ATE300051T1 - Test zum nachweis von prionen-proteinen die in einer mit krankheit assoziierten konformationen vorliegen - Google Patents

Test zum nachweis von prionen-proteinen die in einer mit krankheit assoziierten konformationen vorliegen

Info

Publication number
ATE300051T1
ATE300051T1 AT99951770T AT99951770T ATE300051T1 AT E300051 T1 ATE300051 T1 AT E300051T1 AT 99951770 T AT99951770 T AT 99951770T AT 99951770 T AT99951770 T AT 99951770T AT E300051 T1 ATE300051 T1 AT E300051T1
Authority
AT
Austria
Prior art keywords
sup
prp
disease related
sample
contacted
Prior art date
Application number
AT99951770T
Other languages
English (en)
Inventor
Stanley B Prusiner
Jiri G Safar
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE300051T1 publication Critical patent/ATE300051T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT99951770T 1998-10-09 1999-10-05 Test zum nachweis von prionen-proteinen die in einer mit krankheit assoziierten konformationen vorliegen ATE300051T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/169,574 US6214565B1 (en) 1998-10-09 1998-10-09 Assay for disease related conformation of a protein and isolating same
PCT/US1999/023115 WO2000022438A1 (en) 1998-10-09 1999-10-05 Assay for disease related conformation of a protein

Publications (1)

Publication Number Publication Date
ATE300051T1 true ATE300051T1 (de) 2005-08-15

Family

ID=22616277

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99951770T ATE300051T1 (de) 1998-10-09 1999-10-05 Test zum nachweis von prionen-proteinen die in einer mit krankheit assoziierten konformationen vorliegen

Country Status (12)

Country Link
US (6) US6214565B1 (de)
EP (1) EP1119773B8 (de)
JP (1) JP2002527082A (de)
KR (1) KR20010080064A (de)
AT (1) ATE300051T1 (de)
AU (1) AU765939B2 (de)
BR (1) BR9914373A (de)
CA (1) CA2344853A1 (de)
DE (2) DE69926248T2 (de)
ES (1) ES2245125T3 (de)
NZ (1) NZ510703A (de)
WO (1) WO2000022438A1 (de)

Families Citing this family (53)

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US6221614B1 (en) * 1997-02-21 2001-04-24 The Regents Of The University Of California Removal of prions from blood, plasma and other liquids
US6617119B2 (en) 1997-02-21 2003-09-09 The Regents Of The University Of California Assay for specific strains of multiple disease related conformations of a protein
US6620629B1 (en) 1997-02-21 2003-09-16 The Regents Of The University Of California Method for detecting prions
US6214565B1 (en) * 1998-10-09 2001-04-10 The Regents Of The University Of California Assay for disease related conformation of a protein and isolating same
US6821740B2 (en) * 1998-02-25 2004-11-23 Becton, Dickinson And Company Flow cytometric methods for the concurrent detection of discrete functional conformations of PRB in single cells
US6605445B1 (en) * 1999-02-22 2003-08-12 Bayer Corporation Rapid method of determining clearance of prion protein
FR2801106B1 (fr) * 1999-11-12 2007-10-05 Commissariat Energie Atomique Procede de diagnostic d'une esst provoquee par une souche d'atnc dans un echantillon biologique et son utilisation dans le diagnostic differentiel des differentes souches d'atnc
US7601683B2 (en) * 2001-08-01 2009-10-13 Board Of Regents Of The University Of Texas System Protein conformational isomers, methods of making, methods for using, compositions comprising and products made therewith
US20060018918A1 (en) * 2000-12-27 2006-01-26 Board Of Regents, The University Of Texas System Production of stabilized conformational isomers of disease associated proteins
US6900036B2 (en) * 2000-12-27 2005-05-31 University Of Texas Health Science Center Houston Prion isomers, methods of making, methods of using, and compositions and products comprising prion isomers
US7303907B2 (en) 2001-01-08 2007-12-04 Health Protection Agency Degradation and detection of TSE infectivity
US20020192731A1 (en) * 2001-04-12 2002-12-19 H. Shih Jason C. Method and composition for sterilizing surgical instruments
DE10120562C2 (de) * 2001-04-26 2003-04-10 Horst Messer Verfahren zur Diagnose von übertragbaren spongiformen Enzephalopathien
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
AU2002320045B2 (en) * 2001-05-31 2008-05-08 Adlyfe, Inc. Misfolded protein sensor method
US6591991B2 (en) * 2001-08-06 2003-07-15 Luce Belle Collapsible tire stand
CA2504349A1 (en) * 2001-11-02 2003-05-15 Diagenics International Corporation Monoclonal antibodies specific for beta-amyloid
WO2003040685A2 (en) * 2001-11-09 2003-05-15 King's College London Diagnosis demyelinating or spongiform disease
US20030092090A1 (en) * 2001-11-14 2003-05-15 Kiamars Hajizadeh Rapid prion-detection device, system, and test kit
US20030092199A1 (en) * 2001-11-14 2003-05-15 Kiamars Hajizadeh Prion-detection business methods
US7045297B2 (en) * 2001-11-14 2006-05-16 Prion Developmental Laboratories, Inc. Rapid prion-detection assay
EP1572937B1 (de) * 2002-04-09 2012-02-08 The Scripps Research Institute Hybrid-polypeptide mit eingefügten sequenzmotiven und ihre verwendungen
US20030232016A1 (en) * 2002-04-17 2003-12-18 Russell Heinrich Nerve identification and sparing method
DE60336848D1 (de) * 2002-09-12 2011-06-01 Univ California Immunogene und entsprechende antikörper, die spezifisch sind für häufige hochmolekulare aggregations-zwischenprodukte von amyloiden aus proteinen unterschiedlicher sequenz
US7189520B2 (en) * 2002-12-12 2007-03-13 Strategic Diagnostics Inc. Compositions and methods for detecting animal byproduct in feed
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
US20070003977A1 (en) 2003-08-20 2007-01-04 Amorfix Life Sciences Ltd Epitope protection assay and method for detecting protein conformations
GB0324255D0 (en) * 2003-10-16 2003-11-19 Sec Dep For Environment Food & Diagnostic method
US20050089943A1 (en) * 2003-10-23 2005-04-28 Kang Cai Rapid method of determining clearance of prion protein
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
WO2006033974A2 (en) * 2004-09-16 2006-03-30 Case Western Reserve University Detection of protein aggregates by homologous elisa
US20060110785A1 (en) * 2004-10-15 2006-05-25 The U.S.A. as rep. by the Secretary of Agriculture Methods to differentiate protein conformers
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
EP1848831A4 (de) * 2005-01-13 2008-11-05 Novartis Vaccines & Diagnostic Elisa-tests unter verwendung prionspezifischer peptidreagentien
ATE528649T1 (de) * 2005-02-15 2011-10-15 Adlyfe Inc Verfahren zum nachweis falsch gefalteter proteine und prionen
US8445642B1 (en) * 2005-10-13 2013-05-21 The United States Of America As Represented By The Secretary Of Agriculture Methods to differentiate protein conformers
US7887803B2 (en) 2005-12-02 2011-02-15 Amorfix Life Sciences Methods and compositions to treat misfolded-SOD1 mediated diseases
US7794692B2 (en) 2005-12-02 2010-09-14 Amorfix Life Sciences Ltd. Methods and compositions for detecting amyotrophic lateral sclerosis
US20070196863A1 (en) * 2006-02-17 2007-08-23 Hanson Technologies, Inc. Prion protein detection
CA2642848C (en) 2006-03-03 2016-07-12 Amorfix Life Sciences Ltd. Methods and compositions to treat and detect misfolded-sod1 mediated diseases
US8673579B2 (en) * 2006-07-28 2014-03-18 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
CA2684798A1 (en) * 2007-04-04 2008-10-16 Novartis Ag Prion elisa
EP2142934B1 (de) * 2007-04-04 2011-10-26 Novartis AG Prionentest
GB0718748D0 (en) * 2007-09-25 2007-11-07 Sec Dep For Environment Food & Diagnostic method
DE202007017248U1 (de) * 2007-12-10 2009-04-16 Ramsauer, Dieter Adapter zur Anlenkung einer Stange wie Verriegelungsstange eines Stangenverschlusses an einen Hebel wie Betätigungshebel des Stangenverschlusses
CA2721982A1 (en) * 2008-04-30 2009-11-05 Novartis Ag Assay for pathogenic conformers
WO2010003227A1 (en) * 2008-07-08 2010-01-14 Amorfix Life Sciences Ltd. Detection of protein aggregates
FR2940446A1 (fr) * 2008-12-22 2010-06-25 Lfb Biotechnologies Procede de detection d'une infection par prion
WO2010084201A1 (en) 2009-01-26 2010-07-29 Commissariat A L'energie Atomique Et Aux Energies Alternatives Novel derivative of erythromycin for the treatment and diagnosis of prion disease
JP6013327B2 (ja) * 2011-04-20 2016-10-25 オリンパス株式会社 生体試料中の核酸分子の検出方法
US11246905B2 (en) 2016-08-15 2022-02-15 President And Fellows Of Harvard College Treating infections using IdsD from Proteus mirabilis
EP3406632A1 (de) 2017-05-23 2018-11-28 S.I.S.S.A. Scuola Internazionale Superiore di Studi Avanzati An prionprotein bindende liganden zur verwendung bei der behandlung von synukleinopathien
US11571742B2 (en) 2020-01-03 2023-02-07 The Boeing Company Tuned multilayered material systems and methods for manufacturing

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US4806627A (en) 1987-05-29 1989-02-21 Research Foundation Of Mental Hygiene Inc. Hybrid cell lines producing monoclonal antibodies dircted against scrapie-associated fibril proteins
ES2237747T3 (es) 1991-11-14 2005-08-01 Prionics Ag Animales transgenicos no humanos que carecen de proteinas prionicas.
US5565186A (en) 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
EP0914614B1 (de) 1996-05-14 2003-09-03 Winnacker, Ernst-Ludwig, Prof. Chaperone, die prionproteine binden und zwischen den isoformen prpc und prpsc unterscheiden können
EP0861900A1 (de) 1997-02-21 1998-09-02 Erziehungsdirektion Of The Canton Zurich Immunologischer Nachweis von Prionen
US6214565B1 (en) * 1998-10-09 2001-04-10 The Regents Of The University Of California Assay for disease related conformation of a protein and isolating same
US5977324A (en) * 1998-02-20 1999-11-02 The Regents Of The University Of California Process for concentrating protein with disease-related conformation

Also Published As

Publication number Publication date
EP1119773A1 (de) 2001-08-01
US20050287598A1 (en) 2005-12-29
US6406864B2 (en) 2002-06-18
NZ510703A (en) 2002-10-25
ES2245125T3 (es) 2005-12-16
JP2002527082A (ja) 2002-08-27
US20060172359A1 (en) 2006-08-03
US20040137529A1 (en) 2004-07-15
DE69926248D1 (de) 2005-08-25
US20020123072A1 (en) 2002-09-05
EP1119773B1 (de) 2005-07-20
US6875577B2 (en) 2005-04-05
US7087213B2 (en) 2006-08-08
EP1119773B8 (de) 2006-06-21
WO2000022438A1 (en) 2000-04-20
BR9914373A (pt) 2001-08-07
KR20010080064A (ko) 2001-08-22
DE69926248T2 (de) 2006-09-07
CA2344853A1 (en) 2000-04-20
AU6413799A (en) 2000-05-01
US6677125B2 (en) 2004-01-13
US6214565B1 (en) 2001-04-10
US7163798B2 (en) 2007-01-16
US20010014455A1 (en) 2001-08-16
AU765939B2 (en) 2003-10-02
DE1119773T1 (de) 2001-10-25

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