ATE305934T1 - Verfahren zur herstellung von maytansinol - Google Patents

Verfahren zur herstellung von maytansinol

Info

Publication number
ATE305934T1
ATE305934T1 AT02726608T AT02726608T ATE305934T1 AT E305934 T1 ATE305934 T1 AT E305934T1 AT 02726608 T AT02726608 T AT 02726608T AT 02726608 T AT02726608 T AT 02726608T AT E305934 T1 ATE305934 T1 AT E305934T1
Authority
AT
Austria
Prior art keywords
maytansinol
producing
preparing
producing maytansinol
unreduced
Prior art date
Application number
AT02726608T
Other languages
English (en)
Inventor
Gerald J Terfloth
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE305934T1 publication Critical patent/ATE305934T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AT02726608T 2001-03-16 2002-03-12 Verfahren zur herstellung von maytansinol ATE305934T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27679201P 2001-03-16 2001-03-16
PCT/US2002/007424 WO2002074775A1 (en) 2001-03-16 2002-03-12 Process for preparing maytansinol

Publications (1)

Publication Number Publication Date
ATE305934T1 true ATE305934T1 (de) 2005-10-15

Family

ID=23058083

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02726608T ATE305934T1 (de) 2001-03-16 2002-03-12 Verfahren zur herstellung von maytansinol

Country Status (7)

Country Link
US (2) US20020156274A1 (de)
EP (1) EP1373273B1 (de)
JP (1) JP2004526734A (de)
AT (1) ATE305934T1 (de)
DE (1) DE60206477T2 (de)
ES (1) ES2248550T3 (de)
WO (1) WO2002074775A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
AU2002311919B8 (en) 2001-05-11 2007-03-22 Ludwig Institute For Cancer Research Ltd Specific binding proteins and uses thereof
AU2003228998A1 (en) * 2002-05-13 2003-12-02 Smithkline Beecham Corporation Process for preparing maytansinol
JP2006510349A (ja) * 2002-08-08 2006-03-30 スミスクライン・ビーチャム・コーポレイション アンサミトシンの単離および精製方法
US7432088B2 (en) * 2003-05-08 2008-10-07 Immunogen Inc. Methods for the production of ansamitocins
ES2669585T3 (es) 2004-10-29 2018-05-28 The Regents Of The University Of California Micropartículas porosas de silicio para la entrega de fármaco para el ojo
US20070135629A1 (en) * 2005-12-08 2007-06-14 Millennium Pharmaceuticals, Inc. Isolation of ansamitocins
US9090693B2 (en) 2007-01-25 2015-07-28 Dana-Farber Cancer Institute Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
CA2680854C (en) 2007-03-15 2017-02-14 Ludwig Institute For Cancer Research Treatment method using egfr antibodies and src inhibitors and related formulations
CN108424454B (zh) 2007-08-14 2022-05-31 路德维格癌症研究所有限公司 靶向egf受体的单克隆抗体175及其衍生物和用途
KR20130009760A (ko) 2010-02-10 2013-01-23 이뮤노젠 아이엔씨 Ｃｄ２０ 항체 및 이의 용도
CN103604803B (zh) * 2013-11-11 2015-11-25 深圳大学 一种快速检测红酒中铁离子含量的方法
CN114533898B (zh) 2015-07-09 2025-07-01 加利福尼亚大学董事会 融合脂质体包被的多孔硅纳米颗粒
KR102667230B1 (ko) * 2019-03-01 2024-05-21 셀진 코포레이션 마이탄시놀의 제조
JP7772363B2 (ja) 2019-11-29 2025-11-18 日本マイクロバイオファーマ株式会社 メイタンシノールの酵素的生産方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151042A (en) * 1977-03-31 1979-04-24 Takeda Chemical Industries, Ltd. Method for producing maytansinol and its derivatives
US4162940A (en) * 1977-03-31 1979-07-31 Takeda Chemical Industries, Ltd. Method for producing Antibiotic C-15003 by culturing nocardia
CA2006408A1 (en) * 1988-12-27 1990-06-27 Susumu Iwasa Bispecific monoclonal antibody, its production and use
US5208020A (en) * 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US6333410B1 (en) * 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
US6441163B1 (en) * 2001-05-31 2002-08-27 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents

Also Published As

Publication number Publication date
DE60206477T2 (de) 2006-06-22
EP1373273A1 (de) 2004-01-02
EP1373273A4 (de) 2004-07-14
WO2002074775A1 (en) 2002-09-26
ES2248550T3 (es) 2006-03-16
US20020156274A1 (en) 2002-10-24
DE60206477D1 (de) 2006-02-16
JP2004526734A (ja) 2004-09-02
EP1373273B1 (de) 2005-10-05
US20050113571A1 (en) 2005-05-26

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Legal Events

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