ATE305000T1 - Sysntheseverfahren zur herstellung von indolylquinonen und mono- und bis-indolylquinone, die durch das verfahren hergestellt sind - Google Patents

Sysntheseverfahren zur herstellung von indolylquinonen und mono- und bis-indolylquinone, die durch das verfahren hergestellt sind

Info

Publication number: ATE305000T1
Authority: AT; Austria
Prior art keywords: indolylquinones; mono; bis; sysnthesic; producing
Prior art date: 1996-11-13

Application number

AT97946641T

Other languages

English (en)

Inventor

Peng C Tang

G David Harris

Original Assignee

Sugen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-13

Filing date

1997-11-12

Publication date

2005-10-15

1997-11-12 Application filed by Sugen Inc filed Critical Sugen Inc

2005-10-15 Application granted granted Critical

2005-10-15 Publication of ATE305000T1 publication Critical patent/ATE305000T1/de

Links

238000000034 method Methods 0.000 title abstract 3
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000002475 indoles Chemical class 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
238000010189 synthetic method Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Indole Compounds (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT97946641T 1996-11-13 1997-11-12 Sysntheseverfahren zur herstellung von indolylquinonen und mono- und bis-indolylquinone, die durch das verfahren hergestellt sind ATE305000T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US3060496P	1996-11-13	1996-11-13
US4298997P	1997-04-14	1997-04-14
US08/964,791 US5786488A (en)	1996-11-13	1997-11-05	Synthetic methods for the preparation of indolyquinones
PCT/US1997/020557 WO1998020874A1 (en)	1996-11-13	1997-11-12	Synthetic methods for the preparation of indolylquinones and mono- and bis-indolylquinones prepared therefrom

Publications (1)

Publication Number	Publication Date
ATE305000T1 true ATE305000T1 (de)	2005-10-15

Family

ID=27363680

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97946641T ATE305000T1 (de)	1996-11-13	1997-11-12	Sysntheseverfahren zur herstellung von indolylquinonen und mono- und bis-indolylquinone, die durch das verfahren hergestellt sind

Country Status (9)

Country	Link
US (3)	US5786488A (de)
EP (1)	EP0959881B1 (de)
JP (1)	JP2001504820A (de)
AT (1)	ATE305000T1 (de)
AU (1)	AU5177098A (de)
CA (1)	CA2271737A1 (de)
DE (1)	DE69734246T2 (de)
ES (1)	ES2251035T3 (de)
WO (1)	WO1998020874A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6376529B1 (en)	1995-06-07	2002-04-23	Peng Cho Tang	Mono- and bis-indolylquinones and prophylactic and therapeutic uses thereof
US6147106A (en) *	1997-08-20	2000-11-14	Sugen, Inc.	Indolinone combinatorial libraries and related products and methods for the treatment of disease
US5786488A (en) *	1996-11-13	1998-07-28	Sugen, Inc.	Synthetic methods for the preparation of indolyquinones
US6316429B1 (en)	1997-05-07	2001-11-13	Sugen, Inc.	Bicyclic protein kinase inhibitors
US6486185B1 (en)	1997-05-07	2002-11-26	Sugen, Inc.	3-heteroarylidene-2-indolinone protein kinase inhibitors
US6051597A (en) *	1997-06-13	2000-04-18	Merck & Co., Inc.	Indolylquinones as antidiabetic agents
US6114371A (en) *	1997-06-20	2000-09-05	Sugen, Inc.	3-(cyclohexanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors
CA2328607A1 (en) *	1998-04-02	1999-10-14	Kun Liu	Antidiabetic agents
JP2002516304A (ja) *	1998-05-22	2002-06-04	シオノギ・バイオリサーチ・コーポレーション	生体還元性細胞傷害剤
KR100743287B1 (ko)	1998-05-29	2007-07-26	수젠, 인크.	피롤기로 치환된 2-인돌리논 단백질 인산화 효소 억제제
US6689806B1 (en)	1999-03-24	2004-02-10	Sugen, Inc.	Indolinone compounds as kinase inhibitors
US6878733B1 (en)	1999-11-24	2005-04-12	Sugen, Inc.	Formulations for pharmaceutical agents ionizable as free acids or free bases
HRP20020751B1 (hr)	2000-02-15	2011-01-31	Sugen	Pirolom supstituirani 2-indolinoni kao inhibitori protein kinaze
AR042586A1 (es) *	2001-02-15	2005-06-29	Sugen Inc	3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
JP2005508953A (ja)	2001-10-10	2005-04-07	スージェン・インコーポレーテッド	キナーゼ阻害剤としての３−［４−（置換ヘテロサイクリル）−ピロール−２−イルメチリデン］−２−インドリノン誘導体
US7057052B2 (en) *	2002-09-26	2006-06-06	Duke University	Heterocyclic quinones as pharmaceutical agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3917820A (en) *	1969-05-29	1975-11-04	Canadian Patents Dev	Antibiotic cochliodinol and production by chaetomium, cochliodes and chaetomium globsum
ATE20680T1 (de) *	1982-04-30	1986-07-15	Ici Plc	Delignifizierung von lignocellulosematerial.
JPS6360966A (ja) *	1986-08-29	1988-03-17	Kyoto Yakuhin Kogyo Kk	キノン誘導体
CA2216806A1 (en)	1995-03-31	1996-10-03	Merck & Co., Inc.	Insulin mimetic and enhancer assay
US5786488A (en) *	1996-11-13	1998-07-28	Sugen, Inc.	Synthetic methods for the preparation of indolyquinones
KR19990022369A (ko) *	1995-06-07	1999-03-25	스테판 이반스-프레크	어뎁터 단백질/티로신 카이나제 상호작용을 방해하는 조성물과그 방법
US6376529B1 (en) *	1995-06-07	2002-04-23	Peng Cho Tang	Mono- and bis-indolylquinones and prophylactic and therapeutic uses thereof
US6051597A (en) *	1997-06-13	2000-04-18	Merck & Co., Inc.	Indolylquinones as antidiabetic agents
CA2328607A1 (en)	1998-04-02	1999-10-14	Kun Liu	Antidiabetic agents
US20030073837A1 (en) *	1998-12-31	2003-04-17	Langecker Peter J.	3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activity and for use in cancer chemotherapy

1997
- 1997-11-05 US US08/964,791 patent/US5786488A/en not_active Expired - Fee Related
- 1997-11-12 JP JP52274698A patent/JP2001504820A/ja not_active Withdrawn
- 1997-11-12 AT AT97946641T patent/ATE305000T1/de not_active IP Right Cessation
- 1997-11-12 ES ES97946641T patent/ES2251035T3/es not_active Expired - Lifetime
- 1997-11-12 AU AU51770/98A patent/AU5177098A/en not_active Abandoned
- 1997-11-12 EP EP97946641A patent/EP0959881B1/de not_active Expired - Lifetime
- 1997-11-12 CA CA002271737A patent/CA2271737A1/en not_active Abandoned
- 1997-11-12 WO PCT/US1997/020557 patent/WO1998020874A1/en not_active Ceased
- 1997-11-12 DE DE69734246T patent/DE69734246T2/de not_active Expired - Fee Related
1998
- 1998-05-05 US US09/072,861 patent/US6110957A/en not_active Expired - Fee Related
2000
- 2000-05-03 US US09/563,424 patent/US6750240B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0959881A4 (de)	2001-06-27
EP0959881A1 (de)	1999-12-01
EP0959881B1 (de)	2005-09-21
US6750240B2 (en)	2004-06-15
US6110957A (en)	2000-08-29
US20030060635A1 (en)	2003-03-27
DE69734246T2 (de)	2006-06-22
AU5177098A (en)	1998-06-03
CA2271737A1 (en)	1998-05-22
WO1998020874A1 (en)	1998-05-22
JP2001504820A (ja)	2001-04-10
US5786488A (en)	1998-07-28
ES2251035T3 (es)	2006-04-16
DE69734246D1 (de)	2006-02-02

Legal Events

Date	Code	Title	Description
2006-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69734246D1 (de)	2006-02-02	Sysntheseverfahren zur herstellung von indolylquinonen und mono- und bis-indolylquinone, die durch das verfahren hergestellt sind
ATE153332T1 (de)	1997-06-15	Verfahren zur herstellung von oxetanonen
ATE162529T1 (de)	1998-02-15	Verfahren zur herstellung von verbrückten, chiralen metallocenkatalysatoren des types bisindenyl
DE69020376D1 (de)	1995-08-03	Verfahren zur Herstellung von Mono- oder Dicarbonsäure-Stoffen, die durch langkettige Kohlenwasserstoffe substituiert sind.
DE69320980D1 (de)	1998-10-15	Verfahren zur herstellung von phytosphingosin-enthaltenden ceramiden und kosmetische zusammensetzungen, die diese enthalten
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ATE194142T1 (de)	2000-07-15	Verfahren zur herstellung von nukleotiden
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MY107819A (en)	1996-06-29	Preparation of substituted piperidines.
DE69007800D1 (de)	1994-05-11	Verfahren zur fermentativen Herstellung von L-Arginin.
ATA278988A (de)	1990-05-15	Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer
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HUT47091A (en)	1989-01-30	Process for producing tetrahydrobenzthiazols