ATE29497T1 - 5-aroyl-6-alkylthio-1,2-dihydro-3h-pyrrolo 1,2-a pyrrol-1-carbonsaeuren und deren derivate, verfahren zu ihrer herstellung und zwischenprodukte dafuer. - Google Patents

5-aroyl-6-alkylthio-1,2-dihydro-3h-pyrrolo 1,2-a pyrrol-1-carbonsaeuren und deren derivate, verfahren zu ihrer herstellung und zwischenprodukte dafuer.

Info

Publication number: ATE29497T1
Authority: AT; Austria
Prior art keywords: sub; alkylthio; aroyl; pyrrolo; dihydro
Prior art date: 1982-06-08

Application number

AT83303285T

Other languages

English (en)

Inventor

Joseph Martin Muchowski

Robert James Greenhouse

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-06-08

Filing date

1983-06-07

Publication date

1987-09-15

1983-06-07 Application filed by Syntex Inc filed Critical Syntex Inc

1987-09-15 Application granted granted Critical

1987-09-15 Publication of ATE29497T1 publication Critical patent/ATE29497T1/de

Links

239000013067 intermediate product Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 2
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
231100000252 nontoxic Toxicity 0.000 abstract 2
230000003000 nontoxic effect Effects 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
INKBRQRMBPEPLY-UHFFFAOYSA-N 6-methylsulfonyl-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid Chemical class OC(=O)C1CCN2C=C(S(=O)(=O)C)C=C21 INKBRQRMBPEPLY-UHFFFAOYSA-N 0.000 abstract 1
NPDLYUOYAGBHFB-WDSKDSINSA-N Asn-Arg Chemical group NC(=O)C[C@H](N)C(=O)N[C@H](C(O)=O)CCCN=C(N)N NPDLYUOYAGBHFB-WDSKDSINSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
229940035676 analgesics Drugs 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
230000001760 anti-analgesic effect Effects 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1
-1 trifluoromethoxy, nitro, amino Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
229920002554 vinyl polymer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Public Health (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Plural Heterocyclic Compounds (AREA)

AT83303285T 1982-06-08 1983-06-07 5-aroyl-6-alkylthio-1,2-dihydro-3h-pyrrolo 1,2-a pyrrol-1-carbonsaeuren und deren derivate, verfahren zu ihrer herstellung und zwischenprodukte dafuer. ATE29497T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/386,174 US4612325A (en)	1982-06-08	1982-06-08	5-Aroyl-6-alkylthio-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1-carboxylic acids and use thereof as analgesics and anti-inflammatories
EP83303285A EP0096583B1 (de)	1982-06-08	1983-06-07	5-Aroyl-6-alkylthio-1,2-dihydro-3H-pyrrolo 1,2-a pyrrol-1-Carbonsäuren und deren Derivate, Verfahren zu ihrer Herstellung und Zwischenprodukte dafür

Publications (1)

Publication Number	Publication Date
ATE29497T1 true ATE29497T1 (de)	1987-09-15

Family

ID=23524483

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT83303285T ATE29497T1 (de)	1982-06-08	1983-06-07	5-aroyl-6-alkylthio-1,2-dihydro-3h-pyrrolo 1,2-a pyrrol-1-carbonsaeuren und deren derivate, verfahren zu ihrer herstellung und zwischenprodukte dafuer.

Country Status (16)

Country	Link
US (1)	US4612325A (de)
EP (1)	EP0096583B1 (de)
JP (1)	JPS595190A (de)
KR (1)	KR880000393B1 (de)
AT (1)	ATE29497T1 (de)
AU (1)	AU556295B2 (de)
CA (1)	CA1200244A (de)
DE (1)	DE3373474D1 (de)
DK (1)	DK260483A (de)
ES (4)	ES523063A0 (de)
FI (1)	FI77245C (de)
HU (1)	HU190106B (de)
IL (1)	IL68909A (de)
NO (1)	NO162386B (de)
NZ (1)	NZ204487A (de)
ZA (1)	ZA834137B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4560699A (en) *	1983-01-17	1985-12-24	Syntex (U.S.A.) Inc.	5-(4-Vinylbenzoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof and use as analgesics and anti-inflammatories
JPH0739418B2 (ja) *	1987-09-10	1995-05-01	久光製薬株式会社	新規な３−アロイル−６，７−ジヒドロ−５Ｈ−ピロロ〔１，２−ｃ〕イミダゾール−７−カルボン酸誘導体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4097579A (en) *	1977-03-31	1978-06-27	Syntex (U.S.A.) Inc.	5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4232038A (en) *	1979-08-31	1980-11-04	Syntex (U.S.A.) Inc.	5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids
US4344943A (en) *	1980-06-09	1982-08-17	Syntex (U.S.A.) Inc.	6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4353829A (en) *	1980-11-21	1982-10-12	Syntex (U.S.A.) Inc.	Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4511724A (en) *	1982-06-10	1985-04-16	Merck & Co., Inc.	5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents

1982
- 1982-06-08 US US06/386,174 patent/US4612325A/en not_active Expired - Fee Related
1983
- 1983-06-07 FI FI832045A patent/FI77245C/fi not_active IP Right Cessation
- 1983-06-07 AU AU15464/83A patent/AU556295B2/en not_active Ceased
- 1983-06-07 HU HU832030A patent/HU190106B/hu not_active IP Right Cessation
- 1983-06-07 IL IL68909A patent/IL68909A/xx unknown
- 1983-06-07 AT AT83303285T patent/ATE29497T1/de not_active IP Right Cessation
- 1983-06-07 KR KR1019830002524A patent/KR880000393B1/ko not_active Expired
- 1983-06-07 ES ES523063A patent/ES523063A0/es active Granted
- 1983-06-07 NZ NZ204487A patent/NZ204487A/xx unknown
- 1983-06-07 DK DK260483A patent/DK260483A/da not_active Application Discontinuation
- 1983-06-07 DE DE8383303285T patent/DE3373474D1/de not_active Expired
- 1983-06-07 ZA ZA834137A patent/ZA834137B/xx unknown
- 1983-06-07 NO NO832053A patent/NO162386B/no unknown
- 1983-06-07 JP JP58102535A patent/JPS595190A/ja active Pending
- 1983-06-07 EP EP83303285A patent/EP0096583B1/de not_active Expired
- 1983-06-07 CA CA000429837A patent/CA1200244A/en not_active Expired
1984
- 1984-11-16 ES ES537695A patent/ES537695A0/es active Granted
- 1984-11-16 ES ES537694A patent/ES8600294A1/es not_active Expired
- 1984-11-16 ES ES537696A patent/ES537696A0/es active Granted

Also Published As

Publication number	Publication date
NO162386B (no)	1989-09-11
US4612325A (en)	1986-09-16
KR880000393B1 (ko)	1988-03-21
ES8600295A1 (es)	1985-10-16
FI77245B (fi)	1988-10-31
FI832045L (fi)	1983-12-09
IL68909A (en)	1987-02-27
FI832045A0 (fi)	1983-06-07
EP0096583B1 (de)	1987-09-09
ES537694A0 (es)	1985-10-16
ES537695A0 (es)	1985-10-16
ES8600296A1 (es)	1985-10-16
CA1200244A (en)	1986-02-04
FI77245C (fi)	1989-02-10
ES8502999A1 (es)	1985-02-16
JPS595190A (ja)	1984-01-12
DE3373474D1 (en)	1987-10-15
NO832053L (no)	1983-12-09
ZA834137B (en)	1985-01-30
ES8600294A1 (es)	1985-10-16
ES537696A0 (es)	1985-10-16
DK260483D0 (da)	1983-06-07
KR840005144A (ko)	1984-11-03
AU1546483A (en)	1983-12-15
AU556295B2 (en)	1986-10-30
ES523063A0 (es)	1985-02-16
DK260483A (da)	1983-12-09
EP0096583A3 (en)	1985-05-02
NZ204487A (en)	1986-06-11
IL68909A0 (en)	1983-10-31
HU190106B (en)	1986-08-28
EP0096583A2 (de)	1983-12-21

Legal Events

Date	Code	Title	Description
1988-03-15	UEP	Publication of translation of european patent specification
1991-03-15	REN	Ceased due to non-payment of the annual fee

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