ATE482713T1 - Von muskeln stammende zellen (mdcs) zur förderung und verbesserung der nervenreparatur und - regeneration - Google Patents
Von muskeln stammende zellen (mdcs) zur förderung und verbesserung der nervenreparatur und - regenerationInfo
- Publication number
- ATE482713T1 ATE482713T1 AT04750822T AT04750822T ATE482713T1 AT E482713 T1 ATE482713 T1 AT E482713T1 AT 04750822 T AT04750822 T AT 04750822T AT 04750822 T AT04750822 T AT 04750822T AT E482713 T1 ATE482713 T1 AT E482713T1
- Authority
- AT
- Austria
- Prior art keywords
- mdcs
- methods
- tissue
- damage
- muscle
- Prior art date
Links
- 210000003205 muscle Anatomy 0.000 title abstract 3
- 210000005036 nerve Anatomy 0.000 title abstract 2
- 230000008929 regeneration Effects 0.000 title 1
- 238000011069 regeneration method Methods 0.000 title 1
- 230000006378 damage Effects 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- 210000001519 tissue Anatomy 0.000 abstract 4
- 208000027418 Wounds and injury Diseases 0.000 abstract 2
- 230000004064 dysfunction Effects 0.000 abstract 2
- 208000014674 injury Diseases 0.000 abstract 2
- 230000030214 innervation Effects 0.000 abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 2
- 210000000056 organ Anatomy 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 208000028389 Nerve injury Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000018109 developmental process Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000008764 nerve damage Effects 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 210000002569 neuron Anatomy 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 210000001428 peripheral nervous system Anatomy 0.000 abstract 1
- 208000027232 peripheral nervous system disease Diseases 0.000 abstract 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 210000002027 skeletal muscle Anatomy 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46584603P | 2003-04-25 | 2003-04-25 | |
| PCT/US2004/013115 WO2004096245A2 (en) | 2003-04-25 | 2004-04-26 | Muscle derived cells (mdcs) for promoting and enhancing nerve repair and regeneration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE482713T1 true ATE482713T1 (de) | 2010-10-15 |
Family
ID=33418304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04750822T ATE482713T1 (de) | 2003-04-25 | 2004-04-26 | Von muskeln stammende zellen (mdcs) zur förderung und verbesserung der nervenreparatur und - regeneration |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9617516B2 (de) |
| EP (2) | EP2289526B1 (de) |
| CN (2) | CN103230415B (de) |
| AT (1) | ATE482713T1 (de) |
| DE (1) | DE602004029349D1 (de) |
| ES (1) | ES2354304T3 (de) |
| WO (1) | WO2004096245A2 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7115417B1 (en) | 1998-05-01 | 2006-10-03 | Chancellor Michael B | Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof |
| US6866842B1 (en) | 1998-05-01 | 2005-03-15 | University Of Pittsburgh | Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction |
| AU5159901A (en) * | 2000-04-14 | 2001-10-30 | Univ Pittsburgh | Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof |
| US20020155096A1 (en) * | 2001-02-23 | 2002-10-24 | Chancellor Michael B. | Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair |
| ATE482713T1 (de) | 2003-04-25 | 2010-10-15 | Univ Pittsburgh | Von muskeln stammende zellen (mdcs) zur förderung und verbesserung der nervenreparatur und - regeneration |
| EP1924276A4 (de) * | 2005-08-05 | 2009-07-22 | Araim Pharmaceuticals Inc | Gewebeschützende peptide und ihre verwendungszwecke |
| CU23526B6 (es) | 2006-10-03 | 2010-05-19 | Ct Ingenieria Genetica Biotech | Método para la restauración morfofuncional de nervios periféricos en la neuropatía diabética |
| US20100158875A1 (en) | 2006-12-18 | 2010-06-24 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Muscle derived cells for the treatment of gastro-esophageal pathologies and methods of making and using the same |
| ES2678416T3 (es) * | 2007-01-11 | 2018-08-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Células derivadas de músculo para el tratamiento de patologías de las vías urinarias y métodos de fabricación y uso de las mismas |
| EP2328596B1 (de) * | 2008-08-18 | 2019-03-06 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Knochenaufbau anhand von vorläuferzusammensetzungen aus muskeln in biokompatibler matrix und behandlungen |
| GB2463861B (en) | 2008-09-10 | 2012-09-26 | Univ Manchester | Medical device |
| EP2680864B1 (de) | 2011-03-03 | 2019-05-08 | Ramot at Tel-Aviv University Ltd. | Genetisch modifizierte muskelzellen mit expression von neurotrophen faktoren |
| WO2016039339A1 (ja) * | 2014-09-08 | 2016-03-17 | 国立大学法人大阪大学 | 脱髄疾患の予防又は治療剤 |
| GB201518263D0 (en) * | 2015-10-15 | 2015-12-02 | Oxford Bioelectronics Ltd | Method |
| US10064938B2 (en) | 2016-03-11 | 2018-09-04 | University Of Wyoming | Localized immunosuppression of allografts for peripheral nerve repair |
| CN105907709A (zh) * | 2016-04-08 | 2016-08-31 | 王晓冰 | 一种原代小鼠或大鼠骨骼肌细胞的分离培养方法 |
| US11413316B2 (en) * | 2016-11-18 | 2022-08-16 | Societe Des Produits Nestle S.A. | In vitro production of muscle stem cells |
| KR102780297B1 (ko) * | 2017-12-14 | 2025-03-12 | 이노바셀 바이오테크놀로지 아게 | 근육 유래 세포를 수득하는 방법 |
| CN108048396A (zh) * | 2017-12-29 | 2018-05-18 | 山西农业大学 | 一种绵羊肌肉干细胞的分离方法 |
| US11376219B2 (en) | 2018-07-30 | 2022-07-05 | University Of Wyoming | Localized immunosuppression of allografts for peripheral nerve repair |
| CN110859854A (zh) * | 2018-08-08 | 2020-03-06 | 上海市东方医院 | 治疗神经源性肌肉萎缩的药物组合物及其制法和应用 |
| CN111494422B (zh) * | 2019-01-29 | 2022-04-29 | 中国科学院遗传与发育生物学研究所 | 治疗脊髓损伤的产品及其应用 |
| CN109847069A (zh) * | 2019-02-01 | 2019-06-07 | 广东医科大学 | 用于修复臂丛撕脱神经损伤的水凝胶包裹HIF-1α过表达慢病毒载体复合物及制备方法 |
| KR20220002315A (ko) | 2019-03-22 | 2022-01-06 | 이노바셀 아게 | 유도된 평활근 세포를 수득하는 방법 |
| CN110917217B (zh) * | 2019-12-25 | 2021-07-27 | 苏州大学 | 肌肉干细胞在制备抗炎药物中的应用 |
| JP2025529176A (ja) | 2022-09-02 | 2025-09-04 | ウニベルシタット チューリッヒ | 注射装置 |
| EP4627056A1 (de) | 2022-12-01 | 2025-10-08 | Universität Zürich | Verfahren zur herstellung einer massenkultur von muskelvorläuferzellen (mps) und verwendungen davon |
| CN117379532B (zh) * | 2023-11-02 | 2024-09-10 | 徐州医科大学附属医院 | 破伤风类毒素在促进个体长皮瓣生长中的应用 |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4424208A (en) * | 1982-01-11 | 1984-01-03 | Collagen Corporation | Collagen implant material and method for augmenting soft tissue |
| US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| US5510254A (en) * | 1986-04-18 | 1996-04-23 | Advanced Tissue Sciences, Inc. | Three dimensional cell and tissue culture system |
| US5863531A (en) * | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
| US5902741A (en) * | 1986-04-18 | 1999-05-11 | Advanced Tissue Sciences, Inc. | Three-dimensional cartilage cultures |
| US5266480A (en) * | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
| US5026365A (en) * | 1987-04-29 | 1991-06-25 | The University Of Massachusetts | Method and apparatus for therapeutically treating immunological disorders and disease states |
| US5053050A (en) * | 1988-04-29 | 1991-10-01 | Samuel Itay | Compositions for repair of cartilage and bone |
| US5130141A (en) * | 1988-05-24 | 1992-07-14 | Law Peter K | Compositions for and methods of treating muscle degeneration and weakness |
| US5082670A (en) | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
| US5045601A (en) * | 1989-06-13 | 1991-09-03 | Biointerface Technologies, Inc. | Pressure-sensitive adhesive compositions suitable for medical uses |
| US5538722A (en) | 1989-06-13 | 1996-07-23 | Stanford University | Isolation, growth, differentiation and genetic engineering of human muscle cells |
| WO1991007992A1 (en) | 1989-11-24 | 1991-06-13 | Monash University | Proliferative action of leukaemia inhibitory factor on satellite cells |
| US5206028A (en) * | 1991-02-11 | 1993-04-27 | Li Shu Tung | Dense collagen membrane matrices for medical uses |
| US6497872B1 (en) | 1991-07-08 | 2002-12-24 | Neurospheres Holdings Ltd. | Neural transplantation using proliferated multipotent neural stem cells and their progeny |
| JP3004724B2 (ja) * | 1992-04-06 | 2000-01-31 | ユーロプラスティ インコーポレイテッド | ミクロ粒子注入による逆流障害の処置 |
| EP0663951B1 (de) | 1992-09-28 | 2002-06-05 | Brown University Research Foundation | Chitozanmatrizes für eingekapselte zellen |
| JP2995090B2 (ja) | 1993-03-19 | 1999-12-27 | キユー・メド・アクチエボラーグ | 組織増大のための組成物および方法 |
| US5709854A (en) | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
| US6001654A (en) * | 1994-01-28 | 1999-12-14 | California Institute Of Technology | Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factors |
| US5656478A (en) * | 1994-02-25 | 1997-08-12 | The Regents Of The University Of California | Smooth muscle tissue formation in vivo using cultured smooth muscle cells combined with an extracellular matrix |
| US6174333B1 (en) * | 1994-06-06 | 2001-01-16 | Osiris Therapeutics, Inc. | Biomatrix for soft tissue regeneration using mesenchymal stem cells |
| US5516532A (en) * | 1994-08-05 | 1996-05-14 | Children's Medical Center Corporation | Injectable non-immunogenic cartilage and bone preparation |
| US5594032A (en) * | 1994-11-10 | 1997-01-14 | Gonzalez-Cadavid; Nestor F. | Amelioration of human erectile dysfunction by treatment with iNOS, inducers of iNOS or iNOS cDNA |
| EP1407788A2 (de) | 1994-12-13 | 2004-04-14 | Peter K. Law | Myoblast-Therapie für Säugetierkrankheiten |
| US7141072B2 (en) * | 1998-10-05 | 2006-11-28 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Method for promoting regeneration of surface cartilage in a damaged joint using multi-layer covering |
| US5833978A (en) * | 1995-03-16 | 1998-11-10 | Universite Laval | Method of in vitro preconditioning healthy donor's myoblasts before transplantation thereof in compatible patients suffering of recessive myopathies like muscular dystrophy, for improving transplantation success |
| US5733337A (en) * | 1995-04-07 | 1998-03-31 | Organogenesis, Inc. | Tissue repair fabric |
| US6121042A (en) * | 1995-04-27 | 2000-09-19 | Advanced Tissue Sciences, Inc. | Apparatus and method for simulating in vivo conditions while seeding and culturing three-dimensional tissue constructs |
| US5855610A (en) * | 1995-05-19 | 1999-01-05 | Children's Medical Center Corporation | Engineering of strong, pliable tissues |
| EP0852463B1 (de) | 1995-06-06 | 2008-09-03 | Case Western Reserve University | Myogene differenzierung menschlicher mesenchymaler stammzellen |
| US5591444A (en) * | 1995-07-28 | 1997-01-07 | Isolagen Technologies, Inc. | Use of autologous dermal fibroblasts for the repair of skin and soft tissue defects |
| US5869041A (en) * | 1996-01-12 | 1999-02-09 | The Miriam Hospital | Delivery of bioactive compounds to an organism |
| US6200606B1 (en) * | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
| US5858351A (en) * | 1996-01-18 | 1999-01-12 | Avigen, Inc. | Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors |
| US5876447A (en) * | 1996-02-14 | 1999-03-02 | Implantech Associates | Silicone implant for facial plastic surgery |
| US5842477A (en) * | 1996-02-21 | 1998-12-01 | Advanced Tissue Sciences, Inc. | Method for repairing cartilage |
| US6299905B1 (en) * | 1996-04-16 | 2001-10-09 | Depuy Orthopaedics, Inc. | Bioerodable polymeric adhesives for tissue repair |
| US5895745A (en) * | 1996-09-25 | 1999-04-20 | W.R. Grace & Co.-Conn. | Method of thawing cryopreserved cells |
| US6150338A (en) | 1997-02-13 | 2000-11-21 | Albert Einstein College Of Medicine Of Yeshiva University | Gene therapy for alleviating erectile dysfunction |
| WO1998044142A1 (en) | 1997-04-01 | 1998-10-08 | The General Hospital Corporation | Molecular marker for muscle stem cells |
| US6110459A (en) | 1997-05-28 | 2000-08-29 | Mickle; Donald A. G. | Transplants for myocardial scars and methods and cellular preparations |
| US6099832A (en) * | 1997-05-28 | 2000-08-08 | Genzyme Corporation | Transplants for myocardial scars |
| US20020068048A1 (en) * | 1997-09-05 | 2002-06-06 | Patrick A. Dreyfus | Method for the treatment or diagnosis of human pathologies with disseminated or difficult to access cells or tissues |
| US6171340B1 (en) * | 1998-02-27 | 2001-01-09 | Mcdowell Charles L. | Method and device for regenerating cartilage in articulating joints |
| CA2322954C (en) * | 1998-03-06 | 2011-06-07 | Biosepra Inc. | Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles |
| DE69922933T2 (de) | 1998-03-13 | 2005-12-29 | Osiris Therapeutics, Inc. | Anwendungen für humane nicht autologe, mesenchymale stammzellen |
| WO1999047163A2 (en) | 1998-03-18 | 1999-09-23 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
| US7115417B1 (en) * | 1998-05-01 | 2006-10-03 | Chancellor Michael B | Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof |
| US8211423B2 (en) * | 2006-11-28 | 2012-07-03 | University Of Pittsburgh | Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same |
| US6866842B1 (en) * | 1998-05-01 | 2005-03-15 | University Of Pittsburgh | Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction |
| DE69939956D1 (de) * | 1998-05-01 | 2009-01-02 | Univ Pittsburgh | Verwendung von Myoblasten zur Herstellung eines Medikaments zur Behandlung der stressbedingten Harninkontinenz |
| WO1999056786A1 (de) | 1998-05-05 | 1999-11-11 | Institut für Diagnostikforschung GmbH an der Freien Universität Berlin | Diagnostisches mittel 2 oder 3 komponenten für die mr-diagnostik |
| ATE424147T1 (de) * | 1998-06-05 | 2009-03-15 | Organogenesis Inc | Biotechnisch erzeugte gefässprothese für die implantation |
| US6190893B1 (en) | 1998-09-18 | 2001-02-20 | Massachusetts Institute Of Technology | Electroactive materials for stimulation of biological activity of bone marrow stromal cells |
| WO2000029552A1 (en) | 1998-11-16 | 2000-05-25 | Osiris Therapeutics, Inc. | Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells |
| JP2000287683A (ja) * | 1999-04-08 | 2000-10-17 | Frontier:Kk | ニューロン生存活性を有する筋由来成分およびrna |
| US6328762B1 (en) * | 1999-04-27 | 2001-12-11 | Sulzer Biologics, Inc. | Prosthetic grafts |
| US6306424B1 (en) * | 1999-06-30 | 2001-10-23 | Ethicon, Inc. | Foam composite for the repair or regeneration of tissue |
| AU763021B2 (en) * | 1999-09-14 | 2003-07-10 | Children's Medical Center Corporation | Isolation of muscle-derived stem cells and uses therefor |
| CA2390794C (en) * | 1999-12-03 | 2010-04-27 | University Of Leeds | Fixation technology |
| US6368859B1 (en) * | 1999-12-29 | 2002-04-09 | Children's Medical Center Corporation | Methods and compositions for producing a fascial sling |
| AU5159901A (en) * | 2000-04-14 | 2001-10-30 | Univ Pittsburgh | Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof |
| AU2006202380B2 (en) | 2000-04-14 | 2007-06-21 | University Of Pittsburgh | Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof |
| AU2001257115B2 (en) * | 2000-04-20 | 2005-01-27 | Rtp Pharma Inc. | Improved water-insoluble drug particle process |
| FR2810045B1 (fr) * | 2000-06-07 | 2004-09-03 | Assist Publ Hopitaux De Paris | Procede d'obtention de population cellulaires caracterisees d'origine musculaire et utilisations |
| EP1341475A1 (de) * | 2000-12-01 | 2003-09-10 | Nephros Therapeutics, Inc. | Gerät zur konditionierung von intravaskulärem blut |
| US20020155096A1 (en) | 2001-02-23 | 2002-10-24 | Chancellor Michael B. | Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair |
| ATE482713T1 (de) | 2003-04-25 | 2010-10-15 | Univ Pittsburgh | Von muskeln stammende zellen (mdcs) zur förderung und verbesserung der nervenreparatur und - regeneration |
| NZ553695A (en) * | 2004-08-16 | 2009-10-30 | Cellres Corp Pte Ltd | Isolation of stem/progenitor cells from amniotic membrane of umbilical cord |
| JP2008545008A (ja) * | 2005-06-30 | 2008-12-11 | プロシディオン・リミテッド | Gpcrアゴニスト |
| JP5347214B2 (ja) | 2006-06-12 | 2013-11-20 | 東京エレクトロン株式会社 | 載置台構造及び熱処理装置 |
| WO2008076435A1 (en) | 2006-12-18 | 2008-06-26 | University Of Pittsburgh | Muscle derived cells for the treatment of gastro-esophageal pathologies and methods of making and using the same |
| ES2678416T3 (es) | 2007-01-11 | 2018-08-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Células derivadas de músculo para el tratamiento de patologías de las vías urinarias y métodos de fabricación y uso de las mismas |
| US20090155221A1 (en) | 2007-05-29 | 2009-06-18 | Thomas Payne | Bone augmentation utilizing muscle-derived progenitor compositions, and treatments thereof |
| JP5687059B2 (ja) | 2007-10-04 | 2015-03-18 | ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | 筋肉誘導前駆体組成物を利用した骨格筋の強化およびその処置 |
| EP2328596B1 (de) | 2008-08-18 | 2019-03-06 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Knochenaufbau anhand von vorläuferzusammensetzungen aus muskeln in biokompatibler matrix und behandlungen |
-
2004
- 2004-04-26 AT AT04750822T patent/ATE482713T1/de active
- 2004-04-26 EP EP10179058.2A patent/EP2289526B1/de not_active Expired - Lifetime
- 2004-04-26 DE DE602004029349T patent/DE602004029349D1/de not_active Expired - Lifetime
- 2004-04-26 CN CN201210499640.2A patent/CN103230415B/zh not_active Expired - Fee Related
- 2004-04-26 US US10/832,542 patent/US9617516B2/en not_active Expired - Lifetime
- 2004-04-26 ES ES04750822T patent/ES2354304T3/es not_active Expired - Lifetime
- 2004-04-26 EP EP04750822A patent/EP1617852B1/de not_active Expired - Lifetime
- 2004-04-26 CN CN2004800180352A patent/CN1812800B/zh not_active Expired - Fee Related
- 2004-04-26 WO PCT/US2004/013115 patent/WO2004096245A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN103230415A (zh) | 2013-08-07 |
| WO2004096245A3 (en) | 2005-02-10 |
| US20050238625A1 (en) | 2005-10-27 |
| CN1812800A (zh) | 2006-08-02 |
| EP2289526A1 (de) | 2011-03-02 |
| EP1617852A2 (de) | 2006-01-25 |
| US9617516B2 (en) | 2017-04-11 |
| DE602004029349D1 (de) | 2010-11-11 |
| CN103230415B (zh) | 2016-05-04 |
| WO2004096245A2 (en) | 2004-11-11 |
| EP1617852B1 (de) | 2010-09-29 |
| CN1812800B (zh) | 2013-01-16 |
| EP2289526B1 (de) | 2014-06-11 |
| ES2354304T3 (es) | 2011-03-11 |
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