ATE304592T1 - Automatisierung im proteinentwurf durch proteinbibliotheken - Google Patents

Automatisierung im proteinentwurf durch proteinbibliotheken

Info

Publication number
ATE304592T1
ATE304592T1 AT01925092T AT01925092T ATE304592T1 AT E304592 T1 ATE304592 T1 AT E304592T1 AT 01925092 T AT01925092 T AT 01925092T AT 01925092 T AT01925092 T AT 01925092T AT E304592 T1 ATE304592 T1 AT E304592T1
Authority
AT
Austria
Prior art keywords
protein
libraries
automation
design
protein design
Prior art date
Application number
AT01925092T
Other languages
English (en)
Inventor
Bassil I Dahiyat
Robert J Hayes
Joeerg Bentzien
Klaus M Fiebig
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc filed Critical Xencor Inc
Application granted granted Critical
Publication of ATE304592T1 publication Critical patent/ATE304592T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT01925092T 2000-02-10 2001-02-12 Automatisierung im proteinentwurf durch proteinbibliotheken ATE304592T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18163000P 2000-02-10 2000-02-10
US18690400P 2000-03-03 2000-03-03
US19785100P 2000-04-14 2000-04-14
PCT/US2001/040091 WO2001059066A2 (en) 2000-02-10 2001-02-12 Protein design automation for protein libraries

Publications (1)

Publication Number Publication Date
ATE304592T1 true ATE304592T1 (de) 2005-09-15

Family

ID=27391439

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01925092T ATE304592T1 (de) 2000-02-10 2001-02-12 Automatisierung im proteinentwurf durch proteinbibliotheken

Country Status (8)

Country Link
EP (1) EP1255826B1 (de)
JP (1) JP2003521933A (de)
AT (1) ATE304592T1 (de)
AU (1) AU5168701A (de)
CA (1) CA2399839A1 (de)
DE (1) DE60113381T2 (de)
DK (1) DK1255826T3 (de)
WO (1) WO2001059066A2 (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0974111B1 (de) 1997-04-11 2003-01-08 California Institute Of Technology Gerät und verfahren für automatischen protein-entwurf
US20020048772A1 (en) 2000-02-10 2002-04-25 Dahiyat Bassil I. Protein design automation for protein libraries
US6946265B1 (en) 1999-05-12 2005-09-20 Xencor, Inc. Nucleic acids and proteins with growth hormone activity
US7446174B2 (en) 2001-03-02 2008-11-04 Xencor, Inc. Protein based TNF-α variants for the treatment of TNF-α related disorders
US7687461B2 (en) 2000-03-02 2010-03-30 Xencor, Inc. Treatment of TNF-α related disorders with TNF-α variant proteins
US7662367B2 (en) 2000-03-02 2010-02-16 Xencor, Inc. Pharmaceutical compositions for the treatment of TNF-α related disorders
US7244823B2 (en) 2000-03-02 2007-07-17 Xencor TNF-alpha variants proteins for the treatment of TNF-alpha related disorders
US7351690B2 (en) 2000-12-19 2008-04-01 Palatin Technologies, Inc. Knockout identification of target-specific sites in peptides
CA2447407A1 (en) 2001-05-04 2002-11-14 Xencor Nucleic acids and proteins with thioredoxin reductase activity
US7381792B2 (en) 2002-01-04 2008-06-03 Xencor, Inc. Variants of RANKL protein
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US7747391B2 (en) 2002-03-01 2010-06-29 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
US7662925B2 (en) 2002-03-01 2010-02-16 Xencor, Inc. Optimized Fc variants and methods for their generation
US20050084907A1 (en) 2002-03-01 2005-04-21 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
DK2278509T3 (en) * 2002-03-01 2014-12-15 Codexis Mayflower Holdings Llc Methods, systems and software for identification of functional biomolecules
WO2003100701A1 (en) * 2002-05-28 2003-12-04 The Trustees Of The University Of Pennsylvania Methods, systems, and computer program products for computational analysis and design of amphiphilic polymers
DE10233047A1 (de) * 2002-07-19 2004-02-26 Amaxa Gmbh Verfahren zur Herstellung eines künstlichen Polypeptids und nach diesem Verfahren hergestelltes künstliches Protein
US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
US8084582B2 (en) 2003-03-03 2011-12-27 Xencor, Inc. Optimized anti-CD20 monoclonal antibodies having Fc variants
US20090010920A1 (en) 2003-03-03 2009-01-08 Xencor, Inc. Fc Variants Having Decreased Affinity for FcyRIIb
US8388955B2 (en) 2003-03-03 2013-03-05 Xencor, Inc. Fc variants
WO2004089421A2 (en) 2003-03-31 2004-10-21 Xencor, Inc Methods for rational pegylation of proteins
US7610156B2 (en) 2003-03-31 2009-10-27 Xencor, Inc. Methods for rational pegylation of proteins
US7642340B2 (en) 2003-03-31 2010-01-05 Xencor, Inc. PEGylated TNF-α variant proteins
US9051373B2 (en) 2003-05-02 2015-06-09 Xencor, Inc. Optimized Fc variants
US8101720B2 (en) 2004-10-21 2012-01-24 Xencor, Inc. Immunoglobulin insertions, deletions and substitutions
US9714282B2 (en) 2003-09-26 2017-07-25 Xencor, Inc. Optimized Fc variants and methods for their generation
JP2007512846A (ja) 2003-12-04 2007-05-24 ゼンコー・インコーポレイテッド 増加した宿主ストリング含有量を有する変異体タンパク質の生成方法およびその組成物
US7276585B2 (en) 2004-03-24 2007-10-02 Xencor, Inc. Immunoglobulin variants outside the Fc region
US20150010550A1 (en) 2004-07-15 2015-01-08 Xencor, Inc. OPTIMIZED Fc VARIANTS
US8802820B2 (en) 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
US8546543B2 (en) 2004-11-12 2013-10-01 Xencor, Inc. Fc variants that extend antibody half-life
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
DK1817340T3 (da) 2004-11-12 2012-08-13 Xencor Inc Fc-varianter med ændret binding til fcrn
US20090054252A1 (en) * 2005-01-03 2009-02-26 Martin Lanzendoerfer Hemopexin-Like Structure as New Polypeptide-Scaffold
US7557190B2 (en) 2005-07-08 2009-07-07 Xencor, Inc. Optimized proteins that target Ep-CAM
AU2006299429B2 (en) 2005-10-03 2012-02-23 Xencor, Inc. Fc variants with optimized Fc receptor binding properties
US7973136B2 (en) 2005-10-06 2011-07-05 Xencor, Inc. Optimized anti-CD30 antibodies
JP5825756B2 (ja) 2006-08-14 2015-12-02 ゼンコー・インコーポレイテッドＸｅｎｃｏｒ、 Ｉｎｃ． Ｃｄ１９を標的とする最適化抗体
WO2008036688A2 (en) 2006-09-18 2008-03-27 Xencor, Inc. Optimized antibodies that target hm1.24
WO2009008908A2 (en) 2007-02-12 2009-01-15 Codexis, Inc. Structure-activity relationships
DK2176298T3 (en) 2007-05-30 2018-02-12 Xencor Inc Methods and compositions for inhibiting CD32B-expressing cells
US20130338038A1 (en) 2007-12-21 2013-12-19 Pdl Biopharma, Inc. Method of screening complex protein libraries to identify altered properties
PL2808343T3 (pl) 2007-12-26 2019-11-29 Xencor Inc Warianty Fc ze zmienionym wiązaniem do FcRn
US12492253B1 (en) 2008-02-25 2025-12-09 Xencor, Inc. Anti-human C5 antibodies
US9493578B2 (en) 2009-09-02 2016-11-15 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
BR112012006678A2 (pt) * 2009-09-25 2016-05-10 Origene Technologies Inc método para criar um arranjo proteico, arranjo proteico e métodos para determinar a especificidade da ligação de um anticorpo ou preparação de anticorpos, para determinar biomarcadores de doenças, para diagnosticar uma doença, para monitorar as vias de transdução de sinais e para determinar interações entre pequenas moléculas e proteínas
US8362210B2 (en) 2010-01-19 2013-01-29 Xencor, Inc. Antibody variants with enhanced complement activity
CA3026880A1 (en) 2016-06-08 2017-12-14 Xencor, Inc. Methods and compositions for inhibiting cd32b expressing cells in igg4-related diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
GB9701425D0 (en) * 1997-01-24 1997-03-12 Bioinvent Int Ab A method for in vitro molecular evolution of protein function
EP0974111B1 (de) * 1997-04-11 2003-01-08 California Institute Of Technology Gerät und verfahren für automatischen protein-entwurf
AU8886798A (en) * 1997-08-28 1999-03-22 Isao Karube Method for detecting highly functional polypeptides or nucleic acids
WO2000023564A2 (en) * 1998-10-16 2000-04-27 Xencor, Inc. Protein design automation for protein libraries

