ATE302349T1 - Poröses mikroventil - Google Patents

Poröses mikroventil

Info

Publication number
ATE302349T1
ATE302349T1 AT01979716T AT01979716T ATE302349T1 AT E302349 T1 ATE302349 T1 AT E302349T1 AT 01979716 T AT01979716 T AT 01979716T AT 01979716 T AT01979716 T AT 01979716T AT E302349 T1 ATE302349 T1 AT E302349T1
Authority
AT
Austria
Prior art keywords
porous
layers
porous materials
constructed
fluid flow
Prior art date
Application number
AT01979716T
Other languages
English (en)
Inventor
Marci Pezzuto
Stephen D O'connor
Original Assignee
Nanostream Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanostream Inc filed Critical Nanostream Inc
Application granted granted Critical
Publication of ATE302349T1 publication Critical patent/ATE302349T1/de

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0025—Valves using microporous membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0028—Valves having multiple inlets or outlets
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0036—Operating means specially adapted for microvalves operated by temperature variations
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
    • F16K99/0057—Operating means specially adapted for microvalves actuated by fluids the fluid being the circulating fluid itself, e.g. check valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0418—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/0074—Fabrication methods specifically adapted for microvalves using photolithography, e.g. etching
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/0076—Fabrication methods specifically adapted for microvalves using electrical discharge machining [EDM], milling or drilling
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/008—Multi-layer fabrications
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/218—Means to regulate or vary operation of device
    • Y10T137/2191—By non-fluid energy field affecting input [e.g., transducer]
    • Y10T137/2196—Acoustical or thermal energy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/2224—Structure of body of device

Landscapes

  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Materials For Medical Uses (AREA)
AT01979716T 2001-04-20 2001-10-12 Poröses mikroventil ATE302349T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/839,547 US6418968B1 (en) 2001-04-20 2001-04-20 Porous microfluidic valves
PCT/US2001/031825 WO2002086332A1 (en) 2001-04-20 2001-10-12 Porous microfluidic valves

Publications (1)

Publication Number Publication Date
ATE302349T1 true ATE302349T1 (de) 2005-09-15

Family

ID=25280026

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01979716T ATE302349T1 (de) 2001-04-20 2001-10-12 Poröses mikroventil

Country Status (5)

Country Link
US (3) US6418968B1 (de)
EP (1) EP1379787B1 (de)
AT (1) ATE302349T1 (de)
DE (1) DE60112812T2 (de)
WO (1) WO2002086332A1 (de)

Families Citing this family (216)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9808836D0 (en) * 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
GB9809943D0 (en) * 1998-05-08 1998-07-08 Amersham Pharm Biotech Ab Microfluidic device
US7261859B2 (en) * 1998-12-30 2007-08-28 Gyros Ab Microanalysis device
US20080277007A1 (en) * 1999-06-28 2008-11-13 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6899137B2 (en) * 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US20020119079A1 (en) * 1999-12-10 2002-08-29 Norbert Breuer Chemical microreactor and microreactor made by process
WO2002011888A2 (en) * 2000-08-07 2002-02-14 Nanostream, Inc. Fluidic mixer in microfluidic system
US20090118139A1 (en) * 2000-11-07 2009-05-07 Caliper Life Sciences, Inc. Microfluidic method and system for enzyme inhibition activity screening
US7105304B1 (en) * 2000-11-07 2006-09-12 Caliper Life Sciences, Inc. Pressure-based mobility shift assays
US20050221385A1 (en) * 2000-11-07 2005-10-06 Caliper Life Sciences, Inc. Pressure based mobility shift assays
JP3628611B2 (ja) * 2000-11-29 2005-03-16 独立行政法人科学技術振興機構 マイクロシステムにおける流れの制御方法
US6653625B2 (en) * 2001-03-19 2003-11-25 Gyros Ab Microfluidic system (MS)
US7429354B2 (en) * 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
CA2441206A1 (en) 2001-03-19 2002-09-26 Gyros Ab Characterization of reaction variables
US6880576B2 (en) * 2001-06-07 2005-04-19 Nanostream, Inc. Microfluidic devices for methods development
US7318912B2 (en) * 2001-06-07 2008-01-15 Nanostream, Inc. Microfluidic systems and methods for combining discrete fluid volumes
US6981522B2 (en) * 2001-06-07 2006-01-03 Nanostream, Inc. Microfluidic devices with distributing inputs
US6729352B2 (en) * 2001-06-07 2004-05-04 Nanostream, Inc. Microfluidic synthesis devices and methods
US7077152B2 (en) * 2001-07-07 2006-07-18 Nanostream, Inc. Microfluidic metering systems and methods
US7704728B2 (en) * 2001-07-18 2010-04-27 The University Of Michigan Microfluidic gravity pump with constant flow rate
US6919058B2 (en) * 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US7189368B2 (en) * 2001-09-17 2007-03-13 Gyros Patent Ab Functional unit enabling controlled flow in a microfluidic device
US20030138819A1 (en) * 2001-10-26 2003-07-24 Haiqing Gong Method for detecting disease
US7338760B2 (en) 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
US7069952B1 (en) 2001-11-14 2006-07-04 Caliper Life Sciences, Inc. Microfluidic devices and methods of their manufacture
US20030091647A1 (en) * 2001-11-15 2003-05-15 Lewis Jennifer A. Controlled dispersion of colloidal suspensions via nanoparticle additions
US20030098661A1 (en) * 2001-11-29 2003-05-29 Ken Stewart-Smith Control system for vehicle seats
US6877892B2 (en) * 2002-01-11 2005-04-12 Nanostream, Inc. Multi-stream microfluidic aperture mixers
US20040109793A1 (en) * 2002-02-07 2004-06-10 Mcneely Michael R Three-dimensional microfluidics incorporating passive fluid control structures
US20050084645A1 (en) * 2002-02-07 2005-04-21 Selinfreund Richard H. Method and system for optical disc copy-protection
US20030180711A1 (en) * 2002-02-21 2003-09-25 Turner Stephen W. Three dimensional microfluidic device having porous membrane
WO2003072255A1 (en) * 2002-02-23 2003-09-04 Nanostream, Inc. Microfluidic multi-splitter
US7781159B2 (en) * 2002-05-09 2010-08-24 Nanologix, Inc. Micromethod and device for rapid detection, enumeration and identification of entities
US8663909B2 (en) * 2002-05-09 2014-03-04 Nanologix, Inc. Device for rapid detection and identification of single microorganisms without preliminary growth
AU2002320775A1 (en) * 2002-07-05 2004-02-25 Gaspardo Seminatrici S.P.A. A volumetric metering device for the metered delivery of granular and powdery materials, particularly for machines for distributing the said materials
US7235164B2 (en) 2002-10-18 2007-06-26 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
US7517440B2 (en) 2002-07-17 2009-04-14 Eksigent Technologies Llc Electrokinetic delivery systems, devices and methods
US7364647B2 (en) * 2002-07-17 2008-04-29 Eksigent Technologies Llc Laminated flow device
US7214348B2 (en) * 2002-07-26 2007-05-08 Applera Corporation Microfluidic size-exclusion devices, systems, and methods
AU2003303303A1 (en) * 2002-08-19 2004-08-30 Bioprocessors Corporation Microreactor architecture and methods
US6905585B2 (en) * 2002-09-11 2005-06-14 Temple University Of The Commonwealth System Of Higher Education Automated system for high-throughput electrophoretic separations
US6806543B2 (en) 2002-09-12 2004-10-19 Intel Corporation Microfluidic apparatus with integrated porous-substrate/sensor for real-time (bio)chemical molecule detection
US7279134B2 (en) * 2002-09-17 2007-10-09 Intel Corporation Microfluidic devices with porous membranes for molecular sieving, metering, and separations
DE10244154A1 (de) * 2002-09-23 2004-04-08 Prisma Diagnostika Gmbh Trägerelement für diagnostische Tests
US20040226620A1 (en) 2002-09-26 2004-11-18 Daniel Therriault Microcapillary networks
US20040092033A1 (en) * 2002-10-18 2004-05-13 Nanostream, Inc. Systems and methods for preparing microfluidic devices for operation
US6936167B2 (en) * 2002-10-31 2005-08-30 Nanostream, Inc. System and method for performing multiple parallel chromatographic separations
US20040133889A1 (en) * 2002-12-12 2004-07-08 Renzo Colle Scheduling tasks across multiple locations
KR100908949B1 (ko) * 2002-12-20 2009-07-22 어플라이드 머티어리얼스, 인코포레이티드 미세-가공되고 일체화된 유체 전달 시스템
US7147955B2 (en) 2003-01-31 2006-12-12 Societe Bic Fuel cartridge for fuel cells
WO2004067182A2 (ja) * 2003-01-31 2004-08-12 Sumitomo Chemical Company, Limited エマルションの分級装置および分級方法、エマルションの解乳化方法
GB0304082D0 (en) * 2003-02-22 2003-03-26 Synthese O Grande Vitesse Ltd Improvements in and relating to circuits
US20050014134A1 (en) * 2003-03-06 2005-01-20 West Jason Andrew Appleton Viral identification by generation and detection of protein signatures
AU2003901779A0 (en) * 2003-04-15 2003-05-01 Microtechnology Centre Management Limited Microfluidic sealing
US7141617B2 (en) 2003-06-17 2006-11-28 The Board Of Trustees Of The University Of Illinois Directed assembly of three-dimensional structures with micron-scale features
FR2857427B1 (fr) * 2003-07-10 2005-08-26 Biomerieux Sa Vanne a commande electrique comprenant une membrane microporeuse
US7524623B2 (en) * 2003-07-28 2009-04-28 Nanologix, Inc. Method and device for rapid detection of microorganisms by changing the shape of micro-colonies
US7028536B2 (en) * 2004-06-29 2006-04-18 Nanostream, Inc. Sealing interface for microfluidic device
US20050032238A1 (en) * 2003-08-07 2005-02-10 Nanostream, Inc. Vented microfluidic separation devices and methods
CN1784605B (zh) * 2003-10-15 2011-11-23 松下电器产业株式会社 毛细管芯片中流体的流通方法、使用该方法的流通控制装置
US20050095602A1 (en) * 2003-11-04 2005-05-05 West Jason A. Microfluidic integrated microarrays for biological detection
DE10353406A1 (de) * 2003-11-14 2005-06-16 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Verfahren zur Trennung von chemischen Substanzen und/oder Partikeln, Vorrichtung und ihre Verwendung
GB0327094D0 (en) * 2003-11-21 2003-12-24 Inverness Medical Switzerland Laminated device
WO2006025858A2 (en) * 2004-02-17 2006-03-09 Yale University Microfabricated cellular traps based on three-dimensional micro-scale flow geometries
JP2005234389A (ja) * 2004-02-20 2005-09-02 Fuji Photo Film Co Ltd 科学現象の評価装置、理科実験教材、及びその製造方法
JP4450368B2 (ja) * 2004-03-04 2010-04-14 独立行政法人産業技術総合研究所 マイクロ流路チップの製造方法、マイクロ流路チップ、そのマイクロ流路チップを用いる生体分子の分離方法、およびそのマイクロ流路チップを有する電気泳動装置
US7559356B2 (en) * 2004-04-19 2009-07-14 Eksident Technologies, Inc. Electrokinetic pump driven heat transfer system
US7993606B2 (en) * 2004-04-30 2011-08-09 E. I. Du Pont De Nemours And Company Adaptive membrane structure
WO2006078280A2 (en) * 2004-04-30 2006-07-27 E.I. Dupont De Nemours And Company Adaptive membrane structure
US7773227B2 (en) * 2004-06-04 2010-08-10 California Institute Of Technology Optofluidic microscope device featuring a body comprising a fluid channel and having light transmissive regions
US7751048B2 (en) * 2004-06-04 2010-07-06 California Institute Of Technology Optofluidic microscope device
US7692219B1 (en) 2004-06-25 2010-04-06 University Of Hawaii Ultrasensitive biosensors
US7524672B2 (en) * 2004-09-22 2009-04-28 Sandia Corporation Microfluidic microarray systems and methods thereof
US7592139B2 (en) 2004-09-24 2009-09-22 Sandia National Laboratories High temperature flow-through device for rapid solubilization and analysis
US7785785B2 (en) 2004-11-12 2010-08-31 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for DNA and other molecules
WO2006089252A2 (en) * 2005-02-16 2006-08-24 Mcneely Michael R Liquid valving using reactive or responsive materials
US8657120B2 (en) * 2006-11-30 2014-02-25 Palo Alto Research Center Incorporated Trapping structures for a particle separation cell
TWI296711B (en) * 2005-10-11 2008-05-11 Ind Tech Res Inst Biochip with microchannels
US7723120B2 (en) * 2005-10-26 2010-05-25 General Electric Company Optical sensor array system and method for parallel processing of chemical and biochemical information
EP1957794B1 (de) 2005-11-23 2014-07-02 Eksigent Technologies, LLC Elektrokinetische pumpenausführungen und arzneimittelabgabesysteme
US7445027B2 (en) * 2006-03-14 2008-11-04 The Board Of Trustees Of The University Of Illinois Multilayer microfluidic-nanofluidic device
JP5254949B2 (ja) 2006-03-15 2013-08-07 マイクロニクス， インコーポレイテッド 一体型の核酸アッセイ
US8974748B2 (en) * 2007-04-05 2015-03-10 Corning Incorporated Dual inlet microchannel device and method for using same
US9041938B2 (en) 2006-05-02 2015-05-26 California Institute Of Technology Surface wave assisted structures and systems
US7768654B2 (en) 2006-05-02 2010-08-03 California Institute Of Technology On-chip phase microscope/beam profiler based on differential interference contrast and/or surface plasmon assisted interference
US7674924B2 (en) * 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
WO2008007087A1 (en) * 2006-07-14 2008-01-17 Aviza Technology Limited Microfluidic devices
US8656949B2 (en) * 2006-08-15 2014-02-25 University Of Maryland College Park Microfluidic devices and methods of fabrication
WO2008147382A1 (en) * 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
US8403557B2 (en) * 2006-09-28 2013-03-26 University Of Washington Micromixer using integrated three-dimensional porous structure
WO2008040015A2 (en) * 2006-09-28 2008-04-03 University Of Washington 3d micro-scale engineered tissue model systems
FR2907228B1 (fr) * 2006-10-13 2009-07-24 Rhodia Recherches & Tech Dispositif d'ecoulement fluidique,ensemble de determination d'au moins une caracteristique d'un systeme physico-chimique comprenant un tel dispositif,procede de determination et procede de criblage correspondants
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
EP2639578B1 (de) 2006-12-14 2016-09-14 Life Technologies Corporation Vorrichtung zur Messung von Analyten mithilfe großer FET-Arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
CN1996009B (zh) * 2007-01-10 2010-05-19 博奥生物有限公司 一种用于多样品分析的微流体器件和使用方法
US7867592B2 (en) 2007-01-30 2011-01-11 Eksigent Technologies, Inc. Methods, compositions and devices, including electroosmotic pumps, comprising coated porous surfaces
US7956102B2 (en) 2007-04-09 2011-06-07 The Board Of Trustees Of The University Of Illinois Sol-gel inks
EP2152417B1 (de) 2007-05-04 2018-07-11 Opko Diagnostics, LLC Vorrichtung und methode für analysen in mikrofluidsysteme
US7850861B1 (en) 2007-06-18 2010-12-14 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Microfluidic device, and related methods
US8016260B2 (en) 2007-07-19 2011-09-13 Formulatrix, Inc. Metering assembly and method of dispensing fluid
KR20090030084A (ko) * 2007-09-19 2009-03-24 삼성전자주식회사 미세유동장치
US8251672B2 (en) * 2007-12-11 2012-08-28 Eksigent Technologies, Llc Electrokinetic pump with fixed stroke volume
WO2009111573A2 (en) * 2008-03-04 2009-09-11 California Institute Of Technology Optofluidic microscope device with photosensor array
US8325349B2 (en) * 2008-03-04 2012-12-04 California Institute Of Technology Focal plane adjustment by back propagation in optofluidic microscope devices
EP2250485A1 (de) * 2008-03-04 2010-11-17 California Institute of Technology Verfahren zur verwendung optofluidischer mikroskope
US20110041922A1 (en) * 2008-03-12 2011-02-24 Fluimedix Aps Controlled liquid handling
WO2009120642A1 (en) 2008-03-26 2009-10-01 Massachusetts Institute Of Technology Methods for fabricating electrokinetic concentration devices
US8039776B2 (en) 2008-05-05 2011-10-18 California Institute Of Technology Quantitative differential interference contrast (DIC) microscopy and photography based on wavefront sensors
CN102203282B (zh) 2008-06-25 2014-04-30 生命技术公司 使用大规模fet阵列测量分析物的方法和装置
EP2143492A1 (de) * 2008-07-11 2010-01-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren und Mikrofluidvorrichtung zur Kombination von in Flüssigkeit enthaltenden Reaktionskomponenten
US9180453B2 (en) 2008-08-15 2015-11-10 University Of Washington Method and apparatus for the discretization and manipulation of sample volumes
US7922939B2 (en) 2008-10-03 2011-04-12 The Board Of Trustees Of The University Of Illinois Metal nanoparticle inks
US8187500B2 (en) 2008-10-17 2012-05-29 The Board Of Trustees Of The University Of Illinois Biphasic inks
US11951474B2 (en) 2008-10-22 2024-04-09 Life Technologies Corporation Fluidics systems for sequential delivery of reagents
US8546128B2 (en) 2008-10-22 2013-10-01 Life Technologies Corporation Fluidics system for sequential delivery of reagents
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US9137895B2 (en) 2008-12-24 2015-09-15 Stmicroelectronics S.R.L. Micro-electro-mechanical systems (MEMS) and corresponding manufacturing process
WO2010090849A1 (en) * 2009-01-21 2010-08-12 California Institute Of Technology Quantitative differential interference contrast (dic) devices for computed depth sectioning
US8100293B2 (en) 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
WO2010087999A1 (en) * 2009-02-02 2010-08-05 Claros Diagnostics, Inc. Structures for controlling light interaction with microfluidic devices
US8150605B2 (en) 2009-02-17 2012-04-03 Ford Global Technologies, Llc Coordination of variable cam timing and variable displacement engine systems
EP2419216A1 (de) 2009-04-15 2012-02-22 Koninklijke Philips Electronics N.V. Mikrofluidische vorrichtung mit sensor
US8695639B2 (en) * 2009-05-07 2014-04-15 International Business Machines Corporation Multilayer microfluidic probe head and method of fabrication thereof
US9110057B2 (en) * 2009-05-19 2015-08-18 The Regents Of The University Of California Multi-directional microfluidic devices and methods
DE102009022182B4 (de) 2009-05-20 2011-05-12 Fachhochschule Lübeck Regelbare Drosselstrecke
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
US8416400B2 (en) * 2009-06-03 2013-04-09 California Institute Of Technology Wavefront imaging sensor
US8633432B2 (en) * 2009-09-21 2014-01-21 California Institute Of Technology Reflective focusing and transmissive projection device
KR20110046867A (ko) * 2009-10-29 2011-05-06 삼성전자주식회사 기체 제공부를 포함하는 미세 유동 장치, 및 이를 이용한 액체 혼합 방법 및 에멀젼 형성 방법
US9132423B2 (en) 2010-01-29 2015-09-15 Micronics, Inc. Sample-to-answer microfluidic cartridge
DE102010003642A1 (de) * 2010-03-15 2011-09-15 Fresenius Medical Care Deutschland Gmbh Kassette mit einem Sensor zur Bestimmung der Differenz eines ersten und eines zweiten Flüssigkeitsstroms
WO2011119678A2 (en) * 2010-03-23 2011-09-29 California Institute Of Technology Super resolution optofluidic microscopes for 2d and 3d imaging
US8974651B2 (en) 2010-04-17 2015-03-10 C.C. Imex Illuminator for visualization of fluorophores
TW201716791A (zh) 2010-06-30 2017-05-16 生命技術公司 用於測試離子感測場效電晶體（ｉｓｆｅｔ）陣列之裝置及方法
WO2012003363A1 (en) 2010-06-30 2012-01-05 Life Technologies Corporation Ion-sensing charge-accumulation circuits and methods
EP2598804B1 (de) 2010-06-30 2021-10-20 Life Technologies Corporation Verfahren zur erzeugung eines ausgangssignals in einem isfet-array
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
TWI527245B (zh) 2010-07-03 2016-03-21 生命技術公司 具有微摻雜汲極之化學感測器
US20120052250A1 (en) * 2010-08-27 2012-03-01 Derosa Michael Edward Flexible Microfluidic Device with Interconnected Porous Network
WO2012033957A2 (en) 2010-09-09 2012-03-15 California Institute Of Technology Delayed emission detection devices and methods
EP2617061B1 (de) 2010-09-15 2021-06-30 Life Technologies Corporation Verfahren und vorrichtung zur analytmessung
EP2619564B1 (de) 2010-09-24 2016-03-16 Life Technologies Corporation Transistorschaltungen mit zusammengehörigen paaren
JP6133780B2 (ja) 2010-11-23 2017-05-24 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 汎捕捉性の結合領域を備えている多方向マイクロ流体デバイス、及びその使用方法
US9029169B2 (en) 2010-12-03 2015-05-12 The Regents Of The University Of California Protein renaturation microfluidic devices and methods of making and using the same
EP3498208A1 (de) 2011-04-12 2019-06-19 Thermedical, Inc. Vorrichtungen zum erwärmen eines fluids in einer fluidunterstützten ablationstherapie
EP2704759A4 (de) 2011-05-05 2015-06-03 Eksigent Technologies Llc Gelkupplung für elektrokinetische abgabesysteme
WO2013089887A2 (en) 2011-09-30 2013-06-20 The Regents Of The University Of California Microfluidic devices and methods for assaying a fluid sample using the same
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
CN108108590A (zh) 2012-03-05 2018-06-01 阿克蒂克合伙公司 分析系统和方法
US9150907B2 (en) 2012-04-27 2015-10-06 General Electric Company Microfluidic flow cell assemblies and method of use
US8900529B2 (en) 2012-04-27 2014-12-02 General Electric Company Microfluidic chamber device and fabrication
US9080941B2 (en) 2012-04-27 2015-07-14 General Electric Company Microfluidic flow cell assemblies for imaging and method of use
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
US9315187B2 (en) * 2012-06-04 2016-04-19 Inventev, Llc Plug-in hybrid electric vehicle system
DE102012105540A1 (de) * 2012-06-26 2014-04-24 Karlsruher Institut für Technologie Gefäßmodell, Verfahren zu seiner Herstellung und seine Verwendung
US10022176B2 (en) 2012-08-15 2018-07-17 Thermedical, Inc. Low profile fluid enhanced ablation therapy devices and methods
CN102886280B (zh) * 2012-08-28 2014-06-11 博奥生物有限公司 一种微流控芯片及其应用
WO2014093080A1 (en) * 2012-12-11 2014-06-19 The Regents Of The University Of California Microfluidic devices for liquid chromatography-mass spectrometry and microscopic imaging
WO2014100743A2 (en) 2012-12-21 2014-06-26 Micronics, Inc. Low elasticity films for microfluidic use
EP2935559B1 (de) 2012-12-21 2020-09-16 PerkinElmer Health Sciences, Inc. Fluoreszenznachweissystem
EP2935908B1 (de) 2012-12-21 2019-08-14 PerkinElmer Health Sciences, Inc. Fluidkreisläufe und zugehörige herstellungsverfahren
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
US10040018B2 (en) 2013-01-09 2018-08-07 Imagine Tf, Llc Fluid filters and methods of use
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
US20140264472A1 (en) 2013-03-15 2014-09-18 Life Technologies Corporation Chemical sensor with consistent sensor surface areas
KR101653701B1 (ko) * 2013-03-15 2016-09-02 지멘스 헬쓰케어 다이아그노스틱스 인크. 미세유체 분배 장치
WO2014149778A1 (en) 2013-03-15 2014-09-25 Life Technologies Corporation Chemical sensors with consistent sensor surface areas
US9033972B2 (en) 2013-03-15 2015-05-19 Thermedical, Inc. Methods and devices for fluid enhanced microwave ablation therapy
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
EP2972281B1 (de) 2013-03-15 2023-07-26 Life Technologies Corporation Chemische vorrichtung mit dünnem leitenden element
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
US9506934B2 (en) * 2013-04-29 2016-11-29 Honeywell International Inc. Polymer test cartridge mixer for cell lysis
US10386377B2 (en) 2013-05-07 2019-08-20 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
EP2994532B1 (de) 2013-05-07 2017-11-15 Micronics, Inc. Verfahren zur herstellung von nukleinsäurehaltigen proben mittels tonmineralien und alkalischen lösungen
EP2994543B1 (de) 2013-05-07 2018-08-15 Micronics, Inc. Vorrichtung zur herstellung und analyse von nukleinsäuren
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
US9671368B2 (en) 2013-05-10 2017-06-06 The Regents Of The University Of California Two-dimensional microfluidic devices and methods of using the same
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
US11219896B2 (en) 2013-06-25 2022-01-11 University Of Washington Through Its Center For Commercialization Self-digitization of sample volumes
US9835587B2 (en) 2014-04-01 2017-12-05 C.C. Imex Electrophoresis running tank assembly
US9861920B1 (en) 2015-05-01 2018-01-09 Imagine Tf, Llc Three dimensional nanometer filters and methods of use
KR20170016915A (ko) 2014-06-11 2017-02-14 마이크로닉스 인코포레이티드. 핵산의 분석을 위한 통합 검정 대조군을 갖는 마이크로 유체 공학적 카트리지 및 장치
US10730047B2 (en) 2014-06-24 2020-08-04 Imagine Tf, Llc Micro-channel fluid filters and methods of use
WO2016033455A1 (en) 2014-08-29 2016-03-03 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods, devices, and systems for microfluidic stress emulation
US10124275B2 (en) 2014-09-05 2018-11-13 Imagine Tf, Llc Microstructure separation filters
EP3234576B1 (de) 2014-12-18 2023-11-22 Life Technologies Corporation Integrierte schaltung mit hoher datenrate und mit transmitterkonfiguration
US10379079B2 (en) 2014-12-18 2019-08-13 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
US10758849B2 (en) 2015-02-18 2020-09-01 Imagine Tf, Llc Three dimensional filter devices and apparatuses
EP3281004A1 (de) * 2015-04-06 2018-02-14 Göksen Göksenin Yaralio Lu Vorrichtung und verfahren zur messung der physikalischen eigenschaften eines materials
CA3162752A1 (en) 2015-04-09 2016-10-13 Angle Europe Limited Method for performing a biological assay
JP6868289B2 (ja) 2015-07-07 2021-05-12 ユニバーシティ オブ ワシントンＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｗａｓｈｉｎｇｔｏｎ サンプルの自己デジタル化のためのシステム、方法、およびデバイス
US10118842B2 (en) 2015-07-09 2018-11-06 Imagine Tf, Llc Deionizing fluid filter devices and methods of use
US10479046B2 (en) 2015-08-19 2019-11-19 Imagine Tf, Llc Absorbent microstructure arrays and methods of use
US10330643B2 (en) 2016-02-04 2019-06-25 Qorvo Us, Inc. BAW sensing and filtration device and related methods
JP6577404B2 (ja) * 2016-04-05 2019-09-18 ファナック株式会社 絞りユニット及びこれを備えた静圧軸受装置並びに溝付きブロックの製造方法
KR102378100B1 (ko) 2016-04-06 2022-03-23 플루이딕 애널리틱스 리미티드 유동 균형의 향상 또는 이와 관련된 향상
US9743984B1 (en) * 2016-08-11 2017-08-29 Thermedical, Inc. Devices and methods for delivering fluid to tissue during ablation therapy
CN115715676B (zh) 2017-06-08 2025-09-16 贝克顿·迪金森公司 生物流体分离装置
US11083871B2 (en) 2018-05-03 2021-08-10 Thermedical, Inc. Selectively deployable catheter ablation devices
US11918277B2 (en) 2018-07-16 2024-03-05 Thermedical, Inc. Inferred maximum temperature monitoring for irrigated ablation therapy
EP3845790B1 (de) * 2019-12-30 2024-04-17 Imec VZW Mikrofluidische vorrichtung zur steuerung von pneumatischen mikroventilen
US12134095B2 (en) * 2022-01-24 2024-11-05 Siphox, Inc. Apparatus and methods for performing microfluidic-based biochemical assays
EP4683741A1 (de) * 2023-03-18 2026-01-28 Politechnika Warszawska Verfahren zur herstellung mikrofluidischer systeme für medizinische diagnostik in dünnen polyestermaterialien und mikrofluidisches system für medizinische diagnostik
CN117511739B (zh) * 2024-01-04 2024-03-12 中日友好医院(中日友好临床医学研究所) 微流体骨类器官芯片的构建方法及装置
CN121351432A (zh) * 2025-12-18 2026-01-16 江苏国创新能源商用车创新技术有限公司 用于热管理的多通阀的模拟方法及装置

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3568692A (en) * 1967-11-27 1971-03-09 Bowles Eng Corp Optical machining process
US3680576A (en) * 1970-09-02 1972-08-01 Bendix Corp Bonded metal structure having intricate passages formed therein, and a method of making said structures
DD98732A1 (de) * 1971-04-05 1973-07-12
US4676274A (en) 1985-02-28 1987-06-30 Brown James F Capillary flow control
US5770029A (en) 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
JP3305322B2 (ja) 1992-11-06 2002-07-22 バイオログ，インコーポレーテッド 液体及び懸濁液の分析装置
US6129973A (en) 1994-07-29 2000-10-10 Battelle Memorial Institute Microchannel laminated mass exchanger and method of making
US5571410A (en) * 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5879632A (en) * 1996-04-09 1999-03-09 Sarnoff Corporation Apportioning system
DE19739722A1 (de) 1997-09-10 1999-04-01 Lienhard Prof Dr Pagel Zwei- und Dreidimensionale fluidische Mikrosysteme aus Leiterplatten
AU1517999A (en) 1997-10-15 1999-05-03 Aclara Biosciences, Inc. Laminate microstructure device and method for making same
US6111096A (en) 1997-10-31 2000-08-29 Bbi Bioseq, Inc. Nucleic acid isolation and purification
US6074725A (en) 1997-12-10 2000-06-13 Caliper Technologies Corp. Fabrication of microfluidic circuits by printing techniques
WO1999060397A1 (en) 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
US6494614B1 (en) 1998-07-27 2002-12-17 Battelle Memorial Institute Laminated microchannel devices, mixing units and method of making same
CA2347182C (en) 1998-10-13 2004-06-15 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
SE9803772D0 (sv) 1998-11-05 1998-11-05 Astra Ab Pharmaceutical formulation
US6193471B1 (en) 1999-06-30 2001-02-27 Perseptive Biosystems, Inc. Pneumatic control of formation and transport of small volume liquid samples
US6395232B1 (en) 1999-07-09 2002-05-28 Orchid Biosciences, Inc. Fluid delivery system for a microfluidic device using a pressure pulse
AU6117700A (en) 1999-07-23 2001-02-13 Board Of Trustees Of The University Of Illinois, The Microfabricated devices and method of manufacturing the same
WO2001009598A1 (en) 1999-07-28 2001-02-08 University Of Washington Fluidic interconnect, interconnect manifold and microfluidic devices for internal delivery of gases and application of vacuum
US6210986B1 (en) * 1999-09-23 2001-04-03 Sandia Corporation Microfluidic channel fabrication method
JP2003527972A (ja) * 1999-10-04 2003-09-24 ナノストリーム・インコーポレイテッド 挟まれたステンシルを含むモジュラー型マイクロ流体デバイス
AU7853000A (en) * 1999-10-04 2001-05-10 Nanostream, Inc. Modular microfluidic devices comprising layered circuit board-type substrates
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
CA2290731A1 (en) 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
AU2001296809A1 (en) 2000-10-10 2002-04-22 Biotrove, Inc. Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
US6952962B2 (en) 2000-10-24 2005-10-11 Sandia National Laboratories Mobile monolithic polymer elements for flow control in microfluidic devices
US20020189947A1 (en) 2001-06-13 2002-12-19 Eksigent Technologies Llp Electroosmotic flow controller

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