ATE294189T1 - Kristallisation von proteinen - Google Patents

Kristallisation von proteinen

Info

Publication number: ATE294189T1
Authority: AT; Austria
Prior art keywords: solution; value; providing; crystalization; proteins
Prior art date: 1997-02-07

Application number

AT98901323T

Other languages

English (en)

Inventor

Jean Lesley Whittingham

Per Balschmidt

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-07

Filing date

1998-02-03

Publication date

2005-05-15

1998-02-03 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2005-05-15 Application granted granted Critical

2005-05-15 Publication of ATE294189T1 publication Critical patent/ATE294189T1/de

Links

102000004169 proteins and genes Human genes 0.000 title abstract 3
108090000623 proteins and genes Proteins 0.000 title abstract 3
239000013078 crystal Substances 0.000 abstract 2
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
150000003751 zinc Chemical class 0.000 abstract 1
239000011701 zinc Substances 0.000 abstract 1
229910052725 zinc Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/306—Extraction; Separation; Purification by precipitation by crystallization

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Diabetes (AREA)
Crystallography & Structural Chemistry (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)

AT98901323T 1997-02-07 1998-02-03 Kristallisation von proteinen ATE294189T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK14697		1997-02-07
PCT/DK1998/000042 WO1998034953A1 (en)	1997-02-07	1998-02-03	Crystallisation of proteins

Publications (1)

Publication Number	Publication Date
ATE294189T1 true ATE294189T1 (de)	2005-05-15

Family

ID=8090294

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98901323T ATE294189T1 (de)	1997-02-07	1998-02-03	Kristallisation von proteinen

Country Status (7)

Country	Link
EP (1)	EP0966482B1 (de)
JP (1)	JP3343129B2 (de)
AT (1)	ATE294189T1 (de)
AU (1)	AU5749198A (de)
DE (1)	DE69829953T2 (de)
ES (1)	ES2242270T3 (de)
WO (1)	WO1998034953A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SV1998000125A (es)	1997-10-24	1999-05-24	Lilly Co Eli	Composiciones de insulina insoluble ref. x-11232
US6531448B1 (en)	1997-12-23	2003-03-11	Eli Lilly And Company	Insoluble compositions for controlling blood glucose
ES2180511T3 (es) *	1999-01-26	2003-02-16	Lilly Co Eli	Formulaciones monodispersas de analogos de insulina acilados hexamericos.
JP5484041B2 (ja) *	2007-02-23	2014-05-07	学校法人関西学院	蛋白質結晶化剤および蛋白質結晶化剤を用いた蛋白質結晶化方法
PL2464655T3 (pl) *	2009-08-11	2017-08-31	Biocon Limited	Procesy chromatograficzne
JP6110312B2 (ja)	2011-02-01	2017-04-05	ノヴォノルディスクアー／エス	インスリンの精製
US10124040B2 (en)	2014-08-26	2018-11-13	Merck Sharp & Dohme Corp.	Method for preparing crystalline insulin or insulin analog compositions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3856771A (en) *	1973-07-16	1974-12-24	Lilly Co Eli	Process for manufacturing alkali metal or ammonium insulin
DE3327709A1 (de) *	1983-07-29	1985-02-07	Hoechst Ag, 6230 Frankfurt	Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
US5461031A (en) *	1994-06-16	1995-10-24	Eli Lilly And Company	Monomeric insulin analog formulations
US5700904A (en) *	1995-06-07	1997-12-23	Eli Lilly And Company	Preparation of an acylated protein powder

1998
- 1998-02-03 EP EP98901323A patent/EP0966482B1/de not_active Expired - Lifetime
- 1998-02-03 DE DE69829953T patent/DE69829953T2/de not_active Expired - Lifetime
- 1998-02-03 JP JP53358198A patent/JP3343129B2/ja not_active Expired - Fee Related
- 1998-02-03 AT AT98901323T patent/ATE294189T1/de not_active IP Right Cessation
- 1998-02-03 WO PCT/DK1998/000042 patent/WO1998034953A1/en not_active Ceased
- 1998-02-03 AU AU57491/98A patent/AU5749198A/en not_active Abandoned
- 1998-02-03 ES ES98901323T patent/ES2242270T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69829953T2 (de)	2006-03-02
AU5749198A (en)	1998-08-26
EP0966482B1 (de)	2005-04-27
EP0966482A1 (de)	1999-12-29
ES2242270T3 (es)	2005-11-01
JP2000510161A (ja)	2000-08-08
DE69829953D1 (de)	2005-06-02
WO1998034953A1 (en)	1998-08-13
JP3343129B2 (ja)	2002-11-11

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Legal Events

Date	Code	Title	Description
2005-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties