ATE305934T1 - Verfahren zur herstellung von maytansinol - Google Patents

Verfahren zur herstellung von maytansinol

Info

Publication number: ATE305934T1
Authority: AT; Austria
Prior art keywords: maytansinol; producing; preparing; producing maytansinol; unreduced
Prior art date: 2001-03-16

Application number

AT02726608T

Other languages

English (en)

Inventor

Gerald J Terfloth

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-16

Filing date

2002-03-12

Publication date

2005-10-15

2002-03-12 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2005-10-15 Application granted granted Critical

2005-10-15 Publication of ATE305934T1 publication Critical patent/ATE305934T1/de

Links

QWPXBEHQFHACTK-UHFFFAOYSA-N Maytansinol Natural products CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-UHFFFAOYSA-N 0.000 title abstract 3
QWPXBEHQFHACTK-RZKXNLMUSA-N CO[C@@H]([C@@]1(O)C[C@H](OC(=O)N1)[C@@H](C)[C@@H]1O[C@@]1(C)[C@@H](O)CC(=O)N1C)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 Chemical compound CO[C@@H]([C@@]1(O)C[C@H](OC(=O)N1)[C@@H](C)[C@@H]1O[C@@]1(C)[C@@H](O)CC(=O)N1C)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-RZKXNLMUSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
QWPXBEHQFHACTK-KZVYIGENSA-N (10e,12e)-86-chloro-12,14,4-trihydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-15,16-dihydro-14h-7-aza-1(6,4)-oxazina-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-6-one Chemical compound CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-KZVYIGENSA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

AT02726608T 2001-03-16 2002-03-12 Verfahren zur herstellung von maytansinol ATE305934T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US27679201P	2001-03-16	2001-03-16
PCT/US2002/007424 WO2002074775A1 (en)	2001-03-16	2002-03-12	Process for preparing maytansinol

Publications (1)

Publication Number	Publication Date
ATE305934T1 true ATE305934T1 (de)	2005-10-15

Family

ID=23058083

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02726608T ATE305934T1 (de)	2001-03-16	2002-03-12	Verfahren zur herstellung von maytansinol

Country Status (7)

Country	Link
US (2)	US20020156274A1 (de)
EP (1)	EP1373273B1 (de)
JP (1)	JP2004526734A (de)
AT (1)	ATE305934T1 (de)
DE (1)	DE60206477T2 (de)
ES (1)	ES2248550T3 (de)
WO (1)	WO2002074775A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6333410B1 (en)	2000-08-18	2001-12-25	Immunogen, Inc.	Process for the preparation and purification of thiol-containing maytansinoids
US20100056762A1 (en)	2001-05-11	2010-03-04	Old Lloyd J	Specific binding proteins and uses thereof
US7589180B2 (en)	2001-05-11	2009-09-15	Abbott Laboratories Inc.	Specific binding proteins and uses thereof
AU2003228998A1 (en) *	2002-05-13	2003-12-02	Smithkline Beecham Corporation	Process for preparing maytansinol
WO2004015119A2 (en) *	2002-08-08	2004-02-19	Smithkline Beecham Corporation	Methods for the isolation and purification of ansamitocins
US7432088B2 (en) *	2003-05-08	2008-10-07	Immunogen Inc.	Methods for the production of ansamitocins
EP3381446A1 (de) *	2004-10-29	2018-10-03	The Regents of The University of California	Poröse photonische kristalle zur verabreichung von wirkstoffen ins auge
US20070135629A1 (en) *	2005-12-08	2007-06-14	Millennium Pharmaceuticals, Inc.	Isolation of ansamitocins
EP2126127B1 (de)	2007-01-25	2016-09-28	Dana-Farber Cancer Institute, Inc.	Verwendung von anti-egfr-antikörpern bei der behandlung von durch egfr-mutanten vermittelten krankheiten
CA2680854C (en)	2007-03-15	2017-02-14	Ludwig Institute For Cancer Research	Treatment method using egfr antibodies and src inhibitors and related formulations
US9283276B2 (en)	2007-08-14	2016-03-15	Ludwig Institute For Cancer Research Ltd.	Monoclonal antibody 175 targeting the EGF receptor and derivatives and uses thereof
US9173961B2 (en)	2010-02-10	2015-11-03	Immunogen, Inc.	CD20 antibodies and uses thereof
CN103604803B (zh) *	2013-11-11	2015-11-25	深圳大学	一种快速检测红酒中铁离子含量的方法
JP6894423B2 (ja)	2015-07-09	2021-06-30	ザリージェンツオブザユニバーシティオブカリフォルニアＴｈｅＲｅｇｅｎｔｓＯｆＴｈｅＵｎｉｖｅｒｓｉｔｙＯｆＣａｌｉｆｏｒｎｉａ	融合性リポソーム被覆多孔質ケイ素ナノ粒子
CN113825759B (zh) *	2019-03-01	2024-06-04	细胞基因公司	美登醇的制备
JP7772363B2 (ja)	2019-11-29	2025-11-18	日本マイクロバイオファーマ株式会社	メイタンシノールの酵素的生産方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4151042A (en) *	1977-03-31	1979-04-24	Takeda Chemical Industries, Ltd.	Method for producing maytansinol and its derivatives
US4162940A (en) *	1977-03-31	1979-07-31	Takeda Chemical Industries, Ltd.	Method for producing Antibiotic C-15003 by culturing nocardia
CA2006408A1 (en) *	1988-12-27	1990-06-27	Susumu Iwasa	Bispecific monoclonal antibody, its production and use
US5208020A (en) *	1989-10-25	1993-05-04	Immunogen Inc.	Cytotoxic agents comprising maytansinoids and their therapeutic use
US6333410B1 (en) *	2000-08-18	2001-12-25	Immunogen, Inc.	Process for the preparation and purification of thiol-containing maytansinoids
US6441163B1 (en) *	2001-05-31	2002-08-27	Immunogen, Inc.	Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents

2002
- 2002-03-11 US US10/095,927 patent/US20020156274A1/en not_active Abandoned
- 2002-03-12 EP EP02726608A patent/EP1373273B1/de not_active Expired - Lifetime
- 2002-03-12 ES ES02726608T patent/ES2248550T3/es not_active Expired - Lifetime
- 2002-03-12 JP JP2002573784A patent/JP2004526734A/ja active Pending
- 2002-03-12 AT AT02726608T patent/ATE305934T1/de not_active IP Right Cessation
- 2002-03-12 DE DE60206477T patent/DE60206477T2/de not_active Expired - Fee Related
- 2002-03-12 WO PCT/US2002/007424 patent/WO2002074775A1/en not_active Ceased
2004
- 2004-11-30 US US11/000,146 patent/US20050113571A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2004526734A (ja)	2004-09-02
EP1373273B1 (de)	2005-10-05
ES2248550T3 (es)	2006-03-16
US20020156274A1 (en)	2002-10-24
DE60206477T2 (de)	2006-06-22
US20050113571A1 (en)	2005-05-26
WO2002074775A1 (en)	2002-09-26
EP1373273A4 (de)	2004-07-14
EP1373273A1 (de)	2004-01-02
DE60206477D1 (de)	2006-02-16

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Legal Events

Date	Code	Title	Description
2006-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties