ATE301120T1 - Herstellung von (1s-(1a,2b,3b,4(s*)))-4-(7-((1-(3-chlor-2-thien l)methyl)propyl)amino)-3h-imidazo(4,5-b)pyridin 3-yl)-n-ethyl-2,3- dihydroxycyclopentancarboxamid - Google Patents

Herstellung von (1s-(1a,2b,3b,4(s*)))-4-(7-((1-(3-chlor-2-thien l)methyl)propyl)amino)-3h-imidazo(4,5-b)pyridin 3-yl)-n-ethyl-2,3- dihydroxycyclopentancarboxamid

Info

Publication number: ATE301120T1
Authority: AT; Austria
Prior art keywords: dihydroxycyclopentancarboxamide; thien; imidazo; pyridine; chloro
Prior art date: 1996-12-11

Application number

AT97950663T

Other languages

English (en)

Inventor

Michael K O'brien

Herve Garcia

Patrick Leon

Tory H Powner

Laurence W Reilly

Harshavadan C Shah

Michael D Thompson

Ching T Tsuei

Benoit J Vanasse

Francis L Walther

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-11

Filing date

1997-11-24

Publication date

2005-08-15

1997-11-24 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2005-08-15 Application granted granted Critical

2005-08-15 Publication of ATE301120T1 publication Critical patent/ATE301120T1/de

Links

OCBFFGCSTGGPSQ-UHFFFAOYSA-N [CH2]CC Chemical compound [CH2]CC OCBFFGCSTGGPSQ-UHFFFAOYSA-N 0.000 title 1
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)

AT97950663T 1996-12-11 1997-11-24 Herstellung von (1s-(1a,2b,3b,4(s*)))-4-(7-((1-(3-chlor-2-thien l)methyl)propyl)amino)-3h-imidazo(4,5-b)pyridin 3-yl)-n-ethyl-2,3- dihydroxycyclopentancarboxamid ATE301120T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3276496P	1996-12-11	1996-12-11
PCT/US1997/021439 WO1998025921A1 (en)	1996-12-11	1997-11-24	PREPARATION OF [1S-[1a,2b,3b,4a(S*)]]-4-[7-[[1-(3-CHLORO-2-THIENYL) METHYL]PROPYL]AMINO]-3H-IMIDAZO[4,5-b]PYRIDIN-3-yl]-N-ETHYL-2,3-DIHYDROXYCYCLOPENTANECARBOXAMIDE

Publications (1)

Publication Number	Publication Date
ATE301120T1 true ATE301120T1 (de)	2005-08-15

Family

ID=21866680

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97950663T ATE301120T1 (de)	1996-12-11	1997-11-24	Herstellung von (1s-(1a,2b,3b,4(s*)))-4-(7-((1-(3-chlor-2-thien l)methyl)propyl)amino)-3h-imidazo(4,5-b)pyridin 3-yl)-n-ethyl-2,3- dihydroxycyclopentancarboxamid

Country Status (26)

Country	Link
US (2)	US6143894A (de)
EP (2)	EP0946550B1 (de)
JP (1)	JP2001506626A (de)
KR (4)	KR100510389B1 (de)
CN (3)	CN1191251C (de)
AP (1)	AP1063A (de)
AT (1)	ATE301120T1 (de)
AU (1)	AU738581B2 (de)
BG (1)	BG63805B1 (de)
BR (1)	BR9713705A (de)
CA (1)	CA2274630C (de)
DE (1)	DE69733897T2 (de)
DK (1)	DK0946550T3 (de)
EA (1)	EA001989B1 (de)
ES (1)	ES2242984T3 (de)
HU (1)	HUP0000342A3 (de)
IL (1)	IL130397A (de)
MX (1)	MXPA03006730A (de)
NO (2)	NO319722B1 (de)
OA (1)	OA11061A (de)
PT (1)	PT946550E (de)
SI (1)	SI0946550T1 (de)
SK (1)	SK71199A3 (de)
UA (1)	UA54479C2 (de)
WO (1)	WO1998025921A1 (de)
ZA (1)	ZA9711035B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1140933E (pt)	1998-12-31	2004-12-31	Aventis Pharma Inc	Processo para preparar derivados n6-substituidos de desaza-adenosina
US7291603B2 (en) *	2002-07-24	2007-11-06	Ptc Therapeutics, Inc.	Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations
FR2846656B1 (fr) *	2002-11-05	2004-12-24	Servier Lab	Nouveaux derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU654507B2 (en) *	1990-09-25	1994-11-10	Rhone-Poulenc Rorer International (Holdings) Inc.	Compounds having antihypertensive and anti-ischemic properties
PL337888A1 (en) *	1997-07-03	2000-09-11	Du Pont Pharm Co	Imidazoprimidines and imidazopyridines for use in treating neurological disorders
KR20010087425A (ko) *	1998-12-21	2001-09-15	오흘러 로스 제이.	Ｎ6-치환된 데아자-아데노신 유도체의 제조방법

