ATE299931T1 - Kaliumkanal-proteine zur verwendung in gentherapie zur verminderung von erektiler dysfunktion - Google Patents

Kaliumkanal-proteine zur verwendung in gentherapie zur verminderung von erektiler dysfunktion

Info

Publication number
ATE299931T1
ATE299931T1 AT98906170T AT98906170T ATE299931T1 AT E299931 T1 ATE299931 T1 AT E299931T1 AT 98906170 T AT98906170 T AT 98906170T AT 98906170 T AT98906170 T AT 98906170T AT E299931 T1 ATE299931 T1 AT E299931T1
Authority
AT
Austria
Prior art keywords
smooth muscle
regulation
protein involved
present
dna
Prior art date
Application number
AT98906170T
Other languages
English (en)
Inventor
Jan Geliebter
Arnold Melman
George J Christ
Jamil Rehman
Original Assignee
Einstein Coll Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Einstein Coll Med filed Critical Einstein Coll Med
Application granted granted Critical
Publication of ATE299931T1 publication Critical patent/ATE299931T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11013—Protein kinase C (2.7.11.13)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physics & Mathematics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT98906170T 1997-02-13 1998-02-05 Kaliumkanal-proteine zur verwendung in gentherapie zur verminderung von erektiler dysfunktion ATE299931T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/799,144 US6150338A (en) 1997-02-13 1997-02-13 Gene therapy for alleviating erectile dysfunction
PCT/US1998/002249 WO1998036055A1 (en) 1997-02-13 1998-02-05 Gene therapy for alleviating erectile dysfunction

Publications (1)

Publication Number Publication Date
ATE299931T1 true ATE299931T1 (de) 2005-08-15

Family

ID=25175134

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98906170T ATE299931T1 (de) 1997-02-13 1998-02-05 Kaliumkanal-proteine zur verwendung in gentherapie zur verminderung von erektiler dysfunktion

Country Status (12)

Country Link
US (1) US6150338A (de)
EP (1) EP1005538B1 (de)
JP (1) JP4158163B2 (de)
KR (1) KR100535782B1 (de)
AT (1) ATE299931T1 (de)
AU (1) AU745637B2 (de)
CA (1) CA2280770C (de)
DE (1) DE69830910T2 (de)
DK (1) DK1005538T3 (de)
ES (1) ES2246066T3 (de)
PT (1) PT1005538E (de)
WO (1) WO1998036055A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271211B1 (en) 1997-02-13 2001-08-07 Albert Einstein College Of Medicine Of Yeshiva University Gene therapy for regulating penile smooth muscle tone
US7030096B1 (en) * 1997-02-13 2006-04-18 Albert Einstein College Of Medicine Of Yeshiva University Method of enhancing relaxation of penile smooth muscle by introduction of DNA encoding maxi-K potassium channel protein
DE69936785D1 (de) * 1998-05-01 2007-09-20 Univ Pittsburgh Zellvermittelte genverabreichung durch verwendung von aus muskeln derivierten zellen zur behandlung der knochen-verwandten verletzung oder störung
US7115417B1 (en) 1998-05-01 2006-10-03 Chancellor Michael B Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof
US6866842B1 (en) 1998-05-01 2005-03-15 University Of Pittsburgh Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction
KR20010076961A (ko) * 2000-01-29 2001-08-17 김제종 성기능장애 예방 및 치료용 약제
ATE365045T1 (de) 2000-04-14 2007-07-15 Univ Pittsburgh Vermehrung des weich- sowie des knochengewebes anhand von aus muskeln stammenden vorläuferzellen,sowie damit verbundene zusammensetzungen und behandlungsformen
JP4680483B2 (ja) 2001-02-23 2011-05-11 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 組織および臓器の治療および修復に用いるための幹細胞マトリックスの迅速な調製方法
EP2289526B1 (de) 2003-04-25 2014-06-11 The University of Pittsburgh Muskeln abstammande zellen zur wiederherstellung und regenerierung nach nervenschädigung
CN1621094A (zh) * 2003-11-26 2005-06-01 犹太大学阿尔伯特爱因斯坦医学院 用于调节平滑肌张力的基因转移
EP2118271B1 (de) 2007-01-11 2018-04-18 University of Pittsburgh - Of the Commonwealth System of Higher Education Zellen aus muskeln zur behandlung von harnwegserkrankungen sowie verfahren zu ihrer herstellung und verwendung
US20090042208A1 (en) * 2007-07-31 2009-02-12 Davies Kelvin P Assays for erectile and bladder dysfunction and vascular health
US9199003B2 (en) 2008-08-18 2015-12-01 University of Pittsburgh—of the Commonwealth System of Higher Education Bone augmentation utilizing muscle-derived progenitor compositions in biocompatible matrix, and treatments thereof
KR20210094567A (ko) 2018-11-14 2021-07-29 유로반트 사이언시즈 게엠베하 평활근 기능장애의 치료를 위한 조성물 및 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0686695B1 (de) * 1986-06-27 2006-12-06 Takeda Pharmaceutical Company Limited Rattenproteinkinase C und Verfahren zur Herstellung
US5324651A (en) * 1986-06-27 1994-06-28 Takeda Chemical Industries, Ltd. DNA encoding rat and human protein kinase C
DE3943519A1 (de) * 1989-04-27 1991-01-17 Stief Georg Arzneimittel zur behandlung erektiler dysfunktionen
US5594032A (en) * 1994-11-10 1997-01-14 Gonzalez-Cadavid; Nestor F. Amelioration of human erectile dysfunction by treatment with iNOS, inducers of iNOS or iNOS cDNA

Also Published As

Publication number Publication date
JP2001517935A (ja) 2001-10-09
KR20000071061A (ko) 2000-11-25
US6150338A (en) 2000-11-21
ES2246066T3 (es) 2006-02-01
EP1005538A1 (de) 2000-06-07
CA2280770C (en) 2008-07-08
AU745637B2 (en) 2002-03-28
DE69830910T2 (de) 2006-04-20
CA2280770A1 (en) 1998-08-20
PT1005538E (pt) 2005-11-30
EP1005538B1 (de) 2005-07-20
EP1005538A4 (de) 2002-12-04
WO1998036055A1 (en) 1998-08-20
AU6146898A (en) 1998-09-08
JP4158163B2 (ja) 2008-10-01
DK1005538T3 (da) 2005-11-07
KR100535782B1 (ko) 2005-12-12
DE69830910D1 (de) 2005-08-25

Similar Documents

Publication Publication Date Title
ATE299931T1 (de) Kaliumkanal-proteine zur verwendung in gentherapie zur verminderung von erektiler dysfunktion
EE05138B1 (et) Rekombinantne MVA viirus ja selle kasutamine, isoleeritud eukarootne rakk, meetod rekombinantse HIV Nef-proteiini valmistamiseks ning vaktsiin
ATE325533T1 (de) Verfahren zum verbesserten virusvermittelten dns- transfer unter verwendung von molekülen mit virus-und zellbindenden domänen
IL148021A0 (en) Novel b7-4 molecules and uses therefor
DE69840361D1 (de) Neue knochenmineralisierungsproteine, dna, vektoren, expressionssysteme
EP0752874A4 (de) Ein verstärkter, durch viren vermittelter dna-transfer
ATE342359T1 (de) Design von beta-faltblatt-proteinen mit spezifischen bindungseigenschaften
ZA891067B (en) Pox virus vectors
DE60035517D1 (de) Gl50 moleküle, sowie verwendungen derselben
WO2003042362A8 (en) PGC-1β, A NOVEL PGC-1 HOMOLOGUE AND USES THEREFOR
HUP9800329A2 (hu) Nukleinsavkonstrukciók strukturális gének sejtciklus-függő módon szabályozott expresszálására
IL110039A0 (en) Method for producing enzymatically active human superoxide dismutase in bacteria
RU2000122617A (ru) Самореплицирующийся рекомбинантный вектор, способ его получения, вакцина для иммунизации против вич с помощью днк, содержащая указанный вектор, способ лечения или профилактики вич и клетка-хозяин, содержащая указанный вектор
DE60124910D1 (de) Menschliche twik-8 moleküle und ihre verwendung
DE60137222D1 (de) Humanes trp-ähnliches kalziumkanalprotein-2 tlcc-2
ATE234929T1 (de) Vektor zur expression von therapeutisch relevanten genen
Hirashima et al. Production of functional S-II in Bombyxmori cells
AU2002359572A8 (en) 15603, a human ion channel family member
Thiel et al. Intracellular cleavage of an SSV coded gag-related protein

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1005538

Country of ref document: EP