ATE306314T1 - Verfahren zur herstellung von partiklen unter verwendung einer überkritischen flüssigkeit - Google Patents

Verfahren zur herstellung von partiklen unter verwendung einer überkritischen flüssigkeit

Info

Publication number
ATE306314T1
ATE306314T1 AT99962400T AT99962400T ATE306314T1 AT E306314 T1 ATE306314 T1 AT E306314T1 AT 99962400 T AT99962400 T AT 99962400T AT 99962400 T AT99962400 T AT 99962400T AT E306314 T1 ATE306314 T1 AT E306314T1
Authority
AT
Austria
Prior art keywords
substance
compressible fluid
antisolvent
producing particles
stream
Prior art date
Application number
AT99962400T
Other languages
English (en)
Inventor
David Roy Merrified
Christopher Edmund Valder
John Peter Warr
Andrew Robert Souter
Petrus Paulus Corneli Avontuur
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10844704&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE306314(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of ATE306314T1 publication Critical patent/ATE306314T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
AT99962400T 1998-12-21 1999-12-21 Verfahren zur herstellung von partiklen unter verwendung einer überkritischen flüssigkeit ATE306314T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9828204.9A GB9828204D0 (en) 1998-12-21 1998-12-21 Process
PCT/GB1999/004355 WO2000037169A1 (en) 1998-12-21 1999-12-21 Process and apparatus for producing particles using a supercritical fluid

Publications (1)

Publication Number Publication Date
ATE306314T1 true ATE306314T1 (de) 2005-10-15

Family

ID=10844704

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99962400T ATE306314T1 (de) 1998-12-21 1999-12-21 Verfahren zur herstellung von partiklen unter verwendung einer überkritischen flüssigkeit

Country Status (11)

Country Link
US (1) US6830714B1 (de)
EP (1) EP1169117B2 (de)
JP (1) JP4718011B2 (de)
AT (1) ATE306314T1 (de)
AU (1) AU1876100A (de)
CY (1) CY1105172T1 (de)
DE (1) DE69932948T3 (de)
DK (1) DK1169117T4 (de)
ES (1) ES2251250T5 (de)
GB (1) GB9828204D0 (de)
WO (1) WO2000037169A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1049621A1 (zh) * 1999-06-09 2003-05-23 罗伯特‧E‧希弗斯 超临界流体辅助的喷雾和鼓泡乾燥
GB9920148D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel composition
CH694686A5 (it) * 2000-03-04 2005-06-15 Eco2 Sa Prodotto di micronizzazione di sostanze farmaceutiche.
AU2002221320B2 (en) * 2000-12-08 2006-06-15 The University Of Sydney Synthesis of small particles
GB0102075D0 (en) 2001-01-26 2001-03-14 Astrazeneca Ab Process
ATE274995T1 (de) 2001-02-26 2004-09-15 Dompe Spa Apparat und methode zur bildung von mikro- und submikropartikeln
DE10109829A1 (de) * 2001-03-01 2002-09-05 Celanese Ventures Gmbh Polymermembran, Verfahren zu deren Herstellung sowie deren Verwendung
US6869551B2 (en) 2001-03-30 2005-03-22 Picoliter Inc. Precipitation of solid particles from droplets formed using focused acoustic energy
US6596206B2 (en) 2001-03-30 2003-07-22 Picoliter Inc. Generation of pharmaceutical agent particles using focused acoustic energy
US6610223B2 (en) 2001-03-30 2003-08-26 Picoliter Inc. Focused acoustic energy in the generation of solid particles
US7276190B2 (en) 2001-07-02 2007-10-02 Micro & Nano Materials Sagl Process for the production of micro and/or nano particles
JP2005514188A (ja) 2001-12-07 2005-05-19 エイフェル テクノロジーズ リミテッド 小粒子の合成
AU2002365617B2 (en) * 2001-12-07 2008-04-03 Map Pharmaceuticals, Inc. Synthesis of small particles
JP2006512102A (ja) * 2002-04-11 2006-04-13 メディミューン・ヴァクシンズ・インコーポレーテッド 噴霧乾燥による生物活性材料の防腐
EP1494796B1 (de) * 2002-04-12 2014-06-04 Feyecon B.V. Verfahren zur herstellung von kleinen teilchen
DE10248619A1 (de) * 2002-10-18 2004-04-29 Bayer Ag Verfahren zur Herstellung pulverförmiger Wirkstoff-Formulierungen mit kompressiblen Fluiden
JP2004148174A (ja) * 2002-10-29 2004-05-27 Kobe Steel Ltd 超臨界流体を利用して微粒子を製造する方法および装置
JP3663408B2 (ja) * 2003-06-30 2005-06-22 株式会社アイテック 高温高圧水を用いる微粒子製造方法および微粒子製造装置
KR100603974B1 (ko) 2003-12-05 2006-07-25 김갑식 고체상 지질을 용매로 이용한 나노수준의 또는 비결정질입자의 제조 방법
WO2005073285A1 (ja) * 2004-01-28 2005-08-11 Japan Science And Technology Agency 超臨界流体からの貧溶媒中への急速膨張法を用いた微粒子製造法
EP1904219A4 (de) * 2005-07-15 2011-07-27 Map Pharmaceuticals Inc Teilchenbildungsverfahren
CN101772381A (zh) 2007-06-29 2010-07-07 瑞典树木科技公司 利用快速膨胀溶液在固体上制备超疏水表面的方法
PL2229233T3 (pl) * 2007-12-07 2020-03-31 Xspray Pharma Ab (Publ) Sposób wytwarzania cząstek
US20100294986A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Supercritical fluid facilitated particle formation in microfluidic systems
US20100298602A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Systems and methods for microfluidic crystallization
GB0915106D0 (en) 2009-08-28 2009-10-07 Glaxo Group Ltd Process
CN102858682B (zh) 2010-03-22 2014-07-16 株式会社Bio-Synectics 纳米颗粒制备方法
US9138705B2 (en) 2010-11-22 2015-09-22 Hong Kong Polytechnic University Method for precipitating a solute from a solution
DE102011105201A1 (de) * 2011-04-11 2012-10-11 Martin Ruda Luftkappe, Anordnung aus Haltering und Luftkappe und Farbleiteinrich-tung für eine Farbspritzpistole
WO2013136974A1 (ja) * 2012-03-12 2013-09-19 シャープ株式会社 修飾微粒子の精製方法および製造方法、修飾微粒子、機能性材料、光学部材、熱伝部材、ならびに、被覆率分析装置および被覆率分析方法
US8778181B1 (en) * 2013-03-14 2014-07-15 Crititech, Inc. Equipment assembly for and method of processing particles
US10239009B2 (en) 2013-03-14 2019-03-26 Lawrence Livermore National Security, Llc Continuously-operable flow stream processing system and method
US20170050337A1 (en) * 2013-05-02 2017-02-23 Melior Innovations, Inc. Formation apparatus, systems and methods for manufacturing polymer derived ceramic structures
JP6429949B2 (ja) * 2017-01-26 2018-11-28 タナベウィルテック株式会社 微粒子製造装置および微粒子製造方法
AU2018255063A1 (en) 2017-04-21 2018-11-22 Bio-Synectics Inc. Method for preparing active material nanoparticles using lipid as lubricant for milling
CN112007584A (zh) * 2020-08-31 2020-12-01 胡勇刚 一种油脂的超临界颗粒制备工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01176437A (ja) * 1987-12-29 1989-07-12 Ono Pharmaceut Co Ltd 有機物質の微粒化方法
US5639441A (en) † 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
AU709384B2 (en) 1996-03-01 1999-08-26 University Of Kansas, The Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
GB9622173D0 (en) * 1996-10-24 1996-12-18 Glaxo Group Ltd Particulate Products
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles

Also Published As

Publication number Publication date
ES2251250T3 (es) 2006-04-16
DK1169117T4 (da) 2009-06-15
DK1169117T3 (da) 2006-02-20
EP1169117A1 (de) 2002-01-09
CY1105172T1 (el) 2010-03-03
DE69932948T3 (de) 2009-08-13
AU1876100A (en) 2000-07-12
ES2251250T5 (es) 2009-07-06
JP2002532244A (ja) 2002-10-02
WO2000037169A1 (en) 2000-06-29
DE69932948T2 (de) 2007-01-11
US6830714B1 (en) 2004-12-14
DE69932948D1 (de) 2006-10-05
EP1169117B1 (de) 2005-10-12
GB9828204D0 (en) 1999-02-17
EP1169117B2 (de) 2009-03-18
JP4718011B2 (ja) 2011-07-06

Similar Documents

Publication Publication Date Title
DE69932948D1 (de) Verfahren zur herstellung von partiklen unter verwendung einer überkritischen flüssigkeit
DE69905460D1 (de) Verfahren und vorrichtung zur herstellung von partikeln
DE69506707D1 (de) Verfahren und vorrichtung zur herstellung von teilchen
EP0477845A1 (de) In-Linie-Dispersion eines Gases in einer Flüssigkeit
DE59500723D1 (de) Verfahren zur herstellung einer cellulosesuspension
DE19982310D2 (de) Verfahren und Vorrichtung zur Aufbereitung eines Organik enthaltenden Stoffgemisches
DE69501215D1 (de) Mischen flüssiger Substanzen
DE59602569D1 (de) Verfahren zur herstellung von dispersionen und zur durchführung chemischer reaktionen mit disperser phase
DE60201127D1 (de) Apparat und methode zur bildung von mikro- und submikropartikeln
DE69916651D1 (de) Verfahren und vorrichtung zum mischen von hochmolekularen materialien mit flüssigkeiten
GR3015518T3 (en) Method of producing collagen particles, and the use of such particles as substrates for active substances.
DE69100048D1 (de) Verfahren und vorrichtung zum verspruehen einer aufschlaemmung.
ATE105741T1 (de) Verfahren und vorrichtung zum auftragen von mehrkomponentenharzen und anwendungen derselben.
DE69226644D1 (de) Verfahren und vorrichtung zum mischen von gas in eine faser-suspension und bleichverfahren, das das genannte verfahren anwendet
ATE526355T1 (de) Verfahren zur herstellung von wässriger emulsion aus vernetzbarer siliconzusammensetzung sowie suspension von vernetzten siliconpartikeln, und vorrichtung hierzu
ATE336293T1 (de) Verfahren zur membranfiltration von flüssigkeiten und vorrichtung zur durchführung dieses verfahrens
ATE24883T1 (de) Verfahren und vorrichtung zur reduktion der geschwindigkeit von stroemenden medien.
ATE173179T1 (de) Verfahren zum auflösen von knollenförmigen feststoffen in flüssigkeiten und anlage zur durchführung des verfahrens
ATE440670T1 (de) Verfahren und vorrichtung zur bildung von gasblasen in einer flüssigkeit
DE69613850D1 (de) Verfahren und vorrichtung zum mischen von gummi- oder kunststoffmaterialen
ATE223761T1 (de) Verfahren und vorrichtung zur erzeugung eines feststoffaerosols
DE60011623D1 (de) Verfahren und vorrichtungen zur herstellung von emulsionen
NO974799D0 (no) Fremgangsmåte for röking av små partikler eller dråper i dispersjon, emulsjon eller oppslemming
ATE344827T1 (de) Verfahren zur beschichtung eines trägermaterials durch eine bindemittelemulsion

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1169117

Country of ref document: EP

UEP Publication of translation of european patent specification

Ref document number: 1169117

Country of ref document: EP