ATE302194T1 - Metabotrope glutamatrezeptorantagonisten zur behandlung von krankheiten des zentralen nervensystems - Google Patents
Metabotrope glutamatrezeptorantagonisten zur behandlung von krankheiten des zentralen nervensystemsInfo
- Publication number
- ATE302194T1 ATE302194T1 AT00936465T AT00936465T ATE302194T1 AT E302194 T1 ATE302194 T1 AT E302194T1 AT 00936465 T AT00936465 T AT 00936465T AT 00936465 T AT00936465 T AT 00936465T AT E302194 T1 ATE302194 T1 AT E302194T1
- Authority
- AT
- Austria
- Prior art keywords
- metabotropic
- glutama
- treatment
- nervous system
- central nervous
- Prior art date
Links
- 208000015114 central nervous system disease Diseases 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000012902 Nervous system disease Diseases 0.000 abstract 2
- 208000025966 Neurological disease Diseases 0.000 abstract 2
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 abstract 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Quinoline Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13727299P | 1999-06-02 | 1999-06-02 | |
| PCT/US2000/015222 WO2000073283A1 (en) | 1999-06-02 | 2000-06-02 | Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE302194T1 true ATE302194T1 (de) | 2005-09-15 |
Family
ID=22476587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00936465T ATE302194T1 (de) | 1999-06-02 | 2000-06-02 | Metabotrope glutamatrezeptorantagonisten zur behandlung von krankheiten des zentralen nervensystems |
Country Status (15)
| Country | Link |
|---|---|
| EP (2) | EP1595871A3 (de) |
| JP (1) | JP2003500480A (de) |
| CN (2) | CN1789246A (de) |
| AT (1) | ATE302194T1 (de) |
| AU (2) | AU778063C (de) |
| CA (1) | CA2376024A1 (de) |
| CH (1) | CH1196397H1 (de) |
| DE (1) | DE60022050C5 (de) |
| DK (1) | DK1196397T3 (de) |
| ES (1) | ES2249272T3 (de) |
| HK (1) | HK1048635A1 (de) |
| IL (1) | IL146871A0 (de) |
| MX (1) | MXPA01012445A (de) |
| NZ (1) | NZ515894A (de) |
| WO (1) | WO2000073283A1 (de) |
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| TWI298068B (en) * | 2000-06-21 | 2008-06-21 | Dainippon Sumitomo Pharma Co | Pharmaceutical composition for schizophrenia |
| CZ20032341A3 (cs) * | 2001-01-31 | 2004-12-15 | Synaptic Pharmaceutical Corporation | Použití antagonistů GAL3 receptoru pro léčbu deprese a/nebo úzkosti |
| DE10124953A1 (de) * | 2001-05-21 | 2002-12-12 | Marlies Knipper | Substanz für die therapeutische Behandlung von Tinnitus |
| AU2002356525A1 (en) * | 2001-09-24 | 2003-04-07 | Elan Pharmaceuticals, Inc. | Substituted amines for the treatment of neurological disorders |
| DE10153345A1 (de) * | 2001-10-29 | 2003-05-08 | Gruenenthal Gmbh | Substituierte 1H-Chinoxalin-2-on-Verbindungen und substituierte 4-Aryl- und 4-Heteroarylcyclohexan-Verbindungen |
| WO2003068749A1 (en) * | 2002-02-15 | 2003-08-21 | Glaxo Group Limited | Vanilloid receptor modulators |
| TWI314041B (en) * | 2002-10-21 | 2009-09-01 | Sankyo Agro Co Ltd | Quinolyl-3-carboxamide compound |
| WO2004069813A1 (en) * | 2003-01-31 | 2004-08-19 | Astrazeneca Ab | Saturated quinoxaline derivatives and their use as metabotropic glutamate receptor ligands |
| GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
| US7932272B2 (en) | 2003-09-30 | 2011-04-26 | Eisai R&D Management Co., Ltd. | Antifungal agent containing heterocyclic compound |
| CN101133027B (zh) * | 2005-03-04 | 2011-03-30 | 弗·哈夫曼-拉罗切有限公司 | 作为mglur5拮抗剂的吡啶-2-甲酰胺衍生物 |
| WO2006106711A1 (ja) | 2005-03-30 | 2006-10-12 | Eisai R & D Management Co., Ltd. | ピリジン誘導体を含有する抗真菌剤 |
| WO2007037543A1 (ja) * | 2005-09-29 | 2007-04-05 | Banyu Pharmaceutical Co., Ltd. | ビアリールアミド誘導体 |
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| KR20080076962A (ko) * | 2005-12-20 | 2008-08-20 | 노파르티스 아게 | 대사성 글루타메이트 수용체 조절제로서의 니코틴산 유도체 |
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| TW200817385A (en) * | 2006-07-04 | 2008-04-16 | Organon Nv | Heterocyclic derivatives |
| JP2009542798A (ja) | 2006-07-11 | 2009-12-03 | ファイザー株式会社 | 置換n−二環式アルキル二環式カルボキシアミド化合物 |
| MX2009002684A (es) * | 2006-09-11 | 2009-06-05 | Novartis Ag | Derivados de acido nicotinico como moduladores de receptores de glutamato metabotropico. |
| CA2669915C (en) | 2006-11-17 | 2012-02-07 | Pfizer Inc. | Substituted bicyclocarboxyamide compounds |
| HUE032743T2 (en) | 2006-11-22 | 2017-10-30 | Clinical Res Ass Llc | A method for treating Down syndrome, fragilis X syndrome and autism |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| PE20091225A1 (es) | 2007-03-22 | 2009-09-16 | Astrazeneca Ab | Derivados de quinolina como antagonistas del receptor p2x7 |
| SI2203439T1 (sl) | 2007-09-14 | 2011-05-31 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni |
| RU2508107C2 (ru) * | 2007-10-12 | 2014-02-27 | Новартис Аг | Модуляторы метаботропного глутаматного рецептора для лечения болезни паркинсона |
| PE20091036A1 (es) | 2007-11-30 | 2009-08-15 | Astrazeneca Ab | Derivado de quinolina como antagonista del receptor p2x7 |
| US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
| KR20110036797A (ko) | 2008-07-25 | 2011-04-11 | 하. 룬트벡 아크티에 셀스카브 | 아다만틸 디아미드 유도체 및 이의 용도 |
| ES2439291T3 (es) | 2008-09-02 | 2014-01-22 | Janssen Pharmaceuticals, Inc. | Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos |
| AU2009308232B2 (en) | 2008-10-23 | 2016-02-04 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| NZ592685A (en) | 2008-10-23 | 2013-04-26 | Vertex Pharma | Modulators of cystic fibrosis transmembrane conductance regulator |
| MX2011005037A (es) | 2008-11-21 | 2011-06-16 | High Point Pharmaceuticals Llc | Compuestos de adamantilo benzamida. |
| ES2401691T3 (es) | 2008-11-28 | 2013-04-23 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Derivados de indol y de benzoxacina como moduladores de los receptores metabotrópicos de glutamato |
| ES2440001T3 (es) | 2009-05-12 | 2014-01-27 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-A]piridina y su uso para el tratamiento o prevención de trastornos neurológicos y psiquiátricos |
| SG176018A1 (en) | 2009-05-12 | 2011-12-29 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| IN2012DN03312A (de) | 2009-10-22 | 2015-10-23 | Fibrotech Therapeutics Pty Ltd | |
| WO2011087758A1 (en) * | 2009-12-22 | 2011-07-21 | H. Lundbeck A/S | Adamantyl amide derivatives and uses of same |
| WO2011109398A2 (en) | 2010-03-02 | 2011-09-09 | President And Fellows Of Harvard College | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
| WO2011150380A1 (en) | 2010-05-28 | 2011-12-01 | Xenoport, Inc. | Methods of treatment of fragile x syndrome, down's syndrome, autism and related disorders |
| US20120016021A1 (en) | 2010-07-15 | 2012-01-19 | Xenoport, Inc. | Methods of treating fragile x syndrome, down's syndrome, autism and related disorders |
| US8513430B2 (en) | 2010-07-27 | 2013-08-20 | High Point Pharmaceuticals, Llc | Substituted thiazol-2-ylamine derivatives, pharmaceutical compositions, and methods of use as 11-beta HSD1 modulators |
| WO2012054724A1 (en) | 2010-10-21 | 2012-04-26 | Massachusetts Institute Of Technology | Methods of treating seizure disorders |
| CN103298809B (zh) | 2010-11-08 | 2016-08-31 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| CA2814998C (en) | 2010-11-08 | 2019-10-29 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| ES2552455T3 (es) | 2010-11-08 | 2015-11-30 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| JP5617799B2 (ja) * | 2010-12-07 | 2014-11-05 | 信越化学工業株式会社 | 化学増幅レジスト材料及びパターン形成方法 |
| AR084457A1 (es) | 2010-12-22 | 2013-05-15 | Lundbeck & Co As H | Derivados de biciclo[3,2,1]octilamida |
| EP2709621B1 (de) * | 2011-05-17 | 2016-11-02 | Merck Sharp & Dohme Corp. | Positive allosterische n-vernetzte chinolinamid-m1-rezeptormodulatoren |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| US10537573B2 (en) | 2014-01-21 | 2020-01-21 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
| IL279202B2 (en) | 2014-01-21 | 2023-09-01 | Janssen Pharmaceutica Nv | Combinations containing positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic subtype 2 receptor and their use |
| KR102529578B1 (ko) * | 2014-08-29 | 2023-05-09 | (주)아모레퍼시픽 | 신규 아다만탄 유도체 화합물 |
| CN104860901B (zh) * | 2015-04-20 | 2017-04-19 | 北京工业大学 | 一种苯并噻唑‑2‑羧酸的制备方法 |
| CN108430992A (zh) * | 2015-12-17 | 2018-08-21 | 阿斯特克斯医疗公司 | 作为h-pgds抑制剂的喹啉-3-甲酰胺 |
| EP3577103A1 (de) | 2017-02-03 | 2019-12-11 | Certa Therapeutics Pty Ltd. | Antifibrotische verbindungen |
| WO2018229629A1 (en) | 2017-06-13 | 2018-12-20 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds as h-pgds inhibitors |
| CN111269203A (zh) * | 2018-12-04 | 2020-06-12 | 上海中泽医药科技有限公司 | N-环己基-呋喃-2-甲酰胺类化合物及制法和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1329447A (en) * | 1969-10-27 | 1973-09-05 | Squibb & Sons Inc | 4-adamantylaminoalkylamino-2-styryl-quinolines salts and derivatives thereof |
| AU3414295A (en) * | 1994-08-19 | 1996-03-14 | Nps Pharmaceuticals, Inc. | Methods and compounds active at metabotropic glutamate receptors useful for treatment of neurological disorders and diseases |
| JPH10504569A (ja) * | 1994-08-24 | 1998-05-06 | イーライ・リリー・アンド・カンパニー | 向代謝性グルタメート受容体拮抗剤としてのピロリジニルジカルボン酸誘導体 |
| US5707985A (en) * | 1995-06-07 | 1998-01-13 | Tanabe Seiyaku Co. Ltd. | Naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives as cell adhesion modulators |
| JPH10507934A (ja) | 1995-07-26 | 1998-08-04 | エヌピーエス・ファーマシウティカルズ・インコーポレイテッド | 代謝指向型グルタミン酸受容体に活性を示す化合物を同定するためのキメラ受容体および方法、ならびに神経学的障害および疾患の治療におけるそのような化合物の使用 |
| JP2001515839A (ja) * | 1997-07-18 | 2001-09-25 | ジョージタウン・ユニバーシティ | 二環式向代謝性グルタミン酸受容体リガンド |
| IL136250A0 (en) * | 1997-11-21 | 2001-05-20 | Nps Pharma Inc | Metabotropic glutamate receptor antagonist compounds |
-
2000
- 2000-06-02 HK HK03100778.5A patent/HK1048635A1/zh unknown
- 2000-06-02 CH CH00936465T patent/CH1196397H1/de unknown
- 2000-06-02 AU AU51780/00A patent/AU778063C/en not_active Ceased
- 2000-06-02 IL IL14687100A patent/IL146871A0/xx unknown
- 2000-06-02 CA CA002376024A patent/CA2376024A1/en not_active Abandoned
- 2000-06-02 CN CNA2005101186507A patent/CN1789246A/zh active Pending
- 2000-06-02 EP EP05017791A patent/EP1595871A3/de not_active Withdrawn
- 2000-06-02 DK DK00936465T patent/DK1196397T3/da active
- 2000-06-02 WO PCT/US2000/015222 patent/WO2000073283A1/en not_active Ceased
- 2000-06-02 AT AT00936465T patent/ATE302194T1/de not_active IP Right Cessation
- 2000-06-02 JP JP2000621349A patent/JP2003500480A/ja active Pending
- 2000-06-02 NZ NZ515894A patent/NZ515894A/xx unknown
- 2000-06-02 ES ES00936465T patent/ES2249272T3/es not_active Expired - Lifetime
- 2000-06-02 DE DE60022050T patent/DE60022050C5/de not_active Expired - Fee Related
- 2000-06-02 CN CN00810658A patent/CN1361768A/zh active Pending
- 2000-06-02 EP EP00936465A patent/EP1196397B1/de not_active Expired - Lifetime
- 2000-06-02 MX MXPA01012445A patent/MXPA01012445A/es active IP Right Grant
-
2005
- 2005-02-11 AU AU2005200633A patent/AU2005200633A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003500480A (ja) | 2003-01-07 |
| MXPA01012445A (es) | 2003-09-10 |
| AU2005200633A1 (en) | 2005-03-17 |
| EP1595871A2 (de) | 2005-11-16 |
| EP1196397B1 (de) | 2005-08-17 |
| ES2249272T3 (es) | 2006-04-01 |
| CH1196397H1 (de) | 2007-05-31 |
| DE60022050C5 (de) | 2007-10-11 |
| NZ515894A (en) | 2003-09-26 |
| DE60022050D1 (de) | 2005-09-22 |
| DE60022050T2 (de) | 2006-06-14 |
| AU5178000A (en) | 2000-12-18 |
| CN1361768A (zh) | 2002-07-31 |
| WO2000073283A1 (en) | 2000-12-07 |
| HK1048635A1 (zh) | 2003-04-11 |
| EP1595871A3 (de) | 2005-11-30 |
| AU778063C (en) | 2005-12-15 |
| IL146871A0 (en) | 2002-08-14 |
| EP1196397A1 (de) | 2002-04-17 |
| CN1789246A (zh) | 2006-06-21 |
| DK1196397T3 (da) | 2006-01-02 |
| AU778063B2 (en) | 2004-11-11 |
| CA2376024A1 (en) | 2000-12-07 |
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