ATE297206T1 - Verfahren zur stabilisierung von pranoprofen und stabile flüssige zubereitung von pranoprofen - Google Patents

Verfahren zur stabilisierung von pranoprofen und stabile flüssige zubereitung von pranoprofen

Info

Publication number: ATE297206T1
Authority: AT; Austria
Prior art keywords: pranoprofen; aqueous solution; stabilizing; liquid preparation; stable liquid
Prior art date: 1994-03-15

Application number

AT95103625T

Other languages

English (en)

Inventor

Koji Doi

Hisako Sawa

Yoshie Ozaki

Yoshiyuki Kimura

Original Assignee

Senju Pharma Co

Mitsubishi Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-15

Filing date

1995-03-14

Publication date

2005-06-15

1995-03-14 Application filed by Senju Pharma Co, Mitsubishi Pharma Corp filed Critical Senju Pharma Co

2005-06-15 Application granted granted Critical

2005-06-15 Publication of ATE297206T1 publication Critical patent/ATE297206T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
- Y10T428/139—Open-ended, self-supporting conduit, cylinder, or tube-type article
- Y10T428/1393—Multilayer [continuous layer]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Chemistry (AREA)
Inorganic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Ophthalmology & Optometry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT95103625T 1994-03-15 1995-03-14 Verfahren zur stabilisierung von pranoprofen und stabile flüssige zubereitung von pranoprofen ATE297206T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP4418494		1994-03-15

Publications (1)

Publication Number	Publication Date
ATE297206T1 true ATE297206T1 (de)	2005-06-15

Family

ID=12684495

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95103625T ATE297206T1 (de)	1994-03-15	1995-03-14	Verfahren zur stabilisierung von pranoprofen und stabile flüssige zubereitung von pranoprofen

Country Status (19)

Country	Link
US (2)	US5856345A (de)
EP (2)	EP0672414B1 (de)
KR (1)	KR100338851B1 (de)
CN (1)	CN1091597C (de)
AT (1)	ATE297206T1 (de)
AU (1)	AU707119B2 (de)
BR (1)	BR9501081A (de)
CA (1)	CA2144591A1 (de)
DE (1)	DE69534258T2 (de)
EE (1)	EE9500015A (de)
ES (1)	ES2240966T3 (de)
FI (1)	FI951190L (de)
HU (1)	HUT71245A (de)
LT (1)	LT3969B (de)
LV (1)	LV10922B (de)
NO (1)	NO950970L (de)
PL (1)	PL179534B1 (de)
RU (1)	RU2148402C1 (de)
TW (1)	TW358812B (de)

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US6235781B1 (en)	1998-07-14	2001-05-22	Alcon Laboratories, Inc.	Prostaglandin product
WO2000032157A1 (en) *	1998-12-02	2000-06-08	Copa Distributors, Llc	Gradual hair relaxation composition
BR0313064A (pt) *	2002-07-31	2005-06-28	Pharmacia Corp	Forma de dosagem farmacêutica compreendendo um composto de sulfito
ATE528003T1 (de)	2002-07-31	2011-10-15	Senju Pharma Co	Wässrige, flüssigkeitszubereitungen und lichtstabilisierte wässrige flüssigkeitszubereitungen
US8877168B1 (en)	2002-07-31	2014-11-04	Senju Pharmaceuticals Co., Ltd.	Aqueous liquid preparations and light-stabilized aqueous liquid preparations
EP1586316B1 (de)	2003-01-21	2008-04-30	Senju Pharmaceutical Co., Ltd.	Wässrige flüssige zubereitung mit 2-amino-3-(4-bromobenzoyl)phenylessigsäure
WO2004089427A1 (en) *	2003-04-07	2004-10-21	Jurox Pty Ltd	Stable carprofen composition
US7125497B1 (en) *	2003-05-22	2006-10-24	Sandia Corporation	Reactive formulations for a neutralization of toxic industrial chemicals
WO2004112837A1 (ja) *	2003-05-23	2004-12-29	Hisamitsu Pharmaceutical Co., Inc.	非ステロイド系消炎鎮痛剤含有外用経皮製剤およびインターロイキン－１α生成抑制剤
US20060073172A1 (en) *	2004-10-01	2006-04-06	Schneider L W	Stabilized ophthalmic solution for the treatment of glaucoma and lowering intraocular pressure
ES2363964B1 (es)	2009-11-20	2012-08-22	Gp Pharm, S.A.	Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados.
JP5580944B2 (ja) *	2011-12-27	2014-08-27	千寿製薬株式会社	ジブチルヒドロキシトルエン含有製剤及びジブチルヒドロキシトルエンの安定化方法
CN104136019A (zh) *	2012-02-27	2014-11-05	日本乐敦制药株式会社	眼科用组合物试剂盒
WO2014129466A1 (ja) *	2013-02-19	2014-08-28	ロート製薬株式会社	網膜疾患の予防、改善、又は治療用粘膜適用剤
JP5340498B1 (ja) *	2013-03-11	2013-11-13	千寿製薬株式会社	ソフトコンタクトレンズ用眼科用組成物
CN105283186B (zh) *	2013-05-30	2018-05-18	千寿制药株式会社	氯苯那敏或其盐的稳定化方法
TWI644663B (zh) *	2014-03-10	2018-12-21	日商千壽製藥股份有限公司	二丁基羥基甲苯的穩定化方法，及含二丁基羥基甲苯之製品(一)
TW201540292A (zh) *	2014-03-10	2015-11-01	Senju Pharma Co	二丁基羥基甲苯的穩定化方法（二）
AR102172A1 (es) *	2015-10-05	2017-02-08	Química Luar S R L	Una composición farmacéutica bactericida y virucida
KR102478553B1 (ko) *	2018-02-28	2022-12-16	한림제약(주)	벤조피란 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 용액 형태의 점안제
US12324853B2 (en)	2020-08-10	2025-06-10	Quimica Luar S.R.L.	Methods for treating respiratory viral infections
CN115677733A (zh) *	2022-12-20	2023-02-03	济南宣正药业有限公司	一种用于普拉洛芬质量研究的化合物及其制备方法和应用