1997
- 1997-11-24 ES ES97950663T patent/ES2242984T3/es not_active Expired - Lifetime
- 1997-11-24 DE DE69733897T patent/DE69733897T2/de not_active Expired - Fee Related
- 1997-11-24 EA EA199900527A patent/EA001989B1/ru not_active IP Right Cessation
- 1997-11-24 EP EP97950663A patent/EP0946550B1/de not_active Expired - Lifetime
- 1997-11-24 EP EP05075298A patent/EP1609791A1/de not_active Withdrawn
- 1997-11-24 UA UA99073906A patent/UA54479C2/uk unknown
- 1997-11-24 HU HU0000342A patent/HUP0000342A3/hu unknown
- 1997-11-24 JP JP52670598A patent/JP2001506626A/ja not_active Ceased
- 1997-11-24 IL IL13039797A patent/IL130397A/xx not_active IP Right Cessation
- 1997-11-24 CN CNB011370718A patent/CN1191251C/zh not_active Expired - Fee Related
- 1997-11-24 KR KR10-1999-7005191A patent/KR100510389B1/ko not_active Expired - Fee Related
- 1997-11-24 KR KR1020057023521A patent/KR20060002029A/ko not_active Ceased
- 1997-11-24 BR BR9713705-7A patent/BR9713705A/pt not_active Application Discontinuation
- 1997-11-24 SI SI9730709T patent/SI0946550T1/xx unknown
- 1997-11-24 AU AU53607/98A patent/AU738581B2/en not_active Ceased
- 1997-11-24 SK SK711-99A patent/SK71199A3/sk unknown
- 1997-11-24 PT PT97950663T patent/PT946550E/pt unknown
- 1997-11-24 CN CN2005100037721A patent/CN1660842A/zh active Pending
- 1997-11-24 KR KR1020057004675A patent/KR100571690B1/ko not_active Expired - Fee Related
- 1997-11-24 MX MXPA03006730A patent/MXPA03006730A/es not_active Application Discontinuation
- 1997-11-24 KR KR1020057023522A patent/KR20060002030A/ko not_active Withdrawn
- 1997-11-24 CN CN97180580A patent/CN1090630C/zh not_active Expired - Fee Related
- 1997-11-24 CA CA002274630A patent/CA2274630C/en not_active Expired - Fee Related
- 1997-11-24 AT AT97950663T patent/ATE301120T1/de not_active IP Right Cessation
- 1997-11-24 DK DK97950663T patent/DK0946550T3/da active
- 1997-11-24 WO PCT/US1997/021439 patent/WO1998025921A1/en not_active Ceased
- 1997-11-24 AP APAP/P/1999/001550A patent/AP1063A/en active
- 1997-12-09 ZA ZA9711035A patent/ZA9711035B/xx unknown
1999
- 1999-01-19 US US09/233,591 patent/US6143894A/en not_active Expired - Fee Related
- 1999-06-09 NO NO19992795A patent/NO319722B1/no unknown
- 1999-06-11 BG BG103484A patent/BG63805B1/bg unknown
- 1999-06-11 OA OA9900123A patent/OA11061A/en unknown
2000
- 2000-07-28 US US09/627,657 patent/US6235909B1/en not_active Expired - Fee Related
2005
- 2005-05-12 NO NO20052327A patent/NO20052327D0/no unknown

Also Published As

Publication number	Publication date
AU738581B2 (en)	2001-09-20
US6235909B1 (en)	2001-05-22
EP0946550A1 (de)	1999-10-06
NO992795D0 (no)	1999-06-09
NO319722B1 (no)	2005-09-05
BG103484A (en)	2000-06-30
NO992795L (no)	1999-08-10
DK0946550T3 (da)	2005-08-29
AP1063A (en)	2002-04-26
HUP0000342A3 (en)	2001-01-29
HK1023998A1 (en)	2000-09-29
CN1240445A (zh)	2000-01-05
CN1191251C (zh)	2005-03-02
KR20000057505A (ko)	2000-09-15
PT946550E (pt)	2005-09-30
DE69733897D1 (de)	2005-09-08
CN1090630C (zh)	2002-09-11
KR100510389B1 (ko)	2005-08-31
MXPA03006730A (es)	2003-10-24
EA199900527A1 (ru)	2000-02-28
KR100571690B1 (ko)	2006-04-18
EP1609791A1 (de)	2005-12-28
WO1998025921A1 (en)	1998-06-18
IL130397A (en)	2005-11-20
HK1051862A1 (en)	2003-08-22
ZA9711035B (en)	1998-06-15
ES2242984T3 (es)	2005-11-16
HUP0000342A2 (hu)	2000-10-28
OA11061A (en)	2002-02-27
KR20060002030A (ko)	2006-01-06
CN1394859A (zh)	2003-02-05
BR9713705A (pt)	2000-05-09
BG63805B1 (bg)	2003-01-31
SI0946550T1 (en)	2005-10-31
EP0946550A4 (de)	2003-05-14
IL130397A0 (en)	2000-06-01
UA54479C2 (uk)	2003-03-17
US6143894A (en)	2000-11-07
NO20052327D0 (no)	2005-05-12
KR20050046793A (ko)	2005-05-18
NO20052327L (no)	1999-08-10
JP2001506626A (ja)	2001-05-22
SK71199A3 (en)	2000-07-11
CN1660842A (zh)	2005-08-31
CA2274630C (en)	2000-10-03
KR20060002029A (ko)	2006-01-06
EA001989B1 (ru)	2001-10-22
AP9901550A0 (en)	1999-06-30
AU5360798A (en)	1998-07-03
EP0946550B1 (de)	2005-08-03
DE69733897T2 (de)	2006-06-01

Legal Events

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2006-10-15

UEP

Publication of translation of european patent specification

Ref document number: 0946550

Country of ref document: EP

2007-08-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
NO20020832D0 (no)	2002-02-20	Imidazo(1,2-A)pyridin og pyrazolo(2,3-A)pyridin derivater
DE68911033D1 (de)	1994-01-13	Alkoxy-1,2,4-triazolo (1,5-c) pyrimidine-2-sulfonamide, Verfahren zu ihrer Herstellung und Zwischenprodukte.
IS4570A (is)	1997-09-25	Imidazó[1,2-a]pýridín afleiður
TR199800085A3 (tr)	1998-08-21	8-Sübstitüye edilmis-1,3,8-triaza- spiro(4,5)dekan-4-on türevleri.
DK0931081T3 (da)	2003-01-27	Pyridazino-[4,5-B]-quinolin-5-oxid-derivater, deres fremstilling og deres anvendelse som glycinantagonister
BE888073A (fr)	1981-09-23	DERIVES D'IMIDAZO 4,5-b PYRIDINE LEUR PREPARATION ET LEUR UTILISATION COMME AGENTS CARDIOTONIQUES.
HUP9601240A1 (en)	1997-09-29	Pyridin and pyrimidin derivatives, suitable as beta-adrenerg agonists, pharmaceutical compositions containing the same and their intermediates
FI961564L (fi)	1996-04-10	Imidatso(1,2-a)pyridiinien alkoksialkyylikarbamaatit
AU7849387A (en)	1988-03-24	2- or-3- aryl substituted imidazo(1,2-a)pyridines
ATE218567T1 (de)	2002-06-15	1h-pyrido(3,4-b)indolcarboxamidderivate, ihre herstellung und therapeutische verwendung
NO874302D0 (no)	1987-10-15	Fremgangsmaate for fremstilling av 4,5-dihydro- og 4,5,6,7-tetrahydro- pyrazolo (1,5-a)pyrimidiner.
DE68919731D1 (de)	1995-01-19	Pyrimidin-Derivate, Verfahren zu deren Herstellung und diese enthaltende herbizide Zusammensetzungen.
ATE301120T1 (de)	2005-08-15	Herstellung von (1s-(1a,2b,3b,4(s*)))-4-(7-((1-(3-chlor-2-thien l)methyl)propyl)amino)-3h-imidazo(4,5-b)pyridin 3-yl)-n-ethyl-2,3- dihydroxycyclopentancarboxamid
FI943294L (fi)	1995-12-01	Alkaloidit Mappia foetidasta, niiden käyttö, ja niitä sisältävät formulloinnit
DE69320668D1 (de)	1998-10-08	Verfahren zur Herstellung von Imidazo(4,5-b)Pyridinderivaten
DE59006542D1 (de)	1994-09-01	2,3-substituierte 1,8-Naphthyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Antidots.
DK33684D0 (da)	1984-01-25	Pyrazino (2',3'-3,4)pyrido(1,2-a)-indol-derivater
TR28699A (tr)	1997-01-28	Imidazopiridin türevlerinin hazirlanmasi icin yöntem.
DE68913338D1 (de)	1994-04-07	5-Fluormethyl-1,2,4-triazolo(1,5-a)pyrimidin-2-sulfonamide, Verfahren zu ihrer Herstellung und Zubereitungen als Herbizide.
ZA873507B (en)	1987-11-09	Pyrazolo(3,4-b)pyridine derivatives,processes and intermediate stages for their preparation and their use as herbicides
EE9400439A (et)	1996-06-17	Naftüridiini derivaadid, nende valmistamise meetodid, neid sisaldavad ravimvormid, eriti kasutamiseks antiproliferatiivsete preparaatidena
EE200000029A (et)	2000-10-16	5-asendatud-3-oksadiasolüül-1,6-naftüridiin-2(1H)-ooni derivaadid
DE3776199D1 (de)	1992-03-05	2,3-dihydro-1-(8-methyl-1,2,4-triazolo(4,3-b)pyridazin-6-yl)-4(1h)-pyridinon.
FI943706A7 (fi)	1994-08-10	Menetelmä kiraalisen etyyli-(5-amino-1,2-dihydro-2-metyyli-3-fenyylipyrido(3,4-b)pyratsin-7-yyli)karbamaatin valmistamiseksi
ATE102202T1 (de)	1994-03-15	5-fluormethyl-1,2,4-triazolo(1,5-a)pyrimidin-2sulfonamide, verfahren zu ihrer herstellung und zubereitungen als herbizide.