ATE305037T1 - Peptide, die fähig sind die sh3-domäne des gap- proteins zu binden, ihre kodierende dns, ihre zubereitung und verwendung - Google Patents

Peptide, die fähig sind die sh3-domäne des gap- proteins zu binden, ihre kodierende dns, ihre zubereitung und verwendung

Info

Publication number
ATE305037T1
ATE305037T1 AT95941126T AT95941126T ATE305037T1 AT E305037 T1 ATE305037 T1 AT E305037T1 AT 95941126 T AT95941126 T AT 95941126T AT 95941126 T AT95941126 T AT 95941126T AT E305037 T1 ATE305037 T1 AT E305037T1
Authority
AT
Austria
Prior art keywords
domain
pct
binding
preparation
coding dna
Prior art date
Application number
AT95941126T
Other languages
English (en)
Inventor
Marc Duchesne
Didier Faucher
Fabienne Parker
Fabien Schweighoffer
Bruno Tocque
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9413955A external-priority patent/FR2727116B1/fr
Priority claimed from FR9505753A external-priority patent/FR2734266B1/fr
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE305037T1 publication Critical patent/ATE305037T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C07K14/4706—Guanosine triphosphatase activating protein, GAP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
AT95941126T 1994-11-22 1995-11-22 Peptide, die fähig sind die sh3-domäne des gap- proteins zu binden, ihre kodierende dns, ihre zubereitung und verwendung ATE305037T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9413955A FR2727116B1 (fr) 1994-11-22 1994-11-22 Peptides capables de se lier au domaine sh3 de la proteine gap, sequences nucleotidiques codant pour ces peptides, leur preparation et utilisation
FR9505753A FR2734266B1 (fr) 1995-05-16 1995-05-16 Peptides capables de se lier au domaine sh3 de la proteine gap sequences nucleotidiques codant pour ces peptides, leur preparation et utilisation
PCT/FR1995/001539 WO1996016169A1 (fr) 1994-11-22 1995-11-22 Peptides capables de se lier au domaine sh3 de la proteine gap, sequences nucleotidiques codant pour ces peptides, leur preparation et utilisation

Publications (1)

Publication Number Publication Date
ATE305037T1 true ATE305037T1 (de) 2005-10-15

Family

ID=26231549

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95941126T ATE305037T1 (de) 1994-11-22 1995-11-22 Peptide, die fähig sind die sh3-domäne des gap- proteins zu binden, ihre kodierende dns, ihre zubereitung und verwendung

Country Status (18)

Country Link
US (1) US5886150A (de)
EP (1) EP0793721B1 (de)
JP (2) JPH10509044A (de)
AT (1) ATE305037T1 (de)
AU (1) AU713937B2 (de)
BR (1) BR9510067A (de)
CA (1) CA2204438A1 (de)
CZ (1) CZ292538B6 (de)
DE (1) DE69534471T2 (de)
DK (1) DK0793721T3 (de)
ES (1) ES2248800T3 (de)
FI (1) FI972170L (de)
HU (1) HU221410B1 (de)
IL (1) IL116026A (de)
MX (1) MX9703364A (de)
NO (1) NO972313L (de)
SK (1) SK287034B6 (de)
WO (1) WO1996016169A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2780062B1 (fr) * 1998-06-17 2000-07-28 Rhone Poulenc Rorer Sa Anticorps monoclonaux diriges contre la proteine g3bp, et leurs utilisations
HK1042114B (zh) 1998-10-23 2006-09-29 Amgen K-A, Inc. 与mp1受体结合并具有血小板生成活性的模拟二聚体血小板生成素肽
US6864355B1 (en) 2000-05-02 2005-03-08 Yale University Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain
AU2001266070A1 (en) * 2000-06-16 2001-12-24 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Method for identifying apoptosis-modified proteins
EP1377828A4 (de) * 2001-04-10 2006-11-15 Childrens Medical Center Verfahren zur analyse und markierung von protein-protein-wechselwirkungen
WO2003006060A1 (en) * 2001-07-09 2003-01-23 Kyowa Hakko Kogyo Co., Ltd. Sh3 domain binding inhibitors
US20050069999A1 (en) * 2001-07-09 2005-03-31 Sharma Sreenath V Sh3 domain binding inhibitors
AUPR721101A0 (en) * 2001-08-23 2001-09-13 University Of Queensland, The Nucleic acid and polypeptide linked to breast cancer
CA2572765C (en) * 2004-07-08 2013-05-21 Amgen Inc. Compound having improved bioefficiency when administered in a multidose regimen
US7442778B2 (en) 2004-09-24 2008-10-28 Amgen Inc. Modified Fc molecules
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
US11237168B2 (en) 2019-06-26 2022-02-01 St. Jude Children's Research Hospital Method for identifying modulators of G3BP activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA894726B (en) * 1988-06-27 1990-03-28 Akzo Nv Coccidiosis vaccine
ATE181332T1 (de) * 1989-08-21 1999-07-15 Chiron Corp Vom gtpase-aktivierenden protein (gap) abgeleitete peptide sowie deren diagnostische und therapeutische verwendung
CA2057675A1 (en) * 1990-12-24 1992-06-25 Michael D. Schaber Peptide inhibitors of ras-gap interaction
FR2694296B1 (fr) * 1992-07-30 1994-09-02 Rhone Poulenc Rorer Sa Peptides inhibant l'activité des protéines ras, préparation et utilisation.
JPH08507204A (ja) * 1993-01-15 1996-08-06 シェリング・コーポレーション Ｒａｓ関連ｇａｐ蛋白質

Also Published As

Publication number Publication date
WO1996016169A1 (fr) 1996-05-30
CZ292538B6 (cs) 2003-10-15
FI972170A0 (fi) 1997-05-21
US5886150A (en) 1999-03-23
NO972313D0 (no) 1997-05-21
HU221410B1 (en) 2002-09-28
MX9703364A (es) 1997-08-30
CA2204438A1 (fr) 1996-05-30
CZ154597A3 (en) 1997-10-15
DK0793721T3 (da) 2006-01-30
DE69534471D1 (de) 2006-02-02
IL116026A (en) 2005-08-31
BR9510067A (pt) 1997-12-30
NO972313L (no) 1997-05-21
DE69534471T2 (de) 2006-06-22
JPH10509044A (ja) 1998-09-08
ES2248800T3 (es) 2006-03-16
HUT77029A (hu) 1998-03-02
AU4263696A (en) 1996-06-17
EP0793721B1 (de) 2005-09-21
JP2006122049A (ja) 2006-05-18
FI972170A7 (fi) 1997-05-21
AU713937B2 (en) 1999-12-16
SK287034B6 (sk) 2009-10-07
FI972170L (fi) 1997-05-21
EP0793721A1 (de) 1997-09-10
SK62997A3 (en) 1998-02-04
IL116026A0 (en) 1996-01-31

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