ATE297895T1 - 4-pyridinyl-n-acyl-l-phenylalanine - Google Patents

4-pyridinyl-n-acyl-l-phenylalanine

Info

Publication number
ATE297895T1
ATE297895T1 AT00985117T AT00985117T ATE297895T1 AT E297895 T1 ATE297895 T1 AT E297895T1 AT 00985117 T AT00985117 T AT 00985117T AT 00985117 T AT00985117 T AT 00985117T AT E297895 T1 ATE297895 T1 AT E297895T1
Authority
AT
Austria
Prior art keywords
pyridinyl
phenylalanine
acyl
Prior art date
Application number
AT00985117T
Other languages
English (en)
Inventor
Gerald Lewis Kaplan
Achyutharao Sidduri
Jefferson Wright Tilley
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE297895T1 publication Critical patent/ATE297895T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
AT00985117T 1999-12-06 2000-11-29 4-pyridinyl-n-acyl-l-phenylalanine ATE297895T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16909099P 1999-12-06 1999-12-06
PCT/EP2000/011979 WO2001042215A1 (en) 1999-12-06 2000-11-29 4-pyridinyl-n-acyl-l-phenylalanines

Publications (1)

Publication Number Publication Date
ATE297895T1 true ATE297895T1 (de) 2005-07-15

Family

ID=22614226

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00985117T ATE297895T1 (de) 1999-12-06 2000-11-29 4-pyridinyl-n-acyl-l-phenylalanine

Country Status (33)

Country Link
EP (1) EP1244625B1 (de)
JP (2) JP2003516392A (de)
KR (1) KR100492111B1 (de)
CN (1) CN1196682C (de)
AR (1) AR031083A1 (de)
AT (1) ATE297895T1 (de)
AU (1) AU779063B2 (de)
BR (1) BR0016172A (de)
CA (1) CA2392566A1 (de)
CO (1) CO5080771A1 (de)
CZ (1) CZ20022352A3 (de)
DE (1) DE60020883T2 (de)
DK (1) DK1244625T3 (de)
ES (1) ES2243335T3 (de)
GC (1) GC0000214A (de)
HR (1) HRP20020467A2 (de)
HU (1) HUP0203735A3 (de)
IL (2) IL149622A0 (de)
JO (1) JO2281B1 (de)
MA (1) MA26849A1 (de)
MX (1) MXPA02005240A (de)
MY (1) MY128003A (de)
NO (1) NO322910B1 (de)
NZ (1) NZ518888A (de)
PE (1) PE20010960A1 (de)
PL (1) PL364814A1 (de)
PT (1) PT1244625E (de)
RU (1) RU2270193C2 (de)
TW (1) TWI276629B (de)
UY (1) UY26470A1 (de)
WO (1) WO2001042215A1 (de)
YU (1) YU40502A (de)
ZA (1) ZA200203762B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960597B2 (en) 2000-06-30 2005-11-01 Orth-Mcneil Pharmaceutical, Inc. Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
ATE497385T1 (de) 2000-08-18 2011-02-15 Ajinomoto Kk Neue phenylalanin-derivate
JP4895067B2 (ja) 2000-09-29 2012-03-14 味の素株式会社 新規フェニルアラニン誘導体
WO2003053926A1 (en) 2001-12-13 2003-07-03 Ajinomoto Co.,Inc. Novel phenylalanine derivative
AU2002351412B2 (en) 2001-12-21 2010-05-20 Exelixis Patent Company Llc Modulators of LXR
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
EP1700850B1 (de) 2003-12-22 2015-07-15 Ajinomoto Co., Inc. Phenylalaninderivat
US7618981B2 (en) * 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
CN101006097B (zh) * 2004-08-16 2012-07-11 默沙东公司 Vla-4拮抗剂
JP4784224B2 (ja) 2004-09-24 2011-10-05 味の素株式会社 糖鎖転移方法および糖鎖転移酵素
CA2641160A1 (en) * 2006-02-28 2007-09-07 Elan Pharmaceuticals, Inc. Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds
AR060901A1 (es) * 2006-05-12 2008-07-23 Jerini Ag Compuestos heterociclicos para la inhibicion de integrinas y uso de estos
EP2510941A3 (de) 2007-02-20 2013-01-23 Merrimack Pharmaceuticals, Inc. Verfahren zur Behandlung von multipler Sklerose mittels Verabreichung eines alpha-Fetoproteins in Kombination mit einem Integrinantagonisten
BRPI0911652A2 (pt) 2008-04-11 2015-08-04 Merrimack Pharmaceuticals Inc Ligantes de albumina sérica humana e seus conjugados
ES2494465T3 (es) * 2009-07-23 2014-09-15 Bayer Cropscience Ag Procedimiento para la preparación de alcoxienonas y enaminocetonas
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
CN104023751B (zh) * 2012-01-27 2016-11-09 弗·哈夫曼-拉罗切有限公司 靶向递送至表达vla-4的细胞的整联蛋白拮抗剂结合物
BR112015031040A8 (pt) * 2013-06-11 2018-01-02 Receptos Inc Novos moduladores do receptor de glp-1
AU2017214589B2 (en) 2016-02-05 2020-09-03 Ea Pharma Co., Ltd. Sulfonamide derivative and pharmaceutical composition containing same
AU2019373242B2 (en) 2018-10-30 2023-07-13 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin
KR102630416B1 (ko) 2018-10-30 2024-02-01 길리애드 사이언시즈, 인코포레이티드 알파4베타7 인테그린 억제제로서의 퀴놀린 유도체
ES3013256T3 (en) 2018-10-30 2025-04-11 Gilead Sciences Inc Imidazo[1,2-a]pyridine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases
US11179383B2 (en) 2018-10-30 2021-11-23 Gilead Sciences, Inc. Compounds for inhibition of α4β7 integrin
CN114222730B (zh) 2019-08-14 2024-09-10 吉利德科学公司 用于抑制α4β7整合素的化合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA848275B (en) * 1983-12-28 1985-08-28 Degussa New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring
EP1001764A4 (de) * 1997-05-29 2005-08-24 Merck & Co Inc Heterozyklische amide als zelladhäsionshemmern
DE69833654T2 (de) * 1997-05-29 2006-12-14 Merck & Co., Inc. (A New Jersey Corp.) Biarylalkansäuren in der verwendung als zelladhäsionsinhibitoren
US6197794B1 (en) * 1998-01-08 2001-03-06 Celltech Therapeutics Limited Phenylalanine derivatives
MY153569A (en) * 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
US6329372B1 (en) * 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
ATE273273T1 (de) * 1998-02-26 2004-08-15 Celltech Therapeutics Ltd Phenylalaninderivate als inhibitoren von alpha4 integrinen
GB9811159D0 (en) * 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds
EP1144365B1 (de) * 1998-12-22 2004-03-17 Tanabe Seiyaku Co., Ltd. Inhibitoren der alpha-4 beta-1 vermittelten zelladhäsion
CA2357781A1 (en) * 1999-01-22 2000-07-27 Elan Pharmaceuticals, Inc. Multicyclic compounds which inhibit leukocyte adhesion mediated by vla-4

Also Published As

Publication number Publication date
AU779063B2 (en) 2005-01-06
PL364814A1 (en) 2004-12-13
JP2008094842A (ja) 2008-04-24
GC0000214A (en) 2006-03-29
NZ518888A (en) 2004-02-27
WO2001042215A1 (en) 2001-06-14
DE60020883T2 (de) 2006-03-23
HUP0203735A2 (hu) 2003-03-28
HK1053470A1 (en) 2003-10-24
ZA200203762B (en) 2004-01-28
NO20022650D0 (no) 2002-06-05
RU2270193C2 (ru) 2006-02-20
TWI276629B (en) 2007-03-21
AR031083A1 (es) 2003-09-10
NO20022650L (no) 2002-06-05
MXPA02005240A (es) 2002-11-07
IL149622A0 (en) 2002-11-10
UY26470A1 (es) 2001-05-31
IL149622A (en) 2006-12-10
JO2281B1 (en) 2005-09-12
BR0016172A (pt) 2002-08-20
MA26849A1 (fr) 2004-12-20
MY128003A (en) 2007-01-31
JP2003516392A (ja) 2003-05-13
EP1244625A1 (de) 2002-10-02
NO322910B1 (no) 2006-12-18
KR20020060256A (ko) 2002-07-16
HRP20020467A2 (en) 2004-04-30
DK1244625T3 (da) 2005-10-10
ES2243335T3 (es) 2005-12-01
CN1196682C (zh) 2005-04-13
HUP0203735A3 (en) 2005-03-29
EP1244625B1 (de) 2005-06-15
CN1402709A (zh) 2003-03-12
YU40502A (sh) 2005-03-15
DE60020883D1 (de) 2005-07-21
CO5080771A1 (es) 2001-09-25
PT1244625E (pt) 2005-09-30
CZ20022352A3 (cs) 2003-05-14
KR100492111B1 (ko) 2005-06-01
CA2392566A1 (en) 2001-06-14
PE20010960A1 (es) 2001-09-22
AU2163901A (en) 2001-06-18

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