ATE294864T1 - Äusseres membranprotein von haemophilus - Google Patents

Äusseres membranprotein von haemophilus

Info

Publication number
ATE294864T1
ATE294864T1 AT94900671T AT94900671T ATE294864T1 AT E294864 T1 ATE294864 T1 AT E294864T1 AT 94900671 T AT94900671 T AT 94900671T AT 94900671 T AT94900671 T AT 94900671T AT E294864 T1 ATE294864 T1 AT E294864T1
Authority
AT
Austria
Prior art keywords
haemophilus
nucleic acid
membrane protein
outer membrane
diagnosis
Prior art date
Application number
AT94900671T
Other languages
English (en)
Inventor
Pele Chong
Wayne Thomas
Yan-Ping Yang
Sheena Loosmore
Dwo Yuan Charles Sia
Michel Klein
Original Assignee
Aventis Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pasteur filed Critical Aventis Pasteur
Application granted granted Critical
Publication of ATE294864T1 publication Critical patent/ATE294864T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1242—Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
AT94900671T 1992-11-23 1993-11-23 Äusseres membranprotein von haemophilus ATE294864T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929224584A GB9224584D0 (en) 1992-11-23 1992-11-23 Use of outer membrane protein d15 and its peptides as vaccine against haempohilus influenzae diseases
PCT/CA1993/000501 WO1994012641A1 (en) 1992-11-23 1993-11-23 Haemophilus outer membrane protein

Publications (1)

Publication Number Publication Date
ATE294864T1 true ATE294864T1 (de) 2005-05-15

Family

ID=10725587

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94900671T ATE294864T1 (de) 1992-11-23 1993-11-23 Äusseres membranprotein von haemophilus

Country Status (11)

Country Link
US (3) US6013514A (de)
EP (1) EP0668916B1 (de)
JP (1) JP2907552B2 (de)
AT (1) ATE294864T1 (de)
AU (1) AU683435B2 (de)
BR (1) BR9307510A (de)
CA (1) CA2149319C (de)
DE (1) DE69333802T8 (de)
GB (1) GB9224584D0 (de)
RU (1) RU2141528C1 (de)
WO (1) WO1994012641A1 (de)

Families Citing this family (51)

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ES2270420T3 (es) 1993-11-08 2007-04-01 Sanofi Pasteur Limited Genes receptores de la transferrina de haemophilus.
US6361779B1 (en) 1993-11-08 2002-03-26 Aventis Pasteur Limited Transferrin receptor genes
US5981503A (en) * 1994-06-07 1999-11-09 Connaught Laboratories Limited Analog of Haemophilus Hin47 with reduced protease activity
US5506139A (en) * 1994-07-21 1996-04-09 Connaught Laboratories Limited Analog of haemophilus Hin47 with reduced protease activity
US5939297A (en) * 1994-07-21 1999-08-17 Connaught Laboratories Limited Analog of haemophilus HIN47 with reduced protease activity
ATE268384T1 (de) * 1994-07-21 2004-06-15 Aventis Pasteur Analog von haemophilus hin47 mit verminderter protease aktivität
US6153580A (en) * 1994-07-21 2000-11-28 Loosmore; Sheena M. Analog of haemophilus Hin47 with reduced protease activity
RU2196176C2 (ru) * 1994-07-21 2003-01-10 Коннот Лабораториз Лимитед АНАЛОГ HIN47 Haemophilus С РЕДУЦИРОВАННОЙ ПРОТЕАЗНОЙ АКТИВНОСТЬЮ
US5681570A (en) * 1995-01-12 1997-10-28 Connaught Laboratories Limited Immunogenic conjugate molecules
NZ306316A (en) * 1995-04-17 2001-06-29 Smithkline Beecham Biolog S use of lipoprotein and a type 2T independent antigen to induce an immune response to the antigen
US6355450B1 (en) 1995-04-21 2002-03-12 Human Genome Sciences, Inc. Computer readable genomic sequence of Haemophilus influenzae Rd, fragments thereof, and uses thereof
US5780606A (en) * 1995-06-07 1998-07-14 Connaught Laboratories Limited Neisseria meningitidis capsular polysaccharide conjugates
GB9513074D0 (en) 1995-06-27 1995-08-30 Cortecs Ltd Novel anigen
US6033877A (en) * 1995-11-02 2000-03-07 Research Foundation Of State University Of New York Peptide expression and delivery system
US6048539A (en) * 1995-11-02 2000-04-11 Connaught Laboratories Limited Lactoferrin receptor protein
US6211159B1 (en) * 1997-04-11 2001-04-03 University Of Toronto Flagellin gene, FlaC of campylobacter
US5977337A (en) * 1997-06-03 1999-11-02 Connaught Laboratories Limited Lactoferrin receptor genes of Moraxella
US6068993A (en) * 1997-07-02 2000-05-30 Biobras Sa Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin
ES2274627T3 (es) * 1998-06-03 2007-05-16 Glaxosmithkline Biologicals S.A. Proteinas y genes de moraxella catarrhalis, antigenos, anticuerpos y usos.
US6824997B1 (en) 1998-09-18 2004-11-30 Binax, Inc. Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies
US9134303B1 (en) 1998-08-25 2015-09-15 Alere Scarborough, Inc. ICT immunoassay for Legionella pneumophila serogroup 1 antigen employing affinity purified antibodies thereto
US6610306B2 (en) 1998-10-22 2003-08-26 The University Of Montana OMP85 protein of neisseria meningitidis, compositions containing the same and methods of use thereof
US7241449B1 (en) 1999-04-12 2007-07-10 Aventis Pasteur Limited Transferrin receptor genes of moraxella
EP1246848A1 (de) * 1999-12-27 2002-10-09 University Of Manitoba Genetische impfstoffe zur herstellung von antikörpern aus dem eigelb von hühnern gegen enterotoxigenes escherichia coli und sonstige pathogenen
JP4856836B2 (ja) * 2000-03-01 2012-01-18 バイナックス インコーポレイティッド 標的細菌またはその標的糖質抗原成分の存在を検出する方法
US7192725B2 (en) 2000-05-19 2007-03-20 University Of Toronto Flagellin gene, flaC of Campylobacter
GB0022017D0 (en) * 2000-09-08 2000-10-25 Univ Dundee Cell assays
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
GB0103171D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
DE20321889U1 (de) 2002-08-02 2012-03-12 Glaxosmithkline Biologicals S.A. Impfstoffzusammensetzung
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
CN103251940A (zh) 2005-12-22 2013-08-21 葛兰素史密丝克莱恩生物有限公司 疫苗
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
SG10201600336RA (en) 2006-01-17 2016-02-26 Arne Forsgren A novel surface exposed haemophilus influenzae protein (protein e; pe)
BRPI0808333B8 (pt) * 2007-03-05 2021-05-25 Om Pharma extrato bacteriano para doenças respiratórias e processo para sua preparação
MX2009013949A (es) 2007-06-26 2010-05-24 Glaxosmithkline Biolog Sa Vacuna que comprende conjugados de polisacárido capsular de streptococcus pneumoniae.
GB201003924D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Immunogenic composition
JP2013521326A (ja) 2010-03-10 2013-06-10 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 免疫原性組成物
WO2012170356A1 (en) 2011-06-04 2012-12-13 Rochester General Hospital Research Institute Compositions and methods related to p6 of haemophilus influenzae
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
GB201621686D0 (en) 2016-12-20 2017-02-01 Glaxosmithkline Biologicals Sa Novel methods for inducing an immune response
FR3066920A1 (fr) 2017-05-30 2018-12-07 Glaxosmithkline Biologicals S.A. Nouveaux procedes de fabrication d'un adjuvant
JP2021504424A (ja) 2017-12-01 2021-02-15 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム サポニン精製
EP3833382A1 (de) 2018-08-07 2021-06-16 GlaxoSmithKline Biologicals S.A. Verfahren und impfstoffe
JP2022508713A (ja) * 2018-10-15 2022-01-19 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティ オブ アリゾナ ワクチンポリペプチド組成物および方法
WO2020109365A1 (en) 2018-11-29 2020-06-04 Glaxosmithkline Biologicals Sa Methods for manufacturing an adjuvant
CN110540598B (zh) * 2018-12-20 2021-04-30 湖北工业大学 基于流感嗜血杆菌表面蛋白抗体的流感嗜血杆菌Elisa检测试剂盒及制备方法
BR112021024363A2 (pt) 2019-06-05 2022-03-22 Glaxosmithkline Biologicals Sa Purificação de saponina
GB202205833D0 (en) 2022-04-21 2022-06-08 Glaxosmithkline Biologicals Sa Bacteriophage
EP4558170A1 (de) 2022-07-19 2025-05-28 GlaxoSmithKline Biologicals S.A. Kontinuierliches verfahren zur herstellung von impfstoffen

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4888170A (en) * 1981-10-22 1989-12-19 Research Corporation Vaccines obtained from antigenic gene products of recombinant genes
SU1404512A1 (ru) * 1983-01-27 1988-06-23 Институт биологической физики АН СССР Способ получени динуклеотидов
US5194254A (en) 1986-05-06 1993-03-16 Connaught Laboratories Limited Enhancement of antigen immunogenicity
US5013664A (en) * 1986-05-28 1991-05-07 Brodeur Bernard R Common protein of Haemophilus influenzae type b identified by a monoclonal antibody
US5173294A (en) * 1986-11-18 1992-12-22 Research Foundation Of State University Of New York Dna probe for the identification of haemophilus influenzae
US5192540A (en) * 1988-04-19 1993-03-09 American Cyanamid Company Haemophilus influenzae type b oxidized polysaccharide-outer membrane protein conjugate vaccine
EP0378929A3 (de) * 1988-12-23 1990-08-01 Connaught Laboratories Limited Membran-Proteine und Peptide von Haemophilus influenzae Typ B
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
GB8924473D0 (en) * 1989-10-31 1989-12-20 Connaught Lab Outer membrane protein p1 and peptides of haemophilus influenzae b
DK0531497T3 (da) 1991-04-02 1998-03-23 Biotech Australia Pty Ltd Orale indgivelsessystemer til mikropartikler
US5620896A (en) 1992-03-23 1997-04-15 University Of Massachusetts Medical Center DNA vaccines against rotavirus infections
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization

Also Published As

Publication number Publication date
RU2141528C1 (ru) 1999-11-20
DE69333802D1 (de) 2005-06-09
WO1994012641A1 (en) 1994-06-09
JPH08502417A (ja) 1996-03-19
AU5556594A (en) 1994-06-22
US6264954B1 (en) 2001-07-24
DE69333802T8 (de) 2006-05-11
CA2149319A1 (en) 1994-06-09
BR9307510A (pt) 1999-06-01
US6083743A (en) 2000-07-04
DE69333802T2 (de) 2006-01-26
AU683435B2 (en) 1997-11-13
EP0668916A1 (de) 1995-08-30
EP0668916B1 (de) 2005-05-04
JP2907552B2 (ja) 1999-06-21
GB9224584D0 (en) 1993-01-13
CA2149319C (en) 2008-10-07
US6013514A (en) 2000-01-11

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