ATE304847T1 - Verwendung von cumarin oder seines hydroxy- derivats zur behandlung von mittelschwerem oder schwerem gefäss- und/oder lymphödem - Google Patents
Verwendung von cumarin oder seines hydroxy- derivats zur behandlung von mittelschwerem oder schwerem gefäss- und/oder lymphödemInfo
- Publication number
- ATE304847T1 ATE304847T1 AT01274892T AT01274892T ATE304847T1 AT E304847 T1 ATE304847 T1 AT E304847T1 AT 01274892 T AT01274892 T AT 01274892T AT 01274892 T AT01274892 T AT 01274892T AT E304847 T1 ATE304847 T1 AT E304847T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- hydroxy derivative
- lymphedema
- cumarin
- moderate
- Prior art date
Links
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 title abstract 5
- 230000002792 vascular Effects 0.000 title abstract 2
- PQMOXTJVIYEOQL-UHFFFAOYSA-N Cumarin Natural products CC(C)=CCC1=C(O)C(C(=O)C(C)CC)=C(O)C2=C1OC(=O)C=C2CCC PQMOXTJVIYEOQL-UHFFFAOYSA-N 0.000 title 1
- 206010025282 Lymphoedema Diseases 0.000 title 1
- FSOGIJPGPZWNGO-UHFFFAOYSA-N Meomammein Natural products CCC(C)C(=O)C1=C(O)C(CC=C(C)C)=C(O)C2=C1OC(=O)C=C2CCC FSOGIJPGPZWNGO-UHFFFAOYSA-N 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 title 1
- 208000002502 lymphedema Diseases 0.000 title 1
- 229960000956 coumarin Drugs 0.000 abstract 2
- 235000001671 coumarin Nutrition 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- CJIJXIFQYOPWTF-UHFFFAOYSA-N 7-hydroxycoumarin Natural products O1C(=O)C=CC2=CC(O)=CC=C21 CJIJXIFQYOPWTF-UHFFFAOYSA-N 0.000 abstract 1
- 206010030113 Oedema Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000001926 lymphatic effect Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IT2001/000613 WO2003047566A1 (en) | 2001-12-04 | 2001-12-04 | Use of coumarin or its hydroxy derivative for the treatment of medium or severe vascular and/or lymphatic edema |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE304847T1 true ATE304847T1 (de) | 2005-10-15 |
Family
ID=11133762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01274892T ATE304847T1 (de) | 2001-12-04 | 2001-12-04 | Verwendung von cumarin oder seines hydroxy- derivats zur behandlung von mittelschwerem oder schwerem gefäss- und/oder lymphödem |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1450788B8 (de) |
| AT (1) | ATE304847T1 (de) |
| AU (1) | AU2002217430A1 (de) |
| DE (1) | DE60113569T2 (de) |
| ES (1) | ES2249391T3 (de) |
| WO (1) | WO2003047566A1 (de) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5096887A (en) * | 1984-03-01 | 1992-03-17 | Lamorna Investments Proprietary Limited | Treatment of high protein oedemas |
| GB2168696B (en) * | 1984-12-21 | 1989-01-11 | Boehringer Biochemia Srl | Fluoro coumarins as antilymphoedema agents |
| US4616033A (en) * | 1985-03-14 | 1986-10-07 | Lamorna Investments Proprietary Ltd. | 7 hydroxy-coumarin as a treatment for high protein oedemas |
| DE3715990C2 (de) * | 1987-05-13 | 1993-10-28 | Schaper & Bruemmer Gmbh | Verwendung von Cumarin und 7-Hydroxy-cumarin |
| HUT72887A (en) * | 1994-02-18 | 1996-06-28 | Drossapharm Ag | Transdermal composition with controlled release |
| GB9722600D0 (en) * | 1997-10-24 | 1997-12-24 | Bio Monde Holdings Internation | Pharmaceutical compositon |
-
2001
- 2001-12-04 AT AT01274892T patent/ATE304847T1/de active
- 2001-12-04 WO PCT/IT2001/000613 patent/WO2003047566A1/en not_active Ceased
- 2001-12-04 AU AU2002217430A patent/AU2002217430A1/en not_active Abandoned
- 2001-12-04 DE DE60113569T patent/DE60113569T2/de not_active Expired - Lifetime
- 2001-12-04 EP EP01274892A patent/EP1450788B8/de not_active Expired - Lifetime
- 2001-12-04 ES ES01274892T patent/ES2249391T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1450788B1 (de) | 2005-09-21 |
| EP1450788B8 (de) | 2006-05-03 |
| EP1450788A1 (de) | 2004-09-01 |
| ES2249391T3 (es) | 2006-04-01 |
| DE60113569D1 (de) | 2006-02-02 |
| AU2002217430A1 (en) | 2003-06-17 |
| DE60113569T2 (de) | 2006-05-04 |
| WO2003047566A1 (en) | 2003-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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