ATE305000T1 - Sysntheseverfahren zur herstellung von indolylquinonen und mono- und bis-indolylquinone, die durch das verfahren hergestellt sind - Google Patents
Sysntheseverfahren zur herstellung von indolylquinonen und mono- und bis-indolylquinone, die durch das verfahren hergestellt sindInfo
- Publication number
- ATE305000T1 ATE305000T1 AT97946641T AT97946641T ATE305000T1 AT E305000 T1 ATE305000 T1 AT E305000T1 AT 97946641 T AT97946641 T AT 97946641T AT 97946641 T AT97946641 T AT 97946641T AT E305000 T1 ATE305000 T1 AT E305000T1
- Authority
- AT
- Austria
- Prior art keywords
- indolylquinones
- mono
- bis
- sysnthesic
- producing
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000010189 synthetic method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3060496P | 1996-11-13 | 1996-11-13 | |
| US4298997P | 1997-04-14 | 1997-04-14 | |
| US08/964,791 US5786488A (en) | 1996-11-13 | 1997-11-05 | Synthetic methods for the preparation of indolyquinones |
| PCT/US1997/020557 WO1998020874A1 (en) | 1996-11-13 | 1997-11-12 | Synthetic methods for the preparation of indolylquinones and mono- and bis-indolylquinones prepared therefrom |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE305000T1 true ATE305000T1 (de) | 2005-10-15 |
Family
ID=27363680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97946641T ATE305000T1 (de) | 1996-11-13 | 1997-11-12 | Sysntheseverfahren zur herstellung von indolylquinonen und mono- und bis-indolylquinone, die durch das verfahren hergestellt sind |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US5786488A (de) |
| EP (1) | EP0959881B1 (de) |
| JP (1) | JP2001504820A (de) |
| AT (1) | ATE305000T1 (de) |
| AU (1) | AU5177098A (de) |
| CA (1) | CA2271737A1 (de) |
| DE (1) | DE69734246T2 (de) |
| ES (1) | ES2251035T3 (de) |
| WO (1) | WO1998020874A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6376529B1 (en) | 1995-06-07 | 2002-04-23 | Peng Cho Tang | Mono- and bis-indolylquinones and prophylactic and therapeutic uses thereof |
| US5786488A (en) * | 1996-11-13 | 1998-07-28 | Sugen, Inc. | Synthetic methods for the preparation of indolyquinones |
| US6147106A (en) * | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US6486185B1 (en) | 1997-05-07 | 2002-11-26 | Sugen, Inc. | 3-heteroarylidene-2-indolinone protein kinase inhibitors |
| US6316429B1 (en) * | 1997-05-07 | 2001-11-13 | Sugen, Inc. | Bicyclic protein kinase inhibitors |
| US6051597A (en) * | 1997-06-13 | 2000-04-18 | Merck & Co., Inc. | Indolylquinones as antidiabetic agents |
| US6114371A (en) * | 1997-06-20 | 2000-09-05 | Sugen, Inc. | 3-(cyclohexanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors |
| EP1067925A4 (de) * | 1998-04-02 | 2003-04-16 | Merck & Co Inc | Antidiabetische verbindungen |
| AU750381B2 (en) * | 1998-05-22 | 2002-07-18 | Shionogi Bioresearch Corp. | Bioreductive cytotoxic agents |
| IL139934A0 (en) | 1998-05-29 | 2002-02-10 | Sugen Inc | Pyrrole substituted 2-indolinone derivatives and pharmaceutical compositions containing the same |
| US6689806B1 (en) | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
| US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
| AR034118A1 (es) * | 2000-02-15 | 2004-02-04 | Sugen Inc | Compuestos de 2-indolinonas sustituidas con pirroles inhibidoras de proteinquinasas; sus composiciones farmaceuticas e intermediarios de sintesis |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| MXPA04003385A (es) | 2001-10-10 | 2005-04-11 | Sugen Inc | Derivados de 3-?4-substituido con heterociclilo)-pirrol-2-ilmetilidene?-2-indolinona como inhibidores de cinasa. |
| US7057052B2 (en) * | 2002-09-26 | 2006-06-06 | Duke University | Heterocyclic quinones as pharmaceutical agents |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3917820A (en) * | 1969-05-29 | 1975-11-04 | Canadian Patents Dev | Antibiotic cochliodinol and production by chaetomium, cochliodes and chaetomium globsum |
| EP0095239B1 (de) * | 1982-04-30 | 1986-07-09 | Imperial Chemical Industries Plc | Delignifizierung von Lignocellulosematerial |
| JPS6360966A (ja) * | 1986-08-29 | 1988-03-17 | Kyoto Yakuhin Kogyo Kk | キノン誘導体 |
| EP0817967A4 (de) | 1995-03-31 | 2000-05-17 | Merck & Co Inc | Test für insulin nachahmende und verstärkende substanzen |
| IL122427A0 (en) * | 1995-06-07 | 1998-06-15 | Sugen Inc | Pharmaceutical compositions and methods for inhibition of adaptor protein/tyrosine kinase interactions |
| US6376529B1 (en) * | 1995-06-07 | 2002-04-23 | Peng Cho Tang | Mono- and bis-indolylquinones and prophylactic and therapeutic uses thereof |
| US5786488A (en) * | 1996-11-13 | 1998-07-28 | Sugen, Inc. | Synthetic methods for the preparation of indolyquinones |
| US6051597A (en) * | 1997-06-13 | 2000-04-18 | Merck & Co., Inc. | Indolylquinones as antidiabetic agents |
| EP1067925A4 (de) | 1998-04-02 | 2003-04-16 | Merck & Co Inc | Antidiabetische verbindungen |
| US20030073837A1 (en) * | 1998-12-31 | 2003-04-17 | Langecker Peter J. | 3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activity and for use in cancer chemotherapy |
-
1997
- 1997-11-05 US US08/964,791 patent/US5786488A/en not_active Expired - Fee Related
- 1997-11-12 JP JP52274698A patent/JP2001504820A/ja not_active Withdrawn
- 1997-11-12 AT AT97946641T patent/ATE305000T1/de not_active IP Right Cessation
- 1997-11-12 ES ES97946641T patent/ES2251035T3/es not_active Expired - Lifetime
- 1997-11-12 EP EP97946641A patent/EP0959881B1/de not_active Expired - Lifetime
- 1997-11-12 DE DE69734246T patent/DE69734246T2/de not_active Expired - Fee Related
- 1997-11-12 CA CA002271737A patent/CA2271737A1/en not_active Abandoned
- 1997-11-12 WO PCT/US1997/020557 patent/WO1998020874A1/en not_active Ceased
- 1997-11-12 AU AU51770/98A patent/AU5177098A/en not_active Abandoned
-
1998
- 1998-05-05 US US09/072,861 patent/US6110957A/en not_active Expired - Fee Related
-
2000
- 2000-05-03 US US09/563,424 patent/US6750240B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998020874A1 (en) | 1998-05-22 |
| AU5177098A (en) | 1998-06-03 |
| DE69734246D1 (de) | 2006-02-02 |
| EP0959881A1 (de) | 1999-12-01 |
| CA2271737A1 (en) | 1998-05-22 |
| ES2251035T3 (es) | 2006-04-16 |
| EP0959881B1 (de) | 2005-09-21 |
| JP2001504820A (ja) | 2001-04-10 |
| US5786488A (en) | 1998-07-28 |
| US6110957A (en) | 2000-08-29 |
| US20030060635A1 (en) | 2003-03-27 |
| EP0959881A4 (de) | 2001-06-27 |
| US6750240B2 (en) | 2004-06-15 |
| DE69734246T2 (de) | 2006-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |