ATE297939T1 - Herstellung von kristallinen polymorphen von fosinopril natrium - Google Patents

Herstellung von kristallinen polymorphen von fosinopril natrium

Info

Publication number: ATE297939T1
Authority: AT; Austria
Prior art keywords: crystalline; preparation; polymorphoes; fosinopril sodium; fosinopril
Prior art date: 2001-11-30

Application number

AT02781546T

Other languages

English (en)

Inventor

Pato Sandra Gallego

Coll Antonio Luis Palomo

Nicolau Francisco Eugen Palomo

Original Assignee

Sint Quimica Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-30

Filing date

2002-11-19

Publication date

2005-07-15

2002-11-19 Application filed by Sint Quimica Sa filed Critical Sint Quimica Sa

2005-07-15 Application granted granted Critical

2005-07-15 Publication of ATE297939T1 publication Critical patent/ATE297939T1/de

Links

229960001880 fosinopril sodium Drugs 0.000 title 1
TVTJZMHAIQQZTL-WATAJHSMSA-M sodium;(2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylate Chemical compound [Na+].C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C([O-])=O)CCCC1=CC=CC=C1 TVTJZMHAIQQZTL-WATAJHSMSA-M 0.000 title 1
238000000034 method Methods 0.000 abstract 2
BIDNLKIUORFRQP-XYGFDPSESA-N (2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C(O)=O)CCCC1=CC=CC=C1 BIDNLKIUORFRQP-XYGFDPSESA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
230000015556 catabolic process Effects 0.000 abstract 1
238000006731 degradation reaction Methods 0.000 abstract 1
229960002490 fosinopril Drugs 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT02781546T 2001-11-30 2002-11-19 Herstellung von kristallinen polymorphen von fosinopril natrium ATE297939T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES200102739A ES2195752B1 (es)	2001-11-30	2001-11-30	Procedimiento para la preparacion de polimorfos cristalinos de la sal sodica del fosinopril.
PCT/IB2002/004828 WO2003045961A1 (en)	2001-11-30	2002-11-19	Preparation of crystalline polymorphs of fosinopril sodium

Publications (1)

Publication Number	Publication Date
ATE297939T1 true ATE297939T1 (de)	2005-07-15

Family

ID=8499700

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02781546T ATE297939T1 (de)	2001-11-30	2002-11-19	Herstellung von kristallinen polymorphen von fosinopril natrium

Country Status (12)

Country	Link
US (1)	US20050010054A1 (de)
EP (1)	EP1448576B1 (de)
JP (1)	JP2005510566A (de)
AT (1)	ATE297939T1 (de)
AU (1)	AU2002348926B2 (de)
CA (1)	CA2467884A1 (de)
DE (1)	DE60204721T2 (de)
ES (2)	ES2195752B1 (de)
IL (2)	IL162065A0 (de)
NZ (1)	NZ532923A (de)
WO (1)	WO2003045961A1 (de)
ZA (1)	ZA200403811B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20150046T1 (xx) *	2006-05-26	2015-03-13	Generics	Postupci za pripremu zofenopril kalcija
CN107365268B (zh) *	2016-05-11	2021-02-05	常州制药厂有限公司	一种降压药福辛普利钠及其关键中间体的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5162543A (en) *	1990-02-16	1992-11-10	E. R. Squibb & Sons, Inc.	Selective processes for fosinopril polymorphs
JP2004520440A (ja) *	2001-04-30	2004-07-08	ルピンラボラトリーズリミティド	フォシノプリルナトリウムの製造方法

2001
- 2001-11-30 ES ES200102739A patent/ES2195752B1/es not_active Expired - Fee Related
2002
- 2002-11-19 JP JP2003547410A patent/JP2005510566A/ja active Pending
- 2002-11-19 AU AU2002348926A patent/AU2002348926B2/en not_active Ceased
- 2002-11-19 CA CA002467884A patent/CA2467884A1/en not_active Abandoned
- 2002-11-19 AT AT02781546T patent/ATE297939T1/de not_active IP Right Cessation
- 2002-11-19 IL IL16206502A patent/IL162065A0/xx unknown
- 2002-11-19 US US10/496,748 patent/US20050010054A1/en not_active Abandoned
- 2002-11-19 ES ES02781546T patent/ES2243770T3/es not_active Expired - Lifetime
- 2002-11-19 DE DE60204721T patent/DE60204721T2/de not_active Expired - Fee Related
- 2002-11-19 NZ NZ532923A patent/NZ532923A/en unknown
- 2002-11-19 EP EP02781546A patent/EP1448576B1/de not_active Expired - Lifetime
- 2002-11-19 WO PCT/IB2002/004828 patent/WO2003045961A1/en not_active Ceased
2004
- 2004-05-18 ZA ZA200403811A patent/ZA200403811B/en unknown
- 2004-05-19 IL IL162065A patent/IL162065A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU2002348926A1 (en)	2003-06-10
DE60204721T2 (de)	2006-05-18
AU2002348926B2 (en)	2007-08-09
ES2243770T3 (es)	2005-12-01
ZA200403811B (en)	2005-05-18
ES2195752A1 (es)	2003-12-01
IL162065A (en)	2007-10-31
WO2003045961A1 (en)	2003-06-05
DE60204721D1 (de)	2005-07-21
EP1448576B1 (de)	2005-06-15
US20050010054A1 (en)	2005-01-13
NZ532923A (en)	2005-11-25
JP2005510566A (ja)	2005-04-21
IL162065A0 (en)	2005-11-20
CA2467884A1 (en)	2003-06-05
EP1448576A1 (de)	2004-08-25
ES2195752B1 (es)	2004-10-16

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Legal Events

Date	Code	Title	Description
2005-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties