
| CN105363006A (zh) * | 2015-12-16 | 2016-03-02 | 张景英 | 一种用于护理治疗小儿高热惊厥的中药药膏 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK118660B (da) | 1966-12-09 | 1970-09-21 | Egyt Gyogyszervegyeszeti Gyar | Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid. |
| ZA712798B (en) | 1970-11-06 | 1972-02-23 | Egyt Gyogyszervegyeszeti Gyar | New,pharmaceutically active 2,3-diazabicyclo(5.4.0)undecapentaene derivative and process for preparing same |
| HU179018B (en) | 1978-10-19 | 1982-08-28 | Gyogyszerkutato Intezet | Process for producing new 5h-2,3-benzodiazepine derivatives |
| HU186760B (en) | 1981-03-12 | 1985-09-30 | Gyogyszerkutato Intezet | Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives |
| HU191698B (en) | 1984-07-27 | 1987-03-30 | Gyogyszerkutato Intezet | Process for producing new 1-aryl-5h-2beta-benzodiazepines |
| HU198494B (en) | 1986-08-15 | 1989-10-30 | Gyogyszerkutato Intezet | Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same |
| GB9009861D0 (en) | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
| HU207055B (en) | 1990-10-17 | 1993-03-01 | Gyogyszerkutato Intezet | Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same |
| US5519019A (en) | 1990-12-21 | 1996-05-21 | Gyogyszerkutato Intezet | N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions containing them and process for preparing same |
| HU206719B (en) | 1990-12-21 | 1992-12-28 | Gyogyszerkutato Intezet | Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them |
| US5521174A (en) | 1990-12-21 | 1996-05-28 | Gyogyszerkutato Intezet Kv. | N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith |
| HU219778B (hu) | 1990-12-21 | 2001-07-30 | Gyógyszerkutató Intézet Közös Vállalat | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
| US5639751A (en) | 1990-12-21 | 1997-06-17 | Cyogyszerkutato Intezet Kft | N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders |
| US6017965A (en) | 1993-02-08 | 2000-01-25 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US6071970A (en) | 1993-02-08 | 2000-06-06 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| HU219777B (hu) | 1993-07-02 | 2001-07-30 | Gyógyszerkutató Intézet Kft. | Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására |
| ES2170804T3 (es) | 1994-08-31 | 2002-08-16 | Lilly Co Eli | Derivados de dihidro-2,3-benzodiazepina. |
| HU224435B1 (hu) | 1995-02-09 | 2005-10-28 | EGIS Gyógyszergyár Rt. | Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények |
| US5891871A (en) | 1996-03-21 | 1999-04-06 | Cocensys, Inc. | Substituted 2,3-benzodiazepin-4-ones and the use thereof |
| AU1451900A (en) | 1998-10-27 | 2000-05-15 | Vela Pharmaceuticals Inc. | Use of optically pure (r)-tofisopam for treating and preventing anxiety disorders and composition thereof |
| US6080736A (en) | 1999-10-27 | 2000-06-27 | Janus Pharmaceuticals, Inc. | Methods and compositions for treating and preventing anxiety and anxiety disorders using optically pure (R) tofisopam |
| US6649607B2 (en) * | 2001-05-18 | 2003-11-18 | Vela Pharmaceuticals, Inc. | Compositions and methods for treating or preventing convulsions or seizures |
-
2001
- 2001-11-08 US US10/008,516 patent/US6649607B2/en not_active Expired - Lifetime
-
2002
- 2002-04-11 CA CA002381637A patent/CA2381637A1/en not_active Abandoned
- 2002-04-15 IL IL149134A patent/IL149134A/en not_active IP Right Cessation
- 2002-04-26 AU AU37028/02A patent/AU3702802A/en not_active Abandoned
- 2002-05-01 NZ NZ518675A patent/NZ518675A/en unknown
- 2002-05-15 JP JP2002139802A patent/JP2003012518A/ja active Pending
- 2002-05-16 DE DE60203847T patent/DE60203847T2/de not_active Expired - Fee Related
- 2002-05-16 AT AT02253420T patent/ATE293976T1/de not_active IP Right Cessation
- 2002-05-16 EP EP02253420A patent/EP1262184B1/en not_active Expired - Lifetime
- 2002-05-16 ES ES02253420T patent/ES2241962T3/es not_active Expired - Lifetime
- 2002-05-16 GB GB0211247A patent/GB2377636A/en not_active Withdrawn
- 2002-05-17 BR BR0201862-4A patent/BR0201862A/pt not_active IP Right Cessation
- 2002-05-17 AU AU2002303817A patent/AU2002303817A1/en not_active Abandoned
- 2002-05-17 WO PCT/US2002/015996 patent/WO2002094189A2/en not_active Ceased
-
2003
- 2003-07-23 US US10/625,754 patent/US7078398B2/en not_active Expired - Fee Related
-
2006
- 2006-03-24 US US11/388,399 patent/US20060166976A1/en not_active Abandoned
-
2007
- 2007-07-17 JP JP2007185953A patent/JP2007262096A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US7078398B2 (en) | 2006-07-18 |
| DE60203847D1 (de) | 2005-06-02 |
| WO2002094189A3 (en) | 2003-04-10 |
| AU2002303817A1 (en) | 2002-12-03 |
| US6649607B2 (en) | 2003-11-18 |
| IL149134A0 (en) | 2002-11-10 |
| US20060166976A1 (en) | 2006-07-27 |
| WO2002094189A2 (en) | 2002-11-28 |
| JP2003012518A (ja) | 2003-01-15 |
| ES2241962T3 (es) | 2005-11-01 |
| CA2381637A1 (en) | 2002-11-18 |
| US20050075329A1 (en) | 2005-04-07 |
| DE60203847T2 (de) | 2006-01-26 |
| GB2377636A (en) | 2003-01-22 |
| IL149134A (en) | 2007-06-17 |
| EP1262184A1 (en) | 2002-12-04 |
| US20030055048A1 (en) | 2003-03-20 |
| AU3702802A (en) | 2002-11-21 |
| JP2007262096A (ja) | 2007-10-11 |
| GB0211247D0 (en) | 2002-06-26 |
| EP1262184B1 (en) | 2005-04-27 |
| NZ518675A (en) | 2003-07-25 |
| ATE293976T1 (de) | 2005-05-15 |
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