ATE340025T1 - Vorrichtungen und verfahren für hochdurchsatz- probenentnahme und analyse - Google Patents

Vorrichtungen und verfahren für hochdurchsatz- probenentnahme und analyse

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Publication number
ATE340025T1
ATE340025T1 AT00989616T AT00989616T ATE340025T1 AT E340025 T1 ATE340025 T1 AT E340025T1 AT 00989616 T AT00989616 T AT 00989616T AT 00989616 T AT00989616 T AT 00989616T AT E340025 T1 ATE340025 T1 AT E340025T1
Authority
AT
Austria
Prior art keywords
systems
analysis
thousands
methods
materials
Prior art date
Application number
AT00989616T
Other languages
English (en)
Inventor
Jeffrey A Wolk
Sherri Ann Biondi
John Wallace Parce
Morten J Jensen
Anne R Kopf-Sill
Original Assignee
Caliper Life Sciences Inc
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Publication date
Application filed by Caliper Life Sciences Inc filed Critical Caliper Life Sciences Inc
Application granted granted Critical
Publication of ATE340025T1 publication Critical patent/ATE340025T1/de

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    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N2001/028—Sampling from a surface, swabbing, vaporising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1037—Using surface tension, e.g. pins or wires
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1039—Micropipettes, e.g. microcapillary tubes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

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Families Citing this family (175)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US7285422B1 (en) 1997-01-23 2007-10-23 Sequenom, Inc. Systems and methods for preparing and analyzing low volume analyte array elements
US7112449B1 (en) * 2000-04-05 2006-09-26 Nanogram Corporation Combinatorial chemical synthesis
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6689323B2 (en) * 1998-10-30 2004-02-10 Agilent Technologies Method and apparatus for liquid transfer
DE10017790A1 (de) * 2000-04-10 2001-10-11 Basf Ag Verfahren zur Herstellung von Biopolymer-Feldern mit Echtzeitkontrolle
DE10031587A1 (de) * 2000-06-29 2002-01-10 Basf Ag Dosierung von Suspensionen im Mikromaßstab zur Herstellung von Materialproben in der kombinatorischen Materialforschung sowie deren Prüfung
US20020142483A1 (en) * 2000-10-30 2002-10-03 Sequenom, Inc. Method and apparatus for delivery of submicroliter volumes onto a substrate
AU2001295360A1 (en) * 2000-11-17 2002-05-27 Tecan Trading Ag Device and method for separating samples from a liquid
US20020108860A1 (en) * 2001-01-15 2002-08-15 Staats Sau Lan Tang Fabrication of polymeric microfluidic devices
US6918309B2 (en) * 2001-01-17 2005-07-19 Irm Llc Sample deposition method and system
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US6605438B1 (en) * 2001-03-26 2003-08-12 Louis Dischler Lyophilizing of liquid drops having arbitrary edges and application thereof to microarrays of biological reagents
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US20030040119A1 (en) * 2001-04-11 2003-02-27 The Regents Of The University Of Michigan Separation devices and methods for separating particles
US20020168292A1 (en) * 2001-05-14 2002-11-14 Whisenhunt Donald Wayne Systems and methods for the high throughput preparation and analysis of chemical reactions
GB2379415A (en) * 2001-09-10 2003-03-12 Seiko Epson Corp Monitoring the deposition of organic polymer droplets onto a substrate
US6579724B2 (en) * 2001-09-13 2003-06-17 First Ten Angstroms Dispensing method and apparatus for dispensing very small quantities of fluid
JP3902939B2 (ja) * 2001-10-26 2007-04-11 株式会社日立ハイテクノロジーズ 標本中の微小領域測定装置及び方法
US20030148539A1 (en) * 2001-11-05 2003-08-07 California Institute Of Technology Micro fabricated fountain pen apparatus and method for ultra high density biological arrays
US6926864B2 (en) * 2001-11-09 2005-08-09 Protiveris Inc Microfluidics apparatus and methods for use thereof
WO2003072752A2 (en) * 2002-02-27 2003-09-04 Miragene, Inc. Improved substrate chemistry for protein immobilization on a rigid support
US7354774B2 (en) * 2002-05-13 2008-04-08 Becton, Dickinson And Company Self aliquoting sample storage plate
CA2487944A1 (en) * 2002-06-03 2003-12-11 Pamgene B.V. Biomolecular kinetics method using a flow-through microarray
CA2489077A1 (en) * 2002-06-07 2003-12-18 Picosep A/S Method and system for multi-stage isoelectric focussing
JP2004045241A (ja) * 2002-07-12 2004-02-12 Nisshinbo Ind Inc マイクロアレイの作製方法
US20040067597A1 (en) * 2002-07-31 2004-04-08 Caliper Technologies Corp. High density reagent array preparation methods
US20050074898A1 (en) * 2002-07-31 2005-04-07 Caliper Technologies Corp. High density reagent array preparation methods
GB0219457D0 (en) * 2002-08-21 2002-09-25 Amersham Biosciences Uk Ltd Fluorescence reference plate
AU2003293399A1 (en) * 2002-12-04 2004-06-23 Spinx, Inc. Devices and methods for programmable microscale manipulation of fluids
US7491272B2 (en) * 2002-12-05 2009-02-17 International Business Machines Corporation Confinement of liquids on surfaces
GB0302281D0 (en) * 2003-01-31 2003-03-05 Biorobotics Ltd Liquid transfer system
US20040151635A1 (en) * 2003-01-31 2004-08-05 Leproust Eric M. Array fabrication using deposited drop splat size
US7820030B2 (en) 2003-04-16 2010-10-26 Handylab, Inc. System and method for electrochemical detection of biological compounds
US7138050B2 (en) * 2003-05-29 2006-11-21 Shimadzu Corporation Fractionating/collecting device of liquid chromatograph
EP1654066B1 (de) 2003-07-31 2014-11-12 Handylab, Inc. Verarbeitung von teilchenhaltigen proben
ATE551383T1 (de) 2003-09-23 2012-04-15 Univ North Carolina Photohärtbare perfluorpolyether zur verwendung als neue werkstoffe in mikrofluidischen vorrichtungen
DE102004062281A1 (de) * 2003-12-29 2005-07-28 Siemens Ag Verfahren und Spotting-Lösung zum Herstellen von Microarrays
US8592219B2 (en) * 2005-01-17 2013-11-26 Gyros Patent Ab Protecting agent
US8030057B2 (en) * 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
JP4698613B2 (ja) 2004-01-26 2011-06-08 プレジデント アンド フェロウズ オブ ハーバード カレッジ 流体送達のシステムおよび方法
WO2007021762A2 (en) 2005-08-09 2007-02-22 The University Of North Carolina At Chapel Hill Methods and materials for fabricating microfluidic devices
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
EP2345739B8 (de) 2004-05-03 2016-12-07 Handylab, Inc. Mikrofluidische Vorrichtung zur Verarbeitung polynukleotidhaltiger Proben
US20050247673A1 (en) 2004-05-07 2005-11-10 International Business Machines Corporation Confinement of fluids on surfaces
US7955865B2 (en) * 2004-06-09 2011-06-07 The University Of British Columbia Reagent delivery apparatus and methods
WO2006039293A2 (en) * 2004-09-29 2006-04-13 University Of Virginia Patent Foundation Localized control of thermal properties on microdevices and applications thereof
US8173367B2 (en) * 2004-10-18 2012-05-08 Sherri Boucher In situ dilution of external controls for use in microarrays
US7364807B2 (en) * 2004-12-06 2008-04-29 General Electric Company Thermal barrier coating/environmental barrier coating system for a ceramic-matrix composite (CMC) article to improve high temperature capability
JP2008534914A (ja) * 2005-01-17 2008-08-28 ユィロス・パテント・アクチボラグ 多目的流路
WO2006086292A2 (en) * 2005-02-07 2006-08-17 Advion Biosciences, Inc. Ultra-low volume fraction collection and analysis
KR100666825B1 (ko) * 2005-03-26 2007-01-11 한국표준과학연구원 전기전도성 관을 이용한 전기삼투압류 구동 극미세 피펫장치
US9097723B2 (en) * 2005-04-01 2015-08-04 Caliper Life Sciences, Inc. Method and apparatus for performing peptide digestion on a microfluidic device
CN101663576B (zh) * 2005-04-12 2012-05-23 卡钳生命科学股份有限公司 用于微流体器件的紧凑型光检测系统
US20060263826A1 (en) * 2005-05-18 2006-11-23 Nuclea Biomarkers Llc Antibody protein analysis chip
US7618590B2 (en) * 2005-06-29 2009-11-17 Cascade Microtech, Inc. Fluid dispensing system
US20070068573A1 (en) 2005-08-22 2007-03-29 Applera Corporation Device and method for microfluidic control of a first fluid in contact with a second fluid, wherein the first and second fluids are immiscible
WO2007047336A2 (en) * 2005-10-12 2007-04-26 University Of Virginia Patent Foundation Integrated microfluidic analysis systems
JP4373427B2 (ja) * 2005-11-15 2009-11-25 エフ．ホフマン−ラ ロシュ アーゲー 電気的滴下監視
US20070224055A1 (en) 2005-11-23 2007-09-27 Anex Deon S Electrokinetic pump designs and drug delivery systems
EP1790861A1 (de) * 2005-11-25 2007-05-30 Bonsens AB Mikrofluidisches System
JP2007147456A (ja) * 2005-11-28 2007-06-14 Seiko Epson Corp マイクロ流体システム、試料分析装置、及び標的物質の検出または測定方法
US20070132241A1 (en) * 2005-12-14 2007-06-14 Agilent Technologies, Inc. Coupling with layered sealing
US20070170056A1 (en) * 2006-01-26 2007-07-26 Arnold Don W Microscale electrochemical cell and methods incorporating the cell
US9040288B2 (en) 2006-03-24 2015-05-26 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using the same
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
WO2007123908A2 (en) * 2006-04-18 2007-11-01 Advanced Liquid Logic, Inc. Droplet-based multiwell operations
US7727723B2 (en) 2006-04-18 2010-06-01 Advanced Liquid Logic, Inc. Droplet-based pyrosequencing
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US20080182136A1 (en) * 2007-01-26 2008-07-31 Arnold Don W Microscale Electrochemical Cell And Methods Incorporating The Cell
US7867592B2 (en) 2007-01-30 2011-01-11 Eksigent Technologies, Inc. Methods, compositions and devices, including electroosmotic pumps, comprising coated porous surfaces
US9152150B1 (en) 2007-02-22 2015-10-06 Applied Biosystems, Llc Compositions, systems, and methods for immiscible fluid discrete volume manipulation
CN103495439B (zh) * 2007-05-04 2015-09-16 欧普科诊断有限责任公司 流体连接器和微流体系统
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
ES2648798T3 (es) 2007-07-13 2018-01-08 Handylab, Inc. Materiales de captura de polinucleótidos y métodos de utilización de los mismos
US8016260B2 (en) 2007-07-19 2011-09-13 Formulatrix, Inc. Metering assembly and method of dispensing fluid
US20090180931A1 (en) 2007-09-17 2009-07-16 Sequenom, Inc. Integrated robotic sample transfer device
US8251672B2 (en) 2007-12-11 2012-08-28 Eksigent Technologies, Llc Electrokinetic pump with fixed stroke volume
EP2285491A1 (de) 2008-04-25 2011-02-23 Claros Diagnostics, Inc. Strömungsregelung in mikrofluidiksystemen
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
KR20110047229A (ko) 2008-08-15 2011-05-06 아리조나 보드 오브 리젠츠 퍼 앤 온 비하프 오브 아리조나 스테이트 유니버시티 생물학적 샘플 수집용 다공성 재료
US8888969B2 (en) 2008-09-02 2014-11-18 The Governing Council Of The University Of Toronto Nanostructured microelectrodes and biosensing devices incorporating the same
US9089844B2 (en) 2010-11-01 2015-07-28 Bio-Rad Laboratories, Inc. System for forming emulsions
GB2502409B8 (en) 2008-09-23 2014-10-15 Bio Rad Laboratories Droplet-based assay system
US9598725B2 (en) * 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
US9399215B2 (en) 2012-04-13 2016-07-26 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US8663920B2 (en) 2011-07-29 2014-03-04 Bio-Rad Laboratories, Inc. Library characterization by digital assay
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US12090480B2 (en) 2008-09-23 2024-09-17 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US12162008B2 (en) 2008-09-23 2024-12-10 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
WO2011120020A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet transport system for detection
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US8053239B2 (en) * 2008-10-08 2011-11-08 The Governing Council Of The University Of Toronto Digital microfluidic method for protein extraction by precipitation from heterogeneous mixtures
WO2010080115A2 (en) 2008-12-18 2010-07-15 Claros Diagnostics, Inc. Improved reagent storage in microfluidic systems and related articles and methods
US8100293B2 (en) 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
ES2812260T3 (es) * 2009-02-02 2021-03-16 Opko Diagnostics Llc Estructuras para controlar la interacción de luz con dispositivos microfluídicos
US20100199750A1 (en) 2009-02-06 2010-08-12 Arnold Don W Microfludic Analysis System and Method
US20100224013A1 (en) 2009-03-05 2010-09-09 Van Berkel Gary J Method and system for formation and withdrawal of a sample from a surface to be analyzed
FR2946269B1 (fr) * 2009-06-08 2012-07-06 Univ Paris Curie Dispositif micro-fluidique pour convoyer un produit par diffusion dans un substrat poreux
US9919311B2 (en) 2009-07-20 2018-03-20 Siloam Biosciences, Inc. Microfluidic assay platforms
CA2767056C (en) 2009-09-02 2018-12-04 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
US9005544B2 (en) * 2009-10-15 2015-04-14 The Regents Of The University Of California Digital microfluidic platform for radiochemistry
EP2496716A1 (de) 2009-11-03 2012-09-12 University Of Virginia Patent Foundation Vielseitiges sichtbares verfahren für den nachweis von polymeranalyten
PL2504105T3 (pl) 2009-11-24 2021-06-28 Opko Diagnostics, Llc Mieszanie i dostarczanie płynów w układach mikroprzepływowych
JP2013524171A (ja) 2010-03-25 2013-06-17 クァンタライフ・インコーポレーテッド 液滴ベースのアッセイのための液滴の発生
JP2013524169A (ja) 2010-03-25 2013-06-17 クァンタライフ・インコーポレーテッド 液滴によるアッセイ用の検出システム
JP6104793B2 (ja) 2010-04-16 2017-03-29 オプコ・ダイアグノスティクス・リミテッド・ライアビリティ・カンパニーＯｐｋｏ Ｄｉａｇｎｏｓｔｉｃｓ，Ｌｌｃ マイクロ流体システム内でのフィードバック制御
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
WO2011150226A1 (en) 2010-05-26 2011-12-01 Landers James P Method for detecting nucleic acids based on aggregate formation
WO2012016357A1 (en) 2010-08-06 2012-02-09 Capitalbio Corporation Microarray-based assay integrated with particles for analyzing molecular interactions
US9061279B2 (en) 2010-08-31 2015-06-23 Canon U.S. Life Sciences, Inc. Composition and method for in-system priming microfluidic devices
US8637813B2 (en) * 2010-10-01 2014-01-28 Ut-Battelle, Llc System and method for laser assisted sample transfer to solution for chemical analysis
US8519330B2 (en) 2010-10-01 2013-08-27 Ut-Battelle, Llc Systems and methods for laser assisted sample transfer to solution for chemical analysis
EP3467487A1 (de) 2011-01-11 2019-04-10 The Governing Council Of The University Of Toronto Proteinnachweisverfahren
US12097495B2 (en) 2011-02-18 2024-09-24 Bio-Rad Laboratories, Inc. Methods and compositions for detecting genetic material
CA2830443C (en) 2011-03-18 2021-11-16 Bio-Rad Laboratories, Inc. Multiplexed digital assays with combinatorial use of signals
CN106190806B (zh) 2011-04-15 2018-11-06 贝克顿·迪金森公司 扫描实时微流体热循环仪和用于同步的热循环和扫描光学检测的方法
JP2014512826A (ja) 2011-04-25 2014-05-29 バイオ−ラド ラボラトリーズ インコーポレイテッド 核酸分析のための方法および組成物
WO2012151289A2 (en) 2011-05-02 2012-11-08 University Of Virginia Patent Foundation Method and system to detect aggregate formation on a substrate
WO2012151268A1 (en) 2011-05-02 2012-11-08 University Of Virginia Patent Foundation Method and system for high throughput optical and label free detection of analytes
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
DK2761305T3 (da) 2011-09-30 2017-11-20 Becton Dickinson Co Forenet reagensstrimmel
WO2013067202A1 (en) 2011-11-04 2013-05-10 Handylab, Inc. Polynucleotide sample preparation device
NL2009853A (en) * 2011-12-23 2013-06-26 Asml Netherlands Bv Methods and apparatus for measuring a property of a substrate.
DK2810080T3 (da) 2012-02-03 2024-06-17 Becton Dickinson Co Eksterne filer til fordeling af molekylære diagnostiske tests og bestemmelse af kompatabilitet imellem tests
JP6308954B2 (ja) 2012-03-05 2018-04-11 オサケユキテュア・アークティック・パートナーズ・アクチボラゲットＯｙ Ａｒｃｔｉｃ Ｐａｒｔｎｅｒｓ Ａｂ 前立腺癌のリスク及び前立腺容積を予測する方法及び装置
AU2013267227B2 (en) 2012-05-31 2017-03-02 The University Of North Carolina At Chapel Hill Dissolution guided wetting of structured surfaces
US10519434B2 (en) 2012-07-13 2019-12-31 Diomics Corporation Biologic sample collection devices and methods of production and use thereof
US9518977B2 (en) * 2012-10-19 2016-12-13 University Of Washington Through Its Center For Commercialization Microfluidic assay apparatus and methods of use
US9254487B2 (en) * 2012-12-17 2016-02-09 Taiwan Semiconductor Manufacturing Company, Ltd. Systems and methods for an integrated bio-entity manipulation and processing semiconductor device
US9254485B2 (en) 2012-12-17 2016-02-09 Taiwan Semiconductor Manufacturing Company, Ltd. Systems and methods for an integrated bio-entity manipulation and processing device
CA2900708C (en) 2013-03-13 2021-06-15 Opko Diagnostics, Llc Mixing of fluids in fluidic systems
US10234425B2 (en) 2013-03-15 2019-03-19 Qorvo Us, Inc. Thin film bulk acoustic resonator with signal enhancement
AT514210B1 (de) * 2013-04-25 2016-08-15 Greiner Bio-One Gmbh Dispenser-befülltes mikrofluidisches Testsystem und Verfahren dazu
EP3919896B1 (de) 2013-05-23 2024-07-03 Zomedica Biotechnologies LLC Zweiteilige anordnung
GB201318814D0 (en) * 2013-10-24 2013-12-11 Petroleum & Chemical Corp Microfluidic devices and arrangements for supplying such devices with reagents and biological samples
US10346671B2 (en) 2014-08-15 2019-07-09 Diomics Corporation Films for biologic analyte collection and analysis and methods of production and use thereof
EA038479B1 (ru) 2014-12-12 2021-09-03 Опкоу Дайагностикс, Ллк Устройство для проведения анализа пробы и способ эксплуатации указанного устройства
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
CA3005084A1 (en) 2015-12-11 2017-06-15 Opko Diagnostics, Llc Fluidic systems involving incubation of samples and/or reagents
WO2018146699A1 (en) * 2017-02-07 2018-08-16 Shilps Sciences Private Limited A system for microdroplet manipulation
EP3381560A1 (de) * 2017-03-28 2018-10-03 Eppendorf AG Verfahren und dosiervorrichtung zum kontaktdosieren von flüssigkeiten
CN115722286A (zh) * 2017-07-18 2023-03-03 分子装置有限公司 具有基于成像的移液管吸头定位的对象挑取设备
WO2019136319A1 (en) * 2018-01-05 2019-07-11 Worcester Polytechnic Institute Modular robotic systems for delivering fluid to microfluidic devices
US11541385B2 (en) 2018-07-06 2023-01-03 Qorvo Us, Inc. Methods of measuring hematocrit in fluidic channels including conductivity sensor
CN112384797A (zh) 2018-07-06 2021-02-19 Qorvo美国公司 动态范围增加的体声波谐振器
GB201905181D0 (en) * 2019-04-11 2019-05-29 Arrayjet Ltd Method and apparatus for substrate handling and printing
CN110787848B (zh) * 2019-11-13 2021-05-04 南京理工大学 一种微流控进样系统
US12531225B2 (en) * 2020-05-22 2026-01-20 Dh Technologies Development Pte. Ltd. Overflow sensor for open port sampling probe
CN115668441A (zh) 2020-05-22 2023-01-31 Dh科技发展私人贸易有限公司 用于开放端口采样探头的高流速冲洗
EP4749260A1 (de) * 2024-11-26 2026-05-27 TECAN Trading AG Hängetropfenbeschichtung
CN119909778B (zh) * 2025-01-22 2025-11-04 北京工业大学 一种微流控芯片及其进行双气相自由基同时富集的方法

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4077845A (en) 1977-04-20 1978-03-07 Miles Laboratories, Inc. Disposable inoculation device and process of using same
US4298345A (en) * 1977-11-21 1981-11-03 Damon Corporation Method and apparatus for chemical spot test analysis
US4520086A (en) * 1980-11-18 1985-05-28 The United States Of America As Represented By The United States Department Of Energy Rechargeable solid polymer electrolyte battery cell
US4452903A (en) * 1981-02-17 1984-06-05 Lee Jin P Assay method and reagent kit means for lipid-containing body fluid
JPS57208998A (en) * 1981-06-17 1982-12-22 Fuji Photo Film Co Ltd Multi-layered analytical film for determination of transaminase
DK429682A (da) 1982-09-28 1984-03-29 Inflow Aps Integrerede mikroroersystemer til kontinuerlig gennemstroemningsanalyse
US6265176B1 (en) * 1985-10-29 2001-07-24 Cordis Corporation Dot immunoassay on plastic sheets
US5188963A (en) 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
US5720928A (en) * 1988-09-15 1998-02-24 New York University Image processing and analysis of individual nucleic acid molecules
US6610256B2 (en) * 1989-04-05 2003-08-26 Wisconsin Alumni Research Foundation Image processing and analysis of individual nucleic acid molecules
US5126022A (en) 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
CH679952A5 (de) 1990-03-20 1992-05-15 Ciba Geigy Ag
ATE154981T1 (de) 1990-04-06 1997-07-15 Perkin Elmer Corp Automatisiertes labor für molekularbiologie
JPH04160356A (ja) 1990-10-24 1992-06-03 Shimadzu Corp キャピラリー電気泳動装置の試料注入装置
US6017722A (en) * 1991-04-04 2000-01-25 Board Of Regents, The University Of Texas System Luminous bacteria and methods for the isolation, identification and quantitation of toxicants
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
JPH06508441A (ja) * 1992-03-26 1994-09-22 アスラブ　ソシエテ　アノニム エネルギー源を有し光電池により構成されるホロロジカルピース
CH686206A5 (it) * 1992-03-26 1996-01-31 Asulab Sa Cellule photoelectrochimique regeneratrice transparente.
US5302264A (en) 1992-09-02 1994-04-12 Scientronix, Inc. Capillary eletrophoresis method and apparatus
US5443988A (en) * 1992-09-02 1995-08-22 Fuji Photo Film Co., Ltd. Method for high speed analysis of a dry analytical element
JPH06265447A (ja) 1993-03-16 1994-09-22 Hitachi Ltd 微量反応装置およびこれを使用する微量成分測定装置
JP3741439B2 (ja) * 1993-10-21 2006-02-01 アボット・ラボラトリーズ 流体サンプルの移送装置及び方法
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US7323298B1 (en) * 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US5516487A (en) * 1994-06-22 1996-05-14 Isolab, Inc. Absorbent paper for liquid sampling and impregnated paper calibrators and controls
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5677197A (en) * 1994-11-14 1997-10-14 Hewlett-Packard Company Biochemical assay plate and method for making the same
US5560811A (en) 1995-03-21 1996-10-01 Seurat Analytical Systems Incorporated Capillary electrophoresis apparatus and method
US5922534A (en) * 1995-03-28 1999-07-13 Hewlett-Packard Company Dry biochemical assay plate and method for making the same
US5811306A (en) * 1995-09-04 1998-09-22 Fuji Photo Film Co., Ltd. Liquid spotting method
US6399023B1 (en) * 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5766959A (en) * 1996-05-24 1998-06-16 The Dow Chemical Company Method for determining a component using a liquid film or droplet
CN1173776C (zh) * 1996-06-28 2004-11-03 卡钳技术有限公司 在微规模流体性设备里的高通过量的筛选分析系统
JP3361530B2 (ja) * 1996-06-28 2003-01-07 カリパー・テクノロジーズ・コープ． 電子ピペッタおよび電気泳動バイアスのための補償手段
US5779868A (en) 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
JP2882377B2 (ja) 1996-08-23 1999-04-12 日本電気株式会社 金属の回収容器及び金属の回収方法
ATE290205T1 (de) * 1996-12-12 2005-03-15 Prolume Ltd Vorrichtung und verfahren zum nachweis und identifizieren von infektiösen wirkstoffen
US5890745A (en) 1997-01-29 1999-04-06 The Board Of Trustees Of The Leland Stanford Junior University Micromachined fluidic coupler
US6235471B1 (en) * 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
CA2284612A1 (en) * 1997-04-04 1998-10-15 Michael Knapp Closed-loop biochemical analyzers
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US5876675A (en) * 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
DE19754978C2 (de) * 1997-12-11 2000-07-13 Bruker Daltonik Gmbh Probenträger für die MALDI-Massenspektrometrie nebst Verfahren zur Herstellung der Platten und zum Aufbringen der Proben
US6790652B1 (en) * 1998-01-08 2004-09-14 Bioimage A/S Method and apparatus for high density format screening for bioactive molecules
US6722395B2 (en) * 1998-01-13 2004-04-20 James W. Overbeck Depositing fluid specimens on substrates, resulting ordered arrays, techniques for analysis of deposited arrays
US20040126895A1 (en) * 1998-01-13 2004-07-01 James W. Overbeck Depositing fluid specimens on substrates, resulting ordered arrays, techniques for analysis of deposited arrays
WO1999039829A1 (en) * 1998-02-04 1999-08-12 Merck & Co., Inc. Virtual wells for use in high throughput screening assays
US6756019B1 (en) * 1998-02-24 2004-06-29 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6274089B1 (en) * 1998-06-08 2001-08-14 Caliper Technologies Corp. Microfluidic devices, systems and methods for performing integrated reactions and separations
US6306590B1 (en) * 1998-06-08 2001-10-23 Caliper Technologies Corp. Microfluidic matrix localization apparatus and methods
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
ATE253126T1 (de) * 1998-08-25 2003-11-15 Univ Washington Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
US20010039010A1 (en) * 1998-09-03 2001-11-08 Leigh Alexander Burgoyne Sample collection medium incorporating material for sample visualization
US6103199A (en) 1998-09-15 2000-08-15 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
US6149787A (en) * 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6086740A (en) 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
US6296702B1 (en) * 1999-03-15 2001-10-02 Pe Corporation (Ny) Apparatus and method for spotting a substrate
JP3984748B2 (ja) * 1999-03-17 2007-10-03 株式会社日立製作所 化学分析装置と化学分析システム
US6245297B1 (en) * 1999-04-16 2001-06-12 Pe Corporation (Ny) Apparatus and method for transferring small volumes of substances
US6306599B1 (en) * 1999-07-16 2001-10-23 Agilent Technologies Inc. Biopolymer arrays and their fabrication
JP2001186880A (ja) * 1999-10-22 2001-07-10 Ngk Insulators Ltd Ｄｎａチップの製造方法
US20020151040A1 (en) * 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
IL142026A (en) * 2000-03-14 2008-04-13 Yissum Res Dev Co IN VITRO DEVELOPMENT FACILITY AND METHOD
US6805998B2 (en) * 2000-03-24 2004-10-19 Cymbet Corporation Method and apparatus for integrated-battery devices
WO2001083825A2 (en) * 2000-05-04 2001-11-08 The Center For Blood Research, Inc. Colloid compositions for solid phase biomolecular analytical systems
US7024281B1 (en) * 2000-12-11 2006-04-04 Callper Life Sciences, Inc. Software for the controlled sampling of arrayed materials
US6605438B1 (en) * 2001-03-26 2003-08-12 Louis Dischler Lyophilizing of liquid drops having arbitrary edges and application thereof to microarrays of biological reagents
US7314595B2 (en) * 2001-05-03 2008-01-01 Affymetrix, Inc. High throughput microarray spotting system and method
US7101508B2 (en) * 2002-07-31 2006-09-05 Agilent Technologies, Inc. Chemical array fabrication errors
US7208124B2 (en) * 2002-11-19 2007-04-24 Genetix Limited Microarraying process and apparatus
US20050220675A1 (en) * 2003-09-19 2005-10-06 Reed Mark T High density plate filler
US20060024209A1 (en) * 2004-07-30 2006-02-02 Agnew Brian J Apparatus, methods, and kits for assaying a plurality of fluid samples for a common analyte

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EP1246698A2 (de) 2002-10-09
AU2610201A (en) 2001-07-16
US6620625B2 (en) 2003-09-16
US20010049148A1 (en) 2001-12-06
EP1246698B1 (de) 2006-09-20
WO2001049414A3 (en) 2002-02-21
WO2001049414A2 (en) 2001-07-12
DE60030882D1 (de) 2006-11-02
US20040014239A1 (en) 2004-01-22

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