ATE305934T1 - Verfahren zur herstellung von maytansinol - Google Patents
Verfahren zur herstellung von maytansinolInfo
- Publication number
- ATE305934T1 ATE305934T1 AT02726608T AT02726608T ATE305934T1 AT E305934 T1 ATE305934 T1 AT E305934T1 AT 02726608 T AT02726608 T AT 02726608T AT 02726608 T AT02726608 T AT 02726608T AT E305934 T1 ATE305934 T1 AT E305934T1
- Authority
- AT
- Austria
- Prior art keywords
- maytansinol
- producing
- preparing
- producing maytansinol
- unreduced
- Prior art date
Links
- QWPXBEHQFHACTK-UHFFFAOYSA-N Maytansinol Natural products CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-UHFFFAOYSA-N 0.000 title abstract 3
- QWPXBEHQFHACTK-RZKXNLMUSA-N CO[C@@H]([C@@]1(O)C[C@H](OC(=O)N1)[C@@H](C)[C@@H]1O[C@@]1(C)[C@@H](O)CC(=O)N1C)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 Chemical compound CO[C@@H]([C@@]1(O)C[C@H](OC(=O)N1)[C@@H](C)[C@@H]1O[C@@]1(C)[C@@H](O)CC(=O)N1C)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-RZKXNLMUSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- QWPXBEHQFHACTK-KZVYIGENSA-N (10e,12e)-86-chloro-12,14,4-trihydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-15,16-dihydro-14h-7-aza-1(6,4)-oxazina-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-6-one Chemical compound CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-KZVYIGENSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27679201P | 2001-03-16 | 2001-03-16 | |
| PCT/US2002/007424 WO2002074775A1 (en) | 2001-03-16 | 2002-03-12 | Process for preparing maytansinol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE305934T1 true ATE305934T1 (de) | 2005-10-15 |
Family
ID=23058083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02726608T ATE305934T1 (de) | 2001-03-16 | 2002-03-12 | Verfahren zur herstellung von maytansinol |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20020156274A1 (de) |
| EP (1) | EP1373273B1 (de) |
| JP (1) | JP2004526734A (de) |
| AT (1) | ATE305934T1 (de) |
| DE (1) | DE60206477T2 (de) |
| ES (1) | ES2248550T3 (de) |
| WO (1) | WO2002074775A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| DK1392359T4 (da) | 2001-05-11 | 2013-06-10 | Ludwig Inst For Cancer Res Ltd | Specifikke bindingsproteiner og deres anvendelser. |
| JP2005525423A (ja) * | 2002-05-13 | 2005-08-25 | スミスクライン・ビーチャム・コーポレイション | メイタンシノールの調製方法 |
| JP2006510349A (ja) * | 2002-08-08 | 2006-03-30 | スミスクライン・ビーチャム・コーポレイション | アンサミトシンの単離および精製方法 |
| US7432088B2 (en) * | 2003-05-08 | 2008-10-07 | Immunogen Inc. | Methods for the production of ansamitocins |
| EP1817003B1 (de) | 2004-10-29 | 2018-02-21 | The Regents of The University of California | Poröse silicium-micropartikeln zur verabreichung von wirkstoffen ins auge |
| WO2007067698A2 (en) * | 2005-12-08 | 2007-06-14 | Millennium Pharmaceuticals, Inc. | Isolation of ansamitocins |
| US9090693B2 (en) | 2007-01-25 | 2015-07-28 | Dana-Farber Cancer Institute | Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease |
| JP5618549B2 (ja) | 2007-03-15 | 2014-11-05 | ルードヴィッヒ インスティテュート フォー キャンサーリサーチ リミテッド | Egfr抗体及びsrc阻害剤を用いる治療方法及び関連製剤 |
| JP5532486B2 (ja) | 2007-08-14 | 2014-06-25 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | Egf受容体を標的とするモノクローナル抗体175ならびにその誘導体および用途 |
| AR080154A1 (es) | 2010-02-10 | 2012-03-14 | Immunogen Inc | Anticuerpos cd20 y su utilizacion |
| CN103604803B (zh) * | 2013-11-11 | 2015-11-25 | 深圳大学 | 一种快速检测红酒中铁离子含量的方法 |
| WO2017008059A1 (en) | 2015-07-09 | 2017-01-12 | The Regents Of The University Of California | Fusogenic liposome-coated porous silicon nanoparticles |
| ES2949511T3 (es) * | 2019-03-01 | 2023-09-29 | Celgene Corp | Preparación de maitansinol |
| US12473579B2 (en) | 2019-11-29 | 2025-11-18 | Microbiopharm Japan Co., Ltd. | Method for enzymatically producing maytansinol |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4151042A (en) * | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
| US4162940A (en) * | 1977-03-31 | 1979-07-31 | Takeda Chemical Industries, Ltd. | Method for producing Antibiotic C-15003 by culturing nocardia |
| CA2006408A1 (en) * | 1988-12-27 | 1990-06-27 | Susumu Iwasa | Bispecific monoclonal antibody, its production and use |
| US5208020A (en) * | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US6333410B1 (en) * | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| US6441163B1 (en) * | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
-
2002
- 2002-03-11 US US10/095,927 patent/US20020156274A1/en not_active Abandoned
- 2002-03-12 ES ES02726608T patent/ES2248550T3/es not_active Expired - Lifetime
- 2002-03-12 EP EP02726608A patent/EP1373273B1/de not_active Expired - Lifetime
- 2002-03-12 JP JP2002573784A patent/JP2004526734A/ja active Pending
- 2002-03-12 AT AT02726608T patent/ATE305934T1/de not_active IP Right Cessation
- 2002-03-12 DE DE60206477T patent/DE60206477T2/de not_active Expired - Fee Related
- 2002-03-12 WO PCT/US2002/007424 patent/WO2002074775A1/en not_active Ceased
-
2004
- 2004-11-30 US US11/000,146 patent/US20050113571A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20050113571A1 (en) | 2005-05-26 |
| DE60206477T2 (de) | 2006-06-22 |
| EP1373273A1 (de) | 2004-01-02 |
| ES2248550T3 (es) | 2006-03-16 |
| JP2004526734A (ja) | 2004-09-02 |
| DE60206477D1 (de) | 2006-02-16 |
| EP1373273B1 (de) | 2005-10-05 |
| WO2002074775A1 (en) | 2002-09-26 |
| EP1373273A4 (de) | 2004-07-14 |
| US20020156274A1 (en) | 2002-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |