ATE295360T1 - Kondensierte heterocyclische benzolcarbonsäureamid-derivate und diese enthaltende pgd2 antagonisten - Google Patents
Kondensierte heterocyclische benzolcarbonsäureamid-derivate und diese enthaltende pgd2 antagonistenInfo
- Publication number
- ATE295360T1 ATE295360T1 AT97947865T AT97947865T ATE295360T1 AT E295360 T1 ATE295360 T1 AT E295360T1 AT 97947865 T AT97947865 T AT 97947865T AT 97947865 T AT97947865 T AT 97947865T AT E295360 T1 ATE295360 T1 AT E295360T1
- Authority
- AT
- Austria
- Prior art keywords
- benzenecarbonic
- acid amide
- amide derivatives
- condensed heterocyclic
- containing same
- Prior art date
Links
- 102100029100 Hematopoietic prostaglandin D synthase Human genes 0.000 title 1
- 101000988802 Homo sapiens Hematopoietic prostaglandin D synthase Proteins 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- BHMBVRSPMRCCGG-OUTUXVNYSA-N prostaglandin D2 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O BHMBVRSPMRCCGG-OUTUXVNYSA-N 0.000 title 1
- BHMBVRSPMRCCGG-UHFFFAOYSA-N prostaglandine D2 Natural products CCCCCC(O)C=CC1C(CC=CCCCC(O)=O)C(O)CC1=O BHMBVRSPMRCCGG-UHFFFAOYSA-N 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 210000003630 histaminocyte Anatomy 0.000 abstract 2
- 206010010744 Conjunctivitis allergic Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010063837 Reperfusion injury Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 201000008736 Systemic mastocytosis Diseases 0.000 abstract 1
- 208000024780 Urticaria Diseases 0.000 abstract 1
- 208000002205 allergic conjunctivitis Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000024998 atopic conjunctivitis Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 230000020411 cell activation Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000003979 eosinophil Anatomy 0.000 abstract 1
- 230000008595 infiltration Effects 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 230000009284 tracheal contraction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/74—Naphthothiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/76—Dibenzothiophenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33196296 | 1996-12-12 | ||
| PCT/JP1997/004526 WO1998025915A1 (en) | 1996-12-12 | 1997-12-10 | Fused heterocyclic benzenecarboxylic acid amide derivatives and pgd2 antagonists containing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE295360T1 true ATE295360T1 (de) | 2005-05-15 |
Family
ID=18249599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97947865T ATE295360T1 (de) | 1996-12-12 | 1997-12-10 | Kondensierte heterocyclische benzolcarbonsäureamid-derivate und diese enthaltende pgd2 antagonisten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6069166A (de) |
| EP (1) | EP0945450B1 (de) |
| JP (1) | JP4120993B2 (de) |
| AT (1) | ATE295360T1 (de) |
| AU (1) | AU5409698A (de) |
| DE (1) | DE69733271T2 (de) |
| WO (1) | WO1998025915A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6958772B1 (en) | 1999-01-20 | 2005-10-25 | Canon Kabushiki Kaisha | Image sensing apparatus and image processing method therefor |
| EP1262475A4 (de) | 2000-03-09 | 2005-01-05 | Ono Pharmaceutical Co | Indolderivate, verfahren zu ihrer herstellung und deren verwendung |
| US6933317B2 (en) * | 2000-11-01 | 2005-08-23 | Shionogi & Co. Ltd. | PGD2 receptor antagonistic pharmaceutical compositions |
| EP1361220A4 (de) * | 2001-01-26 | 2005-09-07 | Shionogi & Co | Cyclische verbindungen mit thrombopoietinrezeporagonismus |
| AU2003231509A1 (en) | 2002-05-16 | 2003-12-02 | Shionogi And Co., Ltd. | Compound exhibiting pgd 2 receptor antagonism |
| US6927183B1 (en) * | 2002-09-04 | 2005-08-09 | Diversitech Corporation | Reinforced article |
| US7714132B2 (en) | 2004-03-11 | 2010-05-11 | Actelion Pharmaceuticals, Ltd. | Tetrahydropyridoindole derivatives |
| WO2006039356A2 (en) * | 2004-09-29 | 2006-04-13 | Cytovia, Inc. | Substituted n-aryl-9-oxo-9h-fluorene-1-carboxamides and analogs as activators of caspases and inducers of apoptosis |
| JP5731538B2 (ja) | 2009-12-23 | 2015-06-10 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | Ｃｒｔｈ２モジュレーター |
| WO2011115804A1 (en) | 2010-03-17 | 2011-09-22 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| EP2588465B1 (de) | 2010-06-30 | 2017-01-25 | Ironwood Pharmaceuticals, Inc. | Sgc-stimulatoren |
| WO2012009137A1 (en) | 2010-07-12 | 2012-01-19 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
| US20130259830A1 (en) | 2010-07-12 | 2013-10-03 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
| CN107266433A (zh) | 2010-11-09 | 2017-10-20 | 铁木医药有限公司 | sGC刺激剂 |
| CN106117194A (zh) | 2011-12-27 | 2016-11-16 | 铁木医药有限公司 | 可用作sgc刺激剂的2‑苄基、3‑(嘧啶‑2‑基)取代的吡唑类 |
| WO2014047111A1 (en) | 2012-09-18 | 2014-03-27 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| EP2897953B8 (de) | 2012-09-19 | 2019-06-26 | Cyclerion Therapeutics, Inc. | Sgc-stimulatoren |
| EA033168B1 (ru) | 2013-03-15 | 2019-09-30 | Сайклерион Терапьютикс, Инк. | СТИМУЛЯТОРЫ sGC |
| CA2933250A1 (en) | 2013-12-11 | 2015-06-18 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| EP3094327A1 (de) | 2014-01-13 | 2016-11-23 | Ironwood Pharmaceuticals, Inc. | Verwendung von sgc-stimulatoren zur behandlung von neuromuskulären störungen |
| EP3194386A2 (de) | 2014-09-17 | 2017-07-26 | Ironwood Pharmaceuticals, Inc. | Sgc-stimulatoren |
| EP3194382B1 (de) | 2014-09-17 | 2021-09-08 | Cyclerion Therapeutics, Inc. | Pyrazolderivate als sgc-stimulatoren |
| US20170298055A1 (en) | 2014-09-17 | 2017-10-19 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| JP6770522B2 (ja) | 2015-02-13 | 2020-10-14 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 全身性エリテマトーデスを予防し、及び／又は、治療するためのｐｔｇｄｒ−１及び／又はｐｔｇｄｒ−２アンタゴニスト |
| EA039683B1 (ru) | 2016-07-07 | 2022-02-28 | Сайклерион Терапьютикс, Инк. | ФОСФОРСОДЕРЖАЩИЕ ПРОЛЕКАРСТВА СТИМУЛЯТОРОВ sGC |
| CN109563087A (zh) | 2016-07-07 | 2019-04-02 | 铁木医药有限公司 | sGC刺激剂的固体形式 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3162659D1 (en) * | 1980-07-22 | 1984-04-19 | Ono Pharmaceutical Co | 9,11-methano-13-aza-11a-carbathrombanoic acid analogues and pharmaceutical use thereof |
| JPS6149A (ja) * | 1984-06-12 | 1986-01-06 | Ono Pharmaceut Co Ltd | 新規な１３―アザ―１４―オキソ―ＴｘＡ２類似化合物およびそれらを有効成分として含有するトロンボキサン起因疾患治療剤 |
| CA1278577C (en) * | 1985-11-18 | 1991-01-02 | Tatsuo Tsuri | Bicyclic sulfonamide derivatives |
| JPH0623170B2 (ja) * | 1987-05-08 | 1994-03-30 | 塩野義製薬株式会社 | ビシクロ環系スルホンアミド誘導体およびその製造法 |
| CA1294974C (en) * | 1987-05-08 | 1992-01-28 | Sanji Hagishita | Bicyclic sulfonamide derivatives and process therefor |
| EP0312906A3 (de) * | 1987-10-23 | 1990-09-05 | Ono Pharmaceutical Co., Ltd. | Sulfonamidderivate |
| TW234123B (de) * | 1992-12-16 | 1994-11-11 | Takeda Pharm Industry Co Ltd | |
| CN1134411C (zh) * | 1995-06-21 | 2004-01-14 | 盐野义制药株式会社 | 双环氨基衍生物及含有此类化合物的前列腺素d2拮抗剂 |
| US5763609A (en) * | 1996-03-21 | 1998-06-09 | Neurogen Corporation | Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands |
| US5728846A (en) * | 1996-12-12 | 1998-03-17 | Allergan | Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives |
-
1997
- 1997-12-10 EP EP97947865A patent/EP0945450B1/de not_active Expired - Lifetime
- 1997-12-10 AT AT97947865T patent/ATE295360T1/de not_active IP Right Cessation
- 1997-12-10 US US09/319,022 patent/US6069166A/en not_active Expired - Fee Related
- 1997-12-10 WO PCT/JP1997/004526 patent/WO1998025915A1/ja not_active Ceased
- 1997-12-10 AU AU54096/98A patent/AU5409698A/en not_active Abandoned
- 1997-12-10 JP JP52649198A patent/JP4120993B2/ja not_active Expired - Fee Related
- 1997-12-10 DE DE69733271T patent/DE69733271T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998025915A1 (en) | 1998-06-18 |
| DE69733271D1 (de) | 2005-06-16 |
| EP0945450A1 (de) | 1999-09-29 |
| US6069166A (en) | 2000-05-30 |
| EP0945450B1 (de) | 2005-05-11 |
| EP0945450A4 (de) | 2001-12-12 |
| AU5409698A (en) | 1998-07-03 |
| DE69733271T2 (de) | 2006-01-26 |
| JP4120993B2 (ja) | 2008-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |