ATE296350T1 - Strukturiertes peptidgerüst zur ausstellung von drehung-bibliotheken auf phage - Google Patents

Strukturiertes peptidgerüst zur ausstellung von drehung-bibliotheken auf phage

Info

Publication number
ATE296350T1
ATE296350T1 AT00941412T AT00941412T ATE296350T1 AT E296350 T1 ATE296350 T1 AT E296350T1 AT 00941412 T AT00941412 T AT 00941412T AT 00941412 T AT00941412 T AT 00941412T AT E296350 T1 ATE296350 T1 AT E296350T1
Authority
AT
Austria
Prior art keywords
libraries
peptides
phage
displaying
turned
Prior art date
Application number
AT00941412T
Other languages
English (en)
Inventor
Andrea G Chochran
Nicholas J Skelton
Melissa A Starovasnik
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE296350T1 publication Critical patent/ATE296350T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT00941412T 1999-06-14 2000-06-13 Strukturiertes peptidgerüst zur ausstellung von drehung-bibliotheken auf phage ATE296350T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13901799P 1999-06-14 1999-06-14
PCT/US2000/016368 WO2000077194A1 (en) 1999-06-14 2000-06-13 A structured peptide scaffold for displaying turn libraries on phage

Publications (1)

Publication Number Publication Date
ATE296350T1 true ATE296350T1 (de) 2005-06-15

Family

ID=22484754

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00941412T ATE296350T1 (de) 1999-06-14 2000-06-13 Strukturiertes peptidgerüst zur ausstellung von drehung-bibliotheken auf phage

Country Status (10)

Country Link
US (2) US7235626B1 (de)
EP (1) EP1187914B1 (de)
JP (1) JP2003502304A (de)
AT (1) ATE296350T1 (de)
AU (1) AU782755C (de)
CA (1) CA2376232A1 (de)
DE (1) DE60020366T2 (de)
ES (1) ES2242620T3 (de)
IL (1) IL146798A0 (de)
WO (1) WO2000077194A1 (de)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000077194A1 (en) 1999-06-14 2000-12-21 Genentech, Inc. A structured peptide scaffold for displaying turn libraries on phage
DE10023743A1 (de) * 2000-05-15 2001-11-29 Max Planck Gesellschaft Peptidsubstrate zur direkten Messung enzymatischer Aktivitäten
US6914123B2 (en) * 2001-04-17 2005-07-05 Genentech, Inc. Hairpin peptides with a novel structural motif and methods relating thereto
CA2488441C (en) 2002-06-03 2015-01-27 Genentech, Inc. Synthetic antibody phage libraries
AU2003265865A1 (en) * 2002-08-30 2004-03-19 Rigel Pharmaceuticals, Inc. Methods of screening cyclic peptides and identifying targets therefor
WO2004065416A2 (en) * 2003-01-16 2004-08-05 Genentech, Inc. Synthetic antibody phage libraries
DK1689863T3 (da) 2003-11-15 2014-08-25 Polyphor Ltd Template-fikserede beta-hairpinloopmimetika og deres anvendelse i fag-display
US7785903B2 (en) 2004-04-09 2010-08-31 Genentech, Inc. Variable domain library and uses
US20090099031A1 (en) * 2005-09-27 2009-04-16 Stemmer Willem P Genetic package and uses thereof
JP2010536341A (ja) * 2007-08-15 2010-12-02 アムニクス， インコーポレイテッド 生物学的に活性なポリペプチドの特性を改変するための組成物および方法
ES2610356T3 (es) 2009-02-03 2017-04-27 Amunix Operating Inc. Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos
WO2011024887A1 (ja) * 2009-08-26 2011-03-03 国立大学法人 岡山大学 環状ペプチドを含む結合体およびその作製方法
KR20120125455A (ko) * 2009-12-11 2012-11-15 광주과학기술원 세포내 타겟 결합용 바이포달 펩타이드 바인더
KR101341640B1 (ko) * 2010-02-05 2013-12-16 한국전자통신연구원 단백질 미세 구조 분석 방법 및 단백질 미세 구조 분석용 어레이
JP4955795B2 (ja) * 2010-05-14 2012-06-20 株式会社日本製鋼所 造粒方法及び造粒装置
JP6092104B2 (ja) 2010-08-13 2017-03-08 ミティ・バイオシステムズ・ゲーエムベーハー 修飾ペプチドディスプレイ
EP4122945A1 (de) 2013-12-23 2023-01-25 University of Rochester Verfahren und zusammensetzungen zur ribosomalen synthese von makrocyclischen peptiden
US12359192B2 (en) 2013-12-23 2025-07-15 University Of Rochester Methods and compositions for display of macrocyclic peptides
EP2940138B1 (de) 2014-04-30 2018-02-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Phagen-Anzeigebibliothek
US10822604B2 (en) 2014-05-02 2020-11-03 Morphosys Ag Peptide libraries
EP3180431A1 (de) * 2014-08-11 2017-06-21 Miti Biosystems GmbH Durch eine genetische packung exprimierte cyclische peptide
AU2015371172B2 (en) * 2014-12-22 2021-05-13 Lanthiopep B.V. Novel methods for displaying cyclic peptides on bacteriophage particles
WO2021007436A1 (en) * 2019-07-09 2021-01-14 Tavotek Biotherapeutics (Hong Kong) Limited Tricyclic peptide as protein binders and modulators and uses thereof
US20210340524A1 (en) 2020-05-01 2021-11-04 Massachusetts Institute Of Technology Methods for identifying chimeric antigen receptor-targeting ligands and uses thereof
US12433954B2 (en) 2020-05-01 2025-10-07 Massachusetts Institute Of Technology Methods of activating anti-CD19 chimeric antigen receptor (CAR) T cells using amphiphilic ligand conjugates comprising CAR-targeting protein sequence motifs
TWI845133B (zh) * 2022-01-27 2024-06-11 中央研究院 胜肽介導的活性劑遞送

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NZ215865A (en) 1985-04-22 1988-10-28 Commw Serum Lab Commission Method of determining the active site of a receptor-binding analogue
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
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US5885780A (en) 1991-07-19 1999-03-23 University Of Utah Method of obtaining small conformationally rigid conopeptides
CA2141447A1 (en) 1992-08-06 1994-02-17 Michael Kahn Conformationally restricted mimetics of reverse turns and peptides containing the same
EP0788370A4 (de) 1993-07-09 1998-07-08 Smithkline Beecham Corp Zyklische, teilzufallige peptidbibliotheken
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US6013458A (en) 1995-10-27 2000-01-11 Molecumetics, Ltd. Reverse-turn mimetics and methods relating thereto
SE506771C2 (sv) 1996-02-06 1998-02-09 Gotpat 105 Ab Fusionsprotein, bakteriofag uttryckande proteinet, dessas användning samt hybridoma celler och monoklonaler producerade av cellerna
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CN1318084C (zh) 2000-05-26 2007-05-30 奥索-麦克尼尔药品公司 神经保护肽

Also Published As

Publication number Publication date
IL146798A0 (en) 2002-07-25
DE60020366T2 (de) 2006-02-02
JP2003502304A (ja) 2003-01-21
ES2242620T3 (es) 2005-11-16
DE60020366D1 (de) 2005-06-30
AU782755B2 (en) 2005-08-25
AU5611900A (en) 2001-01-02
US7235626B1 (en) 2007-06-26
WO2000077194A1 (en) 2000-12-21
AU782755C (en) 2006-04-27
CA2376232A1 (en) 2000-12-21
EP1187914A1 (de) 2002-03-20
US20060110777A1 (en) 2006-05-25
EP1187914B1 (de) 2005-05-25

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