DK3237614T3 - Nye fremgangsmåder til fremvisning af cyklisk peptider på overfladen af bakteriofagpartikler - Google Patents

Nye fremgangsmåder til fremvisning af cyklisk peptider på overfladen af bakteriofagpartikler Download PDF

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Publication number
DK3237614T3
DK3237614T3 DK15817300.5T DK15817300T DK3237614T3 DK 3237614 T3 DK3237614 T3 DK 3237614T3 DK 15817300 T DK15817300 T DK 15817300T DK 3237614 T3 DK3237614 T3 DK 3237614T3
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DK
Denmark
Prior art keywords
new methods
cyclic peptides
bacteriophage particles
displaying cyclic
displaying
Prior art date
Application number
DK15817300.5T
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English (en)
Inventor
Johannes Herbert Urban
Markus Andreas Moosmeier
Tjibbe Bosma
Josef Prassler
Original Assignee
Lanthiopep Bv
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Publication of DK3237614T3 publication Critical patent/DK3237614T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00021—Viruses as such, e.g. new isolates, mutants or their genomic sequences

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK15817300.5T 2014-12-22 2015-12-21 Nye fremgangsmåder til fremvisning af cyklisk peptider på overfladen af bakteriofagpartikler DK3237614T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14199588 2014-12-22
PCT/EP2015/080738 WO2016102434A1 (en) 2014-12-22 2015-12-21 Novel methods for displaying cyclic peptides on bacteriophage particles

Publications (1)

Publication Number Publication Date
DK3237614T3 true DK3237614T3 (da) 2019-09-09

Family

ID=52292661

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15817300.5T DK3237614T3 (da) 2014-12-22 2015-12-21 Nye fremgangsmåder til fremvisning af cyklisk peptider på overfladen af bakteriofagpartikler

Country Status (12)

Country Link
US (2) US10774323B2 (da)
EP (1) EP3237614B1 (da)
JP (1) JP6810041B2 (da)
KR (1) KR20170090509A (da)
CN (1) CN107109403A (da)
AU (1) AU2015371172B2 (da)
CA (1) CA2971672A1 (da)
DK (1) DK3237614T3 (da)
MX (1) MX2017008286A (da)
RU (1) RU2702087C2 (da)
WO (1) WO2016102434A1 (da)
ZA (1) ZA201704674B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103403160A (zh) 2010-08-13 2013-11-20 G·克里斯蒂安森 修饰肽的展示
CN106366168B (zh) * 2016-08-26 2020-09-15 上海交通大学 羊毛硫肽类抗菌肽及其脱氢衍生物的制备方法
CN109432399A (zh) * 2018-12-27 2019-03-08 重庆市科学技术研究院 用于乙型肝炎的环肽药物及其应用
EP3972625A4 (en) * 2019-05-20 2023-04-12 The Texas A&M University System GENETICALLY ENCODED PHAGE DISPLAYED CYCLIC PEPTIDE LIBRARY AND METHODS OF PRODUCTION THEREOF
WO2022020380A1 (en) * 2020-07-20 2022-01-27 Massachusetts Institute Of Technology M13 bacteriophage with a high cysteine content and genetically engineerable hydrogels
CN112851788B (zh) * 2021-02-03 2022-11-01 河北省科学院生物研究所 一种羊毛硫肽LichencinA3及其制备方法和应用
PL443378A1 (pl) * 2022-12-31 2024-07-01 Instytut Biotechnologii I Medycyny Molekularnej 7 aminokwasowe sekwencje oraz klony fagowe wiążące selektywnie jony niklu
CN116790698B (zh) * 2023-06-21 2024-06-18 南京大学 基于氧化脱羧酶的硫醛合成方法及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988006630A1 (en) 1987-03-02 1988-09-07 Genex Corporation Method for the preparation of binding molecules
DE68927933T2 (de) 1988-09-02 1997-08-14 Dyax Corp Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
US6660843B1 (en) * 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
CA2376232A1 (en) 1999-06-14 2000-12-21 Genentech, Inc. A structured peptide scaffold for displaying turn libraries on phage
US7785825B2 (en) * 2004-01-12 2010-08-31 The Board Of Trustees Of The University Of Illinois Compositions and methods for dehydration and cyclization of peptides, synthetic compounds, and lantibiotics
WO2006062398A2 (en) 2004-12-07 2006-06-15 Applied Nanosystems B.V. Methods for the production and secretion of modified peptides
CA2624290A1 (en) * 2005-10-12 2007-04-26 Scripps Research Institute Selective posttranslational modification of phage-displayed polypeptides
JP6074574B2 (ja) 2008-02-05 2017-02-08 バイシクル セラピューティクス リミテッド 方法及び組成物
EP2405008A1 (en) * 2010-07-06 2012-01-11 LanthioPep B.V. Bacterial surface display of thioether-bridge-containing peptides
CN103403160A (zh) * 2010-08-13 2013-11-20 G·克里斯蒂安森 修饰肽的展示
EP2578599A1 (en) 2011-10-07 2013-04-10 LanthioPep B.V. Cyclic analogs of GLP-1 and GLP-1 related peptides
CA2961285A1 (en) * 2014-09-26 2016-03-31 The Board Of Trustees Of The University Of Illinois Biosynthesis and engineering of lanthipeptides

Also Published As

Publication number Publication date
US20180051276A1 (en) 2018-02-22
EP3237614B1 (en) 2019-06-26
RU2017122176A (ru) 2019-01-24
CN107109403A (zh) 2017-08-29
JP6810041B2 (ja) 2021-01-06
WO2016102434A1 (en) 2016-06-30
RU2017122176A3 (da) 2019-04-03
RU2702087C2 (ru) 2019-10-03
KR20170090509A (ko) 2017-08-07
EP3237614A1 (en) 2017-11-01
ZA201704674B (en) 2019-09-25
AU2015371172A1 (en) 2017-07-13
US10774323B2 (en) 2020-09-15
CA2971672A1 (en) 2016-06-30
US20200385705A1 (en) 2020-12-10
AU2015371172B2 (en) 2021-05-13
JP2018500352A (ja) 2018-01-11
MX2017008286A (es) 2018-02-19

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