ATE302210T1 - Histogranin peptide und deren analgetische verwendung - Google Patents
Histogranin peptide und deren analgetische verwendungInfo
- Publication number
- ATE302210T1 ATE302210T1 AT98951127T AT98951127T ATE302210T1 AT E302210 T1 ATE302210 T1 AT E302210T1 AT 98951127 T AT98951127 T AT 98951127T AT 98951127 T AT98951127 T AT 98951127T AT E302210 T1 ATE302210 T1 AT E302210T1
- Authority
- AT
- Austria
- Prior art keywords
- histogranin
- peptides
- compounds
- analgesic use
- compositions
- Prior art date
Links
- 230000000202 analgesic effect Effects 0.000 title 1
- PXOVBYBXCFRNAW-GDBJWOEXSA-N histogranin Chemical compound C([C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=C(O)C=C1 PXOVBYBXCFRNAW-GDBJWOEXSA-N 0.000 title 1
- 108010066405 histogranin Proteins 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 2
- 108010069514 Cyclic Peptides Proteins 0.000 abstract 1
- 102000001189 Cyclic Peptides Human genes 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
- C07K5/126—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2219437 CA2219437A1 (en) | 1997-10-24 | 1997-10-24 | Peptides as analgesics |
| CA002224066A CA2224066A1 (en) | 1997-10-24 | 1998-02-24 | Peptides as analgesics |
| PCT/CA1998/001002 WO1999021877A1 (en) | 1997-10-24 | 1998-10-26 | Histogranin peptide and their analgesic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE302210T1 true ATE302210T1 (de) | 2005-09-15 |
Family
ID=25679768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98951127T ATE302210T1 (de) | 1997-10-24 | 1998-10-26 | Histogranin peptide und deren analgetische verwendung |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6566327B1 (de) |
| EP (1) | EP1025119B1 (de) |
| AT (1) | ATE302210T1 (de) |
| AU (1) | AU9731198A (de) |
| CA (1) | CA2224066A1 (de) |
| DE (1) | DE69831257D1 (de) |
| WO (1) | WO1999021877A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2224066A1 (en) * | 1997-10-24 | 1999-04-24 | Universite D'ottawa/ University Of Ottawa | Peptides as analgesics |
| US6972281B2 (en) * | 2002-02-07 | 2005-12-06 | University Of Ottawa | Histogranin-like peptides and non-peptides, processes for their preparation and uses thereof |
| US8906859B2 (en) | 2006-11-10 | 2014-12-09 | Cera Therapeutics, Inc. | Uses of kappa opioid synthetic peptide amides |
| US7842662B2 (en) | 2006-11-10 | 2010-11-30 | Cara Therapeutics, Inc. | Synthetic peptide amide dimers |
| US7713937B2 (en) | 2006-11-10 | 2010-05-11 | Cara Therapeutics, Inc. | Synthetic peptide amides and dimeric forms thereof |
| US8236766B2 (en) | 2006-11-10 | 2012-08-07 | Cara Therapeutics, Inc. | Uses of synthetic peptide amides |
| JP5244810B2 (ja) | 2006-11-10 | 2013-07-24 | カラ セラピューティクス インコーポレイテッド | 合成ペプチドアミド |
| PT3149025T (pt) | 2014-05-21 | 2019-08-01 | Entrada Therapeutics Inc | Peptídeos penetrantes de células e métodos de fabrico e utilização dos mesmos |
| US10815276B2 (en) | 2014-05-21 | 2020-10-27 | Entrada Therapeutics, Inc. | Cell penetrating peptides and methods of making and using thereof |
| WO2016033368A1 (en) | 2014-08-27 | 2016-03-03 | Ohio State Innovation Foundation | Improved peptidyl calcineurin inhibitors |
| US11339192B2 (en) | 2017-10-04 | 2022-05-24 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitors |
| EP3746105A4 (de) | 2018-01-29 | 2022-05-18 | Ohio State Innovation Foundation | Zyklische peptidylinhibitoren der cal-pdz-bindenden domäne |
| US11576946B2 (en) | 2018-01-29 | 2023-02-14 | Ohio State Innovation Foundation | Peptidyl inhibitors of calcineurin-NFAT interaction |
| WO2019165183A1 (en) | 2018-02-22 | 2019-08-29 | Entrada Therapeutics, Inc. | Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy |
| WO2019217682A1 (en) | 2018-05-09 | 2019-11-14 | Ohio State Innovation Foundation | Cyclic cell-penetrating peptides with one or more hydrophobic residues |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4416871A (en) | 1978-07-10 | 1983-11-22 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition by peptides of tolerance to and physical dependence on morphine |
| US4631270A (en) | 1978-11-20 | 1986-12-23 | Research Corporation | Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use |
| US5780595A (en) | 1989-06-16 | 1998-07-14 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
| US5216124A (en) | 1989-12-15 | 1993-06-01 | G. D. Searle & Co. | Substituted cyclic tetrapeptides |
| US5169833A (en) | 1989-12-15 | 1992-12-08 | G. D. Searle & Co. | Substituted cyclic pentapeptides |
| DK53291D0 (da) * | 1991-03-25 | 1991-03-25 | Carlbiotech Ltd As | Smaa peptider og peptidrelaterede stoffer samt farmaceutiske praeparater indeholdende saadanne forbindelser |
| US5656267A (en) | 1991-08-22 | 1997-08-12 | Sagen; Jacqueline | Implantable cells that alleviate chronic pain in humans |
| EP0625162B1 (de) | 1991-12-30 | 1998-05-13 | Neurex Corporation | Methoden zur erzeugung von analgesie und zur verstärkung von opiat-analgesie |
| CA2097533A1 (en) | 1992-06-03 | 1993-12-04 | Simon Lemaire | Peptides having neuroprotective and immunostimulatory functions |
| US5470753A (en) * | 1992-09-03 | 1995-11-28 | Selectide Corporation | Peptide sequencing using mass spectrometry |
| AUPM473294A0 (en) | 1994-03-25 | 1994-04-21 | Franklyn, Kathleen Mary | Peptides for diagnostics and therapeutics |
| US5811391A (en) | 1994-08-25 | 1998-09-22 | Cytel Corporation | Cyclic CS-1 peptidomimetics, compositions and methods of using same |
| AU7637394A (en) | 1994-08-26 | 1996-03-22 | Avram Goldstein | Analgesic method with dynorphin analogues truncated at the n-terminus |
| US5817750A (en) | 1995-08-28 | 1998-10-06 | La Jolla Cancer Research Foundation | Structural mimics of RGD-binding sites |
| CA2224066A1 (en) * | 1997-10-24 | 1999-04-24 | Universite D'ottawa/ University Of Ottawa | Peptides as analgesics |
-
1998
- 1998-02-24 CA CA002224066A patent/CA2224066A1/en not_active Abandoned
- 1998-10-26 AT AT98951127T patent/ATE302210T1/de not_active IP Right Cessation
- 1998-10-26 EP EP98951127A patent/EP1025119B1/de not_active Expired - Lifetime
- 1998-10-26 WO PCT/CA1998/001002 patent/WO1999021877A1/en not_active Ceased
- 1998-10-26 US US09/530,123 patent/US6566327B1/en not_active Expired - Fee Related
- 1998-10-26 AU AU97311/98A patent/AU9731198A/en not_active Abandoned
- 1998-10-26 DE DE69831257T patent/DE69831257D1/de not_active Expired - Lifetime
-
2003
- 2003-05-14 US US10/437,435 patent/US6855692B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU9731198A (en) | 1999-05-17 |
| US20040006013A1 (en) | 2004-01-08 |
| US6566327B1 (en) | 2003-05-20 |
| CA2224066A1 (en) | 1999-04-24 |
| EP1025119B1 (de) | 2005-08-17 |
| EP1025119A1 (de) | 2000-08-09 |
| WO1999021877A1 (en) | 1999-05-06 |
| DE69831257D1 (de) | 2005-09-22 |
| US6855692B2 (en) | 2005-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |