ATE296107T1 - Modulatoren von regulationsproteinen - Google Patents

Modulatoren von regulationsproteinen

Info

Publication number
ATE296107T1
ATE296107T1 AT96907886T AT96907886T ATE296107T1 AT E296107 T1 ATE296107 T1 AT E296107T1 AT 96907886 T AT96907886 T AT 96907886T AT 96907886 T AT96907886 T AT 96907886T AT E296107 T1 ATE296107 T1 AT E296107T1
Authority
AT
Austria
Prior art keywords
regulatory
death domain
modulators
regulatory proteins
modulator
Prior art date
Application number
AT96907886T
Other languages
English (en)
Inventor
David Wallach
Mark P Boldin
Eugene E Varfolomeev
Zeev Pancer
Igor Mett
Tanya M Goncharov
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL112742A external-priority patent/IL112742A/en
Priority claimed from IL11528995A external-priority patent/IL115289A0/xx
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of ATE296107T1 publication Critical patent/ATE296107T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Control Of Eletrric Generators (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
AT96907886T 1995-02-22 1996-02-15 Modulatoren von regulationsproteinen ATE296107T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL112742A IL112742A (en) 1995-02-22 1995-02-22 Antibodies to regulatory proteins
IL11528995A IL115289A0 (en) 1995-09-13 1995-09-13 Modulators of regulatory proteins
PCT/US1996/002326 WO1996025941A1 (en) 1995-02-22 1996-02-15 Modulators of regulatory proteins

Publications (1)

Publication Number Publication Date
ATE296107T1 true ATE296107T1 (de) 2005-06-15

Family

ID=26322993

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96907886T ATE296107T1 (de) 1995-02-22 1996-02-15 Modulatoren von regulationsproteinen

Country Status (8)

Country Link
EP (2) EP1588712A1 (de)
JP (1) JP3860608B2 (de)
AT (1) ATE296107T1 (de)
CA (1) CA2213484A1 (de)
DE (1) DE69634774T2 (de)
ES (1) ES2242195T3 (de)
PT (1) PT813419E (de)
WO (1) WO1996025941A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712381A (en) * 1994-10-19 1998-01-27 Genetics Institute, Inc. MADD, a TNF receptor death domain ligand protein
US5849501A (en) * 1994-10-19 1998-12-15 Genetics Institute, Inc. TNF receptor death domain ligand proteins and method to identify inhibitors of ligand binding
US5852173A (en) * 1994-10-19 1998-12-22 Genetics Institute, Inc. TNF receptor death ligand proteins and inhibitors of ligand binding
US5847099A (en) * 1994-10-19 1998-12-08 Genetics Institute, Inc. TNF receptor death domain ligand proteins
IL114615A0 (en) 1995-07-16 1995-11-27 Yeda Res & Dev Modulators of the function of fas receptors and other proteins
US6399327B1 (en) 1995-07-16 2002-06-04 Yeda Research And Development Co. Ltd. Modulators of the function of FAS receptors and other proteins
AU7457796A (en) * 1995-10-23 1997-05-15 Tularik Inc. Rip: novel human protein involved in tumor necrosis factor signal transduction, and screening assays
GB9608335D0 (en) * 1996-04-23 1996-06-26 Univ Kingston Method of enhancing ngf-mediated neurite growth with low molecular weight analoues of p.75 ngfr 367-379
US5858990A (en) * 1997-03-04 1999-01-12 St. Elizabeth's Medical Center Fas ligand compositions for treatment of proliferative disorders
IL120485A0 (en) * 1997-03-19 1997-07-13 Yeda Res & Dev Modulators of the function of receptors of the TNF/NGF receptor family and other proteins
EP0977846B1 (de) * 1997-04-25 2002-06-19 Wyeth Neuronale mort 1 isoformen
WO1999000499A1 (en) * 1997-06-26 1999-01-07 Chiron Corporation Human fadd-interacting protein (fip)
US6235872B1 (en) * 1998-03-12 2001-05-22 The Burnham Institute Proapoptotic peptides dependence polypeptides and methods of use
EE200900055A (et) * 1998-03-19 2009-10-15 Yeda Research And Development Co. Ltd. TNF/NFG retseptoriperekonna retseptorite ja muude valkude talitluse modulaatorid, nende valmistamine ja kasutamine ning farmatseutiline kompositsioon
IL126024A0 (en) * 1998-03-19 1999-05-09 Yeda Res & Dev Modulators of the function of receptors of the tnf/ngf receptor family and other proteins
US7745579B1 (en) 1998-09-01 2010-06-29 David Wallach Inhibitor of NF-KB activation
IL137524A0 (en) * 2000-07-26 2001-07-24 Yeda Res & Dev A mort-1 interacting protein, its preparation and use
US7379820B2 (en) * 2002-02-11 2008-05-27 Wyeth Solution structure of RIP DD and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101769A (en) * 1992-05-03 2007-02-11 Yeda Res & Dev Modulation of TNF receptor action
IL111125A0 (en) * 1994-05-11 1994-12-29 Yeda Res & Dev Soluble oligomeric tnf/ngf super family ligand receptors and their use
PT871645E (pt) * 1994-12-15 2007-11-14 Yeda Res & Dev Moduladores da função dos receptores fas/apo1

Also Published As

Publication number Publication date
PT813419E (pt) 2005-09-30
ES2242195T3 (es) 2005-11-01
EP0813419B8 (de) 2005-08-24
EP0813419A1 (de) 1997-12-29
JPH11500622A (ja) 1999-01-19
CA2213484A1 (en) 1996-08-29
DE69634774D1 (de) 2005-06-30
JP3860608B2 (ja) 2006-12-20
DE69634774T2 (de) 2006-02-02
EP0813419A4 (de) 1999-07-14
EP0813419B1 (de) 2005-05-25
EP1588712A1 (de) 2005-10-26
WO1996025941A1 (en) 1996-08-29

Similar Documents

Publication Publication Date Title
ATE296107T1 (de) Modulatoren von regulationsproteinen
EP0523140A4 (en) Reagents and methods for modulating gene expression through rna mimicry
MX9600666A (es) Proteinas de protocadherina y su uso.
DE59401407D1 (de) Behälter zur aufnahme von gegenständen
DE68908205D1 (de) Wiederverwertung von oelhaltigen raffinierrueckstaenden.
DE69308673D1 (de) Lösung zur Verwendung bei der Transplantation von Organen
NO940357L (no) Elektro-optisk modulator
DE69421116D1 (de) Gefärbte kosmetische Zusammensetzung
DE3764083D1 (de) Hybride fluessigkeitslagerung mit veraenderter steife bei elektromagnetischer wirkung.
DE69023608D1 (de) Elektro-optischer Modulator.
ATE180409T1 (de) Kollagenzubereitung zur gesteuerten abgabe von wirkstoffen
DE69429336D1 (de) Zusammensetzung von Pflanzenwachstums-Beschleuniger
OA09234A (en) Expression of HIV binding proteins.
DE68908625D1 (de) Modulation von gerichteten Strahlen.
DE68910122D1 (de) Herstellung von wellpappe.
DE59404861D1 (de) Gewebe zur Verstärkung bzw. Armierung von Flächengebilden
DK0984983T3 (da) Modulatorer af intracellulære inflammations-, celledöds- og celleoverlevelsesforlöb indeholdende et CARD- og et kinasedomæne
DE58907554D1 (de) Phenoxyalkylsubstituierte Heteroaromaten, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung von Schädlingen.
DE69323299D1 (de) Treibmittelzusammensetzung, herstellung von schaumstoff mittels dieser zusammensetzung und daraus hergestellte schaumstoffe
DE69020187D1 (de) Anordnung zur Erzeugung von Matrix-Zeichenmustern.
DE68912912D1 (de) Drechslera spp. oder einen ihrer Metaboliten enthaltende Unkrautbekämpfungsmittel und Verfahren zur Unkrautbekämpfung unter Verwendung von Drechslera spp. oder einen ihrer Metaboliten.
DE69013728D1 (de) Faserfolie von Kollagen.
DE68913304D1 (de) Transesterifikation von alkoxyestern.
DE59404066D1 (de) Gewebe zur Verstärkung bzw. Armierung von Flächengebilden
DE3854472D1 (de) Erhaltung der Viabilität von Mikroorganismen zur Anwendung in mikrobiellen Inokulantien.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0813419

Country of ref document: EP

REN Ceased due to non-payment of the annual fee