ATE301714T1 - Insulinartigen wachstumsfaktor bindendes protein -3 variante - Google Patents

Insulinartigen wachstumsfaktor bindendes protein -3 variante

Info

Publication number
ATE301714T1
ATE301714T1 AT99926092T AT99926092T ATE301714T1 AT E301714 T1 ATE301714 T1 AT E301714T1 AT 99926092 T AT99926092 T AT 99926092T AT 99926092 T AT99926092 T AT 99926092T AT E301714 T1 ATE301714 T1 AT E301714T1
Authority
AT
Austria
Prior art keywords
igfbp
variant
disclosed
growth factor
insulin
Prior art date
Application number
AT99926092T
Other languages
English (en)
Inventor
Desmond Mascarenhas
Stephen Danko
David Passmore
Original Assignee
Celtrix Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celtrix Pharma filed Critical Celtrix Pharma
Application granted granted Critical
Publication of ATE301714T1 publication Critical patent/ATE301714T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4743—Insulin-like growth factor binding protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT99926092T 1998-06-01 1999-05-28 Insulinartigen wachstumsfaktor bindendes protein -3 variante ATE301714T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8755998P 1998-06-01 1998-06-01
US09/322,484 US6417330B1 (en) 1998-06-01 1999-05-27 Insulin-like growth factor binding protein variants
PCT/US1999/012087 WO1999063086A2 (en) 1998-06-01 1999-05-28 Insulin-like growth factor binding protein-3 variants

Publications (1)

Publication Number Publication Date
ATE301714T1 true ATE301714T1 (de) 2005-08-15

Family

ID=26777116

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99926092T ATE301714T1 (de) 1998-06-01 1999-05-28 Insulinartigen wachstumsfaktor bindendes protein -3 variante

Country Status (9)

Country Link
US (2) US6417330B1 (de)
EP (1) EP1082427B1 (de)
CN (1) CN1311819A (de)
AT (1) ATE301714T1 (de)
AU (1) AU761630B2 (de)
CA (1) CA2336295A1 (de)
DE (1) DE69926627T2 (de)
ES (1) ES2246088T3 (de)
WO (1) WO1999063086A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7109030B2 (en) * 2000-03-31 2006-09-19 Nuvelo, Inc. Methods of therapy and diagnosis using insulin-like growth factor binding protein-like polypeptides and polynucleotides
WO2002024216A2 (en) 2000-09-19 2002-03-28 Bioexpertise, Llc Method for use of igf-binding protein for selective sensitization of target cells in vivo
EP1399475A2 (de) * 2001-06-07 2004-03-24 F. Hoffmann-La Roche Ag Mutanten igf-bindender proteine und verfahren zur produktion deren antagonisten
AU2005243741B2 (en) * 2001-09-18 2010-01-28 Bioexpertise Llc Methods for delivering MBD peptide- linked agent into cells under conditions of cellular stress
US6914049B2 (en) * 2001-09-18 2005-07-05 Bioexpertise, Llc IGF-binding protein-derived peptide or small molecule
JP4344242B2 (ja) * 2001-09-18 2009-10-14 バイオエキスパータイズ， エルエルシー Ｉｇｆ結合タンパク質由来のペプチドまたは低分子
US6887851B2 (en) * 2001-09-18 2005-05-03 Bioexpertise, Llc IGF-binding protein-derived peptide
WO2005049648A2 (en) * 2003-07-09 2005-06-02 The University Of Iowa Research Foundation Chimeric or fusion constructs of insulin-like growth factor binding proteins as chemotherapeutic agents
US7579157B2 (en) * 2003-07-10 2009-08-25 Hoffmann-La Roche Inc. Antibody selection method against IGF-IR
EP1670822A2 (de) * 2003-10-03 2006-06-21 Genentech, Inc. Igf-bindende proteine
DE602005019784D1 (de) * 2004-12-24 2010-04-15 Insmed Inc Gereinigte rhigf-i/rhigfbp-3-komplexe und herstellungsverfahren dafür
SI1979001T1 (sl) * 2005-12-13 2012-08-31 Medimmune Ltd Vezni proteini specifiäśno za inzulinu podobne rastne faktorje in njih uporaba
DK1979001T3 (da) * 2005-12-13 2012-07-16 Medimmune Ltd Bindingsproteiner, der er specifikke for insulinlignende vækstfaktorer og anvendelser deraf
EP2400985A2 (de) 2009-02-25 2012-01-04 OSI Pharmaceuticals, LLC Kombination eines anti-igf-1r-antikörpers oder eines igf-bindungsproteins und eines kleinmoleküligen igf-1r-kinase-inhibitors
EP2678353B1 (de) 2011-02-24 2018-12-05 INSERM - Institut National de la Santé et de la Recherche Médicale Igfbp-3-derivate und verwendungen davon
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
CN110248672A (zh) * 2017-02-06 2019-09-17 中央研究院 重组蛋白及其用途

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511502A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4512922A (en) 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511503A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US5200509A (en) 1987-04-06 1993-04-06 Celtrix Pharmaceuticals, Inc. Human somatomedin carrier protein subunits and process for producing them; recombinant DNA molecules, hosts, processes and human somatomedin carrier protein-like polypeptides
US5258287A (en) * 1988-03-22 1993-11-02 Genentech, Inc. DNA encoding and methods of production of insulin-like growth factor binding protein BP53
US5187151A (en) 1991-02-12 1993-02-16 Genentech, Inc. Use of binding protein with igf-i as an anabolic growth promoting agent
US5288931A (en) 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
US5407913A (en) 1992-12-03 1995-04-18 Celtrix Pharmaceuticals, Inc. Method and composition for systemic treatment of tissue injury
US5643867A (en) 1992-08-26 1997-07-01 Celtrix Pharmaceuticals, Inc. Method for treating catabolic conditions
US5459051A (en) 1993-03-26 1995-10-17 Celtrix Pharmaceuticals, Inc. Methods and vectors for over-expression of ubiquitin fusion proteins in host cells
US5563046A (en) 1993-08-02 1996-10-08 Celtrix Pharmaceuticals, Inc. Fusion polypeptides and proteins
AU674449B2 (en) 1993-08-03 1996-12-19 Celtrix Pharmaceuticals, Inc. Method of treating reproductive disorders
US5663304A (en) 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I
CA2172158A1 (en) 1993-09-20 1995-03-30 Joseph A. Carlino Treatment of immunologic and hematologic disorders with igfbp alone or complexed with igf
AU693489B2 (en) 1993-11-15 1998-07-02 Celtrix Pharmaceuticals, Inc. Method of treating neurological disorders
CA2176709A1 (en) 1993-11-15 1995-05-26 Howard R. Higley Method of treating renal disease by administering igf-i and igfbp-3
SE9303784D0 (sv) 1993-11-16 1993-11-16 Kabi Pharmacia Ab Igf
US5861273A (en) 1993-12-21 1999-01-19 Celtrix Phamraceuticals, Inc. Chromosomal expression of heterologous genes in bacterial cells
CA2195474A1 (en) 1994-07-20 1996-02-01 Cedo Martin Bagi Igf/igfbp complex for promoting bone formation and for regulating bone remodeling
US5789547A (en) 1995-06-07 1998-08-04 Celtrix Pharmaceuticals, Inc. Method of producing insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) with correct folding and disulfide bonding

Also Published As

Publication number Publication date
DE69926627T2 (de) 2006-05-24
AU4225299A (en) 1999-12-20
DE69926627D1 (de) 2005-09-15
EP1082427A2 (de) 2001-03-14
AU761630B2 (en) 2003-06-05
EP1082427B1 (de) 2005-08-10
ES2246088T3 (es) 2006-02-01
WO1999063086A3 (en) 2000-01-27
US6417330B1 (en) 2002-07-09
WO1999063086B1 (en) 2000-04-20
CN1311819A (zh) 2001-09-05
WO1999063086A2 (en) 1999-12-09
US20020072589A1 (en) 2002-06-13
WO1999063086A8 (en) 2000-08-10
CA2336295A1 (en) 1999-12-09

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