ATE305934T1 - Verfahren zur herstellung von maytansinol - Google Patents

Verfahren zur herstellung von maytansinol

Info

Publication number
ATE305934T1
ATE305934T1 AT02726608T AT02726608T ATE305934T1 AT E305934 T1 ATE305934 T1 AT E305934T1 AT 02726608 T AT02726608 T AT 02726608T AT 02726608 T AT02726608 T AT 02726608T AT E305934 T1 ATE305934 T1 AT E305934T1
Authority
AT
Austria
Prior art keywords
maytansinol
producing
preparing
producing maytansinol
unreduced
Prior art date
Application number
AT02726608T
Other languages
English (en)
Inventor
Gerald J Terfloth
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE305934T1 publication Critical patent/ATE305934T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AT02726608T 2001-03-16 2002-03-12 Verfahren zur herstellung von maytansinol ATE305934T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27679201P 2001-03-16 2001-03-16
PCT/US2002/007424 WO2002074775A1 (en) 2001-03-16 2002-03-12 Process for preparing maytansinol

Publications (1)

Publication Number Publication Date
ATE305934T1 true ATE305934T1 (de) 2005-10-15

Family

ID=23058083

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02726608T ATE305934T1 (de) 2001-03-16 2002-03-12 Verfahren zur herstellung von maytansinol

Country Status (7)

Country Link
US (2) US20020156274A1 (de)
EP (1) EP1373273B1 (de)
JP (1) JP2004526734A (de)
AT (1) ATE305934T1 (de)
DE (1) DE60206477T2 (de)
ES (1) ES2248550T3 (de)
WO (1) WO2002074775A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
DE60234094D1 (de) 2001-05-11 2009-12-03 Ludwig Inst For Cancer Res Ltd Spezifische bindungsproteine und ihre verwendung
US20050152913A1 (en) * 2002-05-13 2005-07-14 Eldridge Ann M. Process for preapring maytansinol
EP1627069A4 (de) * 2002-08-08 2010-06-02 Glaxosmithkline Llc Verfahren zur isolierung und reinigung von ansamitocinen
US7432088B2 (en) * 2003-05-08 2008-10-07 Immunogen Inc. Methods for the production of ansamitocins
ES2669585T3 (es) 2004-10-29 2018-05-28 The Regents Of The University Of California Micropartículas porosas de silicio para la entrega de fármaco para el ojo
US20070135629A1 (en) * 2005-12-08 2007-06-14 Millennium Pharmaceuticals, Inc. Isolation of ansamitocins
CA2676244C (en) 2007-01-25 2017-01-17 Kwok-Kin Wong Use of anti-egfr antibodies in treatment of egfr mutant mediated disease
CN101688229B (zh) 2007-03-15 2013-06-12 路德维格癌症研究所 包含egfr抗体和src抑制剂的组合物及其在制备用于治疗哺乳动物癌症的药物中的用途
CA2696360C (en) 2007-08-14 2018-11-20 Ludwig Institute For Cancer Research Monoclonal antibody targeting the egfr receptor and uses thereof
WO2011100403A1 (en) 2010-02-10 2011-08-18 Immunogen, Inc Cd20 antibodies and uses thereof
CN103604803B (zh) * 2013-11-11 2015-11-25 深圳大学 一种快速检测红酒中铁离子含量的方法
CN107920964B (zh) 2015-07-09 2022-02-25 加利福尼亚大学董事会 融合脂质体包被的多孔硅纳米颗粒
WO2020180709A1 (en) * 2019-03-01 2020-09-10 Celgene Corporation Preparation of maytansinol
EP4067497A4 (de) 2019-11-29 2024-03-13 MicroBiopharm Japan Co., Ltd. Verfahren zur enzymatischen herstellung von maytansinol

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4162940A (en) * 1977-03-31 1979-07-31 Takeda Chemical Industries, Ltd. Method for producing Antibiotic C-15003 by culturing nocardia
US4151042A (en) * 1977-03-31 1979-04-24 Takeda Chemical Industries, Ltd. Method for producing maytansinol and its derivatives
CA2006408A1 (en) * 1988-12-27 1990-06-27 Susumu Iwasa Bispecific monoclonal antibody, its production and use
US5208020A (en) * 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US6333410B1 (en) * 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
US6441163B1 (en) * 2001-05-31 2002-08-27 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents

Also Published As

Publication number Publication date
EP1373273B1 (de) 2005-10-05
DE60206477T2 (de) 2006-06-22
JP2004526734A (ja) 2004-09-02
US20020156274A1 (en) 2002-10-24
ES2248550T3 (es) 2006-03-16
US20050113571A1 (en) 2005-05-26
EP1373273A4 (de) 2004-07-14
EP1373273A1 (de) 2004-01-02
DE60206477D1 (de) 2006-02-16
WO2002074775A1 (en) 2002-09-26

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Legal Events

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