ATE302762T1 - Oxazolidinon-thioamide mit piperazinamid- substituenten - Google Patents

Oxazolidinon-thioamide mit piperazinamid- substituenten

Info

Publication number
ATE302762T1
ATE302762T1 AT01906529T AT01906529T ATE302762T1 AT E302762 T1 ATE302762 T1 AT E302762T1 AT 01906529 T AT01906529 T AT 01906529T AT 01906529 T AT01906529 T AT 01906529T AT E302762 T1 ATE302762 T1 AT E302762T1
Authority
AT
Austria
Prior art keywords
piperazinamide
thioamide
oxazolidinone
substituents
piperazinamide substituents
Prior art date
Application number
AT01906529T
Other languages
English (en)
Inventor
Jackson B Hester Jr
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Application granted granted Critical
Publication of ATE302762T1 publication Critical patent/ATE302762T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT01906529T 2000-02-10 2001-02-07 Oxazolidinon-thioamide mit piperazinamid- substituenten ATE302762T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18164000P 2000-02-10 2000-02-10
PCT/US2001/000682 WO2001058885A1 (en) 2000-02-10 2001-02-07 Oxazolidinone thioamides with piperazine amide substituents

Publications (1)

Publication Number Publication Date
ATE302762T1 true ATE302762T1 (de) 2005-09-15

Family

ID=22665142

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01906529T ATE302762T1 (de) 2000-02-10 2001-02-07 Oxazolidinon-thioamide mit piperazinamid- substituenten

Country Status (17)

Country Link
US (1) US20010047004A1 (de)
EP (1) EP1263742B1 (de)
JP (1) JP2003522763A (de)
KR (1) KR20020072311A (de)
CN (1) CN1395569A (de)
AR (1) AR029226A1 (de)
AT (1) ATE302762T1 (de)
AU (1) AU2001234428A1 (de)
BR (1) BR0107645A (de)
CA (1) CA2395648A1 (de)
CO (1) CO5271737A1 (de)
DE (1) DE60112903T2 (de)
ES (1) ES2248284T3 (de)
MX (1) MXPA02007719A (de)
NZ (1) NZ520696A (de)
PE (1) PE20011089A1 (de)
WO (1) WO2001058885A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6465456B2 (en) * 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
ATE321024T1 (de) * 2000-10-17 2006-04-15 Pharmacia & Upjohn Co Llc Verfahren zur herstellung von oxazolidinonverbindungen
WO2003072576A2 (en) * 2002-02-28 2003-09-04 Astrazeneca Ab Oxazolidinone derivatives, processes for their preparation, and pharmaceutical compositions containing them
NZ535592A (en) 2002-02-28 2006-07-28 Astrazeneca Ab 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents
CA2478502A1 (en) * 2002-04-01 2003-10-09 Cadila Healthcare Limited Novel antiinfective compounds, process for their preparation and pharmaceutical compositions containing them
TW200403240A (en) 2002-06-28 2004-03-01 Upjohn Co Difluorothioacetamides of oxazolidinones as antibacterial agents
TW200404069A (en) * 2002-06-28 2004-03-16 Upjohn Co Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent
EP1546140A2 (de) * 2002-07-11 2005-06-29 Wockhardt Limited Antimikrobielle oxazolidinone, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen
AU2003272071A1 (en) * 2002-07-11 2004-02-02 Wockhardt Limited Antibacterial substituted cyanomethyl (ene) piperidinophenyl oxazolidinones, process or their preparation, and pharmaceutical compositions containing them
AU2003253141A1 (en) * 2002-08-22 2004-03-11 Orchid Chemicals And Pharmaceuticals Ltd Novel antibacterial agents
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
ATE344036T1 (de) * 2002-11-21 2006-11-15 Pharmacia & Upjohn Co Llc N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinon-5- carbonsäureamid-derivate und verwandte verbindungen als antibakterielle mittel
MXPA06000228A (es) 2003-07-02 2006-06-27 Merck & Co Inc Antibioticos de oxazolidinona sustituidos con un grupo ciclopropilo y derivados de los mismos.
AU2004256085B2 (en) * 2003-07-02 2007-12-06 Kyorin, Pharmaceutical Co., Ltd. Cyclopropyl Group Substituted Oxazolydinone Antibiotics and Derivatives Thereof
EP2716647A3 (de) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Makrocyclische Verbindungen Und Verfahren Zu Deren Herstellung Und Anwendung
EP1928893A2 (de) 2005-08-24 2008-06-11 Rib-X Pharmaceuticals, Inc. Triazolverbindungen und verfahren zu ihrer herstellung und verwendung
EP1934237A2 (de) 2005-08-24 2008-06-25 Rib-X Pharmaceuticals, Inc. Triazolverbindungen und verfahren zu deren herstellung und anwendung
US20100210602A1 (en) * 2006-12-12 2010-08-19 The Johns Hopkins University PhoU (PerF), A PERSISTENCE SWITCH INVOLVED IN PERSISTER FORMATION AND TOLERANCE TO MULTIPLE ANTIBIOTICS AND STRESSES AS A DRUG TARGET FOR PERSISTER BACTERIA
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
JP5443342B2 (ja) * 2007-06-08 2014-03-19 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ピペリジン／ピペラジン誘導体
EP2152270B1 (de) 2007-06-08 2015-03-04 Janssen Pharmaceutica, N.V. Piperidin-/piperazin-derivate
ES2483898T3 (es) 2007-06-08 2014-08-08 Janssen Pharmaceutica, N.V. Derivados de piperidina/piperazina
WO2009001192A2 (en) * 2007-06-22 2008-12-31 Orchid Research Laboratories Limited Novel compounds and their use
PE20100083A1 (es) 2008-06-05 2010-02-17 Janssen Pharmaceutica Nv Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar
CN115466253B (zh) * 2021-06-16 2024-08-20 沈阳药科大学 含二硫代氨基甲酸酯结构的噁唑烷酮类化合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL238158A1 (en) * 1981-09-08 1984-11-19 Lilly Co Eli Method of obtaining new cephalosporin derivatives
FI19992555A7 (fi) * 1997-05-30 1999-11-30 Upjohn Co Antibakteerisia oksatosolidinoniaineita, joilla on tiokarbonyylifunktionaalisuus
AU9001598A (en) * 1997-09-11 1999-03-29 Hokuriku Seiyaku Co. Ltd Thiourea derivatives
JPH11322729A (ja) * 1998-03-09 1999-11-24 Hokuriku Seiyaku Co Ltd ジチオカルバミド酸誘導体
JP2000204084A (ja) * 1998-11-11 2000-07-25 Hokuriku Seiyaku Co Ltd チオカルバミド酸誘導体
EP1181288B1 (de) * 1999-05-27 2003-07-30 PHARMACIA & UPJOHN COMPANY Bizyklische oxazolidinone als antibakterielle mittel

Also Published As

Publication number Publication date
NZ520696A (en) 2004-03-26
CO5271737A1 (es) 2003-04-30
MXPA02007719A (es) 2002-10-11
WO2001058885A1 (en) 2001-08-16
JP2003522763A (ja) 2003-07-29
AR029226A1 (es) 2003-06-18
EP1263742B1 (de) 2005-08-24
KR20020072311A (ko) 2002-09-14
DE60112903T2 (de) 2006-06-14
PE20011089A1 (es) 2001-10-04
CN1395569A (zh) 2003-02-05
CA2395648A1 (en) 2001-08-16
DE60112903D1 (de) 2005-09-29
US20010047004A1 (en) 2001-11-29
ES2248284T3 (es) 2006-03-16
EP1263742A1 (de) 2002-12-11
BR0107645A (pt) 2002-10-08
AU2001234428A1 (en) 2001-08-20

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Legal Events

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