ATE302283T1 - Einfaches enzymatisches verfahren zur herstellung von cefazolin - Google Patents

Einfaches enzymatisches verfahren zur herstellung von cefazolin

Info

Publication number: ATE302283T1
Authority: AT; Austria
Prior art keywords: acid; cefazolin; producing; enzymatic process; cephem
Prior art date: 2002-10-31

Application number

AT02380224T

Other languages

English (en)

Inventor

Ferrer Alvaro Sanchez

Carmona Francisco Garcia

Original Assignee

Bioferma Murcia S A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-31

Filing date

2002-10-31

Publication date

2005-09-15

2002-10-31 Application filed by Bioferma Murcia S A filed Critical Bioferma Murcia S A

2005-09-15 Application granted granted Critical

2005-09-15 Publication of ATE302283T1 publication Critical patent/ATE302283T1/de

Links

MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 title abstract 3
229960001139 cefazolin Drugs 0.000 title abstract 3
230000002255 enzymatic effect Effects 0.000 title 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 6
108010073038 Penicillin Amidase Proteins 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 3
HJSGHKMSDOLGJJ-IOJJLOCKSA-N (6r)-7-amino-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)C(N)[C@H]2SC1 HJSGHKMSDOLGJJ-IOJJLOCKSA-N 0.000 abstract 2
108090000790 Enzymes Proteins 0.000 abstract 2
102000004190 Enzymes Human genes 0.000 abstract 2
239000011942 biocatalyst Substances 0.000 abstract 2
230000001376 precipitating effect Effects 0.000 abstract 2
150000003536 tetrazoles Chemical class 0.000 abstract 2
150000001408 amides Chemical class 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
- C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Mycology (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Cephalosporin Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT02380224T 2002-10-31 2002-10-31 Einfaches enzymatisches verfahren zur herstellung von cefazolin ATE302283T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02380224A EP1416054B1 (de)	2002-10-31	2002-10-31	Einfaches enzymatisches Verfahren zur Herstellung von Cefazolin

Publications (1)

Publication Number	Publication Date
ATE302283T1 true ATE302283T1 (de)	2005-09-15

Family

ID=32088098

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02380224T ATE302283T1 (de)	2002-10-31	2002-10-31	Einfaches enzymatisches verfahren zur herstellung von cefazolin

Country Status (5)

Country	Link
EP (2)	EP1416054B1 (de)
AT (1)	ATE302283T1 (de)
AU (1)	AU2003282071A1 (de)
DE (1)	DE60205635D1 (de)
WO (1)	WO2004039997A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100432214C (zh) *	2005-04-08	2008-11-12	中国船舶重工集团公司第七二五研究所	一种产氨菌
CN100368554C (zh) *	2005-04-26	2008-02-13	华南理工大学	酶催化“一锅法”制备β-内酰胺抗生素的方法
CN102605033B (zh) *	2012-01-17	2013-11-27	湖南福来格生物技术有限公司	头孢唑啉中间体tda的制备方法
CN102617607B (zh) *	2012-03-31	2014-04-16	哈药集团制药总厂	一种制备头孢唑啉化合物的方法
CN103937692B (zh) *	2014-04-30	2016-03-23	江南大学	一株丝枝霉菌株及其生产β-葡萄糖苷酶的方法
WO2024262578A1 (en) *	2023-06-23	2024-12-26	The University Of Tokyo	Synthesis of cefazolin under sequential continuous-flow conditions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR0171897B1 (ko) *	1989-12-27	1999-02-01	후지사와 도모끼찌로	7-아미노세펨 화합물 또는 그 염류의 제조 방법
WO1999013058A2 (en) *	1997-09-09	1999-03-18	Biochemie Gesellschaft Mbh	Esterase free enzymes
AU2002316862A1 (en) *	2001-04-19	2002-11-05	Bioferma Murcia, S.A.	Enzymatic process for preparing cephalosporin derivatives

2002
- 2002-10-31 AT AT02380224T patent/ATE302283T1/de not_active IP Right Cessation
- 2002-10-31 DE DE60205635T patent/DE60205635D1/de not_active Expired - Lifetime
- 2002-10-31 EP EP02380224A patent/EP1416054B1/de not_active Expired - Lifetime
2003
- 2003-10-30 AU AU2003282071A patent/AU2003282071A1/en not_active Abandoned
- 2003-10-30 WO PCT/EP2003/012165 patent/WO2004039997A1/en not_active Ceased
- 2003-10-30 EP EP03773688A patent/EP1556500A1/de not_active Withdrawn

Also Published As

Publication number	Publication date
EP1416054A1 (de)	2004-05-06
AU2003282071A1 (en)	2004-05-25
DE60205635D1 (de)	2005-09-22
WO2004039997A1 (en)	2004-05-13
EP1556500A1 (de)	2005-07-27
EP1416054B1 (de)	2005-08-17

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Legal Events

Date	Code	Title	Description
2006-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties