ATE298890T1 - Gewebeinhibitor der matrix-metalproteinase typ 1 (timp-1) als krebsmarker - Google Patents

Gewebeinhibitor der matrix-metalproteinase typ 1 (timp-1) als krebsmarker

Info

Publication number
ATE298890T1
ATE298890T1 AT00915142T AT00915142T ATE298890T1 AT E298890 T1 ATE298890 T1 AT E298890T1 AT 00915142 T AT00915142 T AT 00915142T AT 00915142 T AT00915142 T AT 00915142T AT E298890 T1 ATE298890 T1 AT E298890T1
Authority
AT
Austria
Prior art keywords
timp
metalproteinase
hibitor
tissue
matrix
Prior art date
Application number
AT00915142T
Other languages
English (en)
Inventor
Mads Holten-Andersen
Ross W Stephens
Hans Jorgen Nielsen
Ib Jarle Christensen
Nils Bruenner
Original Assignee
Rigshospitalet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigshospitalet filed Critical Rigshospitalet
Application granted granted Critical
Publication of ATE298890T1 publication Critical patent/ATE298890T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57515—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the breast
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57535—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • G01N2333/96491—Metalloendopeptidases (3.4.24) with definite EC number
    • G01N2333/96494—Matrix metalloproteases, e. g. 3.4.24.7

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00915142T 1999-04-09 2000-04-10 Gewebeinhibitor der matrix-metalproteinase typ 1 (timp-1) als krebsmarker ATE298890T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199900476 1999-04-09
PCT/DK2000/000170 WO2000062070A2 (en) 1999-04-09 2000-04-10 Tissue inhibitor of matrix metalloproteinases type-1 (timp-1) as a cancer marker

Publications (1)

Publication Number Publication Date
ATE298890T1 true ATE298890T1 (de) 2005-07-15

Family

ID=8093987

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00915142T ATE298890T1 (de) 1999-04-09 2000-04-10 Gewebeinhibitor der matrix-metalproteinase typ 1 (timp-1) als krebsmarker

Country Status (11)

Country Link
US (6) US7108983B1 (de)
EP (2) EP1171771B1 (de)
JP (2) JP4638608B2 (de)
AT (1) ATE298890T1 (de)
AU (1) AU771309B2 (de)
CA (2) CA2652131A1 (de)
DE (1) DE60021068T2 (de)
ES (1) ES2244417T3 (de)
NO (1) NO329725B1 (de)
NZ (1) NZ515311A (de)
WO (1) WO2000062070A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060154245A1 (en) * 1999-04-09 2006-07-13 Rigshospitalet Method for detecting, screening and/or montoring a cancer in individual
US7374886B2 (en) 1999-04-09 2008-05-20 Rigshospitalet Tissue inhibitor of matrix metalloproteinases type-1 (TIMP-1) as a cancer marker and postoperative marker for minimal residual disease or recurrent disease in patients with a prior history of cancer
EP1171771B1 (de) * 1999-04-09 2005-06-29 Rigshospitalet Gewebeinhibitor der matrix-metalproteinase typ 1 (timp-1) als krebsmarker
JP4406206B2 (ja) 2001-04-24 2010-01-27 バイエル コーポレーション ヒトｔｉｍｐ−１抗体
AU2003226925A1 (en) * 2002-04-08 2003-10-27 Hvidovre Hospital Timp-1 as a postoperative marker for recurrent cancer
US20060014224A1 (en) * 2002-09-26 2006-01-19 Hvidovre Hospital Method for detecting, screening and/or monitoring a cancer in an individual
CA2526878A1 (en) * 2003-04-08 2004-10-21 Colotech A/S A method for detection of colorectal cancer in human samples
CA2561835A1 (en) * 2004-03-30 2005-10-13 Den Kgl. Veterinaer-Og Landbohojskole Improvements in cancer treatment and cancer treatment efficacy prediction by blocking and detecting protease inhibitors
US20100196889A1 (en) * 2006-11-13 2010-08-05 Bankaitis-Davis Danute M Gene Expression Profiling for Identification, Monitoring and Treatment of Colorectal Cancer
ES2530209T3 (es) * 2007-02-23 2015-02-27 Physicians Choice Laboratory Services, Llc Métodos diagnósticos dirigidos a intervención clínica
WO2008138522A1 (en) * 2007-05-10 2008-11-20 Roche Diagnostics Gmbh Use of timp-1 as a marker for colorectal cancer
AU2008285557B2 (en) * 2007-07-19 2014-07-03 Biomerieux Method for the assay of liver fatty acid-binding protein, ACE and CA19-9 for the in vitro diagnosis of colorectal cancer
FR2919065B1 (fr) * 2007-07-19 2009-10-02 Biomerieux Sa Procede de dosage de l'apolipoproteine ai pour le diagnostic in vitro du cancer colorectal
FR2919060B1 (fr) * 2007-07-19 2012-11-30 Biomerieux Sa Procede de dosage de l'ezrine pour le diagnostic in vitro du cancer colorectal.
FR2919064B1 (fr) * 2007-07-19 2009-10-02 Biomerieux Sa Procede de dosage de l'apolipoproteine all pour le diagnostic in vitro du cancer colorectal
FR2919062B1 (fr) * 2007-07-19 2009-10-02 Biomerieux Sa Procede de dosage de l'aminoacylase 1 pour le diagnostic in vitro du cancer colorectal.
FR2919063B1 (fr) * 2007-07-19 2009-10-02 Biomerieux Sa Procede de dosage du leucocyte elastase inhibitor pour le diagnostic in vitro du cancer colorectal.
FR2919061B1 (fr) * 2007-07-19 2009-10-02 Biomerieux Sa Procede de dosage de la plastine-i pour le diagnostic in vitro du cancer colorectal.
JP2011510297A (ja) * 2008-01-18 2011-03-31 バトリックス・メディカル・インコーポレイテッド 動脈瘤のための診断バイオマーカー
EP2245459A1 (de) 2008-01-23 2010-11-03 Herlev Hospital Ykl-40 als genereller marker für nichtspezifische erkrankungen
CA2727559A1 (en) * 2008-06-11 2009-12-17 Nils Aage Brunner Selection of colorectal cancer patients for neo-adjuvant and adjuvant systemic anti-cancer treatment
FR2933773B1 (fr) 2008-07-10 2013-02-15 Biomerieux Sa Procede de dosage de la proteine disulfide isomerase pour le diagnostic in vitro du cancer colorectal
AU2009291312A1 (en) 2008-09-15 2010-03-18 Herlev Hospital YKL-40 as a marker for gastrointestinal cancers
DE102009015784A1 (de) * 2009-03-31 2010-12-02 Siemens Aktiengesellschaft In-vitro-Verfahren zur Diagnostik von Tumorerkrankungen
US9141756B1 (en) 2010-07-20 2015-09-22 University Of Southern California Multi-scale complex systems transdisciplinary analysis of response to therapy
JP6182308B2 (ja) * 2012-11-13 2017-08-16 株式会社エイアンドティー 前立腺癌の鑑別診断に用いるための泳動波形データの処理方法
EP3281016A1 (de) 2015-04-10 2018-02-14 Applied Proteomics Inc. Proteinbiomarkertafeln zur detektion von kolorektalkrebs und fortgeschrittenem adenom
US20210148894A1 (en) * 2018-04-13 2021-05-20 Bionomics Limited Method of monitoring response to a treatment
US20220304972A1 (en) * 2019-08-23 2022-09-29 Sumitomo Dainippon Pharma Co., Ltd. Combination therapy and biomarker indicating efficacy thereof
CN121969385A (zh) 2023-09-11 2026-05-01 丹娜-法伯癌症研究院 含有il-2变体以增强car t细胞的功能性的car-衔接子

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US111359A (en) * 1871-01-31 Improvement in sewing-machines
US234776A (en) * 1880-11-23 Belt-coupling
US62070A (en) * 1867-02-12 And jeremiah kimbrough
US2086085A (en) * 1935-05-14 1937-07-06 Handley Page Ltd Aircraft control gear
US3087830A (en) * 1958-12-17 1963-04-30 Schuller Werner Hugo Wilhelm Method and apparatus for producing a dry mat sheet
US3006671A (en) * 1959-08-03 1961-10-31 Gen Precision Inc Internal staking
US6271352B1 (en) 1985-07-12 2001-08-07 Fonden Til Fremme Af Eksperimentel Cancerforskning PAI-1 determination and use thereof
US5356817A (en) * 1988-06-09 1994-10-18 Yale University Methods for detecting the onset, progression and regression of gynecologic cancers
FR2657700A1 (fr) 1990-01-26 1991-08-02 Thomson Csf Modulateur electrooptique spatial et applications.
US5324634A (en) 1992-03-31 1994-06-28 The Research Foundation Of State University Of New York Diagnostic tests measuring gelatinase/inhibitor complexes for detection of aggressive and metastatic cancer
JPH0813654A (ja) 1994-07-01 1996-01-16 Sekisui House Ltd 断熱壁下地パネルの施工構造
US5569458A (en) * 1994-09-14 1996-10-29 Greenberg; Mike Nutritional formula
JPH08136548A (ja) * 1994-11-11 1996-05-31 Morinaga & Co Ltd 泌尿器癌の診断法
JP2864219B2 (ja) * 1995-02-20 1999-03-03 富士薬品工業株式会社 遊離の活性型マトリックスメタロプロテアーゼ類の分別定量法
US5643752A (en) 1996-01-18 1997-07-01 Incyte Pharmaceuticals, Inc. Tissue inhibitor of metalloproteinases
GB9607287D0 (en) 1996-04-09 1996-06-12 British Biotech Pharm Diagnosis method
JPH10287700A (ja) * 1997-04-10 1998-10-27 Fuji Yakuhin Kogyo Kk 活性型マトリライシン（ｍｍｐ−７）に対する抗体及びそれを用いた免疫学的測定法
US5906811A (en) * 1997-06-27 1999-05-25 Thione International, Inc. Intra-oral antioxidant preparations
CN1236102A (zh) 1998-05-20 1999-11-24 徐国光 唾液癌胚抗原快速检测试剂
WO2000020860A1 (en) 1998-10-08 2000-04-13 Calbiochem Novabiochem Corporation Diagnostic assay for matrix metalloproteinase 9 and use thereof
US20060154245A1 (en) 1999-04-09 2006-07-13 Rigshospitalet Method for detecting, screening and/or montoring a cancer in individual
EP1171771B1 (de) 1999-04-09 2005-06-29 Rigshospitalet Gewebeinhibitor der matrix-metalproteinase typ 1 (timp-1) als krebsmarker
US7374886B2 (en) 1999-04-09 2008-05-20 Rigshospitalet Tissue inhibitor of matrix metalloproteinases type-1 (TIMP-1) as a cancer marker and postoperative marker for minimal residual disease or recurrent disease in patients with a prior history of cancer
US6630163B1 (en) * 1999-04-22 2003-10-07 Howard Murad Method of treating dermatological disorders with fruit extracts
BR0013096A (pt) 1999-08-06 2002-05-07 Imi Internat Medical Innovatio Medição espectrofotométrica em análises imunológicos e bioquìmicos com base em cor
US7306643B2 (en) * 2000-01-10 2007-12-11 Sulzer Chemtech Ag Method for introducing additives to liquid metal, ceramic/metallic powder
US7153660B2 (en) 2000-10-13 2006-12-26 Children's Medical Center Corporation Non-invasive enzyme screen for tissue remodelling-associated conditions
WO2002034776A2 (en) 2000-10-26 2002-05-02 K.U.Leuven Research And Development Epitopes of pai-1
EP2357478A3 (de) 2000-11-30 2011-11-16 Crawford Healthcare Holdings Limited Krankheitsdiagnose
JP4406206B2 (ja) 2001-04-24 2010-01-27 バイエル コーポレーション ヒトｔｉｍｐ−１抗体
US6815181B2 (en) 2001-07-09 2004-11-09 Applera Corporation Nucleic acid molecules encoding human secreted hemopexin-related proteins
WO2003053921A2 (en) 2001-07-18 2003-07-03 American Red Cross Mutant proteinase inhibitors and uses thereof
KR100475642B1 (ko) 2001-12-29 2005-03-10 한국생명공학연구원 암 발생 및 전이에 관여하는 단백질의 당쇄 변화를측정하여 암을 진단하는 방법 및 이를 이용한 진단킷트
AU2003226925A1 (en) 2002-04-08 2003-10-27 Hvidovre Hospital Timp-1 as a postoperative marker for recurrent cancer
EP1382969A1 (de) 2002-07-17 2004-01-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Diagnose und Behandlung der Invasion von Krebszellen
US20060014224A1 (en) 2002-09-26 2006-01-19 Hvidovre Hospital Method for detecting, screening and/or monitoring a cancer in an individual
JP2004198419A (ja) 2002-12-13 2004-07-15 Bayer Healthcare Llc Ｔｉｍｐ１を用いた検出方法
ATE511550T1 (de) 2003-07-17 2011-06-15 Pacific Edge Biotechnology Ltd Marker zum nachweis von magenkrebs
CA2561835A1 (en) * 2004-03-30 2005-10-13 Den Kgl. Veterinaer-Og Landbohojskole Improvements in cancer treatment and cancer treatment efficacy prediction by blocking and detecting protease inhibitors

Also Published As

Publication number Publication date
US7108983B1 (en) 2006-09-19
EP1619206A3 (de) 2006-02-15
JP2010266455A (ja) 2010-11-25
US20110060529A1 (en) 2011-03-10
NO329725B1 (no) 2010-12-06
JP4638608B2 (ja) 2011-02-23
ES2244417T3 (es) 2005-12-16
US7807379B2 (en) 2010-10-05
CA2652131A1 (en) 2000-10-19
US20070020707A1 (en) 2007-01-25
AU771309B2 (en) 2004-03-18
CA2366682A1 (en) 2000-10-19
US20110294148A1 (en) 2011-12-01
US20080261246A1 (en) 2008-10-23
EP1171771B1 (de) 2005-06-29
EP1171771A2 (de) 2002-01-16
DE60021068T2 (de) 2006-05-18
NO20014869L (no) 2001-12-04
AU3655600A (en) 2000-11-14
JP2002541481A (ja) 2002-12-03
NZ515311A (en) 2002-11-26
WO2000062070A2 (en) 2000-10-19
CA2366682C (en) 2009-06-23
US20090035794A1 (en) 2009-02-05
EP1619206A2 (de) 2006-01-25
WO2000062070A3 (en) 2001-01-25
DE60021068D1 (de) 2005-08-04
NO20014869D0 (no) 2001-10-05

Similar Documents

Publication Publication Date Title
DE60021068D1 (de) Gewebeinhibitor der matrix-metalproteinase typ 1 (timp-1) als krebsmarker
ATE283485T1 (de) Verfahren zur diagnose und zur charakterisierung von schlaganfall
ATE438737T1 (de) Verfahren für den nachweis von erkrankungen
FI904534A0 (fi) Foerfarande och anordning foer amperometrisk diagnosanalys.
DE69941429D1 (de) 1-deoxy-galactonojirimycin-derivate zur vewendung bei der behandlung von lysosomalen speicherkrankheiten mittels steigerung der lysosomalen alpha galactosidase a
ES2107465T3 (es) Ensayo antioxidante.
ATE412749T1 (de) Chemisch modifizierter gewebeinhibitor für metalloproteasen type 3 (timp-3)
ATE302286T1 (de) Sequenzierungsverfahren mit signalverstärkern
AU4694499A (en) Trace level detection of analytes using artificial olfactometry
ATE532070T1 (de) Entzündungsmarker zum nachweis und zur prävention von diabetes mellitus
ATE179459T1 (de) Verfahren zur typisierung von hcv-isolaten
PT1058738E (pt) Metodo de seleccao por via de polarizacao de fluorescencia
DE60036536D1 (de) Verfahren zur diagnose von endometriose
WO2001063293A8 (en) Diagnosis and treatment of schizophrenia
WO2001090408A3 (fr) Detection et caracterisation de l'activite de proteines impliquees dans la reparation de lesions de l'adn
BR0115689A (pt) Análise de expressão de inibidor de diferenciação de ácidos nucléicos e polipeptìdeos úteis na diagnose e tratamento de câncer da próstata
ATE414784T1 (de) Blut- und urintest
DK0760482T3 (da) Metode til bedømmelse af udryddelse af H. Pylori på basis af graden af ændringer i pepsinogen I/II-forholdet
DE60137368D1 (de) Marker für therapie mit antidepressiva und damit in zusammenhang stehende verfahren
EP1445327A4 (de) Screeningverfahren für einen auf die zellwand wirkenden arzneistoff
ATE481498T1 (de) Verfahren zur messung von neprilysinaktivität
ATE306559T1 (de) Verfahren zum screenen von verbindungen mit bioaktivität in organgeweben
GB0016460D0 (en) Assay
ATE195151T1 (de) Verfahren zur bewertung von substanzen zum steigen bzw. zur modifizierung der apc-aktivität
DE69003323D1 (de) Flüssige zubereitung für intraokulare perfusion.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties