ATE298631T1 - Analytisches system und verfahren - Google Patents

Analytisches system und verfahren

Info

Publication number
ATE298631T1
ATE298631T1 AT97935142T AT97935142T ATE298631T1 AT E298631 T1 ATE298631 T1 AT E298631T1 AT 97935142 T AT97935142 T AT 97935142T AT 97935142 T AT97935142 T AT 97935142T AT E298631 T1 ATE298631 T1 AT E298631T1
Authority
AT
Austria
Prior art keywords
methods
analytical system
substrate
reservoirs
fluids
Prior art date
Application number
AT97935142T
Other languages
English (en)
Inventor
Calvin Y H Chow
Original Assignee
Caliper Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24777319&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE298631(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Caliper Life Sciences Inc filed Critical Caliper Life Sciences Inc
Application granted granted Critical
Publication of ATE298631T1 publication Critical patent/ATE298631T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00326—Analysers with modular structure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
AT97935142T 1996-08-02 1997-07-31 Analytisches system und verfahren ATE298631T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/691,632 US6399023B1 (en) 1996-04-16 1996-08-02 Analytical system and method
PCT/US1997/013178 WO1998005424A1 (en) 1996-08-02 1997-07-31 Analytical system and method

Publications (1)

Publication Number Publication Date
ATE298631T1 true ATE298631T1 (de) 2005-07-15

Family

ID=24777319

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97935142T ATE298631T1 (de) 1996-08-02 1997-07-31 Analytisches system und verfahren

Country Status (11)

Country Link
US (6) US6399023B1 (de)
EP (2) EP0952890B1 (de)
JP (1) JP3686932B2 (de)
CN (1) CN1096297C (de)
AT (1) ATE298631T1 (de)
AU (1) AU717981B2 (de)
CA (1) CA2259929C (de)
DE (1) DE69733663T2 (de)
TW (1) TW350914B (de)
WO (1) WO1998005424A1 (de)
ZA (1) ZA976887B (de)

Families Citing this family (431)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US6399023B1 (en) 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
CN1173776C (zh) 1996-06-28 2004-11-03 卡钳技术有限公司 在微规模流体性设备里的高通过量的筛选分析系统
US6149869A (en) * 1996-10-23 2000-11-21 Glaxo Wellcome Inc. Chemical synthesizers
US6042789A (en) * 1996-10-23 2000-03-28 Glaxo Group Limited System for parallel synthesis of organic compounds
US6083761A (en) * 1996-12-02 2000-07-04 Glaxo Wellcome Inc. Method and apparatus for transferring and combining reagents
GB9705667D0 (en) * 1997-03-19 1997-05-07 Jackson James R Diagnostic and analytical devices
CA2284612A1 (en) 1997-04-04 1998-10-15 Michael Knapp Closed-loop biochemical analyzers
US6391622B1 (en) 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
US6235471B1 (en) 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
US7033474B1 (en) 1997-04-25 2006-04-25 Caliper Life Sciences, Inc. Microfluidic devices incorporating improved channel geometries
AU727083B2 (en) * 1997-04-25 2000-11-30 Caliper Life Sciences, Inc. Microfluidic devices incorporating improved channel geometries
US6524790B1 (en) * 1997-06-09 2003-02-25 Caliper Technologies Corp. Apparatus and methods for correcting for variable velocity in microfluidic systems
US6425972B1 (en) 1997-06-18 2002-07-30 Calipher Technologies Corp. Methods of manufacturing microfabricated substrates
US6001231A (en) 1997-07-15 1999-12-14 Caliper Technologies Corp. Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems
US5876675A (en) * 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US5989402A (en) * 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
US6818110B1 (en) * 1997-09-30 2004-11-16 Symyx Technologies, Inc. Combinatorial electrochemical deposition and testing system
US6083682A (en) 1997-12-19 2000-07-04 Glaxo Group Limited System and method for solid-phase parallel synthesis of a combinatorial collection of compounds
US7407811B2 (en) 1997-12-22 2008-08-05 Roche Diagnostics Operations, Inc. System and method for analyte measurement using AC excitation
US7494816B2 (en) 1997-12-22 2009-02-24 Roche Diagnostic Operations, Inc. System and method for determining a temperature during analyte measurement
US7390667B2 (en) 1997-12-22 2008-06-24 Roche Diagnostics Operations, Inc. System and method for analyte measurement using AC phase angle measurements
US6893877B2 (en) * 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
US6756019B1 (en) 1998-02-24 2004-06-29 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US7497994B2 (en) 1998-02-24 2009-03-03 Khushroo Gandhi Microfluidic devices and systems incorporating cover layers
US6251343B1 (en) 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6444474B1 (en) * 1998-04-22 2002-09-03 Eltron Research, Inc. Microfluidic system for measurement of total organic carbon
US6123798A (en) * 1998-05-06 2000-09-26 Caliper Technologies Corp. Methods of fabricating polymeric structures incorporating microscale fluidic elements
CA2332919A1 (en) * 1998-06-08 1999-12-16 Caliper Technologies Corporation Microfluidic devices, systems and methods for performing integrated reactions and separations
US6306590B1 (en) 1998-06-08 2001-10-23 Caliper Technologies Corp. Microfluidic matrix localization apparatus and methods
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US7155344B1 (en) 1998-07-27 2006-12-26 Caliper Life Sciences, Inc. Distributed database for analytical instruments
US20020049694A1 (en) 1998-07-27 2002-04-25 J. Wallace Parce Distributed database for analytical instruments
US6540896B1 (en) 1998-08-05 2003-04-01 Caliper Technologies Corp. Open-Field serial to parallel converter
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6716394B2 (en) 1998-08-11 2004-04-06 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
US6447724B1 (en) 1998-08-11 2002-09-10 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
US6326612B1 (en) * 1998-10-13 2001-12-04 Texas Instruments Incorporated System and method for optical sensing utilizing a portable, detachable sensor cartridge
US6149787A (en) 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6498497B1 (en) * 1998-10-14 2002-12-24 Caliper Technologies Corp. Microfluidic controller and detector system with self-calibration
DE19854096A1 (de) * 1998-11-24 2000-05-25 Merck Patent Gmbh Anschlußträger für plattenförmige Mikrokomponenten
US6773671B1 (en) 1998-11-30 2004-08-10 Abbott Laboratories Multichemistry measuring device and test strips
BR9915637A (pt) * 1998-11-30 2001-11-06 Abbott Lab Dispositivo de medição de múltiplos produtos quìmicos e tiras de teste
EP1155435A4 (de) * 1999-01-08 2004-08-11 Univ Northeastern Elektropneumatischer verteiler für zeitmultiplexte analytischemicrosystemen
US6416642B1 (en) 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
CN1296703C (zh) * 1999-02-02 2007-01-24 卡钳生命科学股份有限公司 鉴定蛋白质的方法、装置和系统
ATE508200T1 (de) 1999-02-23 2011-05-15 Caliper Life Sciences Inc Sequenzierung durch inkorporation
US6239445B1 (en) * 1999-03-01 2001-05-29 Bayer Corporation Optical inspection apparatus with removable inserts
US6749814B1 (en) 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
US6171850B1 (en) 1999-03-08 2001-01-09 Caliper Technologies Corp. Integrated devices and systems for performing temperature controlled reactions and analyses
US6326083B1 (en) 1999-03-08 2001-12-04 Calipher Technologies Corp. Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety
US6306578B1 (en) * 1999-03-19 2001-10-23 Genencor International, Inc. Multi-through hole testing plate for high throughput screening
US6500323B1 (en) 1999-03-26 2002-12-31 Caliper Technologies Corp. Methods and software for designing microfluidic devices
US6303343B1 (en) 1999-04-06 2001-10-16 Caliper Technologies Corp. Inefficient fast PCR
US6322683B1 (en) * 1999-04-14 2001-11-27 Caliper Technologies Corp. Alignment of multicomponent microfabricated structures
US6605475B1 (en) * 1999-04-16 2003-08-12 Perspective Biosystems, Inc. Apparatus and method for sample delivery
DE19917433C2 (de) * 1999-04-19 2003-05-22 Fraunhofer Ges Forschung Mikroreaktorsystem zum Erzeugen und Testen von Substanzen und Wirkstoffen
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
WO2002043864A2 (en) * 2000-11-03 2002-06-06 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US20020177135A1 (en) 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6458259B1 (en) 1999-05-11 2002-10-01 Caliper Technologies Corp. Prevention of surface adsorption in microchannels by application of electric current during pressure-induced flow
WO2000070080A1 (en) 1999-05-17 2000-11-23 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
US6592821B1 (en) 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
AU5291600A (en) 1999-06-01 2000-12-18 Caliper Technologies Corporation Microscale assays and microfluidic devices for transporter, gradient induced, and binding activities
AU5405100A (en) * 1999-06-16 2001-01-02 Gesellschaft Zur Forderung Der Spektrochemie Und Angewandten Spektroskopie E.V. Device for preparing samples
DE19927534B4 (de) * 1999-06-16 2008-01-31 Merck Patent Gmbh Vorrichtung zur Probenaufgabe
EP1360992A3 (de) * 1999-06-22 2004-05-19 Caliper Life Sciences, Inc. Apparat zur Bedienung eines mikrofluidischen Gerätes
WO2000078454A1 (en) * 1999-06-22 2000-12-28 Agilent Technologies, Inc. Apparatus for the operation of a microfluidic device
DE19928412C2 (de) * 1999-06-22 2002-03-21 Agilent Technologies Inc Versorgungselement für einen Labor-Mikrochip
US7396444B2 (en) * 1999-06-22 2008-07-08 Agilent Technologies Inc. Device to operate a laboratory microchip
DE19964399B4 (de) * 1999-06-22 2005-06-16 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Einrichtung zum Betrieb eines Labor-Mikrochips mit einem mittels eines Bajonettverschlusses befestigbaren Schnittstellenelement
US6811668B1 (en) 1999-06-22 2004-11-02 Caliper Life Sciences, Inc. Apparatus for the operation of a microfluidic device
DE19964315B4 (de) * 1999-06-22 2005-01-13 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Analyseneinheit mit einem Schnittstellenelement und einem Labor-Mikrochip
DE19928410C2 (de) * 1999-06-22 2002-11-28 Agilent Technologies Inc Gerätegehäuse mit einer Einrichtung zum Betrieb eines Labor-Mikrochips
US7052545B2 (en) * 2001-04-06 2006-05-30 California Institute Of Technology High throughput screening of crystallization of materials
US8709153B2 (en) 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
US7195670B2 (en) * 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
WO2001002850A1 (en) 1999-07-06 2001-01-11 Caliper Technologies Corp. Microfluidic systems and methods for determining modulator kinetics
DE19933458B4 (de) * 1999-07-15 2015-08-20 Eppendorf Ag Einrichtungen und Systeme zum Handhaben von Flüssigkeitsproben
US6692697B1 (en) 1999-07-30 2004-02-17 Texas Instruments Incorporated Versatile flow cell front-end for optically-based integrated sensors
EP1072881A3 (de) * 1999-07-30 2002-04-24 Texas Instruments Incorporated Ein integrierter optischer Sensor
US6495104B1 (en) * 1999-08-19 2002-12-17 Caliper Technologies Corp. Indicator components for microfluidic systems
US6858185B1 (en) 1999-08-25 2005-02-22 Caliper Life Sciences, Inc. Dilutions in high throughput systems with a single vacuum source
US6613581B1 (en) 1999-08-26 2003-09-02 Caliper Technologies Corp. Microfluidic analytic detection assays, devices, and integrated systems
AU7101000A (en) 1999-09-10 2001-04-10 Caliper Technologies Corporation Microfabrication methods and devices
US6767440B1 (en) * 2001-04-24 2004-07-27 Roche Diagnostics Corporation Biosensor
WO2001027253A1 (en) 1999-10-08 2001-04-19 Caliper Technologies Corp. Use of nernstein voltage sensitive dyes in measuring transmembrane voltage
US6361958B1 (en) 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US6386014B1 (en) 1999-11-18 2002-05-14 Eagle Research Corporation Energy measurement device for flowing gas using microminiature gas chromatograph
US6271038B1 (en) 1999-12-15 2001-08-07 Glaxo Wellcome Inc. Methods for high throughout determination and ranking of formulations and solubility
ATE340025T1 (de) * 2000-01-06 2006-10-15 Caliper Life Sciences Inc Vorrichtungen und verfahren für hochdurchsatz- probenentnahme und analyse
US6468761B2 (en) 2000-01-07 2002-10-22 Caliper Technologies, Corp. Microfluidic in-line labeling method for continuous-flow protease inhibition analysis
JP2004530860A (ja) * 2000-01-11 2004-10-07 クリニカル・マイクロ・センサーズ・インコーポレイテッド バイオチップ多重化デバイスおよび方法
US7037416B2 (en) 2000-01-14 2006-05-02 Caliper Life Sciences, Inc. Method for monitoring flow rate using fluorescent markers
US6556923B2 (en) * 2000-01-26 2003-04-29 Caliper Technologies Corp. Software for high throughput microfluidic systems
EP1125959A1 (de) 2000-02-17 2001-08-22 Mitsui Chemicals, Inc. Mikrozelluläres Polyurethanelastomer und Verfahren zu dessen Herstellung
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
WO2001062887A1 (en) * 2000-02-23 2001-08-30 Zyomyx, Inc. Chips having elevated sample surfaces
US7041206B2 (en) * 2000-03-09 2006-05-09 Clinical Analysis Corporation Medical diagnostic system
US7141152B2 (en) * 2000-03-16 2006-11-28 Le Febre David A Analyte species separation system
US6749735B1 (en) 2000-03-16 2004-06-15 David Le Febre Electromobility focusing controlled channel electrophoresis system
US20020012971A1 (en) 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
US6358387B1 (en) * 2000-03-27 2002-03-19 Caliper Technologies Corporation Ultra high throughput microfluidic analytical systems and methods
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US6733645B1 (en) 2000-04-18 2004-05-11 Caliper Technologies Corp. Total analyte quantitation
WO2001086249A2 (en) 2000-05-11 2001-11-15 Caliper Technologies Corp. Microfluidic devices and methods to regulate hydrodynamic and electrical resistance utilizing bulk viscosity enhancers
AU6152301A (en) 2000-05-12 2001-11-26 Caliper Techn Corp Detection of nucleic acid hybridization by fluorescence polarization
US8329118B2 (en) * 2004-09-02 2012-12-11 Honeywell International Inc. Method and apparatus for determining one or more operating parameters for a microfluidic circuit
EP1161985B1 (de) * 2000-06-05 2005-10-26 STMicroelectronics S.r.l. Verfahren zur Herstellung integrierter chemischer Mikroreaktoren aus Halbleitermaterial sowie integrierter Mikroreaktor
US6602400B1 (en) 2000-06-15 2003-08-05 Motorola, Inc. Method for enhanced bio-conjugation events
US6632400B1 (en) * 2000-06-22 2003-10-14 Agilent Technologies, Inc. Integrated microfluidic and electronic components
US6627159B1 (en) * 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
WO2002010732A1 (en) * 2000-08-02 2002-02-07 Caliper Technologies Corp. High throughput separations based analysis systems
US20070119711A1 (en) * 2000-08-02 2007-05-31 Caliper Life Sciences, Inc. High throughput separations based analysis systems and methods
AU2001284700B2 (en) * 2000-08-03 2005-12-08 Caliper Life Sciences, Inc. Methods and devices for high throughput fluid delivery
US20020142618A1 (en) * 2000-08-04 2002-10-03 Caliper Technologies Corp. Control of operation conditions within fluidic systems
US6581020B1 (en) * 2000-10-10 2003-06-17 Velquest Corporation Process-linked data management system
WO2002037091A1 (en) 2000-10-31 2002-05-10 Caliper Technologies Corp. Microfluidic methods, devices and systems for in situ material concentration
US20050011761A1 (en) * 2000-10-31 2005-01-20 Caliper Technologies Corp. Microfluidic methods, devices and systems for in situ material concentration
US20030057092A1 (en) * 2000-10-31 2003-03-27 Caliper Technologies Corp. Microfluidic methods, devices and systems for in situ material concentration
US20090118139A1 (en) 2000-11-07 2009-05-07 Caliper Life Sciences, Inc. Microfluidic method and system for enzyme inhibition activity screening
US8097471B2 (en) 2000-11-10 2012-01-17 3M Innovative Properties Company Sample processing devices
US8900811B2 (en) 2000-11-16 2014-12-02 Caliper Life Sciences, Inc. Method and apparatus for generating thermal melting curves in a microfluidic device
US6878755B2 (en) * 2001-01-22 2005-04-12 Microgen Systems, Inc. Automated microfabrication-based biodetector
EP1355823A4 (de) 2001-01-29 2005-04-20 Caliper Life Sciences Inc Nichtmechanische ventile für strömungssysteme
US6613284B2 (en) * 2001-02-01 2003-09-02 V&P Scientific, Inc. Microarrayer
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7670559B2 (en) 2001-02-15 2010-03-02 Caliper Life Sciences, Inc. Microfluidic systems with enhanced detection systems
EP1360472B1 (de) * 2001-02-15 2009-12-02 Caliper Life Sciences, Inc. Mikrofluidische systeme mit verbesserten detektionssystemen
US6720148B1 (en) 2001-02-22 2004-04-13 Caliper Life Sciences, Inc. Methods and systems for identifying nucleotides by primer extension
US7867776B2 (en) * 2001-03-02 2011-01-11 Caliper Life Sciences, Inc. Priming module for microfluidic chips
US20060108218A1 (en) * 2001-03-05 2006-05-25 Clinical Analysis Corporation Test cell for use with medical diagnostic instrument
WO2002072264A1 (en) * 2001-03-09 2002-09-19 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
US7150999B1 (en) 2001-03-09 2006-12-19 Califer Life Sciences, Inc. Process for filling microfluidic channels
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US6575188B2 (en) 2001-07-26 2003-06-10 Handylab, Inc. Methods and systems for fluid control in microfluidic devices
US6852287B2 (en) * 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7192557B2 (en) 2001-03-28 2007-03-20 Handylab, Inc. Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7270786B2 (en) 2001-03-28 2007-09-18 Handylab, Inc. Methods and systems for processing microfluidic samples of particle containing fluids
US6727479B2 (en) * 2001-04-23 2004-04-27 Stmicroelectronics S.R.L. Integrated device based upon semiconductor technology, in particular chemical microreactor
US7723123B1 (en) 2001-06-05 2010-05-25 Caliper Life Sciences, Inc. Western blot by incorporating an affinity purification zone
US7294478B1 (en) * 2001-06-06 2007-11-13 Rosetta Inpharmatics Llc Microarray reaction cartridge
US20020187564A1 (en) * 2001-06-08 2002-12-12 Caliper Technologies Corp. Microfluidic library analysis
US6977163B1 (en) 2001-06-13 2005-12-20 Caliper Life Sciences, Inc. Methods and systems for performing multiple reactions by interfacial mixing
US6381516B1 (en) * 2001-06-16 2002-04-30 Data I/O Corporation Modular off-line micro device processing system
US20030077570A1 (en) * 2001-09-20 2003-04-24 Coventor, Inc. Small molecule substrate based enzyme activity assays
WO2003006133A2 (en) * 2001-07-13 2003-01-23 Caliper Technologies Corp. Microfluidic devices and systems for separating components of a mixture
US6825127B2 (en) 2001-07-24 2004-11-30 Zarlink Semiconductor Inc. Micro-fluidic devices
US7060171B1 (en) * 2001-07-31 2006-06-13 Caliper Life Sciences, Inc. Methods and systems for reducing background signal in assays
WO2003015890A1 (en) * 2001-08-20 2003-02-27 President And Fellows Of Harvard College Fluidic arrays and method of using
US20030062833A1 (en) * 2001-10-03 2003-04-03 Wen-Yen Tai Mini-type decorative bulb capable of emitting light through entire circumferential face
CA2463420A1 (en) * 2001-10-24 2003-05-01 Singulex, Inc. Methods for detecting genetic haplotypes by interaction with probes
US7247274B1 (en) 2001-11-13 2007-07-24 Caliper Technologies Corp. Prevention of precipitate blockage in microfluidic channels
US20030116552A1 (en) * 2001-12-20 2003-06-26 Stmicroelectronics Inc. Heating element for microfluidic and micromechanical applications
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US7524459B2 (en) * 2002-01-24 2009-04-28 California Institute Of Technology In Pasadena Optoelectronic and microfluidic integration for miniaturized spectroscopic devices
DE10203211A1 (de) * 2002-01-28 2003-08-14 Siemens Ag Mikrofluidikprobenmodul mit Mitteln zur Temperaturbeeinflussung
US7459127B2 (en) * 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
EP2497564B1 (de) 2002-03-05 2014-05-14 Caliper Life Sciences, Inc. Elektrophoretische Trennung in einem mikrofluidischen Kanalnetzwerk
US7303727B1 (en) 2002-03-06 2007-12-04 Caliper Life Sciences, Inc Microfluidic sample delivery devices, systems, and methods
US7252928B1 (en) 2002-03-12 2007-08-07 Caliper Life Sciences, Inc. Methods for prevention of surface adsorption of biological materials to capillary walls in microchannels
WO2003082730A1 (en) * 2002-03-31 2003-10-09 Gyros Ab Efficient mmicrofluidic devices
US7419784B2 (en) * 2002-04-02 2008-09-02 Dubrow Robert S Methods, systems and apparatus for separation and isolation of one or more sample components of a sample biological material
US20030203504A1 (en) * 2002-04-26 2003-10-30 John Hefti Diffusion-based system and method for detecting and monitoring activity of biologic and chemical species
US7161356B1 (en) 2002-06-05 2007-01-09 Caliper Life Sciences, Inc. Voltage/current testing equipment for microfluidic devices
EP1385006A3 (de) * 2002-07-24 2004-09-01 F. Hoffmann-La Roche Ag System und Patrone zur Verarbeitung einer biologischen Probe
US7803322B2 (en) * 2002-08-14 2010-09-28 Detekt Biomedical, L.L.C. Universal optical imaging and processing system
US7267799B1 (en) 2002-08-14 2007-09-11 Detekt Biomedical, L.L.C. Universal optical imaging and processing system
US8277753B2 (en) * 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
EP1569510B1 (de) 2002-09-27 2011-11-02 The General Hospital Corporation Mikrofluidische vorrichtung zur zelltrennung und verwendungen davon
AU2003293399A1 (en) * 2002-12-04 2004-06-23 Spinx, Inc. Devices and methods for programmable microscale manipulation of fluids
US7094354B2 (en) 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
US7507376B2 (en) * 2002-12-19 2009-03-24 3M Innovative Properties Company Integrated sample processing devices
US7125711B2 (en) * 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
EP1608952B1 (de) 2002-12-20 2016-08-10 Life Technologies Corporation Assay vorrichtung und verfahren unter verwendung von mikrofluiden matrixstrukturen
US20060094108A1 (en) * 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
US20040175821A1 (en) * 2003-03-07 2004-09-09 Ehman Michael F. Integrated photodetector for heavy metals and biological activity analysis
EP1473084B1 (de) * 2003-03-31 2015-07-29 Canon Kabushiki Kaisha Behälter für biochemische Reaktionen
EP1473085B1 (de) * 2003-03-31 2015-07-22 Canon Kabushiki Kaisha Behälter für biochemische Reaktionen
GB0307999D0 (en) * 2003-04-07 2003-05-14 Glaxo Group Ltd A system
US20040265184A1 (en) * 2003-04-18 2004-12-30 Kyocera Corporation Microchemical chip and method for producing the same
DE10320957A1 (de) * 2003-05-09 2004-12-09 Evotec Technologies Gmbh Andockeinrichtung für ein fluidisches Mikrossystem
US7011793B2 (en) * 2003-05-15 2006-03-14 Kionix, Inc. Reconfigurable modular microfluidic system and method of fabrication
US7435381B2 (en) * 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
US7118713B2 (en) * 2003-06-03 2006-10-10 Bayer Healthcare Llc Tray assembly for optical inspection apparatus
US20040248306A1 (en) * 2003-06-09 2004-12-09 Hernandez Juan J. Microfluidic water analytical device
US7488601B2 (en) 2003-06-20 2009-02-10 Roche Diagnostic Operations, Inc. System and method for determining an abused sensor during analyte measurement
US7452457B2 (en) 2003-06-20 2008-11-18 Roche Diagnostics Operations, Inc. System and method for analyte measurement using dose sufficiency electrodes
US7604721B2 (en) 2003-06-20 2009-10-20 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US7597793B2 (en) 2003-06-20 2009-10-06 Roche Operations Ltd. System and method for analyte measurement employing maximum dosing time delay
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
US20040265172A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method and apparatus for entry and storage of specimens into a microfluidic device
US20080257754A1 (en) * 2003-06-27 2008-10-23 Pugia Michael J Method and apparatus for entry of specimens into a microfluidic device
JP2005030847A (ja) * 2003-07-10 2005-02-03 Sysmex Corp 電子機器および分析システム
JP4228808B2 (ja) * 2003-07-23 2009-02-25 株式会社日立製作所 マイクロ分光計測装置及びマイクロ化学システム
US20090088982A1 (en) * 2003-07-31 2009-04-02 Fukushima Noelle H Co-detection of single polypeptide and polynucleotide molecules
EP1654066B1 (de) 2003-07-31 2014-11-12 Handylab, Inc. Verarbeitung von teilchenhaltigen proben
US20050037508A1 (en) * 2003-08-12 2005-02-17 Juan Hernandez Microfluidic titration apparatus
US7347617B2 (en) 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
CA2479452C (en) * 2003-08-30 2008-11-04 F.Hoffmann-La Roche Ag Method and device for determining analytes in a liquid
US7431883B2 (en) * 2003-09-30 2008-10-07 Beckman Coulter, Inc. Clinical analysis system
US20080021674A1 (en) * 2003-09-30 2008-01-24 Robert Puskas Methods for Enhancing the Analysis of Particle Detection
US7718133B2 (en) * 2003-10-09 2010-05-18 3M Innovative Properties Company Multilayer processing devices and methods
AU2004313572B2 (en) * 2003-12-23 2008-07-03 Caliper Life Sciences, Inc. Analyte injection system
CA2554240A1 (en) * 2004-01-25 2005-08-11 Fluidigm Corporation Crystal forming devices and systems and methods for making and using the same
US8030057B2 (en) * 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
JP4698613B2 (ja) 2004-01-26 2011-06-08 プレジデント アンド フェロウズ オブ ハーバード カレッジ 流体送達のシステムおよび方法
EP1561507A1 (de) * 2004-01-27 2005-08-10 Future Diagnostics B.V. System für das Kennzeichnen einer Flüssigkeit, microfluidische Vorrichtung für das Kennzeichnen oder das Analysieren der Bestandteile einer Konzentration, eine Methode des Kennzeichnens oder des Analysierens solcher Konzentrationen und einer Messvorrichtung
WO2005078118A1 (en) 2004-02-06 2005-08-25 Bayer Healthcare Llc Oxidizable species as an internal reference for biosensors and method of use
WO2005089945A1 (en) 2004-03-12 2005-09-29 Biotrove, Inc. Nanoliter array loading
KR100534615B1 (ko) * 2004-03-15 2005-12-07 삼성전자주식회사 접철가능한 급지카세트를 구비한 화상형성장치
US20070071641A1 (en) * 2004-04-09 2007-03-29 Brock David A Tray assembly for optical inspection apparatus
EP2345739B8 (de) 2004-05-03 2016-12-07 Handylab, Inc. Mikrofluidische Vorrichtung zur Verarbeitung polynukleotidhaltiger Proben
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
US7556723B2 (en) 2004-06-18 2009-07-07 Roche Diagnostics Operations, Inc. Electrode design for biosensor
US7984443B2 (en) 2004-07-22 2011-07-19 Computer Associates Think, Inc. System and method for normalizing job properties
US7932090B2 (en) * 2004-08-05 2011-04-26 3M Innovative Properties Company Sample processing device positioning apparatus and methods
KR100579831B1 (ko) * 2004-09-07 2006-05-15 삼성전자주식회사 조립 가능한 미세유동형 바이오시료 처리장치
JP4506375B2 (ja) * 2004-09-22 2010-07-21 ウシオ電機株式会社 吸光度測定ユニット
EP1805500A4 (de) * 2004-09-28 2008-05-07 Singulex Inc System und verfahren zur spektroskopischen analyse einzelner partikel
US8685711B2 (en) 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
US7572640B2 (en) * 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
US9040305B2 (en) * 2004-09-28 2015-05-26 Singulex, Inc. Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry
US20070243627A1 (en) * 2004-09-30 2007-10-18 Shuichi Takayama Computerized control method and system for microfluidics and computer program product for use therein
US7727477B2 (en) * 2004-12-10 2010-06-01 Bio-Rad Laboratories, Inc. Apparatus for priming microfluidics devices with feedback control
US7582263B2 (en) * 2005-01-27 2009-09-01 Octrolix Bv Universal interface for a micro-fluidic chip
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US7838283B2 (en) * 2005-04-21 2010-11-23 Celerus Diagnostics, Inc. Wicking cassette method and apparatus for automated rapid immunohistochemistry
JP2006322720A (ja) * 2005-05-17 2006-11-30 Ushio Inc マイクロチップ吸光光度測定装置
JP4635728B2 (ja) * 2005-06-03 2011-02-23 ウシオ電機株式会社 マイクロチップ検査装置
US7763210B2 (en) * 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7323660B2 (en) * 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
EP3483599A1 (de) 2005-07-20 2019-05-15 Ascensia Diabetes Care Holdings AG Verfahren zur messung der konzentration eines analyten in lösung und zum kalibrieren der messung sowie tragbare geräte dafür
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
EP1928603A1 (de) * 2005-09-02 2008-06-11 California Institute Of Technology Verfahren und vorrichtung zur mechanischen auslösung von ventilen in fluidischen vorrichtungen
JP2007114189A (ja) * 2005-09-20 2007-05-10 Yamaha Corp マイクロ化学チップ用温度制御装置
CA2624243C (en) * 2005-09-29 2013-12-31 Siemens Medical Solutions Usa, Inc. Microfluidic chip for synthesizing radioactively labeled molecules suitable for human imaging with positron emission tomography
CN103048442B (zh) 2005-09-30 2015-04-08 拜尔健康护理有限责任公司 门控伏特安培法
US7727371B2 (en) * 2005-10-07 2010-06-01 Caliper Life Sciences, Inc. Electrode apparatus for use with a microfluidic device
US8449837B2 (en) * 2005-10-11 2013-05-28 The Johns Hopkins University Microfluidic device for high-throughput cellular gradient and dose response studies
US8822206B2 (en) * 2005-10-11 2014-09-02 The Johns Hopkins University Device for high-throughput stimulation, immunostaining, and visualization of single cells
JP2009511059A (ja) * 2005-10-11 2009-03-19 ハンディーラブ インコーポレイテッド ポリヌクレオチドサンプル調製装置
JP2007147456A (ja) * 2005-11-28 2007-06-14 Seiko Epson Corp マイクロ流体システム、試料分析装置、及び標的物質の検出または測定方法
EP1963480A2 (de) * 2005-12-08 2008-09-03 Protein Discovery, Inc. Verfahren und vorrichtungen zur konzentration und fraktionierung von analyten für die chemische analyse
WO2007075922A2 (en) * 2005-12-22 2007-07-05 Honeywell International Inc. Portable sample analyzer cartridge
CN101432619A (zh) * 2006-01-22 2009-05-13 爱科来株式会社 具有废弃机构的分析装置
EP1815785A1 (de) * 2006-02-02 2007-08-08 Bioception B.V.i.o. Diagnosegerät in Form einer Kassette zur Diagnose von Flüssigkeit und deren Inhalt
US7862000B2 (en) * 2006-02-03 2011-01-04 California Institute Of Technology Microfluidic method and structure with an elastomeric gas-permeable gasket
US7815868B1 (en) * 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US9040288B2 (en) 2006-03-24 2015-05-26 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using the same
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
AU2007233320B2 (en) 2006-04-04 2013-12-12 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
EP3156799B1 (de) 2006-04-04 2024-01-24 Novilux, LLC Analysator und verfahren zur hochempfindlichen detektion von analyten
WO2007115378A1 (en) * 2006-04-11 2007-10-18 Minifab (Australia) Pty Ltd Microfluidic package housing
US8658111B2 (en) 2006-04-18 2014-02-25 Advanced Liquid Logic, Inc. Droplet actuators, modified fluids and methods
WO2010027894A2 (en) * 2008-08-27 2010-03-11 Advanced Liquid Logic, Inc. Droplet actuators, modified fluids and methods
US7674924B2 (en) 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
JP4292279B2 (ja) * 2006-07-18 2009-07-08 ファルマ・アクセス株式会社 結晶作製器具
JP4912096B2 (ja) * 2006-09-07 2012-04-04 ローム株式会社 マイクロチップ検査装置
WO2008039875A1 (en) * 2006-09-28 2008-04-03 California Institute Of Technology System and method for interfacing with a microfluidic chip
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
EP2089699B1 (de) 2006-11-21 2016-09-14 CE-Mate B.V. Ionensensor für flüssigkeit und verfahren zur herstellung davon
US7829032B2 (en) * 2007-01-23 2010-11-09 Siemens Medical Solutions Usa, Inc. Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography
US20080245740A1 (en) * 2007-01-29 2008-10-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US7799656B2 (en) * 2007-03-15 2010-09-21 Dalsa Semiconductor Inc. Microchannels for BioMEMS devices
US8071035B2 (en) * 2007-04-12 2011-12-06 Siemens Medical Solutions Usa, Inc. Microfluidic radiosynthesis system for positron emission tomography biomarkers
US8691164B2 (en) * 2007-04-20 2014-04-08 Celula, Inc. Cell sorting system and methods
CN103495439B (zh) * 2007-05-04 2015-09-16 欧普科诊断有限责任公司 流体连接器和微流体系统
WO2009020682A2 (en) 2007-05-08 2009-02-12 The Trustees Of Boston University Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
EP2562537B1 (de) * 2007-05-18 2016-07-13 CE-Mate B.V. Probenanalysemethode und -gerät mit Testchip und Handhabungseinheit
JP5237359B2 (ja) * 2007-05-18 2013-07-17 メディメイト ホールディング ビー.ブイ. 液体中の検体の濃度を測定するためのプラグを持つ検査チップ、検査チップのための筺体、およびプラグのためのソケット
WO2009002152A1 (en) * 2007-06-26 2008-12-31 Micronit Microfluidics B.V. Device and method for fluidic coupling of fluidic conduits to a microfluidic chip, and uncoupling thereof
EP2008716A1 (de) * 2007-06-28 2008-12-31 Bp Oil International Limited Probenplatte
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
ES2648798T3 (es) 2007-07-13 2018-01-08 Handylab, Inc. Materiales de captura de polinucleótidos y métodos de utilización de los mismos
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
CN104307581B (zh) * 2007-08-09 2017-04-12 诺思可有限公司 关联的多参数单细胞测定及残余生物材料回收的方法和装置
US20090087860A1 (en) * 2007-08-24 2009-04-02 Todd John A Highly sensitive system and methods for analysis of prostate specific antigen (psa)
CN104297506B (zh) 2007-10-02 2017-05-03 赛拉诺斯股份有限公司 模块化现场护理装置及其应用
WO2009076302A1 (en) 2007-12-10 2009-06-18 Bayer Healthcare Llc Control markers for auto-detection of control solution and methods of use
AU2008352940B2 (en) 2007-12-19 2014-06-05 Singulex, Inc. Scanning analyzer for single molecule detection and methods of use
CN102016552A (zh) * 2008-03-05 2011-04-13 神谷来克斯公司 用于分子的高灵敏性检测的方法和组合物
US7919062B2 (en) * 2008-03-20 2011-04-05 Corning Incorporated Modular microfluidic system and method for building a modular microfludic system
US20090250345A1 (en) * 2008-04-03 2009-10-08 Protea Biosciences, Inc. Microfluidic electroelution devices & processes
US20090250347A1 (en) * 2008-04-03 2009-10-08 Protea Biosciences, Inc. Microfluidic devices & processes for electrokinetic transport
EP2285491A1 (de) 2008-04-25 2011-02-23 Claros Diagnostics, Inc. Strömungsregelung in mikrofluidiksystemen
CN101625996B (zh) * 2008-07-08 2011-03-23 中芯国际集成电路制造(上海)有限公司 用以减少暗电流的ono侧墙刻蚀工艺
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
US20100009351A1 (en) * 2008-07-11 2010-01-14 Handylab, Inc. Polynucleotide Capture Materials, and Method of Using Same
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
DE202008009938U1 (de) 2008-07-23 2008-10-09 Bürkert Werke GmbH & Co.KG Sensorsystem
GB2464183A (en) * 2008-09-19 2010-04-14 Singulex Inc Sandwich assay
US20100093098A1 (en) * 2008-10-14 2010-04-15 Siemens Medical Solutions Nonflow-through appratus and mehod using enhanced flow mechanisms
GB2465842A (en) * 2008-12-05 2010-06-09 Accunostics Ltd Adaptor for an analyte measuring device
WO2010080115A2 (en) 2008-12-18 2010-07-15 Claros Diagnostics, Inc. Improved reagent storage in microfluidic systems and related articles and methods
US7927904B2 (en) 2009-01-05 2011-04-19 Dalsa Semiconductor Inc. Method of making BIOMEMS devices
ES2812260T3 (es) * 2009-02-02 2021-03-16 Opko Diagnostics Llc Estructuras para controlar la interacción de luz con dispositivos microfluídicos
US8354080B2 (en) * 2009-04-10 2013-01-15 Canon U.S. Life Sciences, Inc. Fluid interface cartridge for a microfluidic chip
WO2010126897A1 (en) * 2009-04-27 2010-11-04 Protein Discovery, Inc. Programmable electrophoretic notch filter systems and methods
AU2010257118B2 (en) 2009-06-04 2014-08-28 Lockheed Martin Corporation Multiple-sample microfluidic chip for DNA analysis
WO2010144358A1 (en) * 2009-06-08 2010-12-16 Singulex, Inc. Highly sensitive biomarker panels
WO2011040996A1 (en) 2009-09-30 2011-04-07 Quantapore, Inc. Ultrafast sequencing of biological polymers using a labeled nanopore
US20140152801A1 (en) 2009-10-28 2014-06-05 Alentic Microscience Inc. Detecting and Using Light Representative of a Sample
US9075225B2 (en) 2009-10-28 2015-07-07 Alentic Microscience Inc. Microscopy imaging
WO2011053631A1 (en) 2009-10-28 2011-05-05 Alentic Microscience Inc. Microscopy imaging
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
PL2504105T3 (pl) 2009-11-24 2021-06-28 Opko Diagnostics, Llc Mieszanie i dostarczanie płynów w układach mikroprzepływowych
CN102906573B (zh) 2010-02-23 2015-02-18 瑞昂尼克公司 独立式生物检测装置、方法和应用
JP6104793B2 (ja) 2010-04-16 2017-03-29 オプコ・ダイアグノスティクス・リミテッド・ライアビリティ・カンパニーOpko Diagnostics,Llc マイクロ流体システム内でのフィードバック制御
ITTO20100068U1 (it) * 2010-04-20 2011-10-21 Eltek Spa Dispositivi microfluidici e/o attrezzature per dispositivi microfluidici
JP2013525820A (ja) 2010-05-06 2013-06-20 シングレクス、インコーポレイテッド 関節リウマチの発症に関するリスクを診断し、病期分類し、予測し、治療レスポンダーを同定するための方法
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
JP5426476B2 (ja) * 2010-05-21 2014-02-26 株式会社エンプラス 分析用具及びマイクロ分析システム
JP2013527458A (ja) * 2010-05-27 2013-06-27 スリーエム イノベイティブ プロパティズ カンパニー 試料処理用の一体化されたシステム及び組立品
GB2483858A (en) * 2010-09-21 2012-03-28 Univ Hull Amplifying nucleic acids using microfluidic device to perform PRC
AU2011315951B2 (en) 2010-10-15 2015-03-19 Lockheed Martin Corporation Micro fluidic optic design
CN103477197B (zh) 2011-01-21 2016-08-17 提拉诺斯公司 样品使用最大化的系统和方法
FR2973720B1 (fr) * 2011-04-08 2016-02-26 Commissariat Energie Atomique Dispositif de connexion d'une carte microfluidique
CN106190806B (zh) 2011-04-15 2018-11-06 贝克顿·迪金森公司 扫描实时微流体热循环仪和用于同步的热循环和扫描光学检测的方法
CN103501908B (zh) 2011-05-18 2016-03-16 3M创新有限公司 用于样品处理装置上阀调的系统和方法
KR102110174B1 (ko) 2011-05-18 2020-05-14 디아소린 에스.피.에이. 샘플 처리 장치 상의 체적 계량을 위한 시스템 및 방법
US9168523B2 (en) 2011-05-18 2015-10-27 3M Innovative Properties Company Systems and methods for detecting the presence of a selected volume of material in a sample processing device
WO2013033726A1 (en) * 2011-09-02 2013-03-07 Quinonez Carlo Joseph Universal hardware platform and toolset for operating and fabricating microfluidic devices
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
DK2761305T3 (da) 2011-09-30 2017-11-20 Becton Dickinson Co Forenet reagensstrimmel
WO2013067202A1 (en) 2011-11-04 2013-05-10 Handylab, Inc. Polynucleotide sample preparation device
DK2810080T3 (da) 2012-02-03 2024-06-17 Becton Dickinson Co Eksterne filer til fordeling af molekylære diagnostiske tests og bestemmelse af kompatabilitet imellem tests
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
JP6308954B2 (ja) 2012-03-05 2018-04-11 オサケユキテュア・アークティック・パートナーズ・アクチボラゲットOy Arctic Partners Ab 前立腺癌のリスク及び前立腺容積を予測する方法及び装置
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9081001B2 (en) 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9675973B2 (en) * 2012-06-14 2017-06-13 Paratus Diagnostics, LLC Specimen delivery apparatus
US9957553B2 (en) 2012-10-24 2018-05-01 Genmark Diagnostics, Inc. Integrated multiplex target analysis
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
US9651539B2 (en) 2012-10-28 2017-05-16 Quantapore, Inc. Reducing background fluorescence in MEMS materials by low energy ion beam treatment
TW201422817A (zh) * 2012-12-14 2014-06-16 Ardic Instr Co 生物感測晶片結構
JP2014132228A (ja) * 2013-01-04 2014-07-17 Sony Corp 液体注入用治具セット
US9597685B2 (en) 2013-01-31 2017-03-21 Luminex Corporation Fluid retention plates and analysis cartridges
US9518920B2 (en) 2013-06-26 2016-12-13 Alentic Microscience Inc. Sample processing improvements for microscopy
US10502666B2 (en) 2013-02-06 2019-12-10 Alentic Microscience Inc. Sample processing improvements for quantitative microscopy
CA2900708C (en) 2013-03-13 2021-06-15 Opko Diagnostics, Llc Mixing of fluids in fluidic systems
US9163277B2 (en) 2013-03-14 2015-10-20 Formulatrix, Inc. Microfluidic device
US9039993B2 (en) 2013-03-14 2015-05-26 Formulatrix, Inc. Microfluidic device
CN107866286A (zh) 2013-03-15 2018-04-03 金马克诊断股份有限公司 用于操纵可变形流体容器的系统、方法和设备
JP2013156268A (ja) * 2013-03-28 2013-08-15 Medimate Holding B V 液体で満たされてシールされたチャネルを有する測定試料ハンドリング・デバイス
US9671368B2 (en) * 2013-05-10 2017-06-06 The Regents Of The University Of California Two-dimensional microfluidic devices and methods of using the same
US9862997B2 (en) 2013-05-24 2018-01-09 Quantapore, Inc. Nanopore-based nucleic acid analysis with mixed FRET detection
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US10220387B2 (en) 2013-12-05 2019-03-05 The General Hospital Corporation Modular instrumentation for analyzing biological fluids
WO2015121887A1 (en) * 2014-02-14 2015-08-20 Elements S.R.L. High sensitivity multichannel detection device
US9694361B2 (en) 2014-04-10 2017-07-04 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
WO2016027782A1 (ja) * 2014-08-20 2016-02-25 株式会社シン・コーポレイション 検査用装置
EP3204519B1 (de) 2014-10-10 2020-04-29 Quantapore Inc. Analyse nanoporenbasierter polymere mit gegenseitig löschenden fluoreszenzmarkern
WO2016062788A1 (en) 2014-10-24 2016-04-28 Ait Austrian Institute Of Technology Gmbh Microfluidic chip for biological analysis
CN107002126B (zh) 2014-10-24 2021-05-25 昆塔波尔公司 使用纳米结构阵列的聚合物的高效光学分析
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
EA038479B1 (ru) 2014-12-12 2021-09-03 Опкоу Дайагностикс, Ллк Устройство для проведения анализа пробы и способ эксплуатации указанного устройства
CN105772117A (zh) * 2014-12-22 2016-07-20 卡梅德生物科技(天津)有限公司 一种用于生物实验室检测化学成份的实验芯片
US12290811B2 (en) 2015-01-23 2025-05-06 Unchained Labs Microfluidic serial dilution platform based well-plate using an oil-free immiscible phase driven by manual or electronic pipettors
CN107001026A (zh) * 2015-01-30 2017-08-01 惠普发展公司,有限责任合伙企业 微流体感测系统
US9739751B2 (en) * 2015-02-05 2017-08-22 International Business Machines Corporation Devices for trapping and controlling microparticles with radiation
WO2016149639A1 (en) * 2015-03-19 2016-09-22 The Board Of Trustees Of The Leland Stanford Junior University Devices and methods for high-throughput single cell and biomolecule analysis and retrieval in a microfluidic chip
PT3100587T (pt) 2015-04-07 2020-10-12 Cell Id Pte Ltd Um aquecedor de cc
EP3093656A1 (de) * 2015-05-13 2016-11-16 ARKRAY, Inc. Analytisches werkzeug und analytisches system
US10519493B2 (en) 2015-06-22 2019-12-31 Fluxergy, Llc Apparatus and method for image analysis of a fluid sample undergoing a polymerase chain reaction (PCR)
US11371091B2 (en) 2015-06-22 2022-06-28 Fluxergy, Inc. Device for analyzing a fluid sample and use of test card with same
US10214772B2 (en) 2015-06-22 2019-02-26 Fluxergy, Llc Test card for assay and method of manufacturing same
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
US10184102B2 (en) * 2015-08-26 2019-01-22 EMULATE, Inc. Controlling pressure
WO2017044527A1 (en) * 2015-09-09 2017-03-16 Life Technologies Corporation Clamp devices for receiving a cartridge and methods for using same
AU2016335374A1 (en) * 2015-10-09 2018-04-26 Sysmex Corporation Specimen treatment chip, specimen treatment device, and specimen treatment method
CA3005084A1 (en) 2015-12-11 2017-06-15 Opko Diagnostics, Llc Fluidic systems involving incubation of samples and/or reagents
US10444184B2 (en) 2015-12-28 2019-10-15 International Business Machines Corporation Operation of diagnostic devices involving microchannels and electrodes
GB2547753B (en) * 2015-12-28 2020-07-08 Ibm Operation of diagnostic devices involving microchannels and electrodes
US10088468B2 (en) * 2016-02-04 2018-10-02 Nova Biomedical Corporation Analyte system and method for determining hemoglobin parameters in whole blood
US11446671B2 (en) 2016-03-29 2022-09-20 Leica Microsystems Cms Gmbh Self-contained slide processing unit for biological specimens
WO2017197343A2 (en) 2016-05-12 2017-11-16 10X Genomics, Inc. Microfluidic on-chip filters
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
EP3482196B1 (de) 2016-07-05 2022-02-23 Quantapore, Inc. Optisch basierte nanoporensequenzierung
WO2018200896A1 (en) 2017-04-28 2018-11-01 Neofluidics, Llc Fluidic devices with reaction wells and uses thereof
CA3072328A1 (en) 2017-08-09 2019-02-14 Neofluidics, Llc Devices and methods for bioassay
AU2017434549B2 (en) * 2017-09-28 2022-01-06 Oxford Nanopore Technologies Plc Kit of first and second parts adapted for connection to each other
JP7256198B2 (ja) * 2017-11-10 2023-04-11 ネオフルーイディクス,リミティド ライアビリティ カンパニー 液滴操作のための統合された流体回路およびデバイスならびにその方法
JP7390305B2 (ja) * 2017-12-23 2023-12-01 ルマサイト, インコーポレイティド マイクロ流体チップ構成および動力学を用いた光力測定および細胞画像化のためのマイクロ流体チップデバイス
US11154864B2 (en) 2018-01-17 2021-10-26 Qiagen Sciences, Llc Microfluidic device with vented microchambers
USD878622S1 (en) * 2018-04-07 2020-03-17 Precision Nanosystems Inc. Microfluidic chip
WO2019200166A1 (en) * 2018-04-11 2019-10-17 The Trustees Of Indiana University Cartridges, systems and methods for mass spectrometry
WO2020009896A1 (en) * 2018-07-06 2020-01-09 Qorvo Us, Inc. Methods of measuring hematocrit in fluidic channels including conductivity sensor
US11541385B2 (en) 2018-07-06 2023-01-03 Qorvo Us, Inc. Methods of measuring hematocrit in fluidic channels including conductivity sensor
EP3797279A4 (de) * 2018-07-11 2022-08-03 The University of Hong Kong Automatisches mikrofluidisches system zur kontinuierlichen und quantitativen sammlung von tröpfchen
KR102185961B1 (ko) * 2018-07-11 2020-12-03 부산대학교 산학협력단 교류 전위 변조를 이용한 마이크로 플루이딕 채널 기반의 진단 키트
EP3870369A4 (de) 2018-10-26 2022-11-09 Neofluidics, LLC Fluidische vorrichtungen mit reaktionsmulden und verengungskanälen und verwendungen davon
US11484881B2 (en) 2019-06-27 2022-11-01 Axbio Inc. Biomolecule diagnostic systems
USD1016324S1 (en) 2020-07-08 2024-02-27 NanoCav, LLC Biological cell processing chip
DE102020128003A1 (de) 2020-10-23 2020-12-31 Bmg Labtech Gmbh Mikroplatten-Lesegerät
USD983405S1 (en) * 2021-04-15 2023-04-11 Cytoaurora Biotechnologies, Inc. Microfluidic chip
JP7777701B2 (ja) * 2022-06-17 2025-11-28 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド 導電性電極を有する音響泳動デバイスおよび方法

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS533674B2 (de) 1972-11-29 1978-02-08
EP0006031B1 (de) 1978-06-05 1983-06-22 EASTMAN KODAK COMPANY (a New Jersey corporation) Vorrichtung zur Aufnahme von Magazinen und dafür geeignete Magazine
US4170737A (en) * 1978-07-06 1979-10-09 Spetsialnoe Konstruktorskoe Bjuro Biologicheskogo Priborotroenia Akademii Nauk SSSR Top-entry transmission electron microscope
EP0189316B1 (de) 1985-01-25 1993-03-31 Mallinckrodt Sensor Systems, Inc. Gerät zum Nachweis oder zur Messung von chemischen Komponenten
JPS61198041A (ja) 1985-02-28 1986-09-02 Konishiroku Photo Ind Co Ltd 生化学分析装置
CN1014551B (zh) 1986-09-16 1991-10-30 尼泰库株式会社 自动分析装置
US5004582A (en) 1987-07-15 1991-04-02 Fuji Photo Film Co., Ltd. Biochemical analysis apparatus
JPS6480864A (en) 1987-09-24 1989-03-27 Fuji Photo Film Co Ltd Biochemical analyzer
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5106758A (en) * 1988-12-12 1992-04-21 Technicon Instruments Corporation Analytical test device and the use thereof
JP2779676B2 (ja) 1989-06-14 1998-07-23 横河電機株式会社 クロマトグラフィ装置及び成分分離手段の形成方法
JPH03101752A (ja) 1989-09-16 1991-04-26 Canon Inc 画像形成装置
US5219526A (en) 1990-04-27 1993-06-15 Pb Diagnostic Systems Inc. Assay cartridge
GB2244135B (en) * 1990-05-04 1994-07-13 Gen Electric Co Plc Sensor devices
JP2543243B2 (ja) 1990-09-05 1996-10-16 株式会社京都第一科学 検体自動分析装置
CA2044929C (en) 1991-06-18 1997-11-18 Maxime Ferris Teaching method and system
FR2679661B1 (fr) 1991-07-26 1994-10-14 Sfri Appareil d'analyse automatique d'echantillons.
WO1993019827A1 (en) * 1992-04-02 1993-10-14 Abaxis, Inc. Analytical rotor with dye mixing chamber
JP2745091B2 (ja) 1992-04-03 1998-04-28 東亞医用電子株式会社 免疫凝集測定装置
US5223219A (en) 1992-04-10 1993-06-29 Biotrack, Inc. Analytical cartridge and system for detecting analytes in liquid samples
US5486335A (en) 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5232667A (en) * 1992-05-21 1993-08-03 Diametrics Medical, Inc. Temperature control for portable diagnostic system using a non-contact temperature probe
US5334349A (en) 1992-07-16 1994-08-02 Schiapparelli Biosystems, Inc. Liquid transfer module for a chemical analyzer
US5302348A (en) * 1992-12-10 1994-04-12 Itc Corporation Blood coagulation time test apparatus and method
US5510082A (en) 1993-01-25 1996-04-23 Fuji Photo Film Co., Ltd. Chemical analysis film supplier
JPH06265447A (ja) 1993-03-16 1994-09-22 Hitachi Ltd 微量反応装置およびこれを使用する微量成分測定装置
US5534328A (en) * 1993-12-02 1996-07-09 E. I. Du Pont De Nemours And Company Integrated chemical processing apparatus and processes for the preparation thereof
EP1130383B1 (de) 1993-04-23 2004-09-15 Roche Diagnostics GmbH Diskette mit kreisförmig angeordneten Testelementen
JP3101752B2 (ja) 1993-06-28 2000-10-23 新明和工業株式会社 パレット保持装置
AU7245094A (en) 1993-07-07 1995-02-06 Abaxis, Inc. System and method for incorporating analytical instruments within personal computers
JP2948069B2 (ja) 1993-09-20 1999-09-13 株式会社日立製作所 化学分析装置
US5580523A (en) 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
KR100314996B1 (ko) * 1994-11-10 2002-01-15 윌리암 제이. 버크 액체분배시스템
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
JP3220158B2 (ja) 1994-11-14 2001-10-22 トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア 分析対象物質の確定及び処理のためのメソ規模の試料前処理装置及びシステム
US5728352A (en) * 1994-11-14 1998-03-17 Advanced Care Products Disposable electronic diagnostic instrument
US5731212A (en) * 1994-12-20 1998-03-24 International Technidyne Corporation Test apparatus and method for testing cuvette accommodated samples
US5716825A (en) * 1995-11-01 1998-02-10 Hewlett Packard Company Integrated nucleic acid analysis system for MALDI-TOF MS
US5833924A (en) * 1995-12-22 1998-11-10 Universal Healthwatch, Inc. Sampling-assay device and interface system
US5863502A (en) * 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US6399023B1 (en) * 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
EP0802267B1 (de) * 1996-04-18 2000-01-05 Alusuisse Technology & Management AG Aluminiumoberfläche mit Interferenzfarben
US5876675A (en) * 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US5989402A (en) * 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
US6167910B1 (en) * 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
US6027360A (en) 1998-06-10 2000-02-22 Yazaki Corporation Junction block bracket for floating connector attachment

Also Published As

Publication number Publication date
US6432720B2 (en) 2002-08-13
US6399023B1 (en) 2002-06-04
US20020015667A1 (en) 2002-02-07
TW350914B (en) 1999-01-21
US20020192112A1 (en) 2002-12-19
JP2000515630A (ja) 2000-11-21
CA2259929C (en) 2007-01-09
DE69733663D1 (de) 2005-08-04
CA2259929A1 (en) 1998-02-12
US5955028A (en) 1999-09-21
CN1226845A (zh) 1999-08-25
AU3815697A (en) 1998-02-25
EP1426109A1 (de) 2004-06-09
CN1096297C (zh) 2002-12-18
US6071478A (en) 2000-06-06
WO1998005424A1 (en) 1998-02-12
DE69733663T2 (de) 2006-05-04
JP3686932B2 (ja) 2005-08-24
US6503757B1 (en) 2003-01-07
ZA976887B (en) 1998-05-11
EP0952890B1 (de) 2005-06-29
EP0952890A1 (de) 1999-11-03
US6399025B1 (en) 2002-06-04
AU717981B2 (en) 2000-04-06

Similar Documents

Publication Publication Date Title
DE69733663D1 (de) Analytisches system und verfahren
GB2323666B (en) Device for determination of an analyte in a body fluid
GB2317180A (en) Methods and systems for biological reagent placement
IT236020Y1 (it) Dispositivi e corredi per saggio
SE9401858L (sv) Indikeringsanordning
GB9922064D0 (en) Analytical test device and method of use
BR9306979A (pt) Dispositivo de obtenção de fluido oral e superfície de suporte-sólido
DE69633015D1 (de) Vorrichtung für Kapillarelektrophorese
DE69423840D1 (de) Kontaktelementüberprüfungsmethode und Kontaktelementüberprüfungsvorrichtung
DE69734379D1 (de) Vorrichtung zur Prüfung von integrierten Schaltungen
DE69021888D1 (de) Mikroelektroden und amperometrische tests.
DE69623494D1 (de) Elektrochemische erkennung von nukleinsäurehybridation
DE59812896D1 (de) Vorrichtung zum optischen prüfen von oberflächen
DE69834694D1 (de) Informationsaufzeichnungsapparat mit Interferenzvorrichtung zur Positionsbestimmung und Positionierung
DE69834084D1 (de) Drehtischgerät zur Erzeugung von Beschleunigungen
DE69837869D1 (de) Betrieb einer elektrisch bedienbaren Vorrichtung
DE69633695D1 (de) Konfigurierbare Kontaktleiste zur bequemen parallellen Prüfung von integrierten Schaltungen
BR9610041A (pt) Mola de contacto e dispositivo em um circuito eletro-ótico
DE69728469D1 (de) Gerät und Verfahren zur Ermitlung der Zeichenlinie mittels vereinfachter Projektionsinformation; Zeichenerkennungsgerät und Verfahren
DE59508755D1 (de) Vorrichtung zur rasterstereografischen vermessung von körperoberflächen
EP0909949A3 (de) Messwertaufnehmer zur Erfassung der elektrischen Leitfähigkeit eines flüssigen Mediums
AU5247790A (en) Capillary flow device and reading instrument
DE59303995D1 (de) Einrichtung zur prüfung von stutzenschweissnähten
ITFI970244A0 (it) Strumento e metodo per la misura della viscosita' di un liquido
KR970051239U (ko) 필기구의 클립형 필심 출몰장치

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties