ES8600295A1 - Procedimiento para preparar acidos 5-aroil-6-alcohiltio-1, 2-dihidro-3h-pirrolo (1, 2-a) pirrol-1-carboxilicos - Google Patents

Procedimiento para preparar acidos 5-aroil-6-alcohiltio-1, 2-dihidro-3h-pirrolo (1, 2-a) pirrol-1-carboxilicos

Info

Publication number
ES8600295A1
ES8600295A1 ES537695A ES537695A ES8600295A1 ES 8600295 A1 ES8600295 A1 ES 8600295A1 ES 537695 A ES537695 A ES 537695A ES 537695 A ES537695 A ES 537695A ES 8600295 A1 ES8600295 A1 ES 8600295A1
Authority
ES
Spain
Prior art keywords
aroyl
pyrrolo
pyrrole
dihydro
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537695A
Other languages
English (en)
Other versions
ES537695A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES8600295A1 publication Critical patent/ES8600295A1/es
Publication of ES537695A0 publication Critical patent/ES537695A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS 5-AROIL-6-ALCOHILTIO-1,2-DIHIDRO-3H-PIRROLO1,2-APIRROL-1-CARBOXILICOS Y DE SUS ESTERES Y SALES NO TOXICOS, FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I) O (II), EN LAS QUE R1, R2 Y X PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA HIDROLISIS DE UN ESTER O UNA SAL DE FORMULA (I) O (II) PARA FORMAR EL CORRESPONDIENTE ACIDO LIBRE DE FORMULA (I) O (II). LA HIDROLISIS SE LLEVA A CABO POR TRATAMIENTO DE LA DISOLUCION ALCOHOLICA DEL ESTER O SAL CON UNA BASE ACUOSA, TAL COMO HIDROXIDO SODICO, CON AGITACION A TEMPERATURA AMBIENTE. SE ELIMINA EL ALCOHOL Y EL RESIDUO SE EXTRAE CON UN DISOLVENTE ORGANICO; DE LA FASE ACUOSA SE SEPARA EL PRODUCTO Y SE PURIFICA.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIINFLAMATORIOS, ANALGESICOS, ANTIPIRETICOS, FIBRINOLITICOS Y RELAJANTES.
ES537695A 1982-06-08 1984-11-16 Procedimiento para preparar acidos 5-aroil-6-alcohiltio-1, 2-dihidro-3h-pirrolo (1, 2-a) pirrol-1-carboxilicos Granted ES537695A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/386,174 US4612325A (en) 1982-06-08 1982-06-08 5-Aroyl-6-alkylthio-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1-carboxylic acids and use thereof as analgesics and anti-inflammatories

Publications (2)

Publication Number Publication Date
ES8600295A1 true ES8600295A1 (es) 1985-10-16
ES537695A0 ES537695A0 (es) 1985-10-16

Family

ID=23524483

Family Applications (4)

Application Number Title Priority Date Filing Date
ES523063A Granted ES523063A0 (es) 1982-06-08 1983-06-07 Procedimiento para preparar acidos 5-aroil-6-alcohiltio-1,2, dihidro-3h-pirrolo 1,2-a pirrol-1-carboxilicos
ES537696A Granted ES537696A0 (es) 1982-06-08 1984-11-16 Procedimiento para preparar acidos 5-aroil-6-alcohiltio-1, 2-dihidro-3h-pirrolo (1, 2-a) pirrol-1-carboxilicos
ES537695A Granted ES537695A0 (es) 1982-06-08 1984-11-16 Procedimiento para preparar acidos 5-aroil-6-alcohiltio-1, 2-dihidro-3h-pirrolo (1, 2-a) pirrol-1-carboxilicos
ES537694A Granted ES537694A0 (es) 1982-06-08 1984-11-16 Procedimiento para preparar acidos 5-aroil-6-alcohiltio-1, 2-dihidro-3h-pirrolo (1, 2-a) pirrol-1-carboxilicos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES523063A Granted ES523063A0 (es) 1982-06-08 1983-06-07 Procedimiento para preparar acidos 5-aroil-6-alcohiltio-1,2, dihidro-3h-pirrolo 1,2-a pirrol-1-carboxilicos
ES537696A Granted ES537696A0 (es) 1982-06-08 1984-11-16 Procedimiento para preparar acidos 5-aroil-6-alcohiltio-1, 2-dihidro-3h-pirrolo (1, 2-a) pirrol-1-carboxilicos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES537694A Granted ES537694A0 (es) 1982-06-08 1984-11-16 Procedimiento para preparar acidos 5-aroil-6-alcohiltio-1, 2-dihidro-3h-pirrolo (1, 2-a) pirrol-1-carboxilicos

Country Status (16)

Country Link
US (1) US4612325A (es)
EP (1) EP0096583B1 (es)
JP (1) JPS595190A (es)
KR (1) KR880000393B1 (es)
AT (1) ATE29497T1 (es)
AU (1) AU556295B2 (es)
CA (1) CA1200244A (es)
DE (1) DE3373474D1 (es)
DK (1) DK260483A (es)
ES (4) ES523063A0 (es)
FI (1) FI77245C (es)
HU (1) HU190106B (es)
IL (1) IL68909A (es)
NO (1) NO162386B (es)
NZ (1) NZ204487A (es)
ZA (1) ZA834137B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560699A (en) * 1983-01-17 1985-12-24 Syntex (U.S.A.) Inc. 5-(4-Vinylbenzoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof and use as analgesics and anti-inflammatories
JPH0739418B2 (ja) * 1987-09-10 1995-05-01 久光製薬株式会社 新規な３−アロイル−６，７−ジヒドロ−５Ｈ−ピロロ〔１，２−ｃ〕イミダゾール−７−カルボン酸誘導体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097579A (en) * 1977-03-31 1978-06-27 Syntex (U.S.A.) Inc. 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4232038A (en) * 1979-08-31 1980-11-04 Syntex (U.S.A.) Inc. 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids
US4344943A (en) * 1980-06-09 1982-08-17 Syntex (U.S.A.) Inc. 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4511724A (en) * 1982-06-10 1985-04-16 Merck & Co., Inc. 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents

Also Published As

Publication number Publication date
EP0096583A2 (en) 1983-12-21
IL68909A (en) 1987-02-27
ES8600294A1 (es) 1985-10-16
KR840005144A (ko) 1984-11-03
NZ204487A (en) 1986-06-11
DK260483D0 (da) 1983-06-07
ES8502999A1 (es) 1985-02-16
AU556295B2 (en) 1986-10-30
DE3373474D1 (en) 1987-10-15
NO832053L (no) 1983-12-09
NO162386B (no) 1989-09-11
FI77245B (fi) 1988-10-31
KR880000393B1 (ko) 1988-03-21
HU190106B (en) 1986-08-28
EP0096583A3 (en) 1985-05-02
ES523063A0 (es) 1985-02-16
ES8600296A1 (es) 1985-10-16
US4612325A (en) 1986-09-16
ATE29497T1 (de) 1987-09-15
FI77245C (fi) 1989-02-10
DK260483A (da) 1983-12-09
FI832045A0 (fi) 1983-06-07
AU1546483A (en) 1983-12-15
CA1200244A (en) 1986-02-04
ES537696A0 (es) 1985-10-16
JPS595190A (ja) 1984-01-12
ES537694A0 (es) 1985-10-16
IL68909A0 (en) 1983-10-31
FI832045L (fi) 1983-12-09
EP0096583B1 (en) 1987-09-09
ES537695A0 (es) 1985-10-16
ZA834137B (en) 1985-01-30

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