ATE294864T1 - Äusseres membranprotein von haemophilus - Google Patents

Äusseres membranprotein von haemophilus

Info

Publication number
ATE294864T1
ATE294864T1 AT94900671T AT94900671T ATE294864T1 AT E294864 T1 ATE294864 T1 AT E294864T1 AT 94900671 T AT94900671 T AT 94900671T AT 94900671 T AT94900671 T AT 94900671T AT E294864 T1 ATE294864 T1 AT E294864T1
Authority
AT
Austria
Prior art keywords
haemophilus
nucleic acid
membrane protein
outer membrane
diagnosis
Prior art date
Application number
AT94900671T
Other languages
English (en)
Inventor
Pele Chong
Wayne Thomas
Yan-Ping Yang
Sheena Loosmore
Dwo Yuan Charles Sia
Michel Klein
Original Assignee
Aventis Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pasteur filed Critical Aventis Pasteur
Application granted granted Critical
Publication of ATE294864T1 publication Critical patent/ATE294864T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1242—Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT94900671T 1992-11-23 1993-11-23 Äusseres membranprotein von haemophilus ATE294864T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929224584A GB9224584D0 (en) 1992-11-23 1992-11-23 Use of outer membrane protein d15 and its peptides as vaccine against haempohilus influenzae diseases
PCT/CA1993/000501 WO1994012641A1 (en) 1992-11-23 1993-11-23 Haemophilus outer membrane protein

Publications (1)

Publication Number Publication Date
ATE294864T1 true ATE294864T1 (de) 2005-05-15

Family

ID=10725587

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94900671T ATE294864T1 (de) 1992-11-23 1993-11-23 Äusseres membranprotein von haemophilus

Country Status (11)

Country Link
US (3) US6013514A (de)
EP (1) EP0668916B1 (de)
JP (1) JP2907552B2 (de)
AT (1) ATE294864T1 (de)
AU (1) AU683435B2 (de)
BR (1) BR9307510A (de)
CA (1) CA2149319C (de)
DE (1) DE69333802T8 (de)
GB (1) GB9224584D0 (de)
RU (1) RU2141528C1 (de)
WO (1) WO1994012641A1 (de)

Families Citing this family (51)

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US6361779B1 (en) * 1993-11-08 2002-03-26 Aventis Pasteur Limited Transferrin receptor genes
CA2175332C (en) * 1993-11-08 2009-04-07 Sheena M. Loosmore Haemophilus transferrin receptor genes
US5981503A (en) * 1994-06-07 1999-11-09 Connaught Laboratories Limited Analog of Haemophilus Hin47 with reduced protease activity
US5939297A (en) * 1994-07-21 1999-08-17 Connaught Laboratories Limited Analog of haemophilus HIN47 with reduced protease activity
US5506139A (en) * 1994-07-21 1996-04-09 Connaught Laboratories Limited Analog of haemophilus Hin47 with reduced protease activity
WO1996003506A2 (en) * 1994-07-21 1996-02-08 Connaught Laboratories Limited Analog of haemophilus hin47 with reduced protease activity
US6153580A (en) * 1994-07-21 2000-11-28 Loosmore; Sheena M. Analog of haemophilus Hin47 with reduced protease activity
RU2196176C2 (ru) * 1994-07-21 2003-01-10 Коннот Лабораториз Лимитед АНАЛОГ HIN47 Haemophilus С РЕДУЦИРОВАННОЙ ПРОТЕАЗНОЙ АКТИВНОСТЬЮ
US5681570A (en) 1995-01-12 1997-10-28 Connaught Laboratories Limited Immunogenic conjugate molecules
CA2218385A1 (en) * 1995-04-17 1996-10-24 Pierre Hauser Induction and enhancement of the immune response to polysaccharides with bacterial lipoproteins
US6355450B1 (en) 1995-04-21 2002-03-12 Human Genome Sciences, Inc. Computer readable genomic sequence of Haemophilus influenzae Rd, fragments thereof, and uses thereof
US5780606A (en) * 1995-06-07 1998-07-14 Connaught Laboratories Limited Neisseria meningitidis capsular polysaccharide conjugates
GB9513074D0 (en) 1995-06-27 1995-08-30 Cortecs Ltd Novel anigen
US6048539A (en) * 1995-11-02 2000-04-11 Connaught Laboratories Limited Lactoferrin receptor protein
US6033877A (en) * 1995-11-02 2000-03-07 Research Foundation Of State University Of New York Peptide expression and delivery system
US6211159B1 (en) 1997-04-11 2001-04-03 University Of Toronto Flagellin gene, FlaC of campylobacter
US5977337A (en) 1997-06-03 1999-11-02 Connaught Laboratories Limited Lactoferrin receptor genes of Moraxella
US6068993A (en) * 1997-07-02 2000-05-30 Biobras Sa Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin
TR200003608T2 (tr) * 1998-06-03 2001-04-20 Smithkline Beecham Biologicals S.A. Moraxella Catarrhalis'e ait BASB027 proteinleri ve genleri.
US9134303B1 (en) 1998-08-25 2015-09-15 Alere Scarborough, Inc. ICT immunoassay for Legionella pneumophila serogroup 1 antigen employing affinity purified antibodies thereto
US6824997B1 (en) 1998-09-18 2004-11-30 Binax, Inc. Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies
US6610306B2 (en) 1998-10-22 2003-08-26 The University Of Montana OMP85 protein of neisseria meningitidis, compositions containing the same and methods of use thereof
US7241449B1 (en) 1999-04-12 2007-07-10 Aventis Pasteur Limited Transferrin receptor genes of moraxella
CA2395840A1 (en) * 1999-12-27 2001-07-05 The University Of Manitoba Genetic vaccines for the production of chicken egg-yolk antibodies against enterotoxigenic escherichia coli and other pathogens
JP4856836B2 (ja) * 2000-03-01 2012-01-18 バイナックス インコーポレイティッド 標的細菌またはその標的糖質抗原成分の存在を検出する方法
US7192725B2 (en) 2000-05-19 2007-03-20 University Of Toronto Flagellin gene, flaC of Campylobacter
GB0022017D0 (en) * 2000-09-08 2000-10-25 Univ Dundee Cell assays
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
GB0103171D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
US20060057160A1 (en) 2002-08-02 2006-03-16 Ralph Biemans Vaccine composition
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
KR101515078B1 (ko) 2005-12-22 2015-04-24 글락소스미스클라인 바이오로지칼즈 에스.에이. 백신
MY150105A (en) 2006-01-17 2013-11-29 Forsgren Arne A novel surface exposed haemophilus influenzae protein (protein e; pe)
SI2114421T1 (en) * 2007-03-05 2018-04-30 Om Pharma A bacterial extract for respiratory disorders and a process for its preparation
CA2690708A1 (en) 2007-06-26 2008-12-31 Glaxosmithkline Biologicals S.A. Vaccine
GB201003924D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Immunogenic composition
CA2792687A1 (en) 2010-03-10 2011-09-15 Glaxosmithkline Biologicals S.A. Immunogenic composition
CA2838188C (en) 2011-06-04 2017-04-18 Rochester General Hospital Research Institute Compositions and methods related to p6 of haemophilus influenzae
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
GB201621686D0 (en) 2016-12-20 2017-02-01 Glaxosmithkline Biologicals Sa Novel methods for inducing an immune response
GB2600653B (en) 2017-05-30 2022-11-02 Glaxosmithkline Biologicals Sa Novel methods
BR112020010790A2 (pt) 2017-12-01 2020-11-10 Glaxosmithkline Biologicals S.A. purificação da saponina
EP3833382A1 (de) 2018-08-07 2021-06-16 GlaxoSmithKline Biologicals S.A. Verfahren und impfstoffe
CN113226361A (zh) * 2018-10-15 2021-08-06 代表亚利桑那大学的亚利桑那校董会 疫苗多肽组合物及方法
EP3886901A1 (de) 2018-11-29 2021-10-06 GlaxoSmithKline Biologicals S.A. Verfahren zur herstellung eines adjuvans
CN110540598B (zh) * 2018-12-20 2021-04-30 湖北工业大学 基于流感嗜血杆菌表面蛋白抗体的流感嗜血杆菌Elisa检测试剂盒及制备方法
WO2020245207A1 (en) 2019-06-05 2020-12-10 Glaxosmithkline Biologicals Sa Saponin purification
GB202205833D0 (en) 2022-04-21 2022-06-08 Glaxosmithkline Biologicals Sa Bacteriophage
EP4558170A1 (de) 2022-07-19 2025-05-28 GlaxoSmithKline Biologicals S.A. Kontinuierliches verfahren zur herstellung von impfstoffen

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US4888170A (en) * 1981-10-22 1989-12-19 Research Corporation Vaccines obtained from antigenic gene products of recombinant genes
SU1404512A1 (ru) * 1983-01-27 1988-06-23 Институт биологической физики АН СССР Способ получени динуклеотидов
US5194254A (en) 1986-05-06 1993-03-16 Connaught Laboratories Limited Enhancement of antigen immunogenicity
US5013664A (en) * 1986-05-28 1991-05-07 Brodeur Bernard R Common protein of Haemophilus influenzae type b identified by a monoclonal antibody
US5173294A (en) * 1986-11-18 1992-12-22 Research Foundation Of State University Of New York Dna probe for the identification of haemophilus influenzae
US5192540A (en) * 1988-04-19 1993-03-09 American Cyanamid Company Haemophilus influenzae type b oxidized polysaccharide-outer membrane protein conjugate vaccine
EP0378929A3 (de) * 1988-12-23 1990-08-01 Connaught Laboratories Limited Membran-Proteine und Peptide von Haemophilus influenzae Typ B
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
GB8924473D0 (en) * 1989-10-31 1989-12-20 Connaught Lab Outer membrane protein p1 and peptides of haemophilus influenzae b
HK1002252A1 (en) 1991-04-02 1998-08-07 Biotech Australia Pty. Limited Oral delivery systems for microparticles
US5620896A (en) 1992-03-23 1997-04-15 University Of Massachusetts Medical Center DNA vaccines against rotavirus infections
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization

Also Published As

Publication number Publication date
CA2149319C (en) 2008-10-07
DE69333802D1 (de) 2005-06-09
US6013514A (en) 2000-01-11
JP2907552B2 (ja) 1999-06-21
WO1994012641A1 (en) 1994-06-09
EP0668916A1 (de) 1995-08-30
CA2149319A1 (en) 1994-06-09
AU683435B2 (en) 1997-11-13
DE69333802T2 (de) 2006-01-26
RU2141528C1 (ru) 1999-11-20
AU5556594A (en) 1994-06-22
JPH08502417A (ja) 1996-03-19
BR9307510A (pt) 1999-06-01
US6083743A (en) 2000-07-04
DE69333802T8 (de) 2006-05-11
GB9224584D0 (en) 1993-01-13
EP0668916B1 (de) 2005-05-04
US6264954B1 (en) 2001-07-24

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