ATE298571T1 - Flüssige pharmazeutische formulierungen mit verbesserter oraler veträglichkeit - Google Patents

Flüssige pharmazeutische formulierungen mit verbesserter oraler veträglichkeit

Info

Publication number
ATE298571T1
ATE298571T1 AT01987156T AT01987156T ATE298571T1 AT E298571 T1 ATE298571 T1 AT E298571T1 AT 01987156 T AT01987156 T AT 01987156T AT 01987156 T AT01987156 T AT 01987156T AT E298571 T1 ATE298571 T1 AT E298571T1
Authority
AT
Austria
Prior art keywords
pharmaceutical formulations
liquid pharmaceutical
improved oral
oral tolerability
tolerability
Prior art date
Application number
AT01987156T
Other languages
English (en)
Inventor
Kuo-Chung Mark Lee
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Application granted granted Critical
Publication of ATE298571T1 publication Critical patent/ATE298571T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01987156T 2000-12-04 2001-11-30 Flüssige pharmazeutische formulierungen mit verbesserter oraler veträglichkeit ATE298571T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/729,406 US6391886B1 (en) 2000-12-04 2000-12-04 Oral compositions having improved consumer aesthetics
PCT/US2001/045035 WO2002045714A1 (en) 2000-12-04 2001-11-30 Drug formulation having improved oral tolerability

Publications (1)

Publication Number Publication Date
ATE298571T1 true ATE298571T1 (de) 2005-07-15

Family

ID=24930887

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01987156T ATE298571T1 (de) 2000-12-04 2001-11-30 Flüssige pharmazeutische formulierungen mit verbesserter oraler veträglichkeit

Country Status (11)

Country Link
US (1) US6391886B1 (de)
EP (1) EP1339408B1 (de)
JP (1) JP2004515478A (de)
CN (1) CN100577166C (de)
AR (1) AR031450A1 (de)
AT (1) ATE298571T1 (de)
AU (1) AU2002239397A1 (de)
DE (1) DE60111769T2 (de)
MX (1) MXPA03004941A (de)
PE (1) PE20020694A1 (de)
WO (1) WO2002045714A1 (de)

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US20030060422A1 (en) 2001-08-31 2003-03-27 Balaji Venkataraman Tannate compositions and methods of treatment
DE10208313A1 (de) * 2002-02-27 2003-09-11 Boehringer Ingelheim Pharma Ambroxol für die Behandlung von schmerzhaften Zuständen im Mund und Rachenraum
US20040028622A1 (en) * 2002-08-12 2004-02-12 Michael Gurin Multifunctional flavor systems and method of use
RU2005119299A (ru) * 2002-11-22 2005-11-20 Фирмениш Са (Ch) Составы для ухода за полостью рта, маскирующие соленый вкус солей
US20040142084A1 (en) * 2003-01-21 2004-07-22 Knueven Carl J. Alkali metal bisulfates to mask aftertaste of artificial sweeteners
US20040185093A1 (en) * 2003-03-18 2004-09-23 Szymczak Christopher E. Compositions containing sucralose
EP1466949A1 (de) * 2003-04-10 2004-10-13 Symrise GmbH & Co. KG Nichttoxische Beschichtungszusammensetzung, Verwendungsverfahren und gegen die Anlagerung von Biofouling-Organismen behandelte Gegenstände
US7361376B2 (en) * 2003-04-11 2008-04-22 International Flavors & Fragrances Inc. Alkyldienamides exhibiting taste and sensory effect in flavor compositions
US7632531B2 (en) * 2003-04-11 2009-12-15 International Flavors & Fragnances Inc. Alkyldienamides exhibiting taste and sensory effect in flavor compositions
US6884906B2 (en) * 2003-07-01 2005-04-26 International Flavors & Fragrances Inc. Menthyl half acid ester derivatives, processes for preparing same, and uses thereof for their cooling/refreshing effect in consumable materials
US7141686B2 (en) * 2003-07-10 2006-11-28 International Flavors & Fragrances Inc. E2, E4, Z8-undecatrienoic acid and ester and carboxamide derivatives thereof, organoleptic uses thereof and processes for preparing same
US7329767B2 (en) * 2003-10-03 2008-02-12 International Flavors & Fragrances Inc. Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof
US8007839B2 (en) * 2003-10-03 2011-08-30 International Flavors & Fragrances Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof
US7482378B2 (en) * 2004-05-28 2009-01-27 Millenium Specialty Chemicals, Inc. Physiological cooling compositions
US20060034784A1 (en) * 2004-08-12 2006-02-16 The Procter & Gamble Company Oral compositions and systems
EP1669056A3 (de) * 2004-08-12 2007-05-30 The Procter and Gamble Company Mundpflegemittel und System
US7541055B2 (en) * 2004-09-10 2009-06-02 International Flavors & Fragrances Inc. Saturated and unsaturated N-alkamides exhibiting taste and flavor enhancement effect in flavor compositions
US7427421B2 (en) * 2004-09-10 2008-09-23 International Flavors & Fragrances Inc. Saturated and unsaturated N-alkamides exhibiting taste and flavor enhancement effect in flavor compositions
US20060062811A1 (en) 2004-09-21 2006-03-23 Szymczak Christopher E Medicinal cooling emulsions
JP5128483B2 (ja) * 2005-10-24 2013-01-23 テイコク ファーマ ユーエスエー インコーポレーテッド Ｎ，２，３−トリメチル−２−イソプロピルブタナミドの局所用疼痛緩和組成物並びにその使用法
EP2001448A2 (de) * 2006-01-27 2008-12-17 Cadbury Adams USA LLC Geschmacksverstärkende zusammensetzungen sowie herstellungsverfahren und verwendungsverfahren
US7803353B2 (en) * 2006-03-29 2010-09-28 The Procter & Gamble Company Oral care compositions having improved consumer aesthetics and taste
EP1958627A3 (de) * 2007-01-04 2010-09-01 Symrise GmbH & Co. KG Verwendung bestimmter Menthyl-3-oxocarbonsäureester als physiologisch wirksame Kühlsubstanzen
JP2009007311A (ja) * 2007-06-29 2009-01-15 Lintec Corp ジフェンヒドラミン−アセスルファム付加物、その製造方法及び該付加物を含有する経口製剤
EP2560626A4 (de) * 2010-04-21 2013-09-18 Teikoku Pharma Usa Inc Emulsionszusammensetzungen für lokalanästhesie sowie verfahren zu ihrer herstellung und verwendung
KR101297354B1 (ko) * 2011-01-13 2013-08-19 동광제약주식회사 안정하고 불쾌한 맛이 차폐된 덱시부프로펜을 함유한 투명한 시럽 조성물
AU2012236355A1 (en) * 2011-03-31 2013-10-17 Mcneil-Ppc, Inc. Menthol liquids composition
HRP20220112T1 (hr) 2013-12-24 2022-04-15 Virginia Commonwealth University Upotreba oksidacijskog sulfata kolesterola (ocs) za liječenje akutne insuficijencije jetre
US9867779B2 (en) 2015-03-26 2018-01-16 Patheon Softgels Inc. Liquisoft capsules
JP6794758B2 (ja) * 2015-10-21 2020-12-02 大正製薬株式会社 経口液体医薬組成物
GB2551971B (en) * 2016-06-29 2020-09-16 Syri Ltd Taste masked liquid pharmaceutical composition of mebeverine or pharmaceutically acceptable salts thereof
US20180055938A1 (en) * 2016-09-01 2018-03-01 The Procter & Gamble Company Medication With Improved Taste And Sensory Experience
US12427120B2 (en) * 2018-10-09 2025-09-30 Symrise Ag Compositions comprising guaifenesin and flavour compounds containing an isovanillyl group
US12053447B2 (en) 2019-06-25 2024-08-06 NuBioPharma, LLC Oral solution and powder to liquid compositions of balsalazide
CN112439072A (zh) * 2019-08-29 2021-03-05 鲁南制药集团股份有限公司 一种掩味组合物及其制备方法、用途
CN112439077A (zh) * 2019-08-29 2021-03-05 鲁南制药集团股份有限公司 一种矫味剂组合物、制备方法及其用途
EP4132476A1 (de) 2020-04-10 2023-02-15 The Procter & Gamble Company Rheologische feste orale zusammensetzung
CN111714477B (zh) * 2020-07-23 2021-06-15 山东迅达康兽药有限公司 祛痰组合物及其口服液制备方法

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CA1027347A (en) 1972-07-20 1978-03-07 David G. Rowsell Compounds having a physiological cooling effect and compositions containing them
JPS5888334A (ja) 1981-11-20 1983-05-26 Takasago Corp ３−ｌ−メントキシプロパン−１、２−ジオ−ル
US4822597A (en) 1987-07-13 1989-04-18 Warner-Lambert Company Anesthetic-containing chewing gum compositions
US4853212A (en) 1987-07-13 1989-08-01 Warner-Lambert Company Reduced base content chewing gum compositions having anesthetic properties
US5009893A (en) * 1989-07-17 1991-04-23 Warner-Lambert Company Breath-freshening edible compositions of methol and a carboxamide
US5196436A (en) * 1990-10-31 1993-03-23 The Procter & Gamble Company Dextromethorphan antitussive compositions
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JPH09504293A (ja) * 1993-10-28 1997-04-28 ザ、プロクター、エンド、ギャンブル、カンパニー マグネシウムアルミニウムシリケート及び複数の活性成分を含有した速溶解性剤形
US5616621A (en) 1995-01-30 1997-04-01 American Home Products Corporation Taste masking liquids
US5725865A (en) 1995-08-29 1998-03-10 V. Mane Fils S.A. Coolant compositions
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Also Published As

Publication number Publication date
CN100577166C (zh) 2010-01-06
DE60111769D1 (de) 2005-08-04
DE60111769T2 (de) 2006-04-20
AU2002239397A1 (en) 2002-06-18
US6391886B1 (en) 2002-05-21
MXPA03004941A (es) 2003-09-10
AR031450A1 (es) 2003-09-24
WO2002045714A1 (en) 2002-06-13
JP2004515478A (ja) 2004-05-27
PE20020694A1 (es) 2002-09-25
EP1339408B1 (de) 2005-06-29
EP1339408A1 (de) 2003-09-03
CN1575175A (zh) 2005-02-02

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Legal Events

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