ID27840A - Turunan-turunan asam hidroksi pipekolat hidroksamat sebagai inhibitor-inhibitor mmp - Google Patents

Turunan-turunan asam hidroksi pipekolat hidroksamat sebagai inhibitor-inhibitor mmp

Info

Publication number: ID27840A
Authority: ID; Indonesia
Prior art keywords: hydrocsamic; hydrocamats; mmp inhibitors; pipecolate; acid
Prior art date: 1998-08-12

Application number

IDW20010327A

Other languages

English (en)

Inventor

Kim Francis Mcclure

Mark Carl Noe

Michael Anthony Letavic

Louis Stanley Chupak

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-12

Filing date

1999-08-05

Publication date

2001-04-26

1999-08-05 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2001-04-26 Publication of ID27840A publication Critical patent/ID27840A/id

Links

229940124761 MMP inhibitor Drugs 0.000 title 1
239000002253 acid Substances 0.000 title 1
ZHFMVVUVCALAMY-UHFFFAOYSA-N pipecolate Natural products OC1CNC(C(O)=O)C(O)C1O ZHFMVVUVCALAMY-UHFFFAOYSA-N 0.000 title 1
HXEACLLIILLPRG-UHFFFAOYSA-N pipecolic acid Chemical compound OC(=O)C1CCCCN1 HXEACLLIILLPRG-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/54—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Molecular Biology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Transplantation (AREA)

IDW20010327A 1998-08-12 1999-08-05 Turunan-turunan asam hidroksi pipekolat hidroksamat sebagai inhibitor-inhibitor mmp ID27840A (id)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US9623298P	1998-08-12	1998-08-12

Publications (1)

Publication Number	Publication Date
ID27840A true ID27840A (id)	2001-04-26

Family

ID=22256467

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IDW20010327A ID27840A (id)	1998-08-12	1999-08-05	Turunan-turunan asam hidroksi pipekolat hidroksamat sebagai inhibitor-inhibitor mmp

Country Status (43)

Country	Link
US (2)	US6329397B1 (id)
EP (1)	EP1104403B1 (id)
JP (1)	JP2002522528A (id)
KR (1)	KR20010085374A (id)
CN (1)	CN1316995A (id)
AP (1)	AP2001002070A0 (id)
AR (1)	AR019241A1 (id)
AT (1)	ATE325791T1 (id)
AU (1)	AU766366B2 (id)
BG (1)	BG105323A (id)
BR (1)	BR9912909A (id)
CA (1)	CA2340202C (id)
CZ (1)	CZ2001484A3 (id)
DE (1)	DE69931266T2 (id)
DZ (1)	DZ2870A1 (id)
EA (1)	EA200100126A1 (id)
EE (1)	EE200100086A (id)
ES (1)	ES2263279T3 (id)
GE (1)	GEP20033117B (id)
GT (1)	GT199900131A (id)
HK (1)	HK1040242A1 (id)
HN (1)	HN1999000131A (id)
HR (1)	HRP20010098A2 (id)
HU (1)	HUP0103452A3 (id)
ID (1)	ID27840A (id)
IL (1)	IL141030A0 (id)
IS (1)	IS5813A (id)
MA (1)	MA26675A1 (id)
NO (1)	NO20010686L (id)
NZ (1)	NZ509296A (id)
OA (1)	OA11594A (id)
PA (1)	PA8479201A1 (id)
PE (1)	PE20000951A1 (id)
PL (1)	PL346041A1 (id)
SK (1)	SK1872001A3 (id)
SV (1)	SV1999000123A (id)
TN (1)	TNSN99156A1 (id)
TR (1)	TR200100474T2 (id)
UA (1)	UA59453C2 (id)
UY (1)	UY25993A1 (id)
WO (1)	WO2000009485A1 (id)
YU (1)	YU5201A (id)
ZA (1)	ZA200101042B (id)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6846799B1 (en)	1998-08-18	2005-01-25	The Regents Of The University Of California	Preventing airway mucus production by administration of EGF-R antagonists
US7354894B2 (en)	1998-08-18	2008-04-08	The Regents Of The University Of California	Preventing airway mucus production by administration of EGF-R antagonists
AU754719B2 (en) *	1998-08-31	2002-11-21	Merck & Co., Inc.	Method of treating neurodegenerative diseases
US6509337B1 (en) *	1998-09-17	2003-01-21	Pfizer Inc.	Arylsulfonyl Hydroxamic Acid derivatives as MMP and TNF inhibitors
US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
EP1081137A1 (en)	1999-08-12	2001-03-07	Pfizer Products Inc.	Selective inhibitors of aggrecanase in osteoarthritis treatment
EP1138680A1 (en) *	2000-03-29	2001-10-04	Pfizer Products Inc.	Gem substituted sulfonyl hydroxamic acids as MMP inhibitors
JP2001322977A (ja) *	2000-05-12	2001-11-20	Kotobuki Seiyaku Kk	ピペコリン酸誘導体及びその製造方法並びにこれを含有する医薬組成物
JP2002105073A (ja) *	2000-09-27	2002-04-10	Shionogi & Co Ltd	新規マトリックスメタロプロテアーゼ阻害剤
PA8539501A1 (es)	2001-02-14	2002-09-30	Warner Lambert Co	Compuestos triazolo como inhibidores de mmp
DOP2002000332A (es)	2001-02-14	2002-08-30	Warner Lambert Co	Inhibidores de piridina de metaloproteinasas de la matriz
WO2002064571A1 (en)	2001-02-14	2002-08-22	Warner-Lambert Company Llc	Pyrimidine matrix metalloproteinase inhibitors
DOP2002000333A (es)	2001-02-14	2002-09-30	Warner Lambert Co	Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz
US6924276B2 (en)	2001-09-10	2005-08-02	Warner-Lambert Company	Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
US6962922B2 (en)	2001-10-12	2005-11-08	Warner-Lambert Company Llc	Alkynylated quinazoline compounds
BR0213233A (pt)	2001-10-12	2005-01-04	Warner Lambert Co	Alcinos inibidores de metaloproteinase de matriz
PE20030701A1 (es)	2001-12-20	2003-08-21	Schering Corp	Compuestos para el tratamiento de trastornos inflamatorios
US6894057B2 (en)	2002-03-08	2005-05-17	Warner-Lambert Company	Oxo-azabicyclic compounds
MXPA04012932A (es) *	2002-06-26	2005-06-03	Japan Bioindustry Ass	Nuevo derivado de azasugar y farmaco que lo contiene como ingrediente activo.
WO2004006914A1 (en) *	2002-07-17	2004-01-22	Warner-Lambert Company Llc	Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib
AU2003281168A1 (en) *	2002-07-17	2004-02-02	Warner-Lambert Company Llc	Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with a selective inhibitor of cyclooxygenase-2 that is not celecoxib or valdecoxib
AU2003250470A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Pyrimidinone fused bicyclic metalloproteinase inhibitors
JP2005539020A (ja)	2002-08-13	2005-12-22	ワーナー−ランバートカンパニーリミティドライアビリティーカンパニー	マトリクスメタロプロテイナーゼ阻害物質としてのクロモン誘導体
PA8578101A1 (es)	2002-08-13	2004-05-07	Warner Lambert Co	Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz
MXPA05001783A (es)	2002-08-13	2005-04-25	Warner Lambert Co	Derivados de pirimidina-2,4-diona como inhibidores de las metaloproteinasas de matriz.
EP1539709A1 (en)	2002-08-13	2005-06-15	Warner-Lambert Company LLC	Azaisoquinoline derivatives as matrix metalloproteinase inhibitors
WO2004014375A2 (en)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Fused bicyclic metalloproteinase inhibitors
WO2004014909A1 (en)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors
WO2004014378A1 (en)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	3-isoquinolinone derivatives as matrix metalloproteinase inhiitors
AU2003249477A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Heterobicylcic metalloproteinase inhibitors
WO2004014892A1 (en)	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Monocyclic derivatives as matrix metalloproteinase inhibitors
CN101252926A (zh) *	2005-03-22	2008-08-27	因诺迪亚有限公司	用于预防和治疗肥胖症及相关综合征的化合物与组合物
CN102046240B (zh)	2008-03-25	2014-06-25	阿费克蒂斯药品公司	新的p2x7r拮抗剂及其应用
WO2010118921A1 (en)	2009-04-14	2010-10-21	Affectis Pharmaceuticals Ag	Novel p2x7r antagonists and their use
WO2012110190A1 (en)	2011-02-17	2012-08-23	Affectis Pharmaceuticals Ag	Novel p2x7r antagonists and their use
WO2012163456A1 (en)	2011-05-27	2012-12-06	Affectis Pharmaceuticals Ag	Novel p2x7r antagonists and their use
WO2012163792A1 (en)	2011-05-27	2012-12-06	Affectis Pharmaceuticals Ag	Novel p2x7r antagonists and their use
DE202016007195U1 (de)	2016-11-16	2017-11-17	Bernhard Kohler	Strombegrenzende Schalteinrichtung
WO2020160140A1 (en) *	2019-01-29	2020-08-06	Darsha Llc	Compositions and methods for treating pulmonary disease with matrix metalloproteinase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0821671T3 (da) *	1995-04-20	2001-04-23	Pfizer	Arylsulfonylhydroxamsyrederivater som MMP- og TNF-inhibitorer
CA2238306A1 (en) *	1995-12-08	1997-06-12	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation
RU2221782C2 (ru) *	1996-08-28	2004-01-20	Дзе Проктер Энд Гэмбл Компани	Замещенные циклические аминовые ингибиторы металлопротеаз
EP0977733B1 (en) *	1997-02-03	2003-09-03	Pfizer Products Inc.	Arylsulfonylamino hydroxamic acid derivatives
EA002546B1 (ru) *	1997-02-11	2002-06-27	Пфайзер Инк.	Производные арилсульфонилгидроксамовой кислоты
AU7294098A (en) *	1997-05-09	1998-11-27	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses

1999
- 1999-05-08 UA UA2001010473A patent/UA59453C2/uk unknown
- 1999-07-30 PA PA19998479201A patent/PA8479201A1/es unknown
- 1999-08-03 YU YU5201A patent/YU5201A/sh unknown
- 1999-08-05 CA CA002340202A patent/CA2340202C/en not_active Expired - Fee Related
- 1999-08-05 AT AT99933076T patent/ATE325791T1/de not_active IP Right Cessation
- 1999-08-05 OA OA1200100035A patent/OA11594A/en unknown
- 1999-08-05 EE EEP200100086A patent/EE200100086A/xx unknown
- 1999-08-05 WO PCT/IB1999/001388 patent/WO2000009485A1/en not_active Ceased
- 1999-08-05 CN CN99810697A patent/CN1316995A/zh active Pending
- 1999-08-05 EP EP99933076A patent/EP1104403B1/en not_active Expired - Lifetime
- 1999-08-05 PL PL99346041A patent/PL346041A1/xx not_active Application Discontinuation
- 1999-08-05 JP JP2000564939A patent/JP2002522528A/ja not_active Ceased
- 1999-08-05 SK SK187-2001A patent/SK1872001A3/sk unknown
- 1999-08-05 ID IDW20010327A patent/ID27840A/id unknown
- 1999-08-05 AP APAP/P/2001/002070A patent/AP2001002070A0/en unknown
- 1999-08-05 EA EA200100126A patent/EA200100126A1/ru unknown
- 1999-08-05 AU AU49247/99A patent/AU766366B2/en not_active Ceased
- 1999-08-05 HU HU0103452A patent/HUP0103452A3/hu unknown
- 1999-08-05 KR KR1020017001847A patent/KR20010085374A/ko not_active Withdrawn
- 1999-08-05 ES ES99933076T patent/ES2263279T3/es not_active Expired - Lifetime
- 1999-08-05 BR BR9912909-4A patent/BR9912909A/pt not_active Application Discontinuation
- 1999-08-05 DE DE69931266T patent/DE69931266T2/de not_active Expired - Fee Related
- 1999-08-05 HK HK02101437.7A patent/HK1040242A1/zh unknown
- 1999-08-05 HR HR20010098A patent/HRP20010098A2/hr not_active Application Discontinuation
- 1999-08-05 CZ CZ2001484A patent/CZ2001484A3/cs unknown
- 1999-08-05 NZ NZ509296A patent/NZ509296A/en unknown
- 1999-08-05 TR TR2001/00474T patent/TR200100474T2/xx unknown
- 1999-08-05 IL IL14103099A patent/IL141030A0/xx unknown
- 1999-08-05 GE GEAP19995744A patent/GEP20033117B/en unknown
- 1999-08-09 HN HN1999000131A patent/HN1999000131A/es unknown
- 1999-08-10 PE PE1999000807A patent/PE20000951A1/es not_active Application Discontinuation
- 1999-08-10 AR ARP990103994A patent/AR019241A1/es not_active Application Discontinuation
- 1999-08-11 TN TNTNSN99156A patent/TNSN99156A1/fr unknown
- 1999-08-11 DZ DZ990170A patent/DZ2870A1/xx active
- 1999-08-11 MA MA25730A patent/MA26675A1/fr unknown
- 1999-08-11 SV SV1999000123A patent/SV1999000123A/es not_active Application Discontinuation
- 1999-08-12 GT GT199900131A patent/GT199900131A/es unknown
- 1999-08-12 US US09/372,946 patent/US6329397B1/en not_active Expired - Fee Related
2000
- 2000-01-28 UY UY25993A patent/UY25993A1/es unknown
2001
- 2001-01-16 IS IS5813A patent/IS5813A/is unknown
- 2001-02-07 ZA ZA200101042A patent/ZA200101042B/en unknown
- 2001-02-09 NO NO20010686A patent/NO20010686L/no not_active Application Discontinuation
- 2001-03-09 BG BG105323A patent/BG105323A/xx unknown
- 2001-12-03 US US10/008,943 patent/US20030008901A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1104403A1 (en)	2001-06-06
HRP20010098A2 (en)	2002-02-28
EE200100086A (et)	2002-08-15
ATE325791T1 (de)	2006-06-15
US20030008901A1 (en)	2003-01-09
AU4924799A (en)	2000-03-06
DZ2870A1 (fr)	2003-12-15
MA26675A1 (fr)	2004-12-20
HUP0103452A3 (en)	2002-10-28
CA2340202A1 (en)	2000-02-24
BG105323A (en)	2001-10-31
AR019241A1 (es)	2001-12-26
PE20000951A1 (es)	2000-09-27
HK1040242A1 (zh)	2002-05-31
IL141030A0 (en)	2002-02-10
NO20010686L (no)	2001-04-09
IS5813A (is)	2001-01-16
CZ2001484A3 (cs)	2002-05-15
GEP20033117B (en)	2003-11-25
TNSN99156A1 (fr)	2005-11-10
GT199900131A (es)	2001-02-02
WO2000009485A1 (en)	2000-02-24
HN1999000131A (es)	2000-03-24
US6329397B1 (en)	2001-12-11
TR200100474T2 (tr)	2001-06-21
JP2002522528A (ja)	2002-07-23
DE69931266T2 (de)	2007-02-15
OA11594A (en)	2004-07-11
EA200100126A1 (ru)	2001-08-27
EP1104403B1 (en)	2006-05-10
ZA200101042B (en)	2002-10-07
PA8479201A1 (es)	2000-09-29
PL346041A1 (en)	2002-01-14
AU766366B2 (en)	2003-10-16
NZ509296A (en)	2003-10-31
SK1872001A3 (en)	2002-08-06
KR20010085374A (ko)	2001-09-07
CA2340202C (en)	2006-02-07
UY25993A1 (es)	2000-03-31
NO20010686D0 (no)	2001-02-09
ES2263279T3 (es)	2006-12-01
HUP0103452A2 (hu)	2002-04-29
AP2001002070A0 (en)	2001-03-31
YU5201A (sh)	2003-07-07
UA59453C2 (uk)	2003-09-15
DE69931266D1 (en)	2006-06-14
BR9912909A (pt)	2001-05-08
SV1999000123A (es)	2000-07-06
CN1316995A (zh)	2001-10-10

Publication	Publication Date	Title
ID27840A (id)	2001-04-26	Turunan-turunan asam hidroksi pipekolat hidroksamat sebagai inhibitor-inhibitor mmp
ID24626A (id)	2000-07-27	Turunan-turunan asam hidroksamat sebagai penghambat metaloprotease matriks (mmp)
ID26222A (id)	2000-12-07	Hidroksamida asam(4-arilsulfonilamino)-tetrahidropiran-4-karboksilat
ID28833A (id)	2001-07-05	Turunan asam 3-aril-2-hidroksipropionat
ID22095A (id)	1999-09-02	Asam aril-akrilat ester
DK2253620T3 (da)	2014-03-31	Substituerede 3-cyanoquinoliner som protein-tyrosinkinase-inhibitorer
ATE269861T1 (de)	2004-07-15	Substituierte indolalkansäure
ID26089A (id)	2000-11-23	Turunan-turunan asam hidroksamat bisiklik
NO20000877L (no)	2000-11-28	Forbedret syrekorrosjonsinhibitor
DK1100769T3 (da)	2003-03-24	Aminomethylcarboxylsyrederivater
ID20809A (id)	1999-03-11	Asam diaminokarboksilat tersubstitusi
ID20807A (id)	1999-03-11	Asam sulfonilaminokarboksilat
FI962800L (fi)	1996-09-06	Fenyyliheterosyklisiä yhdisteitä COX-2 inhibiittoreina
NO20006114L (no)	2001-02-02	Nytt 3-aryl-2-hydroksypropionsyrederivat III
DE60009675D1 (de)	2004-05-13	Protonenpumpinhibitoren enthaltende zusammensetzung
ID27390A (id)	2001-04-05	Pembuatan asam akrilat
NO20014243L (no)	2001-10-17	Dihetero-substituerte metalloproteaseinhibitorer
EE9900180A (et)	1999-12-15	Asendatud 4-bifenüül-4-hüdroksübutaanhappe derivaadid metalloproteaasimaatriksi inhibiitoritena
NO20014875D0 (no)	2001-10-08	Promedikamenter for trombin inhibitorer
NO20003814D0 (no)	2000-07-25	Trombininhibitorer
ID28810A (id)	2001-07-05	Senyawa-senyawa amida-omega asam n-arilsulfonilamino
NO20003105D0 (no)	2000-06-16	Fenylaminoalkylkarboksylsyre-derivater samt medisinske sammensetninger omfattende slike
ATE252547T1 (de)	2003-11-15	Matrixmetalloproteinaseinhibitoren
DE60009260D1 (de)	2004-04-29	Thiopyranderivate as mmp-inhibitoren
NO20024880D0 (no)	2002-10-09	Sammensetning inneholdende fosfat