ATE307583T1 - Wasserfreie kristalline formen i und ii der 1- cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-1- piperazinyl) 4-oxo-1, 4-dihydroquinoline-3- carbonsäure (gatifloxacin) - Google Patents
Wasserfreie kristalline formen i und ii der 1- cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-1- piperazinyl) 4-oxo-1, 4-dihydroquinoline-3- carbonsäure (gatifloxacin)Info
- Publication number
- ATE307583T1 ATE307583T1 AT03723931T AT03723931T ATE307583T1 AT E307583 T1 ATE307583 T1 AT E307583T1 AT 03723931 T AT03723931 T AT 03723931T AT 03723931 T AT03723931 T AT 03723931T AT E307583 T1 ATE307583 T1 AT E307583T1
- Authority
- AT
- Austria
- Prior art keywords
- gatifloxacin
- dihydroquinoline
- piperazinyl
- cyclopropyl
- oxo
- Prior art date
Links
- XUBOMFCQGDBHNK-UHFFFAOYSA-N gatifloxacin Chemical compound FC1=CC(C(C(C(O)=O)=CN2C3CC3)=O)=C2C(OC)=C1N1CCNC(C)C1 XUBOMFCQGDBHNK-UHFFFAOYSA-N 0.000 title abstract 3
- 229960003923 gatifloxacin Drugs 0.000 title abstract 3
- XUBOMFCQGDBHNK-JTQLQIEISA-N (S)-gatifloxacin Chemical compound FC1=CC(C(C(C(O)=O)=CN2C3CC3)=O)=C2C(OC)=C1N1CCN[C@@H](C)C1 XUBOMFCQGDBHNK-JTQLQIEISA-N 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN259CH2002 | 2002-04-08 | ||
| IN285CH2002 | 2002-04-12 | ||
| PCT/US2003/010708 WO2003086402A1 (en) | 2002-04-08 | 2003-04-07 | ANHYDROUS CRYSTALLINE FORMS I AND II OF 1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-(3-METHYL-1-PIPERAZINYL) 4-OXO-l, 4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID (GATIFLOXACIN) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE307583T1 true ATE307583T1 (de) | 2005-11-15 |
Family
ID=33436351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03723931T ATE307583T1 (de) | 2002-04-08 | 2003-04-07 | Wasserfreie kristalline formen i und ii der 1- cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-1- piperazinyl) 4-oxo-1, 4-dihydroquinoline-3- carbonsäure (gatifloxacin) |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20060142300A1 (de) |
| EP (1) | EP1492535B1 (de) |
| AT (1) | ATE307583T1 (de) |
| AU (1) | AU2003230831A1 (de) |
| CA (1) | CA2481308A1 (de) |
| DE (1) | DE60302054T2 (de) |
| ES (1) | ES2248743T3 (de) |
| WO (1) | WO2003086402A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7423153B2 (en) | 2002-05-10 | 2008-09-09 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of gatifloxacin |
| EP1471911A1 (de) | 2002-06-14 | 2004-11-03 | Teva Pharmaceutical Industries Ltd. | Neue kristalline formen von gatifloxacin |
| JP2006508909A (ja) | 2002-08-06 | 2006-03-16 | テバ ファーマシューティカル インダストリーズ リミティド | ガチフロキサシンの新規な結晶形 |
| WO2004101527A1 (en) * | 2003-05-13 | 2004-11-25 | Cadila Healthcare Limited | Process for preparing omega-anhydrous gatifloxacin |
| ES2232310B1 (es) * | 2003-11-13 | 2006-08-01 | Quimica Sintetica, S.A. | Formula cristalina no higroscopica de gatifloxacino. |
| ES2232311B1 (es) * | 2003-11-13 | 2006-08-01 | Quimica Sintetica, S.A. | Forma cristalina de gatifloxacino. |
| US7781585B2 (en) | 2004-06-04 | 2010-08-24 | Matrix Laboratories Ltd | Crystalline forms of Gatifloxacin |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH089597B2 (ja) * | 1986-01-21 | 1996-01-31 | 杏林製薬株式会社 | 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法 |
| JPS63198664A (ja) * | 1986-03-31 | 1988-08-17 | Sankyo Co Ltd | キノロンカルボン酸誘導体 |
| JP3449658B2 (ja) * | 1994-12-21 | 2003-09-22 | 杏林製薬株式会社 | 安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法 |
-
2003
- 2003-04-07 AT AT03723931T patent/ATE307583T1/de not_active IP Right Cessation
- 2003-04-07 US US10/510,892 patent/US20060142300A1/en not_active Abandoned
- 2003-04-07 CA CA002481308A patent/CA2481308A1/en not_active Abandoned
- 2003-04-07 AU AU2003230831A patent/AU2003230831A1/en not_active Abandoned
- 2003-04-07 DE DE60302054T patent/DE60302054T2/de not_active Expired - Fee Related
- 2003-04-07 ES ES03723931T patent/ES2248743T3/es not_active Expired - Lifetime
- 2003-04-07 EP EP03723931A patent/EP1492535B1/de not_active Expired - Lifetime
- 2003-04-07 WO PCT/US2003/010708 patent/WO2003086402A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE60302054D1 (en) | 2005-12-01 |
| DE60302054T2 (de) | 2006-07-20 |
| EP1492535A1 (de) | 2005-01-05 |
| AU2003230831A1 (en) | 2003-10-27 |
| CA2481308A1 (en) | 2003-10-23 |
| EP1492535B1 (de) | 2005-10-26 |
| US20060142300A1 (en) | 2006-06-29 |
| ES2248743T3 (es) | 2006-03-16 |
| WO2003086402A1 (en) | 2003-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |