ATE297980T1 - Verfahren zur klonierung von schweinen - Google Patents
Verfahren zur klonierung von schweinenInfo
- Publication number
- ATE297980T1 ATE297980T1 AT99958900T AT99958900T ATE297980T1 AT E297980 T1 ATE297980 T1 AT E297980T1 AT 99958900 T AT99958900 T AT 99958900T AT 99958900 T AT99958900 T AT 99958900T AT E297980 T1 ATE297980 T1 AT E297980T1
- Authority
- AT
- Austria
- Prior art keywords
- cloning
- cells
- porcine
- relates
- porcine animals
- Prior art date
Links
- 238000010367 cloning Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 241000282887 Suidae Species 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 3
- 210000002257 embryonic structure Anatomy 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8778—Swine embryos
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0608—Germ cells
- C12N5/0611—Primordial germ cells, e.g. embryonic germ cells [EG]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Cell Biology (AREA)
- Reproductive Health (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/199,138 US6258998B1 (en) | 1998-11-24 | 1998-11-24 | Method of cloning porcine animals |
| PCT/US1999/026710 WO2000031237A2 (fr) | 1998-11-24 | 1999-11-12 | Procede de clonage de porcins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE297980T1 true ATE297980T1 (de) | 2005-07-15 |
Family
ID=22736378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99958900T ATE297980T1 (de) | 1998-11-24 | 1999-11-12 | Verfahren zur klonierung von schweinen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6258998B1 (fr) |
| EP (2) | EP1131409B1 (fr) |
| JP (1) | JP2002530105A (fr) |
| AT (1) | ATE297980T1 (fr) |
| AU (1) | AU774430B2 (fr) |
| BR (1) | BR9915642A (fr) |
| CA (1) | CA2350831A1 (fr) |
| DE (1) | DE69925856T2 (fr) |
| IL (1) | IL143326A0 (fr) |
| NZ (1) | NZ530018A (fr) |
| WO (1) | WO2000031237A2 (fr) |
| ZA (1) | ZA200104230B (fr) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000022098A1 (fr) | 1998-10-12 | 2000-04-20 | Geron Bio-Med Limited | Ovocytes porcins presentant des capacites de developpement ameliorees |
| US6700037B2 (en) * | 1998-11-24 | 2004-03-02 | Infigen, Inc. | Method of cloning porcine animals |
| US20050255596A1 (en) * | 1999-09-07 | 2005-11-17 | West Michael D | Methods of repairing tandemly repeated DNA sequences and extending cell life-span nuclear transfer |
| US20040180430A1 (en) * | 1999-09-07 | 2004-09-16 | West Michael D. | Methods of restoring telomere length and extending cell lifespan using nuclear transfer |
| US7074983B2 (en) * | 1999-11-19 | 2006-07-11 | Kirin Beer Kabushiki Kaisha | Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin |
| US7414170B2 (en) * | 1999-11-19 | 2008-08-19 | Kirin Beer Kabushiki Kaisha | Transgenic bovines capable of human antibody production |
| US7820878B2 (en) * | 1999-11-19 | 2010-10-26 | Kyowa Hakko Kirin Co., Ltd. | Production of ungulates, preferably bovines that produce human immunoglobulins |
| WO2001035735A1 (fr) * | 1999-11-19 | 2001-05-25 | Hematech, Llc | Production d'ongules, de preference des bovins, qui produisent des immunoglobulines humaines |
| US20060174358A1 (en) * | 2001-01-04 | 2006-08-03 | Xiangzhong Yang | Method for cloning animals with targetted genetic alterations by transfer of long-term cultured male or female somatic cell nuclei, comprising artificially-induced genetic alterations, to enucleated recipient cells |
| US7071372B2 (en) * | 2000-01-04 | 2006-07-04 | University Of Connecticut | Method for cloning animals with targetted genetic alterations by transfer of long-term cultured male or female somatic cell nuclei, comprising artificially-induced genetic alterations, to enucleated recipient cells |
| AU2002232858B2 (en) * | 2000-12-22 | 2007-01-11 | Sab, Llc | Methods for cloning mammals using reprogrammed donor chromatin or donor cells |
| US20020142397A1 (en) * | 2000-12-22 | 2002-10-03 | Philippe Collas | Methods for altering cell fate |
| US7491534B2 (en) * | 2000-12-22 | 2009-02-17 | Kirin Holdings Kabushiki Kaisha | Methods for altering cell fate to generate T-cells specific for an antigen of interest |
| AUPR247901A0 (en) * | 2001-01-10 | 2001-02-01 | Garelag Pty Ltd | Activation of nuclear transfer embryos |
| US20050177883A1 (en) | 2001-01-30 | 2005-08-11 | Rebholtz Paul C. | Systems of transferring embryos and managing recipients |
| AU2002250020A1 (en) * | 2001-02-02 | 2002-08-19 | Erik Forsberg | Method of cloning transgenic mammalian animals using pseudonuclei |
| AU2002242854A1 (en) | 2001-03-21 | 2002-10-03 | Geron Corporation | Use of telomerase reverse transcriptase to create homozygous knockout animals |
| AUPR446701A0 (en) | 2001-04-18 | 2001-05-17 | Gene Stream Pty Ltd | Transgenic mammals for pharmacological and toxicological studies |
| US20030101469A1 (en) * | 2001-07-09 | 2003-05-29 | Kenneth Bondioli | Cloned non-human mammals from contact inhibited donor cells |
| US20030170678A1 (en) * | 2001-10-25 | 2003-09-11 | Neurogenetics, Inc. | Genetic markers for Alzheimer's disease and methods using the same |
| US20030224380A1 (en) * | 2001-10-25 | 2003-12-04 | The General Hospital Corporation | Genes and polymorphisms on chromosome 10 associated with Alzheimer's disease and other neurodegenerative diseases |
| AU2002364945A1 (en) * | 2001-10-25 | 2003-07-09 | Neurogenetics, Inc. | Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases |
| WO2003055302A1 (fr) * | 2001-12-21 | 2003-07-10 | The Curators Of The University Of Missouri | Porc knock-out et leurs procedes de fabrication |
| JP4153878B2 (ja) * | 2001-12-29 | 2008-09-24 | ソウル ナショナル ユニバーシティー インダストリー ファウンデーション | Gt遺伝子が除去された複製豚及びその生産方法 |
| JP2003225089A (ja) * | 2002-02-04 | 2003-08-12 | National Institute Of Agrobiological Sciences | ブタrag−1遺伝子およびその利用 |
| US20030161818A1 (en) * | 2002-02-25 | 2003-08-28 | Kansas State University Research Foundation | Cultures, products and methods using stem cells |
| US7736892B2 (en) | 2002-02-25 | 2010-06-15 | Kansas State University Research Foundation | Cultures, products and methods using umbilical cord matrix cells |
| US20030217378A1 (en) * | 2002-04-05 | 2003-11-20 | The University Of Georgia Research Foundation, Inc | Cloning using rapidly matured oocytes |
| US7371922B2 (en) * | 2002-07-31 | 2008-05-13 | The Board Of Trustees Of The University Of Illinois | Nuclear transfer with porcine embryonic stem cells |
| AU2003254298A1 (en) | 2002-08-02 | 2004-02-23 | Stratatech Corporation | Species specific dna detection |
| AU2003257155A1 (en) * | 2002-08-02 | 2004-02-23 | The General Hospital Corporation | Methods for the production of cells and mammals with desired genetic modifications |
| PT1534819E (pt) * | 2002-08-21 | 2010-03-11 | Revivicor Inc | Animais porcinos carecendo de qualquer expressão de alfa 1,3-galactosiltransferase funcional |
| US20040077077A1 (en) * | 2002-10-18 | 2004-04-22 | Xiangzhong Yang | Novel methods for the production of cloned mammals, mammals cloned according to the methods, and methods of use of same |
| JP2006505291A (ja) * | 2002-11-08 | 2006-02-16 | ヘマテック,エルエルシー | プリオンタンパク質活性が低減されたトランスジェニック有蹄動物及びその用途 |
| AU2004290006A1 (en) * | 2003-11-05 | 2005-05-26 | University Of Pittsburgh | Porcine isogloboside 3 synthase protein, cDNA, genomic organization, and regulatory region |
| EP1734814B1 (fr) | 2004-03-17 | 2015-01-21 | Revivicor, Inc. | Produits de tissus derives d'animaux depourvus d'expression de l'alpha 1,3 galactosyltransferase fonctionnelle |
| CA2563064A1 (fr) * | 2004-04-22 | 2005-11-10 | Kirin Beer Kabushiki Kaisha | Animaux transgeniques et leurs utilisations |
| JP2006081542A (ja) * | 2004-08-18 | 2006-03-30 | Institute Of Physical & Chemical Research | クローン哺乳動物の作成方法 |
| WO2006036975A2 (fr) * | 2004-09-28 | 2006-04-06 | Viagen, Inc. | Procedes de transfert d'embryons |
| US20060147429A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Facilitated cellular reconstitution of organs and tissues |
| US20060148080A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Methods for supporting and producing human cells and tissues in non-human mammal hosts |
| CA2909775A1 (fr) | 2005-08-09 | 2007-03-29 | Revivicor, Inc. | Ongules transgeniques exprimant la ctla4-ig et leurs utilisations |
| KR100807644B1 (ko) | 2007-03-19 | 2008-02-28 | 충남대학교산학협력단 | 체외수정 수정란 및 체세포 복제 수정란의 동시 이식에의한 돼지 생산 방법 |
| US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
| CN103492576A (zh) | 2011-02-14 | 2014-01-01 | 雷维维科公司 | 用于血管化异种移植物及其衍生物的异种移植的遗传修饰的猪 |
| US9781919B2 (en) | 2011-06-01 | 2017-10-10 | Inguran, Llc | Compositions and methods for improving the quality of processed sperm |
| US9347038B2 (en) | 2011-06-01 | 2016-05-24 | Inguran, Llc | Compositions and methods for processing sperm |
| US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
| US20160102319A1 (en) | 2013-04-30 | 2016-04-14 | Konkuk University Industrial Cooperation Corp. | Cmp-acetylneuraminic acid hydroxylase targeting vector, transgenic animal for xenotransplantation introduced with the vector, and method of manufacturing the same |
| GB201314452D0 (en) * | 2013-08-13 | 2013-09-25 | Ostara Biomedical Ltd | Embryo implantation |
| GB201501302D0 (en) | 2015-01-27 | 2015-03-11 | Ostara Biomedical Ltd | Embryo implantation |
| GB201517523D0 (en) | 2015-10-05 | 2015-11-18 | Ostara Biomedical Ltd | Methods and compositions for managing reproduction |
| IL302983A (en) | 2020-11-20 | 2023-07-01 | Revivicor Inc | Multitransgenic pigs with growth hormone receptor silencing for xenotransplantation |
| EP4404740A1 (fr) | 2021-09-20 | 2024-07-31 | Revivicor Inc. | Porcs multitransgéniques comprenant dix modifications génétiques pour la xénotransplantation |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4664097A (en) | 1984-05-09 | 1987-05-12 | The Wistar Institute Of Anatomy & Biology | Nuclear transplantation in the mammalian embryo by microsurgery and cell fusion |
| DE122007000007I1 (de) | 1986-04-09 | 2007-05-16 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US4994384A (en) | 1986-12-31 | 1991-02-19 | W. R. Grace & Co.-Conn. | Multiplying bovine embryos |
| US5346990A (en) | 1987-04-08 | 1994-09-13 | Cytogam, Inc. | Sex-associated membrane proteins and methods for increasing the probability that offspring will be of a desired sex |
| US5021244A (en) | 1988-12-06 | 1991-06-04 | Cytogam, Inc. | Sex-associated membrane antibodies and their use for increasing the probability that offspring will be of a desired sex |
| US5057420A (en) | 1987-06-05 | 1991-10-15 | Granada Biosciences, Inc. | Bovine nuclear transplantation |
| US5213979A (en) | 1987-12-30 | 1993-05-25 | W. R. Grace & Co.-Conn. | In vitro culture of bovine embryos |
| US5633076A (en) | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| US5160312A (en) | 1990-02-09 | 1992-11-03 | W. R. Grace & Co.-Conn. | Cryopreservation process for direct transfer of embryos |
| US5096822A (en) | 1990-07-26 | 1992-03-17 | W. R. Grace & Co.- Conn. | Bovine embryo medium |
| WO1992003917A1 (fr) | 1990-08-29 | 1992-03-19 | Genpharm International | Recombinaison homologue dans des cellules de mammiferes |
| US5858359A (en) | 1992-02-28 | 1999-01-12 | Bazin; Herve | Antibodies for and treatment to prevent or reduce the severity of xenograft rejection |
| WO1993022432A1 (fr) | 1992-05-01 | 1993-11-11 | Genzyme Corporation | Procedes d'identification d'embryons de preimplantation transgeniques |
| US5645986A (en) | 1992-05-13 | 1997-07-08 | Board Of Reagents, The University Of Texas System | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
| US5453357A (en) | 1992-10-08 | 1995-09-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
| US5589582A (en) | 1992-10-27 | 1996-12-31 | Biotransplant, Inc. | Polynucleotides en coding porcine cytokines |
| US5496720A (en) | 1993-02-10 | 1996-03-05 | Susko-Parrish; Joan L. | Parthenogenic oocyte activation |
| DK0804070T3 (da) | 1993-03-09 | 2000-08-07 | Genzyme Corp | Fremgangsmåde til isolering af proteiner fra mælk |
| US5523226A (en) * | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| WO1995010599A1 (fr) | 1993-10-15 | 1995-04-20 | The University Of Melbourne | Cellules analogues a des cellules souches embryonnaires |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| GB9401380D0 (en) | 1994-01-25 | 1994-03-23 | Pharmaceutical Proteins Ltd | Embryonic cell isolation |
| JPH10504442A (ja) | 1994-04-13 | 1998-05-06 | バイオトランスプラント,インコーポレイテッド | α(1,3)ガラクトシルトランスフェラーゼ陰性ブタ |
| CA2196311A1 (fr) | 1994-08-19 | 1996-02-29 | David H. Sachs | Cellules porcines traitees par genie genetique |
| GB9417831D0 (en) | 1994-09-05 | 1994-10-26 | Biotech & Biolog Scien Res | Biological manipulation |
| GB9517780D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| GB9517779D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| US6166288A (en) | 1995-09-27 | 2000-12-26 | Nextran Inc. | Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor |
| WO1997020035A1 (fr) * | 1995-11-29 | 1997-06-05 | Utah State University | Creation, maintenance et transfection de cellules souches embryonnaires totipotentes a partir d'embryons d'animaux domestiques |
| US5905042A (en) | 1996-04-01 | 1999-05-18 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Cultured inner cell mass cell lines derived from bovine or porcine embryos |
| JP2002511732A (ja) | 1996-10-11 | 2002-04-16 | ザ・テキサス・エイ・アンド・エム・ユニヴァーシティ・システム | トランスジェニック動物を発生させるための組成物および方法 |
| NZ337495A (en) * | 1997-03-06 | 2001-06-29 | Infigen Inc | Bovine primordial germ cells and their use in cloning |
| WO1999009141A1 (fr) * | 1997-08-14 | 1999-02-25 | Biotransplant, Inc. | Cellules totipotentes porcines et procede de culture a long terme |
-
1998
- 1998-11-24 US US09/199,138 patent/US6258998B1/en not_active Expired - Fee Related
-
1999
- 1999-11-12 DE DE69925856T patent/DE69925856T2/de not_active Expired - Fee Related
- 1999-11-12 JP JP2000584048A patent/JP2002530105A/ja active Pending
- 1999-11-12 BR BR9915642-3A patent/BR9915642A/pt not_active IP Right Cessation
- 1999-11-12 IL IL14332699A patent/IL143326A0/xx unknown
- 1999-11-12 EP EP99958900A patent/EP1131409B1/fr not_active Expired - Lifetime
- 1999-11-12 AU AU16175/00A patent/AU774430B2/en not_active Ceased
- 1999-11-12 EP EP05012673A patent/EP1586633A1/fr not_active Withdrawn
- 1999-11-12 AT AT99958900T patent/ATE297980T1/de not_active IP Right Cessation
- 1999-11-12 CA CA002350831A patent/CA2350831A1/fr not_active Abandoned
- 1999-11-12 NZ NZ530018A patent/NZ530018A/en unknown
- 1999-11-12 WO PCT/US1999/026710 patent/WO2000031237A2/fr not_active Ceased
-
2001
- 2001-05-23 ZA ZA200104230A patent/ZA200104230B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000031237A3 (fr) | 2000-11-16 |
| IL143326A0 (en) | 2002-04-21 |
| CA2350831A1 (fr) | 2000-06-02 |
| AU774430B2 (en) | 2004-06-24 |
| ZA200104230B (en) | 2002-08-23 |
| EP1131409B1 (fr) | 2005-06-15 |
| EP1131409A2 (fr) | 2001-09-12 |
| DE69925856D1 (de) | 2005-07-21 |
| WO2000031237A2 (fr) | 2000-06-02 |
| EP1586633A1 (fr) | 2005-10-19 |
| AU1617500A (en) | 2000-06-13 |
| DE69925856T2 (de) | 2006-05-11 |
| BR9915642A (pt) | 2001-08-07 |
| NZ530018A (en) | 2005-08-26 |
| JP2002530105A (ja) | 2002-09-17 |
| US6258998B1 (en) | 2001-07-10 |
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