ATE302647T1 - Verfahren und vorrichtung zur herstellung von teilchen - Google Patents

Verfahren und vorrichtung zur herstellung von teilchen

Info

Publication number
ATE302647T1
ATE302647T1 AT00930027T AT00930027T ATE302647T1 AT E302647 T1 ATE302647 T1 AT E302647T1 AT 00930027 T AT00930027 T AT 00930027T AT 00930027 T AT00930027 T AT 00930027T AT E302647 T1 ATE302647 T1 AT E302647T1
Authority
AT
Austria
Prior art keywords
fluid gas
vehicle system
mixing chamber
disorder
controlled
Prior art date
Application number
AT00930027T
Other languages
English (en)
Inventor
Catherine Boissier
Hakan Glad
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Application granted granted Critical
Publication of ATE302647T1 publication Critical patent/ATE302647T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/26—Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0407—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solute
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0411—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0488—Flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/44—Mixers in which the components are pressed through slits
    • B01F25/441—Mixers in which the components are pressed through slits characterised by the configuration of the surfaces forming the slits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
    • B01J3/008—Processes carried out under supercritical conditions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00162—Controlling or regulating processes controlling the pressure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Accessories For Mixers (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Glanulating (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
AT00930027T 1999-05-07 2000-05-04 Verfahren und vorrichtung zur herstellung von teilchen ATE302647T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9901667A SE9901667D0 (sv) 1999-05-07 1999-05-07 Method and device for forming particles
PCT/SE2000/000877 WO2000067892A1 (en) 1999-05-07 2000-05-04 Method and device for forming particles

Publications (1)

Publication Number Publication Date
ATE302647T1 true ATE302647T1 (de) 2005-09-15

Family

ID=20415513

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00930027T ATE302647T1 (de) 1999-05-07 2000-05-04 Verfahren und vorrichtung zur herstellung von teilchen

Country Status (13)

Country Link
US (1) US6551532B1 (de)
EP (1) EP1191998B1 (de)
JP (1) JP2002543961A (de)
KR (1) KR20020013871A (de)
CN (1) CN1350475A (de)
AT (1) ATE302647T1 (de)
AU (1) AU759786B2 (de)
CA (1) CA2368087A1 (de)
DE (1) DE60022195T2 (de)
MX (1) MXPA01011099A (de)
NZ (1) NZ515146A (de)
SE (1) SE9901667D0 (de)
WO (1) WO2000067892A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
WO2002068107A2 (en) 2001-02-26 2002-09-06 Dompe S.P.A. Apparatus and method for micron and submicron particle formation
FR2824754B1 (fr) * 2001-05-15 2004-05-28 Separex Sa Procede d'obtention de particules solides a partir d'au moins un produit hydrosoluble
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US20050206022A1 (en) * 2002-04-12 2005-09-22 Pellikaan Hubert C Process for small particle formation
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
US6998051B2 (en) * 2002-07-03 2006-02-14 Ferro Corporation Particles from supercritical fluid extraction of emulsion
WO2004098561A2 (en) 2003-05-08 2004-11-18 Nektar Therapeutics Uk Ltd Particulate materials
US7098342B2 (en) * 2003-10-16 2006-08-29 Teva Pharmaceutical Industries Ltd. Preparation of candesartan cilexetil
WO2005077941A2 (en) * 2004-02-11 2005-08-25 Teva Pharmaceutical Industries Ltd. Candesartan cilexetil polymorphs
KR100908308B1 (ko) * 2004-05-05 2009-07-17 테바 파마슈티컬 인더스트리즈 리미티드 순도가 높은 칸데사르탄 실렉세틸의 제조
WO2005123720A1 (en) * 2004-06-18 2005-12-29 Ranbaxy Laboratories Limited Fine particles of the angiotensin ii antagonist candesartan cilexetil and process for production thereof
EP2210888B1 (de) * 2005-05-10 2013-04-24 Teva Pharmaceutical Industries, Ltd. Stabiles mikronisiertes Candesartan-Cilexetil und Herstellungsverfahren
CA2667890C (en) * 2006-10-31 2015-01-27 Surmodics Pharmaceuticals, Inc. Spheronized polymer particles
WO2008097664A1 (en) 2007-02-11 2008-08-14 Map Pharmaceuticals, Inc. Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile
ES2326402B1 (es) * 2008-04-07 2010-08-10 Activery Biotech, S.L. Procedimiento para la preparacion de combinaciones amorfas de antagonistas del receptor de angiotensina ii y diureticos.
MX350838B (es) 2011-02-11 2017-09-18 Grain Proc Corporation * Composicion de sal.

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL44352A (en) 1973-03-16 1977-07-31 Ciba Geigy Ag Preparation of non-dusty easily wetted and readily soluble granulates
JPS5243163A (en) * 1975-10-02 1977-04-04 Matsushita Electric Ind Co Ltd Mixer for fluid
US4179222A (en) 1978-01-11 1979-12-18 Systematix Controls, Inc. Flow turbulence generating and mixing device
ES481924A1 (es) * 1978-06-28 1980-09-01 Gen Foods Ltd Un procedimiento mejorado para obtener un producto alimenti-cio secado por pulverizacion, tal como cafe, destrina y si- milares.
NL8001874A (nl) * 1980-03-29 1981-11-02 Stamicarbon Inrichting voor het versproeien van een vloeistof met behulp van een gas.
US4606939A (en) * 1983-06-22 1986-08-19 The Ohio State University Research Foundation Small particle formation
JPS61138529A (ja) * 1984-12-10 1986-06-26 Idemitsu Petrochem Co Ltd サイズ用乳化液の製造方法
US4606940A (en) 1984-12-21 1986-08-19 The Ohio State University Research Foundation Small particle formation and encapsulation
CH669336A5 (de) * 1985-12-11 1989-03-15 Sulzer Ag
DE3851106T2 (de) 1987-07-13 1994-12-01 Kinematica Gmbh Vorrichtung zum Mischen fliessfähiger Medien.
SE462704B (sv) 1987-12-09 1990-08-20 Hg Tech Ab Foerfarande vid atomisering av vaetskor och anordning foer genomfoerande av foerfarandet
DE3744329A1 (de) 1987-12-28 1989-07-06 Schwarz Pharma Gmbh Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung
AU624421B2 (en) 1988-10-05 1992-06-11 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
US5178325A (en) 1991-06-25 1993-01-12 Union Carbide Chemicals & Plastics Technology Corporation Apparatus and methods for application of coatings with compressible fluids as diluent by spraying from an orifice
US5891471A (en) * 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
WO1997031691A1 (en) * 1996-03-01 1997-09-04 The University Of Kansas Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
PT936893E (pt) * 1996-10-18 2001-12-28 Alza Corp Dispositivo com multiplos percursos de escoamento para a administracao oral de unidades discretas
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
TW580397B (en) * 1997-05-27 2004-03-21 Takeda Chemical Industries Ltd Solid preparation
US6342250B1 (en) * 1997-09-25 2002-01-29 Gel-Del Technologies, Inc. Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices
DE69811233T2 (de) * 1997-10-27 2003-11-20 Merck Patent Gmbh Feste lösungen und dispersionen von eines schlecht wasserlöslichen wirkstoffes

Also Published As

Publication number Publication date
EP1191998A1 (de) 2002-04-03
DE60022195D1 (de) 2005-09-29
MXPA01011099A (es) 2002-06-04
AU4792300A (en) 2000-11-21
AU759786B2 (en) 2003-05-01
NZ515146A (en) 2003-07-25
DE60022195T2 (de) 2006-06-29
EP1191998B1 (de) 2005-08-24
US6551532B1 (en) 2003-04-22
SE9901667D0 (sv) 1999-05-07
CA2368087A1 (en) 2000-11-16
JP2002543961A (ja) 2002-12-24
CN1350475A (zh) 2002-05-22
WO2000067892A1 (en) 2000-11-16
KR20020013871A (ko) 2002-02-21

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties