ATE296792T1 - Benzenoidderivate von 15- hydroxyeicosatetraensäure und verfahren zur verwendung zur behandlung des trockenen auges - Google Patents

Benzenoidderivate von 15- hydroxyeicosatetraensäure und verfahren zur verwendung zur behandlung des trockenen auges

Info

Publication number
ATE296792T1
ATE296792T1 AT00971013T AT00971013T ATE296792T1 AT E296792 T1 ATE296792 T1 AT E296792T1 AT 00971013 T AT00971013 T AT 00971013T AT 00971013 T AT00971013 T AT 00971013T AT E296792 T1 ATE296792 T1 AT E296792T1
Authority
AT
Austria
Prior art keywords
hydroxyeicosatetraenic
dry eye
acid
treating dry
benzenoid
Prior art date
Application number
AT00971013T
Other languages
English (en)
Inventor
Peter G Klimko
David R Pierce
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Application granted granted Critical
Publication of ATE296792T1 publication Critical patent/ATE296792T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT00971013T 1999-11-09 2000-10-23 Benzenoidderivate von 15- hydroxyeicosatetraensäure und verfahren zur verwendung zur behandlung des trockenen auges ATE296792T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16437299P 1999-11-09 1999-11-09
PCT/US2000/029224 WO2001034552A2 (en) 1999-11-09 2000-10-23 Benzenoid derivatives of 15-hydroxyeicosatetraenoic acid and methods of their use in treating dry eye disorders

Publications (1)

Publication Number Publication Date
ATE296792T1 true ATE296792T1 (de) 2005-06-15

Family

ID=22594195

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00971013T ATE296792T1 (de) 1999-11-09 2000-10-23 Benzenoidderivate von 15- hydroxyeicosatetraensäure und verfahren zur verwendung zur behandlung des trockenen auges

Country Status (10)

Country Link
US (1) US6342525B1 (de)
EP (1) EP1228030B1 (de)
JP (1) JP2003513950A (de)
AT (1) ATE296792T1 (de)
AU (1) AU776153B2 (de)
CA (1) CA2388030A1 (de)
DE (1) DE60020591T2 (de)
ES (1) ES2239621T3 (de)
PT (1) PT1228030E (de)
WO (1) WO2001034552A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030109508A1 (en) * 2001-10-11 2003-06-12 Alcon, Inc. Methods for treating dry eye
WO2003030892A1 (en) * 2001-10-11 2003-04-17 Alcon, Inc. Methods for treating dry eye
EP1583527A1 (de) * 2002-06-14 2005-10-12 Alcon, Inc. Verwendung von hydroxyeicosatetraensäure verbindungen zur behandlung augenentzendungen
AU2003221707A1 (en) * 2002-06-14 2003-12-31 Alcon, Inc. Topical use of hydroxyeicosatetraenoic acid compounds to treat psoriasis
JP2006502183A (ja) * 2002-09-20 2006-01-19 アルコン，インコーポレイテッド ドライアイ障害の処置のためのサイトカイン合成インヒビターの使用

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US3819694A (en) * 1971-11-22 1974-06-25 Sandoz Ag 6-(2-(3-hydroxyalkyl)-3,5-disubstituted-phenyl)hexanoic acids and salts thereof
US3824278A (en) * 1972-03-23 1974-07-16 Sandoz Ag 1,6-disubstituted pyrocatechol derivatives
US3991759A (en) 1975-10-28 1976-11-16 Alza Corporation Method and therapeutic system for treating aqueous deficient dry eye
US4032656A (en) * 1975-11-21 1977-06-28 Smithkline Corporation Aromatic prostaglandin derivatives
US4131651A (en) 1977-10-25 1978-12-26 Barnes-Hind Pharmaceuticals, Inc. Treatment of dry eye
US4409205A (en) 1979-03-05 1983-10-11 Cooper Laboratories, Inc. Ophthalmic solution
US4370325A (en) 1979-03-30 1983-01-25 Dermik Laboratories Pharmaceutical compositions and method of treatment
AU546872B2 (en) 1982-06-16 1985-09-26 Unilever Plc Skin treatment compositions containing a fatty acid or ester
US4421748A (en) 1982-07-13 1983-12-20 Trager Seymour F Artificial tear aid
GB8319073D0 (en) 1983-07-14 1983-08-17 Efamol Ltd Fatty acid compositions
US4868154A (en) 1986-02-19 1989-09-19 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with melanocyte stimulating hormones
US4753945A (en) 1986-02-19 1988-06-28 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with phosphodiesterase inhibitors
US4883658A (en) 1986-04-28 1989-11-28 Holly Frank J Ophthalmic solution for treatment of dry-eye syndrome
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US4804539A (en) 1986-07-28 1989-02-14 Liposome Technology, Inc. Ophthalmic liposomes
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DE3909327A1 (de) * 1989-03-17 1990-09-20 Schering Ag Neue leukotrien-b4-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US5075104A (en) 1989-03-31 1991-12-24 Alcon Laboratories, Inc. Ophthalmic carboxy vinyl polymer gel for dry eye syndrome
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DE4009117A1 (de) * 1990-03-19 1991-09-26 Schering Ag Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US5041434A (en) 1991-08-17 1991-08-20 Virginia Lubkin Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
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JP2594486B2 (ja) 1991-01-15 1997-03-26 アルコン ラボラトリーズ インコーポレイテッド 局所的眼薬組成物
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US5696166A (en) 1995-10-31 1997-12-09 Yanni; John M. Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders
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Also Published As

Publication number Publication date
WO2001034552A2 (en) 2001-05-17
US6342525B1 (en) 2002-01-29
AU8031200A (en) 2001-06-06
DE60020591T2 (de) 2005-11-10
JP2003513950A (ja) 2003-04-15
ES2239621T3 (es) 2005-10-01
PT1228030E (pt) 2005-08-31
DE60020591D1 (de) 2005-07-07
CA2388030A1 (en) 2001-05-17
EP1228030A2 (de) 2002-08-07
WO2001034552A3 (en) 2002-01-17
AU776153B2 (en) 2004-08-26
EP1228030B1 (de) 2005-06-01

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