ATE481498T1 - Verfahren zur messung von neprilysinaktivität - Google Patents

Verfahren zur messung von neprilysinaktivität

Info

Publication number
ATE481498T1
ATE481498T1 AT03747225T AT03747225T ATE481498T1 AT E481498 T1 ATE481498 T1 AT E481498T1 AT 03747225 T AT03747225 T AT 03747225T AT 03747225 T AT03747225 T AT 03747225T AT E481498 T1 ATE481498 T1 AT E481498T1
Authority
AT
Austria
Prior art keywords
activity
neprilysin
measuring
present
expression
Prior art date
Application number
AT03747225T
Other languages
English (en)
Inventor
Takaomi Saido
Nobuhisa Iwata
Satoshi Tsubuki
Yoshie Takaki
Takashi Saito
Tadashi Nakaya
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Application granted granted Critical
Publication of ATE481498T1 publication Critical patent/ATE481498T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT03747225T 2002-04-26 2003-04-24 Verfahren zur messung von neprilysinaktivität ATE481498T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002126257 2002-04-26
JP2002261250 2002-09-06
PCT/JP2003/005239 WO2003091449A1 (fr) 2002-04-26 2003-04-24 Methode de mesure de l'activite de la neprilysine

Publications (1)

Publication Number Publication Date
ATE481498T1 true ATE481498T1 (de) 2010-10-15

Family

ID=29272368

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03747225T ATE481498T1 (de) 2002-04-26 2003-04-24 Verfahren zur messung von neprilysinaktivität

Country Status (7)

Country Link
US (2) US7572574B2 (de)
EP (1) EP1500707B1 (de)
AT (1) ATE481498T1 (de)
AU (1) AU2003235113A1 (de)
CA (1) CA2483525C (de)
DE (1) DE60334200D1 (de)
WO (1) WO2003091449A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090023794A1 (en) * 2005-10-21 2009-01-22 Caritas St. Elizabeth Medical Center Of Boston, Inc. Use of Sumoylation Inhibitors for the Treatment of Neurodegenerative Disease
JP5846608B2 (ja) * 2010-03-03 2016-01-20 国立大学法人京都大学 ｉＰＳ細胞由来の神経細胞を用いた蛋白質ミスフォールディング病の診断方法
US9074238B2 (en) 2011-05-08 2015-07-07 Academia Sinica Methods for enhancing neprilysin activity and degrading amyloid-beta peptides and oligomers in a subject with Alzheimer's disease
JP7099717B2 (ja) * 2019-09-30 2022-07-12 株式会社理研バイオ ソマトスタチン受容体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU646635B2 (en) * 1989-03-07 1994-03-03 Syngene, Inc. In-situ hybridization in suspension for detection or separation of cells
IE76319B1 (en) 1990-07-23 1997-10-22 Becton Dickinson Co Preservation of cells as controls or standards in cellular analysis
JP4175678B2 (ja) 1996-06-07 2008-11-05 武田薬品工業株式会社 新規ペプチド、その製造法および用途
CA2260376A1 (en) * 1999-02-11 2000-08-11 Universite De Montreal New metalloproteases of the neprilysin family

Also Published As

Publication number Publication date
EP1500707A1 (de) 2005-01-26
US20060008842A1 (en) 2006-01-12
CA2483525A1 (en) 2003-11-06
AU2003235113A8 (en) 2003-11-10
AU2003235113A1 (en) 2003-11-10
WO2003091449A1 (fr) 2003-11-06
US7572574B2 (en) 2009-08-11
US20090298775A1 (en) 2009-12-03
EP1500707B1 (de) 2010-09-15
EP1500707A4 (de) 2007-05-09
CA2483525C (en) 2013-01-22
DE60334200D1 (de) 2010-10-28

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