ATE295184T1 - Stabilisierung von zusammensetzungen enthaltend ace-hemmer durch magnesiumoxid - Google Patents

Stabilisierung von zusammensetzungen enthaltend ace-hemmer durch magnesiumoxid

Info

Publication number: ATE295184T1
Authority: AT; Austria
Prior art keywords: stabilization; magnesium oxide; compositions containing; ace inhibitors; containing ace
Prior art date: 1998-06-05

Application number

AT99922899T

Other languages

English (en)

Inventor

Jane Ellen Daniel

Michael Ray Harris

Gerard Clifford Hokanson

Jay Weiss

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-05

Filing date

1999-05-10

Publication date

2005-05-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22210458&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE295184(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-05-10 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2005-05-15 Application granted granted Critical

2005-05-15 Publication of ATE295184T1 publication Critical patent/ATE295184T1/de

Links

239000005541 ACE inhibitor Substances 0.000 title 1
229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 title 1
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 title 1
239000000395 magnesium oxide Substances 0.000 title 1
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 title 1
239000000203 mixture Substances 0.000 title 1
230000006641 stabilisation Effects 0.000 title 1
238000011105 stabilization Methods 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Botany (AREA)
Zoology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Oil, Petroleum & Natural Gas (AREA)
Biophysics (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT99922899T 1998-06-05 1999-05-10 Stabilisierung von zusammensetzungen enthaltend ace-hemmer durch magnesiumoxid ATE295184T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8828098P	1998-06-05	1998-06-05
PCT/US1999/010189 WO1999062560A1 (en)	1998-06-05	1999-05-10	Stabilization of compositions containing ace inhibitors using magnesium oxide

Publications (1)

Publication Number	Publication Date
ATE295184T1 true ATE295184T1 (de)	2005-05-15

Family

ID=22210458

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99922899T ATE295184T1 (de)	1998-06-05	1999-05-10	Stabilisierung von zusammensetzungen enthaltend ace-hemmer durch magnesiumoxid

Country Status (32)

Country	Link
US (3)	US6417196B1 (de)
EP (1)	EP1083931B1 (de)
JP (1)	JP3727848B2 (de)
KR (1)	KR20010052557A (de)
CN (1)	CN1144598C (de)
AR (1)	AR019150A1 (de)
AT (1)	ATE295184T1 (de)
AU (1)	AU755616B2 (de)
BR (1)	BR9910947A (de)
CA (1)	CA2330581A1 (de)
CO (1)	CO5011043A1 (de)
DE (1)	DE69925269T2 (de)
ES (1)	ES2242398T3 (de)
GT (1)	GT199900079A (de)
HK (1)	HK1038879B (de)
HN (1)	HN1999000088A (de)
HU (1)	HUP0102260A3 (de)
ID (1)	ID27398A (de)
IL (1)	IL139590A0 (de)
IS (1)	IS2270B (de)
MY (1)	MY119667A (de)
NO (1)	NO20006148L (de)
NZ (1)	NZ508544A (de)
PA (1)	PA8475001A1 (de)
PE (1)	PE20000543A1 (de)
PL (1)	PL344586A1 (de)
SV (1)	SV1999000072A (de)
TR (1)	TR200003600T2 (de)
TW (1)	TW565455B (de)
UY (1)	UY25546A1 (de)
WO (1)	WO1999062560A1 (de)
ZA (1)	ZA200006537B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1083931B1 (de) *	1998-06-05	2005-05-11	Warner-Lambert Company LLC	Stabilisierung von zusammensetzungen enthaltend ace-hemmer durch magnesiumoxid
NZ333206A (en) *	1998-12-08	2000-07-28	Bernard Charles Sherman	Solid pharmaceutical compositions comprising a stable magnesium salt of quinapril that acts as a ACE (Angiotensin Converting Enzyme) inhibitor
GB0001621D0 (en)	2000-01-26	2000-03-15	Astrazeneca Ab	Pharmaceutical compositions
CA2408796C (en) *	2000-05-24	2009-12-15	Otsuka Pharmaceutical Co., Ltd.	Method of stabilizing preparation
EA007981B1 (ru) *	2002-01-15	2007-02-27	Актавис Груп Хф.	Фармацевтический состав, содержащий хинаприл или фармацевтически приемлемую его соль
US20030157165A1 (en) *	2002-02-01	2003-08-21	Sherman Bernard Charles	Stable saccharide-free tablets comprising a salt of quinapril or moexipril
US7638138B2 (en) *	2003-02-21	2009-12-29	Translational Research, Ltd.	Compositions for nasal administration of pharmaceuticals
WO2004087243A1 (ja)	2003-03-27	2004-10-14	Bioactis Limited	鼻腔用粉末薬剤施薬装置
CZ298224B6 (cs) *	2003-04-29	2007-07-25	Pliva Istrazivanje I Razvoj D.O.O.	Farmaceutická kompozice obsahující jako úcinnou látku ribavirin a zpusob její výroby
CA2530788C (en) *	2003-06-26	2010-02-09	Teva Pharmaceutical Industries Ltd	Stable pharmaceutical compositions of 2-aza-bicyclo[3.3.0]-octane-3-carboxylic acid derivatives
WO2006016530A1 (ja) *	2004-08-10	2006-02-16	Translational Research, Ltd.	速効性でかつ高い吸収性を可能とする経鼻投与用組成物
US7799937B2 (en)	2004-10-25	2010-09-21	Synthonics, Inc.	Metal coordinated compositions
US8779175B2 (en)	2004-10-25	2014-07-15	Synthonics, Inc.	Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients
US20060141054A1 (en)	2004-10-25	2006-06-29	Thomas Piccariello	Metal coordinated compositions
ITMI20060026A1 (it) *	2006-01-10	2007-07-11	Truffini & Regge Farmaceutici Srl	Composizioni per uso rale a base di s-adenosilmetionina e processo per il loro ottenimento
EP1815857A1 (de)	2006-02-02	2007-08-08	LEK Pharmaceuticals D.D.	Pharmazeutische Zusammensetzung enthaltend Perindopril
US20070232680A1 (en) *	2006-04-04	2007-10-04	Vijayabhaskar Bolugoddu	Preparation of ramipril and stable pharmaceutical compositions
WO2007120930A2 (en) *	2006-04-19	2007-10-25	Teva Pharmaceutical Industries Ltd.	Stable pharmaceutical compositions of 2-aza-bicyclo[3.3.0]-octane-3-carboxylic acid derivatives
AU2007264414A1 (en) *	2006-06-30	2008-01-03	Alphapharm Pty Ltd	A stabilised composition comprising ACE inhibitors
US20080071141A1 (en) *	2006-09-18	2008-03-20	Abhisuek Gattani	Method and apparatus for measuring attributes of an anatomical feature during a medical procedure
ES2652415T3 (es)	2006-12-26	2018-02-02	Shin Nippon Biomedical Laboratories, Ltd.	Preparación para aplicación transnasal
WO2008132756A1 (en) *	2007-05-01	2008-11-06	Lupin Limited	Stable pharmaceutical compositions of ramipril
JP5113476B2 (ja) *	2007-10-09	2013-01-09	沢井製薬株式会社	保存安定性に優れた塩酸テモカプリルの錠剤
EP2429495A4 (de) *	2009-05-15	2014-01-22	Shin Nippon Biomedical Lab Ltd	Intranasale pharmazeutische zusammensetzung mit verbesserter pharmakokinetik
GB2472327B (en)	2009-07-31	2013-03-13	Shin Nippon Biomedical Lab Ltd	Intranasal granisetron and nasal applicator
TR200906322A2 (tr)	2009-08-17	2011-07-21	Bi̇lgi̇ç Mahmut	Çözünürlük ve stabilite özellikleri geliştirilmiş granüller.
ES2364011B1 (es)	2009-11-20	2013-01-24	Gp Pharm, S.A.	Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados para el tratamiento de enfermedades cardiovasculares.
TN2010000566A1 (en) *	2010-12-03	2012-05-24	Rekik Raouf	Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs
CN102512656B (zh) *	2011-12-27	2013-11-27	天津市嵩锐医药科技有限公司	盐酸喹那普利药物组合物
US11744967B2 (en)	2017-09-26	2023-09-05	Shin Nippon Biomedical Laboratories, Ltd.	Intranasal delivery devices

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US4344949A (en)	1980-10-03	1982-08-17	Warner-Lambert Company	Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4425355A (en)	1981-02-17	1984-01-10	Warner-Lambert Company	Substituted acyl derivatives of chair form of octahydro-1H-indole-2-carboxylic acids
US4793998A (en)	1986-10-20	1988-12-27	Warner-Lambert Company	Stabilized drug compositions
US4830853A (en)	1986-10-20	1989-05-16	Warner-Lambert Company	Drug compositions stabilized against oxidation
US4743450A (en)	1987-02-24	1988-05-10	Warner-Lambert Company	Stabilized compositions
US4830583A (en) *	1988-03-02	1989-05-16	Sri International	Fluid motor-pumping apparatus and system
US5622985A (en) *	1990-06-11	1997-04-22	Bristol-Myers Squibb Company	Method for preventing a second heart attack employing an HMG CoA reductase inhibitor
HU222489B1 (hu) *	1990-07-25	2003-07-28	Novartis Ag.	Stabilizált gyógyszerkészítmények és eljárás az előállításukra
IT1251153B (it) *	1991-08-06	1995-05-04	Vectorpharma Int	Composizioni farmaceutiche solide per somministrazione orale aventi proungata residenza gastrica
JP3414539B2 (ja) *	1994-05-11	2003-06-09	有限会社ドット	経鼻吸収用組成物
IT1282650B1 (it) *	1996-02-19	1998-03-31	Jagotec Ag	Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici
EP1083931B1 (de) *	1998-06-05	2005-05-11	Warner-Lambert Company LLC	Stabilisierung von zusammensetzungen enthaltend ace-hemmer durch magnesiumoxid
NZ333206A (en) *	1998-12-08	2000-07-28	Bernard Charles Sherman	Solid pharmaceutical compositions comprising a stable magnesium salt of quinapril that acts as a ACE (Angiotensin Converting Enzyme) inhibitor

1999
- 1999-05-10 EP EP99922899A patent/EP1083931B1/de not_active Revoked
- 1999-05-10 IL IL13959099A patent/IL139590A0/xx not_active IP Right Cessation
- 1999-05-10 CN CNB998070262A patent/CN1144598C/zh not_active Expired - Fee Related
- 1999-05-10 ID IDW20002515A patent/ID27398A/id unknown
- 1999-05-10 NZ NZ508544A patent/NZ508544A/xx unknown
- 1999-05-10 ES ES99922899T patent/ES2242398T3/es not_active Expired - Lifetime
- 1999-05-10 WO PCT/US1999/010189 patent/WO1999062560A1/en not_active Ceased
- 1999-05-10 DE DE69925269T patent/DE69925269T2/de not_active Revoked
- 1999-05-10 AT AT99922899T patent/ATE295184T1/de not_active IP Right Cessation
- 1999-05-10 US US09/700,883 patent/US6417196B1/en not_active Expired - Fee Related
- 1999-05-10 KR KR1020007013714A patent/KR20010052557A/ko not_active Ceased
- 1999-05-10 HU HU0102260A patent/HUP0102260A3/hu unknown
- 1999-05-10 TR TR2000/03600T patent/TR200003600T2/xx unknown
- 1999-05-10 AU AU39793/99A patent/AU755616B2/en not_active Ceased
- 1999-05-10 BR BR9910947-6A patent/BR9910947A/pt not_active Application Discontinuation
- 1999-05-10 CA CA002330581A patent/CA2330581A1/en not_active Abandoned
- 1999-05-10 HK HK02100407.5A patent/HK1038879B/zh not_active IP Right Cessation
- 1999-05-10 PL PL99344586A patent/PL344586A1/xx not_active Application Discontinuation
- 1999-05-10 JP JP2000551814A patent/JP3727848B2/ja not_active Expired - Fee Related
- 1999-05-18 TW TW088108107A patent/TW565455B/zh not_active IP Right Cessation
- 1999-06-03 MY MYPI99002229A patent/MY119667A/en unknown
- 1999-06-03 HN HN1999000088A patent/HN1999000088A/es unknown
- 1999-06-04 PE PE1999000475A patent/PE20000543A1/es not_active Application Discontinuation
- 1999-06-04 GT GT199900079A patent/GT199900079A/es unknown
- 1999-06-04 SV SV1999000072A patent/SV1999000072A/es not_active Application Discontinuation
- 1999-06-04 CO CO99035274A patent/CO5011043A1/es unknown
- 1999-06-04 UY UY25546A patent/UY25546A1/es not_active IP Right Cessation
- 1999-06-04 PA PA19998475001A patent/PA8475001A1/es unknown
- 1999-06-04 AR ARP990102642A patent/AR019150A1/es not_active Application Discontinuation
2000
- 2000-11-10 IS IS5712A patent/IS2270B/is unknown
- 2000-11-10 ZA ZA200006537A patent/ZA200006537B/en unknown
- 2000-12-04 NO NO20006148A patent/NO20006148L/no unknown
2002
- 2002-04-22 US US10/127,181 patent/US7015232B2/en not_active Expired - Fee Related
2005
- 2005-12-15 US US11/313,123 patent/US20060106057A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HK1038879B (zh)	2004-10-08
EP1083931A1 (de)	2001-03-21
GT199900079A (es)	2000-11-25
PA8475001A1 (es)	2000-09-29
IL139590A0 (en)	2002-02-10
PE20000543A1 (es)	2000-08-10
EP1083931B1 (de)	2005-05-11
AU3979399A (en)	1999-12-20
CA2330581A1 (en)	1999-12-09
TW565455B (en)	2003-12-11
US20060106057A1 (en)	2006-05-18
PL344586A1 (en)	2001-11-05
IS5712A (is)	2000-11-10
ZA200006537B (en)	2001-11-12
CO5011043A1 (es)	2001-02-28
UY25546A1 (es)	1999-09-27
HUP0102260A2 (hu)	2002-03-28
US20020161020A1 (en)	2002-10-31
NZ508544A (en)	2002-10-25
KR20010052557A (ko)	2001-06-25
NO20006148D0 (no)	2000-12-04
AR019150A1 (es)	2001-12-26
WO1999062560A1 (en)	1999-12-09
ID27398A (id)	2001-04-05
AU755616B2 (en)	2002-12-19
CN1144598C (zh)	2004-04-07
HN1999000088A (es)	2000-02-10
HK1038879A1 (en)	2002-04-04
TR200003600T2 (tr)	2001-04-20
BR9910947A (pt)	2001-03-06
DE69925269T2 (de)	2006-02-23
CN1304322A (zh)	2001-07-18
JP3727848B2 (ja)	2005-12-21
JP2002516881A (ja)	2002-06-11
ES2242398T3 (es)	2005-11-01
US6417196B1 (en)	2002-07-09
IS2270B (is)	2007-07-15
SV1999000072A (es)	2000-05-04
HUP0102260A3 (en)	2002-12-28
NO20006148L (no)	2000-12-04
DE69925269D1 (de)	2005-06-16
US7015232B2 (en)	2006-03-21
MY119667A (en)	2005-06-30

Legal Events

Date	Code	Title	Description
2005-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69925269D1 (de)	2005-06-16	Stabilisierung von zusammensetzungen enthaltend ace-hemmer durch magnesiumoxid
DE69919397D1 (de)	2004-09-16	Thrombin-inhibitoren
TR200100472T2 (tr)	2001-07-23	Lipaz inhibitörleri ile sitozan içeren farmasötik bileşimler
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