ATE295153T1 - Verfahren zur herstellung von metoprolol enthaltenden mikropartikeln - Google Patents

Verfahren zur herstellung von metoprolol enthaltenden mikropartikeln

Info

Publication number
ATE295153T1
ATE295153T1 AT02701873T AT02701873T ATE295153T1 AT E295153 T1 ATE295153 T1 AT E295153T1 AT 02701873 T AT02701873 T AT 02701873T AT 02701873 T AT02701873 T AT 02701873T AT E295153 T1 ATE295153 T1 AT E295153T1
Authority
AT
Austria
Prior art keywords
microparticles containing
producing microparticles
metoprolol
containing metoprolol
microparticles
Prior art date
Application number
AT02701873T
Other languages
English (en)
Inventor
Alf Djurle
Mikael Hansson
Malin Soederbom
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE295153T1 publication Critical patent/ATE295153T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
AT02701873T 2001-03-09 2002-03-06 Verfahren zur herstellung von metoprolol enthaltenden mikropartikeln ATE295153T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0100824A SE0100824D0 (sv) 2001-03-09 2001-03-09 Method III to obtain microparticles
PCT/SE2002/000401 WO2002072074A1 (en) 2001-03-09 2002-03-06 Method to prepare microparticles metoprolol that contain

Publications (1)

Publication Number Publication Date
ATE295153T1 true ATE295153T1 (de) 2005-05-15

Family

ID=20283295

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02701873T ATE295153T1 (de) 2001-03-09 2002-03-06 Verfahren zur herstellung von metoprolol enthaltenden mikropartikeln

Country Status (24)

Country Link
US (1) US20040116392A1 (de)
EP (1) EP1370245B1 (de)
JP (1) JP2004522798A (de)
KR (1) KR20030081507A (de)
CN (1) CN1236761C (de)
AT (1) ATE295153T1 (de)
AU (1) AU2002235102B2 (de)
BR (1) BR0207919A (de)
CA (1) CA2440167A1 (de)
DE (1) DE60204125T2 (de)
ES (1) ES2240691T3 (de)
HU (1) HUP0303450A2 (de)
IL (1) IL157777A0 (de)
IS (1) IS6937A (de)
MX (1) MXPA03008088A (de)
NO (1) NO20033967L (de)
NZ (1) NZ528168A (de)
PL (1) PL363972A1 (de)
PT (1) PT1370245E (de)
RU (1) RU2292878C2 (de)
SE (1) SE0100824D0 (de)
UA (1) UA75909C2 (de)
WO (1) WO2002072074A1 (de)
ZA (1) ZA200306880B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0100823D0 (sv) * 2001-03-09 2001-03-09 Astrazeneca Ab Method I to obtain microparticles
US20060159756A1 (en) * 1999-09-10 2006-07-20 Brita Sjoblom Method to obtain microparticles containing an H+,K+-ATP-ASE inhibitor
SE0100822D0 (sv) * 2001-03-09 2001-03-09 Astrazeneca Ab Method II to obtain microparticles
US8006685B2 (en) * 2002-07-05 2011-08-30 Turbochef Technologies, Inc. Re-circulating oven with gas clean-up
DK1915137T3 (da) 2005-08-10 2013-11-04 Add Advanced Drug Delivery Technologies Ltd Oralt præparat med kontrolleret frisætning
US20070053983A1 (en) * 2005-09-06 2007-03-08 Girish Jain Extended release compositions of metoprolol succinate
EP2063876A1 (de) * 2006-07-28 2009-06-03 Farmaprojects, S.A. Pharmazeutische metoprolol-formulierung mit verlängerter freisetzung und herstellungsverfahren dafür
CN101668513A (zh) * 2007-02-23 2010-03-10 格拉特气体技术公司 确定待施用的包衣的重量以形成控释剂型的方法
CN101269056B (zh) * 2007-03-19 2010-05-19 天津药物研究院 一种美托洛尔盐类口服脉冲微丸制剂
CA2702055C (en) * 2007-10-10 2017-12-12 Mallinckrodt Baker, Inc. Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof
US20100055180A1 (en) * 2007-10-10 2010-03-04 Mallinckrodt Baker, Inc. Directly Compressible Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof
CN102641257A (zh) * 2012-03-31 2012-08-22 内蒙古医学院 阿替洛尔缓释微囊及其制备方法
RU2585023C1 (ru) * 2014-12-18 2016-05-27 Общество с ограниченной ответственностью "Нанолек" Способ гранулирования
CN104739805B (zh) * 2015-04-09 2017-12-19 邸蓉 制备琥珀酸美托洛尔缓释微丸的复相乳液法
EP3768378B1 (de) 2018-03-22 2025-08-06 InCarda Therapeutics, Inc. Neuartiges verfahren zur verlangsamung der ventrikulären rate
CN115252913A (zh) * 2022-08-02 2022-11-01 赛诺神畅医疗科技有限公司 一种血管给药涂层及其制备方法和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US653014A (en) * 1899-10-06 1900-07-03 Ashley & Bailey Company Process of silkifying cotton.
SE354851B (de) * 1970-02-18 1973-03-26 Haessle Ab
SE418247B (sv) * 1975-11-17 1981-05-18 Haessle Ab Sett att framstella kroppar med reglerad frigoring av en aktiv komponent
DE3565475D1 (en) * 1984-04-07 1988-11-17 Bayer Ag Process and apparatus for the production of granules
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
SE450087B (sv) * 1985-10-11 1987-06-09 Haessle Ab Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial
SE455836B (sv) * 1985-10-11 1988-08-15 Haessle Ab Beredning med kontrollerad frisettning innehallande ett salt av metoprolol samt metod for framstellning av denna beredning
DE3909455A1 (de) * 1989-03-22 1990-09-27 Hoechst Ag Verfahren zur herstellung von wasserdispergierbaren granulaten
FR2725623A1 (fr) * 1994-10-18 1996-04-19 Flamel Tech Sa Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os
WO1997006787A2 (en) * 1995-08-17 1997-02-27 Dyer, Alison, Margaret Controlled release products
DE19613395A1 (de) * 1996-04-03 1997-10-09 Basf Ag Granulate hygroskopischer, wasserlöslicher Produkte
US6096339A (en) * 1997-04-04 2000-08-01 Alza Corporation Dosage form, process of making and using same
US5891474A (en) * 1997-01-29 1999-04-06 Poli Industria Chimica, S.P.A. Time-specific controlled release dosage formulations and method of preparing same
DE19733094A1 (de) * 1997-07-31 1999-02-04 Merck Patent Gmbh Formulierung auf der Basis von Ascorbinsäure mit verbesserter Farbstabilität
ATE346589T1 (de) * 1997-10-15 2006-12-15 Merck Patent Gmbh Herstellung eines direkt verpressbaren tablettierhilfsstoffes
EP0987020A1 (de) * 1998-09-04 2000-03-22 Pharma Pass LLC Zusammensetzung enthaltend Metoprolol und Verfahren zur Herstellung
US6395300B1 (en) * 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
SE0100823D0 (sv) * 2001-03-09 2001-03-09 Astrazeneca Ab Method I to obtain microparticles
US20060159756A1 (en) * 1999-09-10 2006-07-20 Brita Sjoblom Method to obtain microparticles containing an H+,K+-ATP-ASE inhibitor
US20020058065A1 (en) * 2000-09-20 2002-05-16 Pol-Henri Guivarc'h Insoluble drug particle compositions with improved fasted-fed effects
SE0100822D0 (sv) * 2001-03-09 2001-03-09 Astrazeneca Ab Method II to obtain microparticles

Also Published As

Publication number Publication date
CN1236761C (zh) 2006-01-18
DE60204125T2 (de) 2006-01-19
ES2240691T3 (es) 2005-10-16
MXPA03008088A (es) 2003-12-12
US20040116392A1 (en) 2004-06-17
RU2003127739A (ru) 2005-03-10
NZ528168A (en) 2005-01-28
CA2440167A1 (en) 2002-09-19
PT1370245E (pt) 2005-08-31
NO20033967L (no) 2003-10-28
AU2002235102B2 (en) 2006-08-31
BR0207919A (pt) 2004-04-27
UA75909C2 (en) 2006-06-15
WO2002072074A1 (en) 2002-09-19
EP1370245A1 (de) 2003-12-17
HK1059737A1 (en) 2004-07-16
PL363972A1 (en) 2004-11-29
CN1507345A (zh) 2004-06-23
SE0100824D0 (sv) 2001-03-09
KR20030081507A (ko) 2003-10-17
NO20033967D0 (no) 2003-09-08
IS6937A (is) 2003-09-03
HUP0303450A2 (hu) 2004-01-28
RU2292878C2 (ru) 2007-02-10
EP1370245B1 (de) 2005-05-11
JP2004522798A (ja) 2004-07-29
DE60204125D1 (de) 2005-06-16
ZA200306880B (en) 2004-12-03
IL157777A0 (en) 2004-03-28

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