Also Published As

Publication number Publication date
DK1255826T3 (da) 2006-01-30
JP2003521933A (ja) 2003-07-22
AU5168701A (en) 2001-08-20
WO2001059066A3 (en) 2002-04-11
EP1255826A2 (de) 2002-11-13
CA2399839A1 (en) 2001-08-16
EP1255826B1 (de) 2005-09-14
DE60113381D1 (de) 2005-10-20
DE60113381T2 (de) 2006-06-29
WO2001059066A2 (en) 2001-08-16

Similar Documents

Publication Publication Date Title
ATE304592T1 (de) Automatisierung im proteinentwurf durch proteinbibliotheken
WO2000023564A3 (en) Protein design automation for protein libraries
WO2003014325A3 (en) Protein design automation for protein libraries
DE60019458D1 (de) Stabilisierendes verdünnungsmittel für polypeptide und antigene
CY2019029I2 (el) Anti-tnf αντισωματα, συνθεσεις, μεθοδοi και χρησεις
SG157952A1 (en) Small molecule antagonists of bcl-2 family proteins
AU2002351239A8 (en) Antibody to latent membrane proteins and uses thereof
TNSN05254A1 (en) Derivatives of 2-acylamino-4-phenylthiazole, preparation method thereof and application of same in therapeutics
CY2014038I1 (el) Αντι-il-6 αντισωματα, συνθεσεις, μεθοδοι και χρησεις
ATE398676T2 (de) Antagonistische selektive bindungsagenzien des osteoprotegerin-bindungsproteins
WO2005058283A3 (en) Stabilised compositions of factor vii polypeptides
DK1084146T3 (da) Hybridprotein til inhibering af degranuleringen af mastocyter og anvendelse deraf
WO2002068453A3 (en) Methods and compositions for the construction and use of fusion libraries using computational protein design methods
EP1484699A3 (de) Automatisation im Proteindesign durch Proteinbanken
NO20031860L (no) Kahalalid F
IL145689A0 (en) Methods
DE60118935D1 (de) Dna & protein bindende miniatur proteine
IL176479A0 (en) Methods and compositions for identifying rna-binding proteins
TW200724159A (en) Stable emulsion composition
WO2004081033A3 (en) Synthesis of proteins by cell-free protein expression
AU2002365269A8 (en) Mut-il-18 or mut-il-18r proteins, antibodies, compositions, methods and uses
SE0002835D0 (sv) Method and kit for production of monoclonal antibodies
DK1444356T3 (da) Identifikation af epitoper og mindskelse af allergeniciteten af fødevareproteiner
BR0316544A (pt) Compostos calcilìticos
WO2004006864A3 (en) Methods and compositions for the enhancement of wound healing

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties