ATE303148T1 - Chinolin-harnstoff-derivate zur behandlung von entzugssyndrom und durch entzugssyndrom verursachten gehirnschaden - Google Patents

Chinolin-harnstoff-derivate zur behandlung von entzugssyndrom und durch entzugssyndrom verursachten gehirnschaden

Info

Publication number: ATE303148T1
Authority: AT; Austria
Prior art keywords: withdrawal; compounds; disclosed; withdrawal syndrome; brain damage
Prior art date: 1997-06-06

Application number

AT98926193T

Other languages

English (en)

Inventor

Boris Tabakoff

Lawrence Snell

Paula L Hoffman

Original Assignee

Lohocla Res Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-06

Filing date

1998-06-05

Publication date

2005-09-15

1998-06-05 Application filed by Lohocla Res Corp filed Critical Lohocla Res Corp

2005-09-15 Application granted granted Critical

2005-09-15 Publication of ATE303148T1 publication Critical patent/ATE303148T1/de

Links

208000007271 Substance Withdrawal Syndrome Diseases 0.000 title abstract 4
206010048010 Withdrawal syndrome Diseases 0.000 title abstract 4
230000006931 brain damage Effects 0.000 title abstract 2
231100000874 brain damage Toxicity 0.000 title abstract 2
208000029028 brain injury Diseases 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 2
239000005557 antagonist Substances 0.000 abstract 2
239000003795 chemical substances by application Substances 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 1
108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
229940125717 barbiturate Drugs 0.000 abstract 1
239000003874 central nervous system depressant Substances 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
230000002860 competitive effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229960004756 ethanol Drugs 0.000 abstract 1
231100000318 excitotoxic Toxicity 0.000 abstract 1
230000003492 excitotoxic effect Effects 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000004770 neurodegeneration Effects 0.000 abstract 1
229940127240 opiate Drugs 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
208000024891 symptom Diseases 0.000 abstract 1
102000008538 voltage-gated sodium channel activity proteins Human genes 0.000 abstract 1
108040002416 voltage-gated sodium channel activity proteins Proteins 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Addiction (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT98926193T 1997-06-06 1998-06-05 Chinolin-harnstoff-derivate zur behandlung von entzugssyndrom und durch entzugssyndrom verursachten gehirnschaden ATE303148T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4884897P	1997-06-06	1997-06-06
PCT/US1998/011312 WO1998055125A1 (en)	1997-06-06	1998-06-05	Compounds, compositions and method suitable for amelioration of withdrawal syndromes and withdrawal-induced brain damage

Publications (1)

Publication Number	Publication Date
ATE303148T1 true ATE303148T1 (de)	2005-09-15

Family

ID=21956770

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98926193T ATE303148T1 (de)	1997-06-06	1998-06-05	Chinolin-harnstoff-derivate zur behandlung von entzugssyndrom und durch entzugssyndrom verursachten gehirnschaden

Country Status (5)

Country	Link
EP (1)	EP1011676B1 (de)
AT (1)	ATE303148T1 (de)
AU (1)	AU7808898A (de)
DE (1)	DE69831416T2 (de)
WO (1)	WO1998055125A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7183413B2 (en)	2003-04-11	2007-02-27	Taigen Biotechnology	Aminoquinoline compounds
US7378524B2 (en)	2003-04-11	2008-05-27	Taigen Biotechnology Co., Ltd.	Aminoquinoline compounds
US7923458B2 (en) *	2005-10-07	2011-04-12	Lohocla Research Corporation	Method for treating chronic pain
CA2952451C (en)	2014-06-20	2022-08-23	Lohocla Research Corporation	Multifunctional aminoquinoline therapeutic agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5026700A (en) *	1989-05-16	1991-06-25	Merrell Dow Pharmaceuticals	Certain quinolines and thienopyridines as excitatory amino acid antagonists
US5606063A (en) *	1991-02-27	1997-02-25	Merrell Pharmaceuticals Inc.	NMDA antagonists
US5493027A (en) *	1993-01-22	1996-02-20	Board Of Regents, The University Of Texas System	Anticonvulsive agents and uses thereof

1998
- 1998-06-05 AU AU78088/98A patent/AU7808898A/en not_active Abandoned
- 1998-06-05 WO PCT/US1998/011312 patent/WO1998055125A1/en not_active Ceased
- 1998-06-05 AT AT98926193T patent/ATE303148T1/de not_active IP Right Cessation
- 1998-06-05 DE DE69831416T patent/DE69831416T2/de not_active Expired - Lifetime
- 1998-06-05 EP EP98926193A patent/EP1011676B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69831416D1 (de)	2005-10-06
EP1011676A1 (de)	2000-06-28
DE69831416T2 (de)	2006-06-14
WO1998055125A1 (en)	1998-12-10
EP1011676A4 (de)	2004-08-11
AU7808898A (en)	1998-12-21
EP1011676B1 (de)	2005-08-31

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Legal Events

Date	Code	Title	Description
2006-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties