ATE302779T1 - Dihydro-2,3-benzodiazepinderivate - Google Patents

Dihydro-2,3-benzodiazepinderivate

Info

Publication number: ATE302779T1
Authority: AT; Austria
Prior art keywords: phenyl; alkyl; dihydro; benzodiazepine derivatives; amino
Prior art date: 1994-08-31

Application number

AT01114686T

Other languages

English (en)

Inventor

Benjamin Alan Anderson

Marvin Martin Hansen

Nancy Kay Harn

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-31

Filing date

1995-08-30

Publication date

2005-09-15

1995-08-30 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2005-09-15 Application granted granted Critical

2005-09-15 Publication of ATE302779T1 publication Critical patent/ATE302779T1/de

Links

-1 amino, aminomethyl Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
229940125681 anticonvulsant agent Drugs 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
UKJLNMAFNRKWGR-UHFFFAOYSA-N cyclohexatrienamine Chemical group NC1=CC=C=C[CH]1 UKJLNMAFNRKWGR-UHFFFAOYSA-N 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Anesthesiology (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT01114686T 1994-08-31 1995-08-30 Dihydro-2,3-benzodiazepinderivate ATE302779T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US29864594A	1994-08-31	1994-08-31
US41302995A	1995-03-28	1995-03-28

Publications (1)

Publication Number	Publication Date
ATE302779T1 true ATE302779T1 (de)	2005-09-15

Family

ID=26970798

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT01114686T ATE302779T1 (de)	1994-08-31	1995-08-30	Dihydro-2,3-benzodiazepinderivate
AT95930998T ATE212994T1 (de)	1994-08-31	1995-08-30	Dihydro-2,3-benzodiazepinderivate

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT95930998T ATE212994T1 (de)	1994-08-31	1995-08-30	Dihydro-2,3-benzodiazepinderivate

Country Status (12)

Country	Link
US (1)	US5795886A (de)
EP (3)	EP1157992B1 (de)
JP (1)	JP4131987B2 (de)
AT (2)	ATE302779T1 (de)
CA (1)	CA2198751C (de)
DE (2)	DE69525342T2 (de)
DK (2)	DK1157992T3 (de)
ES (2)	ES2244524T3 (de)
FI (1)	FI113049B (de)
NZ (1)	NZ292417A (de)
PT (2)	PT1157992E (de)
WO (1)	WO1996006606A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA972746B (en) *	1996-04-04	1998-10-09	Egyt Gyogyszervegyeszeti Gyar	Novel 2,3-benzodiazepine derivatives
HUP9701325A1 (hu)	1997-07-31	2000-08-28	Gyógyszerkutató Intézet Kft.	Új 2,3-benzodiazepin-származékok
HU9803014D0 (en) *	1998-12-23	1999-02-01	Egyt Gyogyszervegyeszeti Gyar	Novel phtalazine derivatives, process for their production and pharmaceutical compositions containing the same
HU227128B1 (en) *	1999-07-07	2010-07-28	Egyt Gyogyszervegyeszeti Gyar	New 2,3-benzodiazepine derivatives
US6649607B2 (en) *	2001-05-18	2003-11-18	Vela Pharmaceuticals, Inc.	Compositions and methods for treating or preventing convulsions or seizures
US6858605B2 (en) *	2003-02-04	2005-02-22	Ivax Drug Research Institute, Ltd.	Substituted 2,3-benzodiazepine derivatives
TW200902024A (en) *	2007-04-02	2009-01-16	Teva Pharma	Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents
CU20090172A7 (es)	2009-10-09	2011-10-05	Ct De Investigación Y Desarrollo De Medicamentos	Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU219778B (hu) *	1990-12-21	2001-07-30	Gyógyszerkutató Intézet Közös Vállalat	Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
HU206719B (en) *	1990-12-21	1992-12-28	Gyogyszerkutato Intezet	Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
HU219777B (hu) *	1993-07-02	2001-07-30	Gyógyszerkutató Intézet Kft.	Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására

1995
- 1995-08-30 DK DK01114686T patent/DK1157992T3/da active
- 1995-08-30 DE DE69525342T patent/DE69525342T2/de not_active Expired - Lifetime
- 1995-08-30 ES ES01114686T patent/ES2244524T3/es not_active Expired - Lifetime
- 1995-08-30 NZ NZ292417A patent/NZ292417A/en not_active IP Right Cessation
- 1995-08-30 WO PCT/US1995/010945 patent/WO1996006606A1/en not_active Ceased
- 1995-08-30 EP EP01114686A patent/EP1157992B1/de not_active Expired - Lifetime
- 1995-08-30 AT AT01114686T patent/ATE302779T1/de not_active IP Right Cessation
- 1995-08-30 EP EP95930998A patent/EP0771198B1/de not_active Expired - Lifetime
- 1995-08-30 ES ES95930998T patent/ES2170804T3/es not_active Expired - Lifetime
- 1995-08-30 PT PT01114686T patent/PT1157992E/pt unknown
- 1995-08-30 JP JP50892696A patent/JP4131987B2/ja not_active Expired - Fee Related
- 1995-08-30 DE DE69534407T patent/DE69534407T2/de not_active Expired - Lifetime
- 1995-08-30 US US08/776,892 patent/US5795886A/en not_active Expired - Fee Related
- 1995-08-30 DK DK95930998T patent/DK0771198T3/da active
- 1995-08-30 EP EP05015260A patent/EP1593683A3/de not_active Withdrawn
- 1995-08-30 PT PT95930998T patent/PT771198E/pt unknown
- 1995-08-30 CA CA002198751A patent/CA2198751C/en not_active Expired - Fee Related
- 1995-08-30 AT AT95930998T patent/ATE212994T1/de not_active IP Right Cessation
1997
- 1997-02-27 FI FI970833A patent/FI113049B/fi active

Also Published As

Publication number	Publication date
ES2170804T3 (es)	2002-08-16
EP1593683A2 (de)	2005-11-09
FI970833A0 (fi)	1997-02-27
DK1157992T3 (da)	2005-10-24
EP1593683A3 (de)	2006-10-25
AU689639B2 (en)	1998-04-02
DE69534407D1 (de)	2005-09-29
CA2198751C (en)	2006-07-11
JPH10505066A (ja)	1998-05-19
JP4131987B2 (ja)	2008-08-13
EP1157992B1 (de)	2005-08-24
EP0771198A1 (de)	1997-05-07
NZ292417A (en)	1998-09-24
FI970833L (fi)	1997-02-27
EP0771198A4 (de)	1997-05-28
WO1996006606A1 (en)	1996-03-07
DE69534407T2 (de)	2006-03-16
ATE212994T1 (de)	2002-02-15
CA2198751A1 (en)	1996-03-07
EP1157992A1 (de)	2001-11-28
AU3418695A (en)	1996-03-22
FI113049B (fi)	2004-02-27
HK1013794A1 (en)	1999-09-10
DE69525342T2 (de)	2002-11-07
PT1157992E (pt)	2005-10-31
DK0771198T3 (da)	2002-04-22
EP0771198B1 (de)	2002-02-06
DE69525342D1 (de)	2002-03-21
ES2244524T3 (es)	2005-12-16
PT771198E (pt)	2002-06-28
US5795886A (en)	1998-08-18

Legal Events

Date

Code

Title

Description

2006-11-15

UEP

Publication of translation of european patent specification

Ref document number: 1157992

Country of ref document: EP

2011-05-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE194335T1 (de)	2000-07-15	4,5-diaryloxazol-derivate
MX9800577A (es)	1998-04-30	Derivados de 4,5-diaril oxazol.
TW349098B (en)	1999-01-01	Naphthalene derivatives, process for the preparation thereof, and intermediates therefor
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
DE69328856D1 (de)	2000-07-20	Hypoglykämische Dihydrochalconderivate
NO983900L (no)	1995-10-12	Mellomprodukt for fremstilling av terapeutisk aktive forbindelser
DE69705829D1 (de)	2001-08-30	Meta-substituierte phenylsulphonamidderivate
WO2001062705A3 (en)	2003-01-16	Aminoalcohol derivatives
PE46699A1 (es)	1999-06-12	Compuesto derivado de indol
ES2126075T3 (es)	1999-03-16	Derivados biciclicos nitrogenados como inhibidores de la propil-endopeptidasa.
DK1157992T3 (da)	2005-10-24	Dihydro-2,3-benzodiazepinederivativer
MY128323A (en)	2007-01-31	Thiazole derivatives for inhibition of cytokine production and of cell adhesion
UA26459C2 (uk)	1999-08-30	Іhгібітор впливу амілоїдhих білків
IT1296924B1 (it)	1999-08-03	Composti diolici intermedi per la preparazione di composti ad attivita' antimicotica
DE69914880D1 (de)	2004-03-25	Substituierte 5-(2,2difluor-1,3-benzodioxol-5-yl) cyclopentenopyridinderivate
DE69124017D1 (de)	1997-02-20	Heterocyclische Derivate
MX9203265A (es)	1992-07-01	Compuestos inhibidores de la acil-coenzima a: colesterol acil transferasa.
DE60323862D1 (de)	2008-11-13	1,2,4-triazolderivat, verfahren zu dessen herstellung, und dieses enthaltende pharmazeutische zusammensetzung
ATE228359T1 (de)	2002-12-15	Hemmung der leukotrienbiosynthese mittels harnstoffderivaten
WO1996025933A3 (en)	1996-10-17	Use of vinyl carboxylic acid compounds for the treatment or prevention of transient ischaemic attacks