MA26849A1 - 4-pyridinyle-n-acyl-l-phenylalanines. - Google Patents

4-pyridinyle-n-acyl-l-phenylalanines.

Info

Publication number: MA26849A1
Authority: MA; Morocco
Prior art keywords: pyridinyl; phenylalanine; acyl
Prior art date: 1999-12-06

Application number

MA26672A

Other languages

English (en)

Inventor

Gerald Lewis Kaplan

Jefferson Wright Tilley

Achyutharao Sidduri

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-06

Filing date

2002-06-05

Publication date

2004-12-20

2002-06-05 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-12-20 Publication of MA26849A1 publication Critical patent/MA26849A1/fr

Links

229960005190 phenylalanine Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

MA26672A 1999-12-06 2002-06-05 4-pyridinyle-n-acyl-l-phenylalanines. MA26849A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US16909099P	1999-12-06	1999-12-06

Publications (1)

Publication Number	Publication Date
MA26849A1 true MA26849A1 (fr)	2004-12-20

Family

ID=22614226

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA26672A MA26849A1 (fr)	1999-12-06	2002-06-05	4-pyridinyle-n-acyl-l-phenylalanines.

Country Status (33)

Country	Link
EP (1)	EP1244625B1 (fr)
JP (2)	JP2003516392A (fr)
KR (1)	KR100492111B1 (fr)
CN (1)	CN1196682C (fr)
AR (1)	AR031083A1 (fr)
AT (1)	ATE297895T1 (fr)
AU (1)	AU779063B2 (fr)
BR (1)	BR0016172A (fr)
CA (1)	CA2392566A1 (fr)
CO (1)	CO5080771A1 (fr)
CZ (1)	CZ20022352A3 (fr)
DE (1)	DE60020883T2 (fr)
DK (1)	DK1244625T3 (fr)
ES (1)	ES2243335T3 (fr)
GC (1)	GC0000214A (fr)
HR (1)	HRP20020467A2 (fr)
HU (1)	HUP0203735A3 (fr)
IL (2)	IL149622A0 (fr)
JO (1)	JO2281B1 (fr)
MA (1)	MA26849A1 (fr)
MX (1)	MXPA02005240A (fr)
MY (1)	MY128003A (fr)
NO (1)	NO322910B1 (fr)
NZ (1)	NZ518888A (fr)
PE (1)	PE20010960A1 (fr)
PL (1)	PL364814A1 (fr)
PT (1)	PT1244625E (fr)
RU (1)	RU2270193C2 (fr)
TW (1)	TWI276629B (fr)
UY (1)	UY26470A1 (fr)
WO (1)	WO2001042215A1 (fr)
YU (1)	YU40502A (fr)
ZA (1)	ZA200203762B (fr)

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US6960597B2 (en)	2000-06-30	2005-11-01	Orth-Mcneil Pharmaceutical, Inc.	Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
CN1325480C (zh)	2000-08-18	2007-07-11	味之素株式会社	苯基丙氨酸衍生物
AU2001290303A1 (en)	2000-09-29	2002-04-15	Ajinomoto Co., Inc.	Novel phenylalanine derivatives
JP4452899B2 (ja)	2001-12-13	2010-04-21	味の素株式会社	新規フェニルアラニン誘導体
US7998986B2 (en)	2001-12-21	2011-08-16	Exelixis Patent Company Llc	Modulators of LXR
US7482366B2 (en)	2001-12-21	2009-01-27	X-Ceptor Therapeutics, Inc.	Modulators of LXR
KR20110098980A (ko)	2003-12-22	2011-09-02	아지노모토 가부시키가이샤	신규한 페닐알라닌 유도체
US7618981B2 (en) *	2004-05-06	2009-11-17	Cytokinetics, Inc.	Imidazopyridinyl-benzamide anti-cancer agents
BRPI0514415A (pt) *	2004-08-16	2008-06-10	Merck & Co Inc	composto, composição farmacêutica, e, uso de um composto
JP4784224B2 (ja)	2004-09-24	2011-10-05	味の素株式会社	糖鎖転移方法および糖鎖転移酵素
US8410115B2 (en) *	2006-02-28	2013-04-02	Elan Pharmaceuticals, Inc.	Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds
TW200811164A (en) *	2006-05-12	2008-03-01	Jerini Ag	New heterocyclic compounds for the inhibition of integrins and use thereof
US20100150915A1 (en)	2007-02-20	2010-06-17	Stewart Edward J	Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
EA022201B1 (ru)	2008-04-11	2015-11-30	Мерримак Фармасьютикалз, Инк.	Агент, способный связываться с опухолевой клеткой, содержащий линкер на основе hsa, и его применение
WO2011009552A1 (fr) *	2009-07-23	2011-01-27	Bayer Cropscience Ag	Nouveaux alcoxy-énones et énaminocétones et leur procédé de production
US8877815B2 (en)	2010-11-16	2014-11-04	Novartis Ag	Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
WO2013110680A1 (fr) *	2012-01-27	2013-08-01	F. Hoffmann-La Roche Ag	Conjugués d'antagonistes d'intégrine pour cibler des cellules exprimant le vla-4
CA2913791A1 (fr) *	2013-06-11	2014-12-18	Receptos, Inc.	Nouveaux modulateurs du recepteur glp-1
ES2856125T3 (es)	2016-02-05	2021-09-27	Ea Pharma Co Ltd	Derivado de sulfonamida y composición farmacéutica que contiene la misma
EP3873900B1 (fr)	2018-10-30	2025-01-08	Gilead Sciences, Inc.	Dérivés de imidazo[1,2-a]pyridine en tant qu'inhibiteurs d'integrin alpha4beta7 pour le traitement de maladies inflammatoires
HUE070112T2 (hu)	2018-10-30	2025-05-28	Gilead Sciences Inc	3-(Kinolin-8-il)-1,4-dihidropirido[3,4-d]pirimidin-2,4-dion-származékok mint alpha4beta7 integrin gátlók gyulladásos betegségek kezelésére
JP7189369B2 (ja)	2018-10-30	2022-12-13	ギリアードサイエンシーズ，インコーポレイテッド	アルファ４β７インテグリンの阻害のための化合物
CN112996786B (zh)	2018-10-30	2024-08-20	吉利德科学公司	用于抑制α4β7整合素的化合物
JP7491996B2 (ja)	2019-08-14	2024-05-28	ギリアードサイエンシーズ，インコーポレイテッド	α４β７インテグリンの阻害のための化合物

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ZA848275B (en) *	1983-12-28	1985-08-28	Degussa	New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring
JP2002512625A (ja) *	1997-05-29	2002-04-23	メルクエンドカンパニーインコーポレーテッド	細胞接着阻害薬としての複素環アミド化合物
CA2291762A1 (fr) *	1997-05-29	1998-12-03	Merck & Co., Inc.	Acide biarylalcanoique utilise en tant qu'inhibiteur de l'adhesion cellulaire
US6197794B1 (en) *	1998-01-08	2001-03-06	Celltech Therapeutics Limited	Phenylalanine derivatives
MY153569A (en) *	1998-01-20	2015-02-27	Mitsubishi Tanabe Pharma Corp	Inhibitors of ?4 mediated cell adhesion
US6329372B1 (en) *	1998-01-27	2001-12-11	Celltech Therapeutics Limited	Phenylalanine derivatives
ES2226413T3 (es) *	1998-02-26	2005-03-16	Celltech Therapeutics Limited	Derivados de fenilalanina como inhibidores de alfa-4 integrinas.
GB9811159D0 (en) *	1998-05-22	1998-07-22	Celltech Therapeutics Ltd	Chemical compounds
JP2003524614A (ja) *	1998-12-22	2003-08-19	田辺製薬株式会社	α４β１媒介細胞接着のインヒビター
HK1045495A1 (zh) *	1999-01-22	2002-11-29	依兰制药公司	抑制vla-4介导的白细胞粘着的多环化合物

2000
- 2000-11-29 RU RU2002117419/04A patent/RU2270193C2/ru not_active IP Right Cessation
- 2000-11-29 PL PL00364814A patent/PL364814A1/xx not_active Application Discontinuation
- 2000-11-29 JP JP2001543516A patent/JP2003516392A/ja active Pending
- 2000-11-29 AT AT00985117T patent/ATE297895T1/de not_active IP Right Cessation
- 2000-11-29 CZ CZ20022352A patent/CZ20022352A3/cs unknown
- 2000-11-29 PT PT00985117T patent/PT1244625E/pt unknown
- 2000-11-29 WO PCT/EP2000/011979 patent/WO2001042215A1/fr not_active Ceased
- 2000-11-29 CA CA002392566A patent/CA2392566A1/fr not_active Abandoned
- 2000-11-29 JO JO2000189A patent/JO2281B1/en active
- 2000-11-29 KR KR10-2002-7007201A patent/KR100492111B1/ko not_active Expired - Fee Related
- 2000-11-29 DK DK00985117T patent/DK1244625T3/da active
- 2000-11-29 HR HR20020467A patent/HRP20020467A2/xx not_active Application Discontinuation
- 2000-11-29 DE DE60020883T patent/DE60020883T2/de not_active Expired - Lifetime
- 2000-11-29 NZ NZ518888A patent/NZ518888A/en unknown
- 2000-11-29 BR BR0016172-1A patent/BR0016172A/pt not_active Application Discontinuation
- 2000-11-29 YU YU40502A patent/YU40502A/sh unknown
- 2000-11-29 IL IL14962200A patent/IL149622A0/xx active IP Right Grant
- 2000-11-29 AU AU21639/01A patent/AU779063B2/en not_active Ceased
- 2000-11-29 ES ES00985117T patent/ES2243335T3/es not_active Expired - Lifetime
- 2000-11-29 CN CNB008164800A patent/CN1196682C/zh not_active Expired - Fee Related
- 2000-11-29 MX MXPA02005240A patent/MXPA02005240A/es active IP Right Grant
- 2000-11-29 EP EP00985117A patent/EP1244625B1/fr not_active Expired - Lifetime
- 2000-11-29 HU HU0203735A patent/HUP0203735A3/hu unknown
- 2000-12-02 GC GCP20001072 patent/GC0000214A/en active
- 2000-12-04 MY MYPI20005689A patent/MY128003A/en unknown
- 2000-12-04 AR ARP000106416A patent/AR031083A1/es not_active Application Discontinuation
- 2000-12-05 UY UY26470A patent/UY26470A1/es not_active Application Discontinuation
- 2000-12-05 CO CO00092690A patent/CO5080771A1/es unknown
- 2000-12-05 TW TW089125889A patent/TWI276629B/zh not_active IP Right Cessation
- 2000-12-06 PE PE2000001306A patent/PE20010960A1/es not_active Application Discontinuation
2002
- 2002-05-10 ZA ZA200203762A patent/ZA200203762B/xx unknown
- 2002-05-13 IL IL149622A patent/IL149622A/en not_active IP Right Cessation
- 2002-06-05 NO NO20022650A patent/NO322910B1/no unknown
- 2002-06-05 MA MA26672A patent/MA26849A1/fr unknown
2007
- 2007-10-05 JP JP2007262543A patent/JP2008094842A/ja active Pending

Also Published As

Publication number	Publication date
JP2003516392A (ja)	2003-05-13
PL364814A1 (en)	2004-12-13
HUP0203735A3 (en)	2005-03-29
YU40502A (sh)	2005-03-15
CZ20022352A3 (cs)	2003-05-14
KR100492111B1 (ko)	2005-06-01
ATE297895T1 (de)	2005-07-15
NO20022650D0 (no)	2002-06-05
HUP0203735A2 (hu)	2003-03-28
MXPA02005240A (es)	2002-11-07
RU2270193C2 (ru)	2006-02-20
CA2392566A1 (fr)	2001-06-14
CN1196682C (zh)	2005-04-13
NO322910B1 (no)	2006-12-18
ZA200203762B (en)	2004-01-28
MY128003A (en)	2007-01-31
NO20022650L (no)	2002-06-05
ES2243335T3 (es)	2005-12-01
UY26470A1 (es)	2001-05-31
AU2163901A (en)	2001-06-18
CN1402709A (zh)	2003-03-12
IL149622A (en)	2006-12-10
HRP20020467A2 (en)	2004-04-30
PT1244625E (pt)	2005-09-30
EP1244625B1 (fr)	2005-06-15
EP1244625A1 (fr)	2002-10-02
AR031083A1 (es)	2003-09-10
BR0016172A (pt)	2002-08-20
DE60020883D1 (de)	2005-07-21
PE20010960A1 (es)	2001-09-22
WO2001042215A1 (fr)	2001-06-14
GC0000214A (en)	2006-03-29
DE60020883T2 (de)	2006-03-23
IL149622A0 (en)	2002-11-10
AU779063B2 (en)	2005-01-06
NZ518888A (en)	2004-02-27
JO2281B1 (en)	2005-09-12
HK1053470A1 (en)	2003-10-24
DK1244625T3 (da)	2005-10-10
TWI276629B (en)	2007-03-21
CO5080771A1 (es)	2001-09-25
KR20020060256A (ko)	2002-07-16
JP2008094842A (ja)	2008-04-24

Publication	Publication Date	Title
MA25499A1 (fr)	2002-07-01	Contacteur-disjoncteur.
TR200000520A3 (tr)	2001-06-21	4-Fenil-piridin türevleri.
CU23049A3 (es)	2005-06-24	Dihidropirimidinas.
BR0014932B1 (pt)	2009-01-13	conjunto de retenção.
MA26849A1 (fr)	2004-12-20	4-pyridinyle-n-acyl-l-phenylalanines.
IT1310460B1 (it)	2002-02-18	Dispositivo gommatore .
ITBO990359A0 (it)	1999-06-30	Elettromandrino .
DE60029755D1 (de)	2006-09-14	Congawandschutz.
MXPA01011760A (es)	2003-09-04	Compuestos novedosos de difeniletileno.
ITBO990358A0 (it)	1999-06-30	Elettromandrino .
NL1011488A1 (nl)	2000-09-14	Hoofdtelefoon-microfoon-combinatie.
ES1044838Y (es)	2000-11-16	Friegasuelos.
ITSS990004V0 (it)	1999-06-08	Piramide - ricordo.
ES1044367Y (es)	2000-09-01	Piñata mejorada.
ES1044490Y (es)	2000-09-01	Piñata.
ES1045051Y (es)	2000-12-16	Caja-envase.
ES1041998Y (es)	2000-02-01	Pastillero.
ES1042445Y (es)	2000-02-01	Guardabolsas.
ES1043620Y (es)	2001-02-16	Urna-columbario.
ES1044580Y (es)	2000-09-16	Humidificador-fitosanitario.
IT247637Y1 (it)	2002-09-09	Tritapepe.
IT247490Y1 (it)	2002-08-22	Motocoltivatore .
ES1044797Y (es)	2000-11-16	Collar-bozal antitiro.
ITPC990005V0 (it)	1999-01-27	Infocard.
ITRM990195V0 (it)	1999-09-21	Toto-famiglia.