ATE297399T1 - Neue heteroaromatische amidderivate von 3beta aminoazabicyclooctanen, verfahren zu ihrer herstellung und ihre therapeutische verwendung - Google Patents

Neue heteroaromatische amidderivate von 3beta aminoazabicyclooctanen, verfahren zu ihrer herstellung und ihre therapeutische verwendung

Info

Publication number: ATE297399T1
Authority: AT; Austria
Prior art keywords: sub; pyridine; furo; thieno; group
Prior art date: 2001-11-02

Application number

AT02785568T

Other languages

English (en)

Inventor

Thierry Imbert

Barbara Monse

Wouter Koek

Original Assignee

Pf Medicament

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-02

Filing date

2002-10-30

Publication date

2005-06-15

2002-10-30 Application filed by Pf Medicament filed Critical Pf Medicament

2005-06-15 Application granted granted Critical

2005-06-15 Publication of ATE297399T1 publication Critical patent/ATE297399T1/de

Links

150000001408 amides Chemical class 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
125000003545 alkoxy group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
-1 3-thienylmethyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
239000003210 dopamine receptor blocking agent Substances 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
XEZPQQXHOCEWLB-UHFFFAOYSA-N furo[2,3-b]pyrazine Chemical compound C1=CN=C2OC=CC2=N1 XEZPQQXHOCEWLB-UHFFFAOYSA-N 0.000 abstract 1
RCFDIXKVOHJQPP-UHFFFAOYSA-N furo[2,3-b]pyridine Chemical compound C1=CN=C2OC=CC2=C1 RCFDIXKVOHJQPP-UHFFFAOYSA-N 0.000 abstract 1
ZYXBIOIYWUIXSM-UHFFFAOYSA-N furo[2,3-c]pyridine Chemical compound C1=NC=C2OC=CC2=C1 ZYXBIOIYWUIXSM-UHFFFAOYSA-N 0.000 abstract 1
YRTCKZIKGWZNCU-UHFFFAOYSA-N furo[3,2-b]pyridine Chemical compound C1=CC=C2OC=CC2=N1 YRTCKZIKGWZNCU-UHFFFAOYSA-N 0.000 abstract 1
WJDMEHCIRPKRRQ-UHFFFAOYSA-N furo[3,2-c]pyridine Chemical compound N1=CC=C2OC=CC2=C1 WJDMEHCIRPKRRQ-UHFFFAOYSA-N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
229910052740 iodine Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
YJSKZIATOGOJEB-UHFFFAOYSA-N thieno[2,3-b]pyrazine Chemical compound C1=CN=C2SC=CC2=N1 YJSKZIATOGOJEB-UHFFFAOYSA-N 0.000 abstract 1
SMZMHUCIDGHERP-UHFFFAOYSA-N thieno[2,3-b]pyridine Chemical compound C1=CN=C2SC=CC2=C1 SMZMHUCIDGHERP-UHFFFAOYSA-N 0.000 abstract 1
GDQBPBMIAFIRIU-UHFFFAOYSA-N thieno[2,3-c]pyridine Chemical compound C1=NC=C2SC=CC2=C1 GDQBPBMIAFIRIU-UHFFFAOYSA-N 0.000 abstract 1
DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical compound C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 abstract 1
MKYRMMMSZSVIGD-UHFFFAOYSA-N thieno[3,2-c]pyridine Chemical compound N1=CC=C2SC=CC2=C1 MKYRMMMSZSVIGD-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT02785568T 2001-11-02 2002-10-30 Neue heteroaromatische amidderivate von 3beta aminoazabicyclooctanen, verfahren zu ihrer herstellung und ihre therapeutische verwendung ATE297399T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0114220A FR2831884B1 (fr)	2001-11-02	2001-11-02	Nouveaux derives amides heteroaromatiques de 3 beta-amino azabicyclooctane, leur procede de preparation et leurs applications en therapeutique
PCT/FR2002/003737 WO2003037904A1 (fr)	2001-11-02	2002-10-30	NOUVEAUX DERIVES AMIDES HETEROAROMATIQUES DE 3β-AMINO AZABICYCLOOCTANE, LEUR PROCEDE DE PREPARATION ET LEURS APPLICATIONS EN THERAPEUTIQUE

Publications (1)

Publication Number	Publication Date
ATE297399T1 true ATE297399T1 (de)	2005-06-15

Family

ID=8869022

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02785568T ATE297399T1 (de)	2001-11-02	2002-10-30	Neue heteroaromatische amidderivate von 3beta aminoazabicyclooctanen, verfahren zu ihrer herstellung und ihre therapeutische verwendung

Country Status (9)

Country	Link
US (1)	US7456192B2 (de)
EP (1)	EP1440075B1 (de)
AT (1)	ATE297399T1 (de)
DE (1)	DE60204582T2 (de)
DK (1)	DK1440075T3 (de)
ES (1)	ES2243779T3 (de)
FR (1)	FR2831884B1 (de)
PT (1)	PT1440075E (de)
WO (1)	WO2003037904A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU227684B1 (en) *	2003-08-29	2011-11-28	Sanofi Aventis	Adamantane and azabicyclo-octane and nonane derivatives and their use as dpp-iv inhibitors
CA2721099C (en)	2008-04-11	2017-04-25	Janssen Pharmaceutica Nv	Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase
UY32397A (es) *	2009-01-28	2010-08-31	Astrazeneca Ab	Compuestos de 2-aza-biciclo [2,2,1] heptano y sus usos
JP5690286B2 (ja) *	2009-03-04	2015-03-25	イデニクプハルマセウティカルス，インコーポレイテッド	ホスホチオフェン及びホスホチアゾールｈｃｖポリメラーゼ阻害剤
NZ596137A (en)	2009-05-14	2013-08-30	Janssen Pharmaceutica Nv	Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase
WO2014097150A1 (en)	2012-12-17	2014-06-26	Ranbaxy Laboratories Limited	Process for the preparation of tofacitinib and intermediates thereof
MX2021000293A (es)	2018-07-09	2021-07-15	Boehringer Ingelheim Animal Health Usa Inc	Compuestos heterociclicos antihelminticos.
CN109851551B (zh) *	2018-12-11	2022-05-20	大连金点生物科技有限公司	一种合成3-溴异烟酸中间体的方法
JP7637630B2 (ja)	2019-03-19	2025-02-28	ベーリンガーインゲルハイムフェトメディカゲーエムベーハー	駆虫性アザベンゾチオフェンおよびアザベンゾフラン化合物
PH12022553222A1 (en)	2020-05-29	2024-02-12	Boehringer Ingelheim Animal Health Usa Inc	Anthelmintic heterocyclic compounds
AR127495A1 (es)	2021-11-01	2024-01-31	Boehringer Ingelheim Vetmedica Gmbh	Compuestos de pirrolopiridazina como antihelmínticos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL59004A0 (en)	1978-12-30	1980-03-31	Beecham Group Ltd	Substituted benzamides their preparation and pharmaceutical compositions containing them
FR2476088A2 (fr)	1979-01-16	1981-08-21	Delalande Sa	Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
US4910193A (en)	1985-12-16	1990-03-20	Sandoz Ltd.	Treatment of gastrointestinal disorders
JPH07503461A (ja)	1992-01-28	1995-04-13	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	カルシウムチャンネル拮抗薬としての化合物
FR2738569B1 (fr) *	1995-09-12	1997-11-28	Pf Medicament	Nouveaux derives naphtamide de 3 beta-amino azabicyclo octane ou nonane, leur procede de preparation, leur utilisation a titre de medicament antipsychotique
SE9902987D0 (sv)	1999-08-24	1999-08-24	Astra Pharma Prod	Novel compounds

2001
- 2001-11-02 FR FR0114220A patent/FR2831884B1/fr not_active Expired - Fee Related
2002
- 2002-10-30 WO PCT/FR2002/003737 patent/WO2003037904A1/fr not_active Ceased
- 2002-10-30 DK DK02785568T patent/DK1440075T3/da active
- 2002-10-30 DE DE60204582T patent/DE60204582T2/de not_active Expired - Lifetime
- 2002-10-30 PT PT02785568T patent/PT1440075E/pt unknown
- 2002-10-30 US US10/494,639 patent/US7456192B2/en not_active Expired - Fee Related
- 2002-10-30 ES ES02785568T patent/ES2243779T3/es not_active Expired - Lifetime
- 2002-10-30 AT AT02785568T patent/ATE297399T1/de not_active IP Right Cessation
- 2002-10-30 EP EP02785568A patent/EP1440075B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60204582T2 (de)	2006-03-16
FR2831884B1 (fr)	2003-12-26
US20050080085A1 (en)	2005-04-14
FR2831884A1 (fr)	2003-05-09
PT1440075E (pt)	2005-10-31
DE60204582D1 (de)	2005-07-14
US7456192B2 (en)	2008-11-25
EP1440075A1 (de)	2004-07-28
DK1440075T3 (da)	2005-08-22
ES2243779T3 (es)	2005-12-01
WO2003037904A1 (fr)	2003-05-08
EP1440075B1 (de)	2005-06-08

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