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GB1403487A (en) *	1972-07-21	1975-08-28	Yoshitomi Pharmaceutical	Heterocyclic substituted alkanoic acids and derivatives
US3931295A (en)	1974-07-23	1976-01-06	Universal Oil Products Company	Hydroxylation of aromatic compounds
JPS6056684B2 (ja) *	1977-11-07	1985-12-11	東興薬品工業株式会社	点眼剤
US4565851A (en) *	1983-04-25	1986-01-21	Eastman Kodak Company	Containers having improved gas barrier properties
US4525348A (en) *	1983-12-19	1985-06-25	Yoshitomi Pharmaceutical Industries, Ltd.	Pranoprofen gelled ointment
JPS60184013A (ja) *	1984-03-01	1985-09-19	Yoshitomi Pharmaceut Ind Ltd	点眼剤
US4940728A (en) *	1985-05-17	1990-07-10	Postley John E	Treatment for sino-nasal congestion
US5110492A (en) *	1985-05-24	1992-05-05	Irene Casey	Cleaner and disinfectant with dye
US5032392A (en) *	1986-09-04	1991-07-16	Vision Pharmaceuticals	Aqueous ophthalmic solutions for the treatment of dryness and/or irritation of human or animal eyes
US5414011A (en) *	1987-09-11	1995-05-09	Syntex (U.S.A.) Inc.	Preservative system for ophthalmic formulations
US5110493A (en) *	1987-09-11	1992-05-05	Syntex (U.S.A.) Inc.	Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant
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TW206918B (de) *	1991-05-11	1993-06-01	Kuko Seiyaku Kk
JPH05124092A (ja) *	1991-11-06	1993-05-21	Chisso Corp	ポリオレフイン系樹脂製中空容器
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1995
- 1995-03-14 RU RU95103893A patent/RU2148402C1/ru active
- 1995-03-14 PL PL95307671A patent/PL179534B1/pl unknown
- 1995-03-14 CN CN95114803A patent/CN1091597C/zh not_active Expired - Fee Related
- 1995-03-14 NO NO950970A patent/NO950970L/no unknown
- 1995-03-14 HU HU9500772A patent/HUT71245A/hu unknown
- 1995-03-14 EP EP95103625A patent/EP0672414B1/de not_active Expired - Lifetime
- 1995-03-14 AT AT95103625T patent/ATE297206T1/de not_active IP Right Cessation
- 1995-03-14 CA CA002144591A patent/CA2144591A1/en not_active Abandoned
- 1995-03-14 DE DE69534258T patent/DE69534258T2/de not_active Expired - Lifetime
- 1995-03-14 LV LVP-95-50A patent/LV10922B/en unknown
- 1995-03-14 LT LT95-028A patent/LT3969B/lt not_active IP Right Cessation
- 1995-03-14 FI FI951190A patent/FI951190L/fi unknown
- 1995-03-14 EP EP01120068A patent/EP1163906A3/de not_active Withdrawn
- 1995-03-14 KR KR1019950005273A patent/KR100338851B1/ko not_active Expired - Lifetime
- 1995-03-14 ES ES95103625T patent/ES2240966T3/es not_active Expired - Lifetime
- 1995-03-14 TW TW084102389A patent/TW358812B/zh active
- 1995-03-15 AU AU14852/95A patent/AU707119B2/en not_active Ceased
- 1995-03-15 EE EE9500015A patent/EE9500015A/xx unknown
- 1995-03-15 BR BR9501081A patent/BR9501081A/pt not_active Application Discontinuation
1997
- 1997-01-07 US US08/779,604 patent/US5856345A/en not_active Expired - Fee Related
- 1997-06-12 US US08/873,924 patent/US5889030A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HUT71245A (en)	1995-11-28
EP1163906A3 (de)	2003-05-21
RU2148402C1 (ru)	2000-05-10
US5889030A (en)	1999-03-30
DE69534258T2 (de)	2006-05-04
EP1163906A2 (de)	2001-12-19
CN1091597C (zh)	2002-10-02
EE9500015A (et)	1995-12-15
FI951190A0 (fi)	1995-03-14
AU1485295A (en)	1995-09-21
LT3969B (en)	1996-05-27
FI951190A7 (fi)	1995-09-16
BR9501081A (pt)	1996-06-04
ES2240966T3 (es)	2005-10-16
PL307671A1 (en)	1995-09-18
KR100338851B1 (ko)	2002-10-12
EP0672414B1 (de)	2005-06-08
LT95028A (en)	1995-10-25
KR950032201A (ko)	1995-12-20
LV10922B (en)	1996-08-20
NO950970D0 (no)	1995-03-14
PL179534B1 (pl)	2000-09-29
FI951190L (fi)	1995-09-16
TW358812B (en)	1999-05-21
LV10922A (lv)	1995-12-20
NO950970L (no)	1995-09-18
HU9500772D0 (en)	1995-04-28
CA2144591A1 (en)	1995-09-16
DE69534258D1 (de)	2005-07-14
EP0672414A2 (de)	1995-09-20
EP0672414A3 (de)	1995-12-13
AU707119B2 (en)	1999-07-01
US5856345A (en)	1999-01-05
CN1111510A (zh)	1995-11-15

Legal Events

Date	Code	Title	Description
2005-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE297206T1 (de)	2005-06-15	Verfahren zur stabilisierung von pranoprofen und stabile flüssige zubereitung von pranoprofen
DE69131589D1 (de)	1999-10-14	Ribosomen-inaktivierende Proteine, inaktive Vorläuferformen derselben, Verfahren zur Herstellung und eine Methode zur Nutzung
ATE42206T1 (de)	1989-05-15	Verfahren und zusammensetzung zur gleichzeitigen reinigung und desinfektion von kontaktlinsen.
DE59008910D1 (de)	1995-05-18	Stabile injizierbare lösungen von faktor viii.
DE69304844D1 (de)	1996-10-24	Vorrichtung zur Leistungsstabilisierung von Laserdioden
ATE127659T1 (de)	1995-09-15	Verfahren zur entwicklung von chlordioxyd und zusammensetzungen für die desinfektion.
DE69926030D1 (de)	2005-08-11	Verfahren zur vor Ort Herstellung eines desinfizierenden Peressigsäuresystems
ATE77244T1 (de)	1992-07-15	Verfahren zur sterilisation mit niederdruckwasserstoffperoxid.
EP1082402A4 (de)	2001-10-10	Verfahren zur herstellung von treibstoffen mit hoher schmierfähigkeit und niedrigem schwefelgehalt
ZA909568B (en)	1991-09-25	Stabilized solutions of psychotropic agents
DE69231235D1 (de)	2000-08-17	Verfahren zur Herstellung von Perfluoropolyoxyalkylenen mit hoher Viskosität und niedrigem Peroxidsauerstoffgehalt
DE3689168D1 (de)	1993-11-18	Vorrichtung zur Regulierung der Konzentration einer wässrigen Alkohollösung.
DE3869230D1 (de)	1992-04-23	Verfahren zur herstellung einer loesung hoher spezifischer volumenaktivitaet von einem protein mit gewebe-plasminogenaktivator (t-pa)-aktivitaet, loesung, enthaltend protein mit t-pa-aktivitaet und verwendung der loesung in der human- und veterinaermedizin.
ATE287255T1 (de)	2005-02-15	Stabile flüssigkeiten mit hohem glycerolgehalt, die sulfosuccinsäuremonoester enthalten
DK0952959T3 (da)	2003-07-21	Polyhalophosphazenopløsninger, som er stabile overfor geldannelse
DE69200250D1 (de)	1994-08-25	Verfahren zur verlängerung der gaslebensdauer von excimer-lasern.
ATE177141T1 (de)	1999-03-15	Verfahren zur stabilisierung eines kontaktlinsenpräparats
ATE239038T1 (de)	2003-05-15	Methode zur reinigung von keratinocyten- wachstumsfaktoren
DE59708046D1 (de)	2002-10-02	Verfahren zur Herstellung von Celluloselösungen in wasserhaltigem Aminoxid
ATE34747T1 (de)	1988-06-15	Verfahren zur herstellung von thiotetronsaeure.
DE59501234D1 (de)	1998-02-19	Verfahren zur Herstellung von 2-Nitrobenzaldehyden
DE59802825D1 (de)	2002-02-28	Verfahren zur Herstellung von 4-Nitro-2-sulfo-benzoesäure
DE59304167D1 (de)	1996-11-21	Mikrobiologisches Verfahren zur Herstellung von 5-Hydroxy-2-pyrazincarbonsäure
ATE215929T1 (de)	2002-04-15	Verfahren zur stabilisierung von cyanhydrinen
ATE246874T1 (de)	2003-08-15	Verfahren zur verlängerung der haltbarkeit von schnittblumen